4results about How to "Low acute toxicity" patented technology

The invention provides a spirotetramat polyurethane / polyurea microcapsule suspending agent as well as a preparation method and application thereof, and belongs to the technical field of pesticide preparations. The preparation method comprises the following steps: mixing an oil-phase solution containing spirotetramat raw medicine and polyisocyanate with a water-phase solution containing an emulsifier and a dispersant, carrying out shear emulsification, adding a water-soluble wall material monomer water solution containing polyamine and / or polyol, and carrying out an interfacial polymerization reaction; after the polymerization is finished, sequentially carrying out curing treatment and cooling, then adding an auxiliary agent, and blending to obtain the spirotetramat polyurethane / polyurea microcapsule suspending agent. The spirotetramat microcapsule suspending agent is prepared through an interfacial polymerization method, spirotetramat is coated in a polyurethane or polyurea capsule wall, and the spirotetramat microcapsule suspending agent has the advantages of being high in encapsulation efficiency, good in physical and chemical stability, long in pesticide effect lasting period, safer to non-target organisms (such as bees) and the environment and the like. The preparation method is stable in process, easy for industrial production and excellent in product performance.

The application provides application of a nitrogen-doped carbon-based iron monatomic catalyst in degradation of ADC drugs in wastewater, and belongs to the technical field of advanced oxidation water treatment. The nitrogen-doped carbon-based iron monatomic catalyst with a two-dimensional wrinkled ultrathin morphology is prepared by a nano-magnesium oxide template assisted method. In application, the catalyst is dispersed in wastewater containing ADC drugs, stirred and adsorbed to adsorption equilibrium, then a proportion of persulfate is added, and reaction is carried out under the condition that pH is 3-9, so that efficient degradation of the ADC drugs is realized. The application has the advantages of high degradation efficiency, fast reaction speed, wide pH adaptation range, strong anion interference resistance, good broad-spectrum property, good catalyst stability and the like, and actual wastewater toxicity evaluation proves that the application has good detoxification capacity, and has wide application prospect in the field of treatment of refractory organic wastewater such as pharmaceutical wastewater and hospital wastewater.

The invention discloses a method for combining polygala tenuifolia with semen strychni and application thereof. A certain amount of polygala tenuifolia and semen strychni are decocted together or combined for use, so that the toxicity of the semen strychni can be remarkably reduced, and the LD50 value of several methods is obtained for the first time. Acetic acid twisting, mouse hot plate method experiments and mouse xylene induced ear swelling experiments are adopted to investigate the analgesic and anti-inflammatory effects before and after compatibility of the nux vomica with the polygala tenuifolia, and it is found for the first time that the anti-inflammatory and analgesic effects of the nux vomica can be increased in a polygala tenuifolia dose-dependent manner when the polygala tenuifolia is adopted for compatibility of the nux vomica. By adopting the method for matching the core-removed polygala tenuifolia with the sand-blanched semen strychni, the toxicity of the semen strychni can be remarkably reduced, and the anti-inflammatory and analgesic effects of the semen strychni can The method provides a new thought for the use, compatibility and processing of the nux vomica, and contributes to the improvement of the medication safety of the nux vomica.

The present invention relates to the field of medical technology, and in particular to an alkoxy-coupled naphthamide derivative and its preparation and application. The chemical structural formula of the alkoxy-coupled naphthamide derivative is shown in Formula I. The alkoxy-coupled naphthamide derivative described in Formula I of the present invention retains the basic skeleton of the binaphthyl structure of gossypol, introduces flexible and easily tortuous atomic chains between naphthalene rings to increase the molecular length, and modifies both ends of the molecule with amino acids, thereby reducing its toxicity, having the advantages of low acute toxicity and high drug safety, having broad-spectrum anti-tumor activity, and can be used as a broad-spectrum anti-tumor drug in clinical application.