Adsorption type hemostatic application

Abstract

The invention discloses an adsorption type hemostatic patch, which relates to the technical field of hemostatic patches and is formed by sequentially compounding a bonding layer, a compression layer, a hemostatic layer and a release paper layer, wherein the sticking layer is rectangular; the compression layer is arranged in the center of the adhesive layer; the hemostasis layer is arranged on the surface of the compression layer and completely wraps the compression layer, and the hemostasis layer is connected with the adhesive layer; the hemostatic layer is square or round; the compression layer is circular; the area of the hemostasis layer is larger than that of the compression layer; a binder is arranged on the surface of the bonding layer; the adhesive layer and the release paper layer can be flatly aligned and attached together; the prepared adsorption type hemostatic patch can be applied to the field of hemostasis, bleeding wounds in infusion, blood drawing and the like can be stopped in time, the two hands can be liberated, the purpose of stopping bleeding by manually pressing the wounds is not needed, and the adsorption type hemostatic patch is more convenient and faster.

Description

Technical Field

[0001] The invention belongs to the technical field of hemostatic dressings, in particular to an adsorption-type hemostatic dressing. Background Art

[0002] Hemostasis is a treatment measure taken for bleeding diseases or traumatic bleeding, aimed at controlling or stopping blood outflow; there are many different methods of hemostasis, and different methods of hemostasis can be selected according to the site and situation of bleeding.

[0003] Commonly used hemostasis methods include: compression hemostasis, which is suitable for bleeding in the head, neck, limbs and other parts of the body. It slows down the blood flow by pressing the bleeding area to achieve the hemostasis effect.

[0004] However, when a patient goes to the hospital alone and needs to press and stop bleeding by himself, it will cause many inconveniences.

[0005] Based on this, an adsorption-type hemostatic dressing is provided to solve the existing technical problems. Summary of the invention

[0006] The purpose of the present invention is to provide an adsorption-type hemostatic dressing to solve the deficiencies in the prior art.

[0007] The technical solution adopted by the present invention is as follows: An absorbent hemostatic dressing, which is composed of an adhesive layer, a compression layer, a hemostatic layer, and a release paper layer; Wherein, the adhesive layer is rectangular; The compression layer is arranged at the center of the adhesive layer; The hemostatic layer is arranged on the surface of the compression layer and completely wraps the compression layer, and the hemostatic layer is connected to the adhesive layer at the same time; The hemostatic layer is square or circular; The compression layer is circular; The area of ​​the hemostatic layer is larger than the area of ​​the compression layer; The adhesive layer is provided with an adhesive on its surface; The adhesive layer and the release paper layer can be aligned and bonded together flatly.

[0008] As a further technical solution: the adhesive layer material is spunlace non-woven fabric.

[0009] As a further technical solution: the method for preparing the hemostatic layer material is: Firstly, a sodium alginate aqueous solution is prepared, and the water extract of Bletilla striata is prepared into a water extract of Bletilla striata; The sodium alginate aqueous solution and the Bletilla striata aqueous solution are uniformly mixed in a volume ratio of 5-6:1 to obtain a mixed solution; Adding a modifier to the mixed solution and stirring for 1 hour, then adding a ferric chloride solution, stirring and mixing for 30 minutes, and then freeze-drying to obtain a pre-gel; Wherein, the mass ratio of the mixed liquid to the modifier is 10:1-1.5; The volume ratio of the mixed solution to the ferric chloride solution is 1:1.2; Wherein, the concentration of ferric chloride solution is 250mmol / L; The pregel was washed with deionized water until it was colorless, and then freeze-dried for 10 hours to obtain.

[0010] As a further technical solution: the mass fraction of the sodium alginate aqueous solution is 1.5-1.8%; The mass fraction of the aqueous solution of the Bletilla striata water extract is 0.2-0.3%.

[0011] As a further technical solution: the preparation method of the water extract of Bletilla striata is: The rhizome of Bletilla striata is first dried at 60°C for 20 hours, and then crushed to obtain Bletilla striata powder; Mix the Bletilla striata powder and water in a mass ratio of 1:10, adjust the temperature to 55°C, reflux and extract for 5 hours, then high-speed centrifuge for 10 minutes, let stand for 1 hour, filter, and obtain a Bletilla striata extract; The Bletilla striata extract is spray dried to obtain a Bletilla striata water extract.

