13 results about "Chronic toxicity testing" patented technology

The invention relates to the technical field of environment monitoring, in particular to a sediment heavy metal resuspension pollution evaluation system based on multi-dimensional data, which comprises a parameter acquisition module, a coupling resuspension simulation module, a heavy metal form migration calculation module and an ecological risk entropy evaluation module. The parameter acquisition module is used for acquiring hydrodynamic parameters, sediment heavy metal occurrence forms and biological disturbance intensity indexes; the coupling resuspension simulation module fuses hydrodynamic shear stress and biological irrigation flux and simulates resuspension concentration distribution; the heavy metal form migration calculation module combines the redox sensitive factor field and the exchangeable heavy metal concentration to calculate the dynamic release flux of the dissolved heavy metal; the ecological risk entropy evaluation module introduces an acute and chronic toxicity dual evaluation mechanism, constructs a pollution risk entropy matrix and generates a three-dimensional pollution risk entropy cloud picture. The method is suitable for dynamic evaluation and early warning of resuspension pollution risks in water bodies such as offshore water bodies, river mouths and lakes.

The invention discloses a rare and endangered organism toxicity prediction method based on a machine learning algorithm and a quantitative structure-activity relationship, which constructs a toxicity prediction model through the machine learning algorithm, can effectively assess the toxicity influence of environmental pollutants on rare and endangered organisms, and provides technical support for rare and endangered organism protection and ecological environment risk assessment. Comprising the following steps: 1, collecting data related to rare and endangered organisms from a public database, and establishing a rare and endangered organism toxicity prediction database based on machine learning; 2, generating molecular descriptors for the chemical substances; step 3, data preprocessing; 4, development of acute and chronic toxicity prediction models of rare and endangered organisms based on multiple machine learning is carried out, and performance evaluation is carried out; 5, performing internal and external verification on the rare and endangered biotoxicity prediction model; step 6, analyzing the importance of the features by using the valuable, rare and endangered biotoxicity prediction model, and finding out the most influential features; and 7, predicting the toxicity value of the pollutants in combination with the optimal machine learning model.

The invention relates to the technical field of environmental toxicology and ecological risk assessment, in particular to a system and a method for predicting chronic toxicity of bioaccumulation pollutants, and the system comprises a data acquisition and processing module, a model training and optimization module, a toxicity prediction module and an ecological risk assessment module. According to the method, full-process prediction is realized through data standardization, feature engineering, model training and model prediction; tissue residual toxicity data is obtained and standardized, a multi-dimensional characteristic matrix containing pollutant physicochemical properties, species biological characteristics and experimental conditions is constructed, a toxicity prediction model is optimized by using a machine learning algorithm, and tissue residual toxicity prediction of fishes in different life stages is realized. And calculating a risk quotient based on the predicted value, and generating a risk assessment report. The problems that an existing system depends on water body concentration toxicity data, is lack of biological accumulation pollutant chronic toxicity prediction capacity and does not aim at an endangered characteristic optimization model are solved.

This application discloses an online monitoring device, method, and medium for chronic toxicity of water bodies, relating to the field of water quality monitoring technology. A first culture tank is connected to a first and a second peristaltic pump, receiving nutrient solution and a reference water sample. A second culture tank is connected to a third and a fourth peristaltic pump, receiving nutrient solution and a test water sample. Both culture tanks contain test algal solutions and have overflow holes near the top. An environmental control component adjusts environmental parameters. Two fluorescence detection probes are respectively inserted into the two culture tanks. A control device controls the flow rate of the peristaltic pumps and acquires the fluorescence signals detected by the fluorescence detection probes. The fourth peristaltic pump continuously pumps the test water sample into the second culture tank, ensuring real-time water sample monitoring. The overflow holes in the culture tanks, and the control device adjusting the flow rate of the peristaltic pumps, allow the net algal growth to approach the overflow carry-out amount, maintaining a stable algal concentration within the culture tanks. Continuous replenishment of the nutrient solution meets the needs of the logarithmic growth phase, prolonging the logarithmic growth phase of the algae, thereby meeting the requirements for chronic toxicity monitoring.

