59results about How to "Effective anti-inflammatory effect" patented technology

The invention relates to an external composition, and a preparation and an application thereof and belongs to the field of medicines. The external composition provided by the invention is a medicine composition which contains chlorhexidine or officinal salt thereof, or benzalkonium bromide or officinal salt thereof and a recombinant human epidermal growth factor or a recombinant cattle alkali fibroblast growth factor. According to the invention, the medicine composition is also further prepared into gel, liniment, ointment or paste, and the gel further comprises chitosan or officinal salt thereof and hyaluronic acid or officinal salt thereof. When being used for treating vagina inflammation, the external composition disclosed by the invention can improve a vagina microenvironment, promote growth of granulation tissue and repair vagina micro damage; and when being used for skin wound atraumatic restorative treatment, the external composition also can speed up restoration and regeneration of a wound tissue, promote healing and reduce scar formation, so that the external composition has a wide medical application prospect.

The invention belongs to the technical field of atherosclerotic targeted drugs, and discloses a medicine for resisting atherosclerotic inflammation and an anti-inflammatory effect detection method, and the medicine for resisting atherosclerotic inflammation is artesunate. The method for detecting the anti-inflammatory effect of the medicine for resisting atherosclerotic inflammation comprises thefollowing steps: performing an in-vitro experiment of using ox-LDL to induce VSMC phenotype to be converted into inflammatory phenotype cells; performing an in vivo experiment of using ox-LDL to induce VSMC phenotype to be converted into inflammatory phenotype cells. According to the invention, a molecular biology method is adopted, and the artesunate and target protein NLRP3 binding target is comprehensively investigated through a cell model and an animal model for inhibiting ox-LDL from inducing phenotypic transformation of VSMCs inflammatory cells by artesunate; and the anti-inflammatory effect and the molecular mechanism of artesunate in AS vascular inflammatory injury are illustrated by inhibiting the anti-inflammatory effect and the molecular mechanism of ox-LDL induced VSMCs inflammatory cell phenotypic transformation.

The present invention relates to an application of indole-2, 3-dione for preparing for an anti-inflammation drug. The indole-2, 3-dione is natural product or synthetic product with low toxicity, little side effect and good anti-inflammation and diminishing inflammation effects.

The invention relates to a medicine taking arctiin (or arctigenin) and beta 2 adrenergic receptor stimulant medicines as main active ingredients. The method provided by the invention is good in inflammation-diminishing effect while being used for effectively reducing the level of free calcium ions in cells and improving the relaxant effect of smooth muscle, avoids the risk of side effects caused by hormone after the long-time use of the composition of beta 2 adrenergic receptor stimulant medicines and glucocorticoids at present, and can be applied to treat chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease, and in particular, to treat asthma.

The invention relates to the fields of organic synthesis and pharmaceutical chemistry, and specifically relates to a cleistanone O-(benzimidazolyl) ethyl derivative, a preparation method thereof, and an application of the cleistanone O-(benzimidazolyl) ethyl derivative in the preparation of anti-inflammatory drugs. A novel cleistanone O-(benzimidazolyl) ethyl derivative is synthesized, and a preparation method thereof is disclosed. The pharmacological experiments show that the cleistanone O-(benzimidazolyl) ethyl derivative has an anti-inflammatory effect and can be used to develop anti-inflammatory drugs.

An application of the horny cell growing factor-2 in preparing the medicine in the form of vaginal suppository, effervescent tablet, gel, etc for treating chronic cervcitis is disclosed.

The invention relates to an intravenous injection lipid emulsion having anti-inflammatory and anti-thrombosis functions as well as a preparation method and an application thereof. The lipid emulsion consists of anti-inflammatory lipid, lipid having an anti-platelet aggregation function, an emulsifier, polyhydric alcohol and other pharmaceutical accessories, wherein the anti-inflammatory lipid is lipid which can form timnodonic acid or butyric acid through metabolism in vivo; and the lipid having an anti-platelet aggregation function is lipid which can form docosapentaenoic acid through metabolism in vivo. On one hand, the lipid emulsion disclosed by the invention can effectively relieve inflammatory reaction in patients, and can significantly reduce platelet aggregation and reduce the risk of high-risk thrombosis on the other hand. In addition, by virtue of reasonable lipid composition, the lipid emulsion can improve metabolism rate of fatty acid lipid and accelerate energy supply.

