This invention provides a set of gingival crevicular fluid biomarkers for detecting acute and chronic periodontal
inflammation, their applications,
reagent kits, and methods for preparing the kits, belonging to the field of
biomedical technology. The biomarkers of this invention include one or more of IL-1β, IL-6, IL-8, IL-17A, TNF-α, GM-CSF, IL-17F, MCP-1, and MIP-1a. Using the biomarkers provided by this invention or the kits prepared therefrom for the diagnosis of acute and chronic periodontal
inflammation has the advantages of
rapid detection, accuracy, and low cost, and has broad application prospects.