14 results about "Bleeding wounds" patented technology

The invention is directed to a hemostasis therapeutic compression system including an apparatus and system to stop bleeding and assist recovery at a wound location. The hemostasis therapeutic compression apparatus includes a bladder having a transparent portion to visualize the bleeding wound location as well as having one side with an interface pressure sufficient to stop bleeding at the wound site, and the wrap has as an elongated tab as part of a hook and loop portion for self-application by the user or patient. The hemostasis therapeutic compression apparatus includes compression not just on the bleeding wound site but alongside the site for increased and faster recovery and less complications. The transparent portion of the bladder may be in the shape of a circle, oval, kidney, elongated kidney, square, rectangle, "U", "C", and other known shapes depending on the size and location of the bleeding wound site on the limb.

This invention belongs to the field of biomedical materials technology, specifically relating to an oxidized hyaluronic acid / carboxymethyl chitosan hemostatic sponge and its preparation method. The preparation method includes: oxidizing hyaluronic acid with sodium periodate to obtain oxidized hyaluronic acid; preparing aqueous solutions of oxidized hyaluronic acid and carboxymethyl chitosan; mixing the two solutions and forming a hydrogel through a Schiff base reaction between aldehyde and amino groups; cryogelatinizing the hydrogel at low temperature and then freeze-drying it under vacuum to obtain an expandable hemostatic sponge with a three-dimensional interconnected porous structure. Upon contact with blood, the sponge of this invention rapidly absorbs water and expands, increasing in volume by more than three times, forming a tight physical seal. Simultaneously, it adsorbs and activates platelets to accelerate coagulation, achieving highly efficient hemostasis. This sponge exhibits excellent biocompatibility, is completely degradable in vivo, and the preparation process is mild and requires no toxic cross-linking agents. It can be used for rapid hemostasis of deep, irregular, and non-compressible bleeding wounds.

A wound navigation device and method of evaluating a bleeding wound including the step of inserting the bleeding navigation device into a bleeding wound of an animal. The wound navigation device the bleeding navigation device includes a body, at least one light source arranged on and / or within the body, at least one optoelectronic sensor arranged on and / or within the body, and a processor operatively connected to the at least one light source and configured to receive detection data from the at least one optoelectronic sensor. Light is emitted from the at least one light source while the body is inserted into the bleeding wound. The at least one optoelectronic sensor detects reflected light while the body is inserted into the bleeding wound in order to determine direction of active bleeding source(s).

The invention is directed to a hemostasis therapeutic compression system including an apparatus and system to stop bleeding and assist recovery at a wound location. The hemostasis therapeutic compression apparatus includes a bladder having a transparent portion to visualize the bleeding wound location as well as having one side with an interface pressure sufficient to stop bleeding at the wound site, and the wrap has as an elongated tab as part of a hook and loop portion for self-application by the user or patient. The hemostasis therapeutic compression apparatus includes compression not just on the bleeding wound site but alongside the site for increased and faster recovery and less complications. The transparent portion of the bladder may be in the shape of a circle, oval, kidney, elongated kidney, square, rectangle, "U", "C", and other known shapes depending on the size and location of the bleeding wound site on the limb.

The utility model belongs to the field of surgical instruments, and provides a hemostasis clamping device for surgeries, which comprises a clamping cylinder, a clamping plate in sliding connection is arranged in the clamping cylinder, the vertical section of the clamping plate is U-shaped, the U-shaped vertical sections of the clamping plate are close to each other when the clamping plate moves towards the inside of the clamping cylinder, the front end of the clamping plate is symmetrically connected with mounting boxes, and the mounting boxes are fixedly connected with the clamping cylinder. Clamping parts extending oppositely are arranged in the mounting box, and the vertical sections of the clamping parts are rectangular, oval and triangular; the pulling assembly is located in the clamping cylinder, and the pulling assembly drives the clamping plates to be fixed at different positions in the clamping cylinder; according to the hemostatic clip, the quick change mechanism is arranged on the hemostatic clip, so that hemostatic clips of different models can be changed according to bleeding wounds of different sizes, and the clamping stability is improved.

A medical patch can comprise a biocompatible substrate and a dry hydrogel precursor layer on the substrate, the dry hydrogel precursor layer comprising an electrophilic-hydrogel precursor having a plurality of electrophilic functional groups and a nucleophilic-hydrogel precursor having a plurality of protonated amine groups and no more than about 2 weight percent water. Both the electrophilic-hydrogel precursor and the nucleophilic-hydrogel precursor are substantially uncrosslinked, and are blended or in direct contact with each other. The medical patches can be formed by coating a melt blend of hydrogel precursors in a dry environment or based on solution coating from a dry, non-aqueous solvent, onto a porous, hydrophilic substrate. The medical patches can be used for placement over a bleeding wound or the like and may function as a hemostatic patch. Shredded patches and compositions mimicking a shredded patch can be placed into a wound defect.

The present application provides a kind of degradable bio-based tissue adhesive material, which is formed by the one-step polymerization reaction of the light initiation of the complex of degradable amino acid end-capped bio-based supramolecular aqueous polyurethane, acrylic acid or its derivative and plasticizer, to form a transparent tissue adhesive material with double network structure.The adhesive material has the characteristics of instantaneous tissue adhesion, high bonding strength, high mechanical strength and plastic deformation capacity, and is suitable for biomedical fields such as rapid hemostasis of bleeding wounds, rapid closure of damaged wounds and repair of damaged soft tissues.The material also has biodegradability and excellent biocompatibility.In addition, compared with general tissue adhesive materials, the preparation process of the material is simple, the repetition rate is high, and the application range is wider.