The invention provides application of magnesium hydride in preparation of a composition for preventing and treating chronic periodontitis, and magnesium hydride toothpaste. The weight percentage of magnesium hydride in the composition or the magnesium hydride toothpaste is 1-3%. The toothpaste has the effects of sterilizing, resisting inflammation, resisting oxidation, removing tooth stains, improving breath or halitosis, relieving redness, swelling and bleeding of gingiva and gingival recession, and improving periodontitis symptoms. The invention also discloses application of magnesium hydride in preparation of a composition for preventing and treating chronic periodontitis. According to the invention, a proper amount of magnesium hydride fine particles are added into the toothpaste body;and the magnesium hydride particles can be hydrolyzed into hydrogen and magnesium ions with an anti-inflammatory effect, and also can inhibit alveolar bone absorption. The composition containing magnesium hydride is safe to use, and can effectively prevent the occurrence and development of periodontal diseases after long-term use.

The invention relates to the fields of organic synthesis and medicinal chemistry, in particular to a composition, a preparation method and application of the composition to preparation of anti-inflammatory drugs. Through pharmacological experiments, the composition has anti-inflammatory effect and has anti-inflammatory drug development value.

Men and women general nursing bacteriostasis liquid comprises, by weight, 40-70 parts of lightyellow sophora roots, 20-50 parts of Pu lotus leaves, 10-20 parts of pine barks, 10-20 parts of wild honeysuckle immature flowers, 10-20 parts of dahurian angelica, 5-15 parts of common jasminorange leaf and twig extracts, 5-10 parts of borneol liquid, 0.5-2 parts of polyhexamethylene biguanidine hydrochloride and 1500-2000 parts of deionized water. The invention further provides a preparation method of the men and women general nursing bacteriostasis liquid. The prepared men and women general nursingbacteriostasis liquid serves as an externally applied agent and comprises effective components of the lightyellow sophora roots, the Pu lotus leaves, pine barks, the wild honeysuckle immature flowersand the dahurian angelica roots, the common jasminorange leaf and twig extracts, the borneol liquid and the polyhexamethylene biguanidine hydrochloride, the prepared bacteriostasis liquid is mild indrug property, drug efficacy is achieved from outside to inside, and male and female private inflammation can be effectively treated.

A medicine in the form of suppository for treating chronic cervicitis is prepared from horny cell growth factor-2, matrix, stabilizer, buffering agent and protecting agent.

The invention relates to the field of organic synthesis and medicinal chemistry, and in particular relates to a composition, a preparation method and an application of the composition in preparing an anti-inflammatory drug. The invention discloses a composition and a preparation method thereof. The pharmacology experiment proves that the composition has the anti-inflammatory effect, and has the value of developing anti-inflammatory drugs.

The invention relates to the field of organic synthesis and medicinal chemistry, in particular to a composition, a preparing method and application thereof to preparation of anti-inflammatory drugs. The invention discloses a composition and a preparing method thereof. The pharmacology experiments show that the composition has an anti-inflammatory function and has value of developing the anti-inflammatory drugs.

The invention relates to the field of organic synthesis and medicinal chemistry and in particular relates to a composition, a preparation method and an application of the composition to preparation of anti-inflammatory medicines. The invention discloses the composition and the preparation method thereof. Pharmacological experiments show that the composition has the anti-inflammatory effect and has the value in developing the anti-inflammatory medicines.

The invention relates to the field of organic synthesis and medicinal chemistry, in particular to a Daphmalenine A derivative, a preparation method and application of the Daphmalenine A derivative in preparation of anti-inflammatory drug. A new Daphmalenine A derivative is synthesized. Pharmacological experiments show that the Daphmalenine A derivative has anti-inflammatory effect and has value in developing the anti-inflammatory drug.