This invention discloses a comprehensive toxicity evaluation and source tracing method for wastewater based on multi-indicator responses of algal cells. The method includes: adding the wastewater to be tested into an algal cell culture system for exposure and obtaining algal cell viability index values ​​at multiple exposure times; determining the pollution toxicity type of the wastewater based on a machine learning model and / or a multi-algal species combination detection method, and tracing the pollution source based on the pollution toxicity type; and evaluating the toxicity and risk of the wastewater based on the pollution toxicity type and algal cell viability index values ​​using a comprehensive toxicity evaluation system. This invention can identify toxicity types based on algal cell viability indicators and construct a comprehensive toxicity assessment system to comprehensively evaluate the toxicity and risk of wastewater, solving three major problems of existing technologies: static endpoint determination, neglect of species sensitivity differences, and missed detection of chronic toxicity.

This invention discloses a method and apparatus for mineralizing paralyzing shellfish poisoning by hydroxyl radicals, relating to the field of marine ecological disaster prevention and control. The method involves: oxygen entering an oxygen plasma generator, being ionized and dissociated to generate oxygen-active particle gas, which is injected into a gas-liquid mixer to efficiently generate a •OH solution, and then injected into a liquid-liquid mixer where it is broken down into a large number of tiny droplets; eight sampling ports are evenly spaced after the liquid-liquid mixer to measure the TRO gradient after mixing and dilution; the large number of •OH droplets rapidly mineralize the paralyzing shellfish poisoning while simultaneously killing the toxin-producing dinoflagellates; detection is performed at the eight sampling ports to establish efficacy-time models for •OH mineralization of shellfish poisoning and •OH mineralization of algae, and to determine the threshold values; the acute and chronic toxicity of the shellfish poisoning control group C2 and the treatment group C3 are evaluated, as are the acute and chronic toxicity of the dinoflagellate control group D2 and the treatment group D3; this invention provides a complete solution from source control to end-of-life assessment.

The present application relates to the technical field of environmental monitoring, and particularly relates to a sediment heavy metal resuspension pollution evaluation system based on multi-dimensional data, which comprises a parameter acquisition module, a coupled resuspension simulation module, a heavy metal form migration calculation module and an ecological risk entropy evaluation module. The parameter acquisition module is used for obtaining hydrological dynamic parameters, sediment heavy metal occurrence forms and biological disturbance intensity indexes; the coupled resuspension simulation module fuses hydrodynamic shear stress and biological irrigation flux to simulate resuspension concentration distribution; the heavy metal form migration calculation module combines redox sensitive factor fields and exchangeable heavy metal concentration to calculate dissolved heavy metal dynamic release flux; and the ecological risk entropy evaluation module introduces a dual evaluation mechanism of acute and chronic toxicity, constructs a pollution risk entropy matrix and generates a three-dimensional pollution risk entropy cloud chart. The present application is suitable for dynamic evaluation and early warning of resuspension pollution risk in water bodies such as near-shore, estuary and lake.

The application discloses a method for evaluating environmental risks of drugs in a water environment based on a fish plasma model, and belongs to the technical field of environmental toxicology and ecological risk assessment. The fish plasma-water distribution coefficient is calculated by a drug lipophilicity parameter (Log Dow), the fish steady-state plasma concentration is obtained by combining the measured / predicted environmental concentration, the fish treatment plasma concentration is converted by the difference between the half-inhibitory concentrations of the drug on fish and human, the pharmacological effect risk of the drug on fish is quantitatively evaluated by a risk quotient, and thus high-risk drugs are screened. Compared with the traditional risk quotient method, the application has the advantages of being in line with the drug action mechanism, taking into account the in-vivo enrichment effect, being high in evaluation accuracy, and not needing to rely on a large amount of acute / chronic toxicity data, and can efficiently support the priority control and risk management of drug pollutants in the water environment.

