8 results about "Chronic periodontitis" patented technology

The invention discloses a core-shell structure microneedle patch loaded with tetracycline antibacterial drugs and simvastatin as well as a preparation method and application of the core-shell structure microneedle patch, and belongs to the field of biomedical materials. An antibacterial drug doxycycline is loaded on a shell structure of a substrate layer and a needle body of the microneedle patch, and a core structure contains simvastatin-loaded polydopamine nanoparticles. The microneedle patch can release antibacterial drugs in stages, and the number of bacteria at local parts of a focus can be rapidly reduced in a short time through burst release of the antibacterial drugs in the first stage, so that inflammation spreading is controlled; in the second stage, the antibacterial medicine is slowly released, so that the formation of a new plaque biofilm is inhibited for a long time, meanwhile, simvastatin is slowly released, the effect of locally promoting osteogenesis is achieved, and the synergistic effect of antibiosis and bone regeneration is achieved. The compound has a good application prospect in the treatment of chronic periodontitis, especially intractable periodontitis combined with systemic diseases, such as chronic periodontitis combined with diabetes mellitus.

The application discloses application of Prussian blue in preparation of a medicine for treating chronic periodontitis and belongs to the technical field of medicines. The application solves the problem of treating chronic periodontitis. The application comprises application of Prussian blue in preparation of the medicine for treating chronic periodontitis. The application is mainly used for treating chronic periodontitis.

The invention discloses a periodontal brace for treating periodontitis in Uyghur medicine, and relates to the technical field of auxiliary devices for dental treatment. The tooth socket comprises a customized half-soft membrane tooth socket body, and a medicine storage groove is formed in the inner side of the tooth socket body corresponding to the periphery of gingiva and used for containing Uyghur medicine ointment. The tooth socket is ensured to be fit with the shape of the oral cavity through mold taking customization, the medicine storage groove can prolong the contact time of medicine and periodontium, the medicine storage groove is matched with pure natural Uyghur medicine to avoid the side effect of chemical medicine, and the tooth socket can be repeatedly used. The problems that an existing local treatment medicine is short in treatment effect and obvious in side effect are solved, the treatment effect and safety of chronic periodontitis are improved, and the traditional Chinese medicine composition is suitable for clinical periodontitis local medicine treatment scenes.

This invention provides a set of gingival crevicular fluid biomarkers for detecting acute and chronic periodontal inflammation, their applications, reagent kits, and methods for preparing the kits, belonging to the field of biomedical technology. The biomarkers of this invention include one or more of IL-1β, IL-6, IL-8, IL-17A, TNF-α, GM-CSF, IL-17F, MCP-1, and MIP-1a. Using the biomarkers provided by this invention or the kits prepared therefrom for the diagnosis of acute and chronic periodontal inflammation has the advantages of rapid detection, accuracy, and low cost, and has broad application prospects.

The invention belongs to the technical field of medical instruments, and provides a quantitative dosing device for treating chronic periodontitis, which comprises a dosing assembly and a clamping frame, one end of the clamping frame is provided with a holding rod, the other end of the clamping frame is provided with two groups of dosing heads, and the clamping frame is used for enabling the two dosing heads to clamp a periodontal pocket; the quantitative dosing assembly comprises a dosing box, a liquid medicine injection cavity and a cleaning liquid injection cavity are formed in the dosing box, the liquid medicine injection cavity and the cleaning liquid injection cavity are communicated with connectors respectively, a dosing head is communicated with one connector, and a switchable automatic injection mechanism is arranged in the dosing box. The switchable automatic injection mechanism is used for enabling the cleaning fluid in the cleaning fluid injection cavity to enter the dosing head and flushing a dosing part or enabling the liquid medicine in the liquid medicine injection cavity to enter the dosing head and be smeared on a periodontal pocket. The situation that medicine is unevenly smeared can be avoided, meanwhile, quantitative injection of liquid medicine can be achieved, and the problem that the dosage error is large is avoided.

The application discloses a core-shell structure microneedle patch loaded with tetracycline antibacterial drugs and simvastatin, a preparation method and application thereof, and belongs to the field of biomedical materials. The base layer and the shell structure of the needle body of the microneedle patch are loaded with antibacterial drugs doxycycline, and the inner core structure contains polydopamine nanoparticles loaded with simvastatin. The microneedle patch can release the antibacterial drugs in stages, rapidly reduces the number of bacteria in the lesion locally in a short time through the first stage of explosive release of antibacterial drugs, and then controls the spread of inflammation; the second stage of slow release of antibacterial drugs inhibits the formation of new plaque biofilm for a long time, and slowly releases simvastatin, plays a role in promoting local bone formation, and realizes the synergistic effect of antibiosis and bone regeneration. In chronic periodontitis, especially in refractory periodontitis combined with systemic diseases, for example, chronic periodontitis combined with diabetes, the application has a good application prospect in treatment.

The invention is applicable to the technical field of biological medicines, and provides a preparation method and application of albumin nanoparticles loaded with a phenolic network. According to the invention, an epigallocatechin gallate-copper (EGCG-Cu) metal phenolic network (EC NPs) is loaded in bovine serum albumin nanoparticles (BSANPs), so that an intelligent nano delivery system (BEC NPs) is constructed. The system can specifically target neutrophil at an inflammation site, release EC NPs in response to an inflammation microenvironment, improve the inflammation microenvironment and relieve inflammation damage by removing active oxygen, inhibiting formation of a trap outside the neutrophil, promoting polarization of macrophages to M2 type, inhibiting pyroptosis and other mechanisms. In-vivo experiments show that BEC NPs can promote alveolar bone regeneration and periodontal tissue repair, biocompatibility is good, and a nano treatment strategy with anti-inflammatory, immune regulation and tissue repair functions is provided for chronic periodontitis.

The invention discloses an application of keratin sulfate in diagnosis of chronic periodontitis, and relates to the technical field of biological medicines, and the technical key points are as follows: a detection kit taking keratin sulfate as a molecular marker, a keratin sulfate monoclonal antibody and a human keratin sulfate (KS) enzyme-linked immunosorbent assay kit are utilized, and the application of keratin sulfate in diagnosis of chronic periodontitis is realized. According to the method, the expression level of keratin sulfate in gingival crevicular fluid is detected, clinical diagnosis of chronic periodontitis is assisted, a novel diagnosis and treatment strategy is provided for chronic periodontitis patients with increased keratin sulfate level, and a diagnostic technical foundation is laid for realizing long-acting management of chronic periodontitis by combining a targeted keratin sulfate therapy.