The invention relates to the fields of organic synthesis and medicinal chemistry, and in particular relates to a composition, a preparation method and application of the composition in preparing an anti-inflammatory drug. The invention discloses a composition and a preparation method thereof. Based upon pharmacological experiments, the composition disclosed by the invention has an anti-inflammatory effect, so that the composition has the value of developing the anti-inflammatory drug.

The invention relates to an intravenous injection lipid emulsion having anti-inflammatory and anti-thrombosis functions as well as a preparation method and an application thereof. The lipid emulsion consists of anti-inflammatory lipid, lipid having an anti-platelet aggregation function, an emulsifier, polyhydric alcohol and other pharmaceutical accessories, wherein the anti-inflammatory lipid is lipid which can form timnodonic acid or butyric acid through metabolism in vivo; and the lipid having an anti-platelet aggregation function is lipid which can form docosapentaenoic acid through metabolism in vivo. On one hand, the lipid emulsion disclosed by the invention can effectively relieve inflammatory reaction in patients, and can significantly reduce platelet aggregation and reduce the risk of high-risk thrombosis on the other hand. In addition, by virtue of reasonable lipid composition, the lipid emulsion can improve metabolism rate of fatty acid lipid and accelerate energy supply.

The invention relates to the fields of organic synthesis and medicinal chemistry, in particular to a composition, a preparation method and application of the composition in preparation of anti-inflammatory drugs. The invention discloses the composition and the preparation method thereof. A pharmacological experiment shows that the composition has the anti-inflammatory effect, and has the value for developing anti-inflammatory drugs.

The invention discloses an application of a composition of a pyrrolidine derivative and a morpholinyl derivative of Virosaine A to anti-inflammatory medicine, relates to the field of organic synthesis and medicinal chemistry, in particular to the composition, a preparing method and the application of the composition to anti-inflammatory medicine preparing, and discloses the composition and the preparing method thereof. Pharmacological experiments show that the composition has the anti-inflammatory effect, and has the anti-inflammatory medicine developing value.

The invention discloses application of a derivative composition of Harrisotone A to anti-inflammation, namely, application of a composition of an O-(diethylamine chloride)ethyl derivative and an O-di(2-methylmercapto-ethyl)amino derivative of the Harrisotone A to an anti-inflammation medicament. The invention relates to the fields of organic synthesis and pharmaceutical chemistry, in particular to a composition of Harrisotone A derivatives, a preparation method of the composition and application of the composition to preparation of an anti-inflammation medicament. The invention discloses a composition of Harrisotone A derivatives and a preparation method thereof. As proved by a pharmacology experiment, the composition of the Harrisotone A derivatives has an anti-inflammation effect, and has a value of developing the anti-inflammation medicament.

The invention belongs to the technical field of organic synthesis and medicinal chemistry, and in particular relates to a biotin-labeled naringin, a preparation method and an application thereof. The biotin-labeled naringin probe prepared by the present invention has the structural formula shown in formula (1), and the compound has a stable structure, simple synthesis and anti-inflammatory activity. Pharmacological experiments show that the biotin-labeled naringin probe of the present invention has better anti-inflammatory effect than independent naringin, and has the value of developing anti-inflammatory drugs; on the other hand, the biotin-labeled naringin It can be used as a molecular probe to explore the drug target of naringin, which is of great significance for exploring the mechanism of action of naringin in the inflammatory process.

The invention discloses a plant residue composition with anti-inflammatory effect and application thereof. The plant residue composition disclosed by the invention is composed of the following components by mass percent: 0.6-3.4% of safflower extraction residue, 0.5-4.1% of hawthorn extraction residue and 0.3-2.7% of panax notoginseng extraction residue. The plant residue composition has the effects of balancing oil secretion, inhibiting bacteria, diminishing inflammation and relieving itching when being applied to body wash.

The invention discloses an application of keratinocyte growth factor-2 in the preparation of medicine for treating chronic cervicitis. The keratinocyte growth factor-2 is used as an active ingredient to prepare vaginal suppositories, vaginal effervescent tablets, vaginal gels and other vaginal administration dosage forms. The obtained medicine has good anti-inflammation effect on chronic cervicitis, promotes the repair of cervical epithelium, and has the advantages of simple operation, good effect and no toxic or side effect.