This invention discloses a composite gel material for gingival hemostasis and its preparation method, comprising the following components by weight: 0.8-1.2 parts ZnO@polylysine-modified curcumin, 1.0-1.5 parts sodium alginate, 0.6-1.0 parts gelatin, 0.3-0.5 parts ammonium bicarbonate, and 0.15-0.3 parts β-cyclodextrin. This invention utilizes the hydrophilic chains of polyamino acids and the hydrophobic chains of curcumin, combined with ZnO nanoparticles, to form a stable composite structure. This, along with the carrier structure formed by sodium alginate and gelatin, creates a porous hydrophilic network and rigid support. Hemostatic, coagulation, and swelling properties mutually promote each other, meeting the need for rapid fluid absorption from large-area bleeding wounds while also exhibiting strong adhesion and durability, making it suitable for the dynamic environment of oral chewing and saliva flushing.

This invention belongs to the field of biomedical polymer hydrogel technology, and specifically relates to a photosensitive and thermosensitive hybrid rapid hemostatic hydrogel. The hydrogel components of this invention include poly(N-isopropylacrylamide) grafted modified gelatin, poly(N-isopropylacrylamide) modified hyaluronic acid, quaternized gelatin, photoresponsive molecule-modified hyaluronic acid, and photoinitiator LAP. Due to the presence of modified gelatin and hyaluronic acid, the hydrogel can effectively improve its adhesion to bleeding wounds and achieve effective hemostasis; the modified molecules used have photosensitive or thermosensitive environmental responsiveness, and by applying specific conditions, the curing speed of the hemostatic hydrogel can be accelerated, preventing the hydrogel components from being washed away by blood, thus enabling rapid wound hemostasis.

A medical patch can comprise a biocompatible substrate and a dry hydrogel precursor layer on the substrate, the dry hydrogel precursor layer comprising an electrophilic-hydrogel precursor having a plurality of electrophilic functional groups and a nucleophilic-hydrogel precursor having a plurality of protonated amine groups and no more than about 2 weight percent water. Both the electrophilic-hydrogel precursor and the nucleophilic-hydrogel precursor are substantially uncrosslinked, and are blended or in direct contact with each other. The medical patches can be formed by coating a melt blend of hydrogel precursors in a dry environment or based on solution coating from a dry, non-aqueous solvent, onto a porous, hydrophilic substrate. The medical patches can be used for placement over a bleeding wound or the like and may function as a hemostatic patch. Shredded patches and compositions mimicking a shredded patch can be placed into a wound defect.

The invention provides an entanglement-locked expansion protein-based tissue adhesive as well as a preparation method and application thereof. According to the preparation method, a protein structure is destroyed by utilizing a disulfide bond reducing agent to obtain expanded protein with exposed hydrophobic groups, and then the expanded protein is subjected to strong interaction (electrostatic interaction and hydrogen bond) through polyelectrolyte and the expanded protein; the lock unfolds the exposed hydrophobic groups on the surface of the protein to stably expose the hydrophobic groups and lock chain entanglement therebetween. The entangled-locked expanded protein-based tissue adhesive has a stably exposed hydrophobic group, and has the advantages of strong hydrophobic property, strong adhesive force, stable adhesive property, excellent body performance (high storage modulus), good biocompatibility and good degradability. In addition, when the entangled-locked expansion protein-based tissue adhesive is applied to bleeding wounds, the hemostatic effect is achieved, the hemostatic time is remarkably shortened, the wound blood loss amount is remarkably reduced, and the excellent hemostatic plugging effect is achieved.

A method and composite for treating a wound. A wound is sprayed with a composition that includes a volatile organic solvent, a biocompatible polymer and turmeric powder. The solvent evaporates during the spraying. The resulting composite stops bleeding instantly, can remain on the wound for prolonged periods and adheres with the wound, even under arterial pressure. The composite serves to promote wound healing and hemostasis in bleeding wounds.

This invention belongs to the field of biomedical materials, disclosing a wet-adhesive injectable hydrogel, its preparation method, and its applications. The hydrogel is obtained by mixing and separating the solid and liquid components, specifically an aqueous solution of component A and component B. The aqueous solution of component B is a bioadhesive molecular aqueous solution capable of cross-linking with component A and reaching the tissue interface. The aqueous solutions of component A and component B are, respectively, an aqueous solution of positively charged polyacrylamide hydrochloride and a negatively charged polymaleic acid. This hydrogel exhibits extremely high wet tissue adhesion strength, excellent sealing performance, rapid hemostasis, broad-spectrum antibacterial activity, and wound healing promotion function. As a wound dressing, it is suitable for the closure and repair of joint areas, high-pressure bleeding wounds, and infected wounds.

The invention discloses an injectable self-expanding liquid foam hemostatic material with coagulating activity and wet adhesion as well as a preparation method and application thereof, and relates to the technical field of biological materials and biomedical engineering. The injectable self-expanding liquid foam hemostatic material is prepared from the following raw material components: oxidized hyaluronic acid grafted with trometamol, calcium carbonate particles, gamma-polyglutamic acid grafted with trometamol and adipic dihydrazide, and acetic acid. The prepared foam material can be injected in situ, is suitable for hemostasis of non-oppression bleeding wounds, can quickly form a stable hemostasis barrier, and solves the problems that a traditional hemostasis material is difficult to adapt to complex wounds, insufficient in adhesion, low in hemostasis efficiency and the like.