5 results about "Chronic periodontitis" patented technology

The invention discloses a core-shell structure microneedle patch loaded with tetracycline antibacterial drugs and simvastatin as well as a preparation method and application of the core-shell structure microneedle patch, and belongs to the field of biomedical materials. An antibacterial drug doxycycline is loaded on a shell structure of a substrate layer and a needle body of the microneedle patch, and a core structure contains simvastatin-loaded polydopamine nanoparticles. The microneedle patch can release antibacterial drugs in stages, and the number of bacteria at local parts of a focus can be rapidly reduced in a short time through burst release of the antibacterial drugs in the first stage, so that inflammation spreading is controlled; in the second stage, the antibacterial medicine is slowly released, so that the formation of a new plaque biofilm is inhibited for a long time, meanwhile, simvastatin is slowly released, the effect of locally promoting osteogenesis is achieved, and the synergistic effect of antibiosis and bone regeneration is achieved. The compound has a good application prospect in the treatment of chronic periodontitis, especially intractable periodontitis combined with systemic diseases, such as chronic periodontitis combined with diabetes mellitus.

The application discloses application of Prussian blue in preparation of a medicine for treating chronic periodontitis and belongs to the technical field of medicines. The application solves the problem of treating chronic periodontitis. The application comprises application of Prussian blue in preparation of the medicine for treating chronic periodontitis. The application is mainly used for treating chronic periodontitis.

The invention discloses a periodontal brace for treating periodontitis in Uyghur medicine, and relates to the technical field of auxiliary devices for dental treatment. The tooth socket comprises a customized half-soft membrane tooth socket body, and a medicine storage groove is formed in the inner side of the tooth socket body corresponding to the periphery of gingiva and used for containing Uyghur medicine ointment. The tooth socket is ensured to be fit with the shape of the oral cavity through mold taking customization, the medicine storage groove can prolong the contact time of medicine and periodontium, the medicine storage groove is matched with pure natural Uyghur medicine to avoid the side effect of chemical medicine, and the tooth socket can be repeatedly used. The problems that an existing local treatment medicine is short in treatment effect and obvious in side effect are solved, the treatment effect and safety of chronic periodontitis are improved, and the traditional Chinese medicine composition is suitable for clinical periodontitis local medicine treatment scenes.

This invention provides a set of gingival crevicular fluid biomarkers for detecting acute and chronic periodontal inflammation, their applications, reagent kits, and methods for preparing the kits, belonging to the field of biomedical technology. The biomarkers of this invention include one or more of IL-1β, IL-6, IL-8, IL-17A, TNF-α, GM-CSF, IL-17F, MCP-1, and MIP-1a. Using the biomarkers provided by this invention or the kits prepared therefrom for the diagnosis of acute and chronic periodontal inflammation has the advantages of rapid detection, accuracy, and low cost, and has broad application prospects.

The application discloses a core-shell structure microneedle patch loaded with tetracycline antibacterial drugs and simvastatin, a preparation method and application thereof, and belongs to the field of biomedical materials. The base layer and the shell structure of the needle body of the microneedle patch are loaded with antibacterial drugs doxycycline, and the inner core structure contains polydopamine nanoparticles loaded with simvastatin. The microneedle patch can release the antibacterial drugs in stages, rapidly reduces the number of bacteria in the lesion locally in a short time through the first stage of explosive release of antibacterial drugs, and then controls the spread of inflammation; the second stage of slow release of antibacterial drugs inhibits the formation of new plaque biofilm for a long time, and slowly releases simvastatin, plays a role in promoting local bone formation, and realizes the synergistic effect of antibiosis and bone regeneration. In chronic periodontitis, especially in refractory periodontitis combined with systemic diseases, for example, chronic periodontitis combined with diabetes, the application has a good application prospect in treatment.