The invention discloses an application of a composition of benzimidazolyl and 2-chloroethylamino derivatives of guava dialdehyde heteroterpene in preparing anti-inflammatory drugs, relates to the fields of organic synthesis and medicinal chemistry, and in particular relates to the composition of benzimidazolyl and 2-chloroethylamino derivatives of guava dialdehyde heteroterpene, a prepariaotn method of the composition, and the application of the composition in preparing the anti-inflammatory drugs. The invention discloses the composition of the benzimidazolyl and 2-chloroethylamino derivativesof guava dialdehyde heteroterpene and the preparation method of the composition. The pharmacological experiment shows that the composition of the benzimidazolyl and 2-chloroethylamino derivatives ofguava dialdehyde heteroterpene has the anti-inflammation effect and has the value of being developed into the anti-inflammatory drugs.

The invention provides a skin care product for pregnant women and a preparation method thereof. The preparation method comprises the following steps: adding iris leptophylla Lingelsh, vetiver and germinated quinoa into goat milk, mashing and uniformly mixing to obtain a mixed slurry, inoculating pseudoalteromonas, saccharomycetes and lactobacillus plantarum into the mixed slurry, fermenting to obtain a fermentation broth, adding sialic acid into the fermentation broth, ultrasonically oscillating uniformly to obtain a water phase; then taking moringa seeds, pomegranate seeds and indigo naturalis as raw materials, extracting to obtain mixed oil, then adding soybean lecithin, stirring and uniformly mixing to prepare an oil phase; and finally, slowly adding the water phase into the oil phase at a constant speed while stirring, stirring and emulsifying, and homogenizing to obtain the product. The skin care product provided by the invention adopts natural plant components, is mild and non-irritant, and has good use safety for pregnant women. The skin care product is a water-in-oil system, is more easily absorbed by human skin, plays a role in moisturizing, and effectively prevents and improves striae gravidarum.

The invention relates to the field of organic synthesis and medicinal chemistry, in particular to a composition, a preparation method of the composition and an application of the composition to preparation of anti-inflammatory drugs. According to the composition and the preparation method of the composition, pharmacology experiments show that the composition achieves the anti-inflammatory effect, and has the value for developing the anti-inflammatory drugs.

The invention relates to the field of organic synthesis and medicinal chemistry and particularly to an O-(pyrrolidine) ethyl derivative of Cleistanone, a preparation method for the O-(pyrrolidine) ethyl derivative of the Cleistanone and the application of the O-(pyrrolidine) ethyl derivative of the Cleistanone in preparing anti-inflammatory drugs. The invention synthesizes a novel O-(pyrrolidine) ethyl derivative of the Cleistanone and discloses the preparation method thereof. Pharmacological experiment results show that the O-(pyrrolidine) ethyl derivative of the Cleistanone has the anti-inflammatory effect and has the value of developing anti-inflammatory drugs.

The invention discloses an application of a composition of Salviskinone A benzimidazolyl and di(2-methylmercapto ethyl)amido derivatives in anti-inflammatory drugs, relates to the fields of organic synthesis and medicinal chemistry, and particularly relates to the composition of the Salviskinone A benzimidazolyl and di(2-methylmercapto ethyl)amido derivatives, and a preparation method and the application thereof in preparation of the anti-inflammatory drugs. Provided are the composition of the Salviskinone A benzimidazolyl and di(2-methylmercapto ethyl)amido derivatives and the preparation method thereof. Pharmacological experiments indicate that the composition has an anti-inflammatory effect and has the value for development of the anti-inflammatory drugs.

The invention discloses an application of an Atropurpuran derivative composition in anti-inflammation drugs, relates to the field of organic synthesis and medicinal chemistry and particularly relates to a composition, a preparation method and an application of the composition in preparing anti-inflammation drugs. The invention discloses the composition and the preparation method thereof. Pharmacological experiments indicate that the composition disclosed by the invention has an anti-inflammation effect and a value in developing anti-inflammation drugs.