[0012] As a further technical solution: the preparation method of the modifier is: First, the cocoons are cleaned and then drained for 2 hours; chopping the silkworm cocoons into pieces to obtain silkworm cocoon scraps; The cocoon fragments were mixed with sodium carbonate solution, and then heated to boiling, stirred for 10 minutes, filtered, and the filter residue was washed with 80°C deionized water for 10 minutes, and then dried for 10 minutes. The sodium carbonate solution was used for repeated boiling, filtering, and drying for 3 cycles, and then vacuum dried at 60°C for 14 hours, crushed, and passed through an 80-mesh sieve to obtain.

[0013] As a further technical solution: the mixing ratio of the silkworm cocoon fragments and the sodium carbonate solution is 10-12 g: 200 mL; The mass fraction of the sodium carbonate solution is 0.5%.

[0014] As a further technical solution: the method for preparing the compression layer material is: First, prepare a 10% methanol solution; Add cotton cellulose to the methanol solution, stir and mix evenly, then add it to the reaction, introduce nitrogen into the reactor, exhaust the air in the reactor, then adjust the temperature to 60°C, keep stirring for 2 hours, then cool to 40°C, continue stirring for 10 minutes, then add acrylic acid, methylenebisacrylamide, sodium acrylate, and initiator in sequence, adjust the temperature to 78°C, keep reacting for 4 hours, then filter, wash, and dry to obtain.

[0015] As a further technical solution: the mixing ratio of the cotton cellulose and the methanol solution is 30-35 g: 250 mL; The mass ratio of cotton cellulose, acrylic acid, methylene bisacrylamide, sodium acrylate and initiator is 5-6:10:3:2:0.1; The initiator is benzoyl peroxide.

[0016] As a further technical solution, the adhesive is a medical pressure-sensitive adhesive.

[0017] A production device for an adsorption-type hemostatic dressing comprises a connecting frame, a guide input structure, a negative pressure fan, a protection plate frame, a cutting and separating structure, a synchronous belt and an extrusion and bonding structure, wherein the side end of the connecting frame is fixedly connected to the protection plate frame, the negative pressure fan is installed on the protection plate frame, an extrusion and bonding structure is arranged at the lower center of the protection plate frame, the side end of the extrusion and bonding structure is fixedly connected to the cutting and separating structure, and the cutting and separating structure and the extrusion and bonding structure are connected by a synchronous belt transmission, and the center of the connecting frame is fixedly provided with a guide input structure; The guide input structure includes a storage roller, a rotating rod, a first motor, a side frame, a guide pipe and a negative pressure adsorption seat. The negative pressure adsorption seat is provided with a guide roller, and the rear end of the negative pressure adsorption seat is connected to a guide pipe. The side frame is rotatably connected to the guide roller, and the side frame is fixedly connected to the negative pressure adsorption seat. The rear end of the side frame is installed with a first motor, and the first motor is connected to the storage roller through the rotating rod.

[0018] As a further technical solution, the extrusion bonding structure includes a matching guide roller, a second motor, a mounting plate, a third motor, a first extrusion roller, a transmission toothed disc, a rotating eccentric wheel and a smoothing control component. The second motor is mounted at the rear end of the mounting plate, the second motor is drivingly connected to the matching guide roller, the smoothing control component is mounted at the middle of the mounting plate, the third motor is mounted at the front end of the mounting plate, the third motor is drivingly connected to the first extrusion roller, the side end of the first extrusion roller is fixedly connected to the transmission toothed disc, the side end eccentric position of the transmission toothed disc is fixedly connected to the rotating eccentric wheel, and the rotating eccentric wheel is in contact with the smoothing control component; The cam is fixedly mounted on the drive gear, and the cam is connected to the drive gear of the driving gear of the driving gear. The cam is fixedly mounted on the drive gear of the driving gear, and the cam is connected to the drive gear of the driving gear by the spring. The cam is fixedly mounted on the drive gear, and the cam is connected to the drive gear of the driving gear.

[0019] As a further technical solution, the cutting and separation structure includes a collecting roller, a base frame, a rotating docking plate, a first cutting component, a second cutting component and a second squeezing roller. The upper end of the base frame is rotatably connected to the collecting roller, the rear end of the base frame is rotatably connected to the second cutting component, the lower end of the second cutting component is meshingly connected to the first cutting component, the side end of the first cutting component is fixedly connected to the rotating docking plate, and the end of the base frame facing away from the collecting roller is rotatably connected to the second squeezing roller.