The invention discloses a method for obtaining an effect trigger value of an in-vitro genetic toxicity test of a water environment sample and application of the method. The method comprises the steps of determining and classifying positive compounds, determining the chronic toxicity minimum toxicity equivalent (SAFE TEQ) of the two positive compounds to aquatic organisms, determining the chronic toxicity HC5 TEQ of the two positive compounds to aquatic organisms, determining the clean TEQ of a representative clean water environment, deducing an effect trigger value of SOS / umu and the like. According to the method, the effect trigger value of the SOS / umu test of the water environment sample is effectively established, a method for judging the genetic toxicity risk of the water environment sample is formed, and technical support is provided for water quality risk assessment work.

The present application belongs to the technical field of zooplankton culture, and particularly relates to a culture medium for metal chronic toxicity experiment and application thereof. The culture medium provided by the present application does not contain EDTA or other chelating agents, and can also meet the normal reproduction and growth requirements of model organisms, is suitable for long-term culture of model organisms, is conducive to reducing the influence of the components of the culture medium on the bioavailability and toxicity evaluation and determination results of metals, improving the accuracy and reliability of the evaluation results, and thus more accurately determining the chronic toxicity or bioavailability of rare earth elements, and is conducive to accurately exploring the long-term ecological risk of rare earth elements, and provides a new reference approach for metal environmental standard formulation and scientific environmental decision-making.

The utility model belongs to the technical field of sewage toxicity exposure and detection, and particularly relates to an adjustable wastewater in-situ biological toxicity exposure and detection zoning device which comprises a detection shell, a partition plate which is detachable from the detection shell is arranged in the detection shell, and the interior of the detection shell is divided into a detection area and a biological chronic toxicity exposure area through the partition plate. An equipment storage box is arranged above one side of the detection shell, an aerator and a heating rod device are symmetrically placed in the storage box, and the aerator and the heating rod device penetrate through wire holes formed in the storage box through wires respectively to be connected with an external power source; the aeration machine conveys oxygen to the bottoms of the concentration detection areas and the biological chronic toxicity exposure areas through hoses, and a heating rod device of the aeration machine transmits a heat source to the corresponding detection areas or the biological chronic toxicity exposure areas through small holes in the bottom of the storage box; according to the utility model, simultaneous exposure of acute toxicity and chronic toxicity of wastewater organisms can be realized, and acute toxicity data and chronic toxicity biological samples can be obtained.

The application discloses a kind of triflufensulfuron-methyl metabolite prediction and preparation method, it is related to pesticide detection technical field, including M-1, M-2 and M-3;Wherein the structural formula of M-1: the structural formula of M-2: the structural formula of M-3: the application further provides the preparation method of triflufensulfuron-methyl main metabolite M-1, M-2 and M-3, the determination of its synthetic method is conducive to further carry out triflufensulfuron-methyl main metabolite in the adsorption / desorption of environment, leaching, migration and conversion environmental behavior research and to aquatic organisms (zebrafish, black shell shrimp), terrestrial animals (red aposhechens earthworm) and amphibian (tadpole) acute toxicity and chronic toxicity mechanism research.

The invention discloses a method for obtaining an effect trigger value of an in-vitro acute toxicity test of a water environment sample and application of the method. The method comprises the following steps: determining a photobacterium acute toxicity test positive compound; determining the chronic toxicity minimum toxicity equivalent (SAFE TEQ) of the photobacterium acute toxicity test positive compound to aquatic organisms; determining the chronic toxicity HC5TEQ of the photobacterium acute toxicity test positive compound to the aquatic organisms; determining the clean TEQ of the representative clean water environment; and determining the effect trigger value of the luminous inhibition test of the luminous bacteria in the water environment sample. According to the method, an effect trigger value of a luminous bacterium luminescence inhibition test is established, and particularly, an effect trigger value suitable for the luminous bacterium luminescence inhibition test of a water environment sample is deduced.