Method for predicting and evaluating toxicity of novel non-steroid anti-inflammatory agent pollutant based on daphnia magna toxicity

Abstract

The invention discloses a method for predicting and evaluating toxicity of a novel non-steroid anti-inflammatory agent pollutant based on daphnia magna. According to the method, daphnia magna is exposed to the novel non-steroid anti-inflammatory agent pollutant with equal logarithm spacing concentration, the survival rates of daphnia magna generated when the daphnia magna is exposed for 24 h, 48 h and 72 h, and the survival rate, the body length, the total number of shelling and egg carrying times and the total daphnia magna producing amount of the daphnia magna exposed for 21 d are recorded respectively; corresponding 24 h LC50, 48 h LC50 and 72 h LC50 are obtained through calculation of SPSS software and used for evaluating acute toxicity, and corresponding 21 d LC50, body length EC50, shelling EC50, egg carrying EC 50 and daphnia magna producing EC50 are obtained and used for evaluating chronic toxicity; thus, the toxicity characteristic and the toxicity level of the novel non-steroid anti-inflammatory agent pollutant are analyzed, tested and quantitatively described, meanwhile can serve as indexes for monitoring and evaluating biotoxicity of non-steroid anti-inflammatory agent sewage, and can provide reference for predicting and evaluating potential ecotoxicity risks of the pollutant in water.

Description

technical field [0001] The invention belongs to the technical field of environmental toxicology, and in particular relates to a method for predicting and evaluating the toxicity of non-steroidal anti-inflammatory drug new pollutants based on the toxicity of Daphnia magna. Background technique [0002] Widely used non-steroidal anti-inflammatory drugs not only alleviate the pain of human beings, but also bring a lot of environmental pollution and hazards. Exposure to low concentrations will cause adverse effects on aquatic organisms, and the potential risks cannot be ignored. However, the current toxicological research on NSAIDs still mainly focuses on the acute toxicity of short-term high-dose exposure simulated in the laboratory, and less research on the chronic toxicity caused by exposure to actual environmental levels. However, the acute toxicity data of NSAIDs are often much higher than the actual detection concentration (100-1000 times), therefore, in order to avoid ove...

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Problems solved by technology

[0003] The purpose of the present invention is to provide a non-steroidal anti-inflammatory drug based on the toxicity of Daphnia magna to solve the problem that the conventional physical and chemical indicators in the prior art cannot reflect the chronic toxicity of low-dose non-steroidal anti-inflammatory drug new pollutants in the actual environment. Toxicity prediction and evaluation methods of new pollutants, so as to realize the analysis, testing and quantitative description of the toxicity characteristics and toxicity levels of new pollutants of non-steroidal anti-inflammatory drugs

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