[0020] As a further technical solution, the second cutting component includes a longitudinal cutting knife, a transverse cutting knife, a rotation control roller, a docking shaft and a cooperative toothed disk, the side end of the docking shaft is fixedly connected with a rotation control roller, the rotation control roller is fixedly connected with a transverse cutting knife and a longitudinal cutting knife, and the side end of the rotation control roller is fixedly connected with a cooperative toothed disk.

[0021] As a further technical solution, the cross-cutting knife and the rotating control roller are used for block cutting work, and the docking shaft rotates on the base frame. The first cutting part and the second cutting part are connected by a cooperative toothed disc, and the rotating docking disc is driven by a synchronous belt. Beneficial Effects

[0022] The adsorption hemostatic dressing prepared by the present invention can be applied to the field of hemostasis, and can stop bleeding wounds such as infusion and blood drawing in time. Moreover, it can free hands and does not need to manually press the wound to stop bleeding, which is more convenient and quick.

[0023] The adsorption hemostatic dressing prepared by the present invention is mainly used to deal with acute bleeding wounds. The compression layer contained therein will expand in volume after absorbing a certain amount of blood, thereby exerting a compressive force on the wound. The external pressure will compress the blood vessels and tissues around the wound, making the space in the blood vessels smaller, which can significantly slow down the blood flow rate at the wound. By reducing the blood flow rate, a more favorable action environment can be provided for blood components such as platelets, fibrin and red blood cells. At the same time, this pressure will also promote the activation of platelets and other coagulation factors, accelerate the interaction between them, so that they can gather and form thrombi more quickly. These thrombi can not only directly seal the wound, but also activate more coagulation pathways, further enhance the hemostatic effect, and thus achieve the purpose of controlling bleeding.

[0024] The hemostatic layer prepared by the present invention contains a large number of hydrophilic groups, which can interact with water molecules to achieve the effect of absorbing liquid. By introducing a modifier during the preparation of the hemostatic layer material, the cross-linking strength of the hemostatic layer material can be improved, and the density of the polymer chain in the system can be increased. The hemostatic layer material can maintain better liquid absorption performance.

[0025] By introducing Bletilla striata extract, it can better repair vascular damage and help promote hemostasis. At the same time, the active ingredients in Bletilla striata can also enhance the activity of platelet factors and promote the formation of thrombin, thereby achieving the effect of astringency and hemostasis. Bletilla striata extract can help eliminate muscle edema and at the same time, it also helps promote protein synthesis and accelerate wound healing.

[0026] Through the setting of the production device, the adhesive layer and the release paper layer can be conveniently combined quickly to achieve the purpose of streamlined production. The setting of the cutting and separation structure can separate the adhesive layer and the release paper layer. The setting of the extrusion and bonding structure can guide the transmission of the extrusion and bonding structure, and can perform the bonding and extrusion of the extrusion and bonding structure to achieve the combination of the extrusion and bonding structure. At the same time, the setting of the guiding input structure can realize the guided transmission of the adhesive layer and the release paper layer. The overall structure adopts aseptic treatment to improve the sterility of the hemostatic dressing. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 This is a structural diagram of an adsorption-type hemostatic dressing; Figure 2 It is a structural schematic diagram of the production device of the present invention; Figure 3 It is a three-dimensional side view of the production device of the present invention; Figure 4 It is a structural schematic diagram of the guiding input structure of the present invention; Figure 5It is a schematic structural diagram of the extrusion lamination structure of the present invention; Figure 6 It is a structural schematic diagram of the straightening control component of the present invention; Figure 7 It is a structural schematic diagram of the cutting and separation structure of the present invention; Figure 8 It is a schematic structural diagram of the second cutting component of the present invention.

[0028] In the figure: 1-adhesive layer; 2-release paper layer; 3-compression layer; 4-hemostatic layer; 5-cutting and separating structure; 6-synchronous belt; 7-extrusion and laminating structure; 8-storage roller; 9-rotating rod; 10-first motor; 11-side frame; 12-guide pipe; 13-negative pressure adsorption seat; 14-guide roller; 15-matching guide roller; 16-second motor; 17-mounting plate; 18-third motor; 19-first extrusion roller; 20-transmission gear disc; 21-rotating eccentric wheel; 22-smoothing control component; 23-first contact roller; 24-second contact Roller; 25-connecting plate; 26-limiting seat; 27-positioning rod seat; 28-first return spring seat; 29-swinging rod; 30-second return spring seat; 31-connecting wheel seat; 32-collecting roller; 33-base frame; 34-rotating docking plate; 35-first cutting component; 36-second cutting component; 37-second squeezing roller; 38-cross-cutting knife; 39-rotating control roller; 40-docking shaft; 41-cooperative toothed disc; 42-connecting frame; 43-guiding input structure; 44-negative pressure fan; 45-protective plate frame; 46-longitudinal cutting knife. DETAILED DESCRIPTION

[0029] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. Example 1

[0030] An absorbent hemostatic dressing, which is composed of an adhesive layer 1, a compression layer 3, a hemostatic layer 4, and a release paper layer 2; Wherein, the adhesive layer 1 is rectangular; The compression layer 3 is arranged at the center of the adhesive layer 1; The hemostatic layer 4 is arranged on the surface of the compression layer 3, and the hemostatic layer 4 is connected to the adhesive layer 1; The hemostatic layer 4 is square or circular; The compression layer 3 is circular; The area of ​​the hemostatic layer 4 is larger than that of the compression layer 3; The adhesive layer 1 is provided with an adhesive on its surface, and the adhesive is a medical pressure-sensitive adhesive; The adhesive layer 1 and the release paper layer 2 can be aligned and bonded together flatly.

[0031] The adhesive layer 1 is made of spunlace nonwoven fabric.

[0032] The material preparation method of the hemostatic layer 4 is as follows: Firstly, a sodium alginate aqueous solution is prepared, and the water extract of Bletilla striata is prepared into a water extract of Bletilla striata; The sodium alginate aqueous solution and the Bletilla striata aqueous solution were uniformly mixed in a volume ratio of 5:1 to obtain a mixed solution; Adding a modifier to the mixed solution and stirring for 1 hour, then adding a ferric chloride solution, stirring and mixing for 30 minutes, and then freeze-drying to obtain a pre-gel; Among them, the mass ratio of the mixed liquid to the modifier is 10:1; The volume ratio of the mixed solution to the ferric chloride solution is 1:1.2; Wherein, the concentration of ferric chloride solution is 250mmol / L; The pregel was washed with deionized water until it was colorless, and then freeze-dried for 10 hours to obtain.

[0033] The mass fraction of sodium alginate aqueous solution is 1.5%; The mass fraction of the aqueous solution of the Bletilla striata water extract is 0.2%.

[0034] The preparation method of Bletilla striata water extract is as follows: The rhizome of Bletilla striata is first dried at 60°C for 20 hours, and then crushed to obtain Bletilla striata powder; Mix the Bletilla striata powder and water in a mass ratio of 1:10, adjust the temperature to 55°C, reflux and extract for 5 hours, then high-speed centrifuge for 10 minutes, let stand for 1 hour, filter, and obtain a Bletilla striata extract; The Bletilla striata extract is spray dried to obtain a Bletilla striata water extract.

[0035] The preparation method of the modifier is: First, the cocoons are cleaned and then drained for 2 hours; chopping the silkworm cocoons into pieces to obtain silkworm cocoon scraps; The cocoon fragments were mixed with sodium carbonate solution, and then heated to boiling, stirred for 10 minutes, filtered, and the filter residue was washed with 80°C deionized water for 10 minutes, and then dried for 10 minutes. The sodium carbonate solution was used for repeated boiling, filtering, and drying for 3 cycles, and then vacuum dried at 60°C for 14 hours, crushed, and passed through an 80-mesh sieve to obtain.

[0036] The mixing ratio of silkworm cocoon fragments and sodium carbonate solution is 10g:200mL; The mass fraction of the sodium carbonate solution is 0.5%.

[0037] The preparation method of the compression layer material is as follows: First, prepare a 10% methanol solution; Add cotton cellulose to the methanol solution, stir and mix evenly, then add it to the reaction, introduce nitrogen into the reactor, exhaust the air in the reactor, then adjust the temperature to 60°C, keep stirring for 2 hours, then cool to 40°C, continue stirring for 10 minutes, then add acrylic acid, methylenebisacrylamide, sodium acrylate, benzoyl peroxide in sequence, adjust the temperature to 78°C, keep reacting for 4 hours, then filter, wash, and dry to obtain.

[0038] The mixing ratio of cotton cellulose and methanol solution is 30g:250mL; The mixing mass ratio of cotton cellulose, acrylic acid, methylenebisacrylamide, sodium acrylate and benzoyl peroxide is 5:10:3:2:0.1. Example 2

[0039] Based on Example 1, the difference from Example 1 is as follows: The material preparation method of the hemostatic layer 4 is as follows: Firstly, a sodium alginate aqueous solution is prepared, and the water extract of Bletilla striata is prepared into a water extract of Bletilla striata; The sodium alginate aqueous solution and the Bletilla striata aqueous solution were uniformly mixed in a volume ratio of 5.5:1 to obtain a mixed solution; Adding a modifier to the mixed solution and stirring for 1 hour, then adding a ferric chloride solution, stirring and mixing for 30 minutes, and then freeze-drying to obtain a pre-gel; Among them, the mass ratio of mixed liquid to modifier is 10:1.2; The volume ratio of the mixed solution to the ferric chloride solution is 1:1.2; Wherein, the concentration of ferric chloride solution is 250mmol / L; The pregel was washed with deionized water until it was colorless, and then freeze-dried for 10 hours to obtain.

[0040] The mass fraction of sodium alginate aqueous solution is 1.6%; The mass fraction of the aqueous solution of the Bletilla striata water extract is 0.25%.

[0041] The preparation method of Bletilla striata water extract is as follows: The rhizome of Bletilla striata is first dried at 60°C for 20 hours, and then crushed to obtain Bletilla striata powder; Mix the Bletilla striata powder and water in a mass ratio of 1:10, adjust the temperature to 55°C, reflux and extract for 5 hours, then high-speed centrifuge for 10 minutes, let stand for 1 hour, filter, and obtain a Bletilla striata extract; The Bletilla striata extract is spray dried to obtain a Bletilla striata water extract.

[0042] The preparation method of the modifier is: First, the cocoons are cleaned and then drained for 2 hours; chopping the silkworm cocoons into pieces to obtain silkworm cocoon scraps; The cocoon fragments were mixed with sodium carbonate solution, and then heated to boiling, stirred for 10 minutes, filtered, and the filter residue was washed with 80°C deionized water for 10 minutes, and then dried for 10 minutes. The sodium carbonate solution was used for repeated boiling, filtering, and drying for 3 cycles, and then vacuum dried at 60°C for 14 hours, crushed, and passed through an 80-mesh sieve to obtain.

[0043] The mixing ratio of silkworm cocoon fragments and sodium carbonate solution is 11g:200mL; The mass fraction of the sodium carbonate solution is 0.5%.

[0044] The preparation method of the compression layer material is as follows: First, prepare a 10% methanol solution; Add cotton cellulose to the methanol solution, stir and mix evenly, then add it to the reaction, introduce nitrogen into the reactor, exhaust the air in the reactor, then adjust the temperature to 60°C, keep stirring for 2 hours, then cool to 40°C, continue stirring for 10 minutes, then add acrylic acid, methylenebisacrylamide, sodium acrylate, benzoyl peroxide in sequence, adjust the temperature to 78°C, keep reacting for 4 hours, then filter, wash, and dry to obtain.

[0045] The mixing ratio of cotton cellulose and methanol solution is 32g:250mL; The mixing mass ratio of cotton cellulose, acrylic acid, methylenebisacrylamide, sodium acrylate and benzoyl peroxide is 5.5:10:3:2:0.1. Example 3

[0046] Based on Example 1, the difference from Example 1 is as follows: The material preparation method of the hemostatic layer 4 is as follows: Firstly, a sodium alginate aqueous solution is prepared, and the water extract of Bletilla striata is prepared into a water extract of Bletilla striata; The sodium alginate aqueous solution and the Bletilla striata aqueous solution are uniformly mixed in a volume ratio of 5-6:1 to obtain a mixed solution; Adding a modifier to the mixed solution and stirring for 1 hour, then adding a ferric chloride solution, stirring and mixing for 30 minutes, and then freeze-drying to obtain a pre-gel; Among them, the mass ratio of mixed liquid to modifier is 10:1.3; The volume ratio of the mixed solution to the ferric chloride solution is 1:1.2; Wherein, the concentration of ferric chloride solution is 250mmol / L; The pregel was washed with deionized water until it was colorless, and then freeze-dried for 10 hours to obtain.

[0047] The mass fraction of sodium alginate aqueous solution is 1.7%; The mass fraction of the aqueous solution of the Bletilla striata water extract is 0.22%.

[0048] The preparation method of Bletilla striata water extract is as follows: The rhizome of Bletilla striata is first dried at 60°C for 20 hours, and then crushed to obtain Bletilla striata powder; Mix the Bletilla striata powder and water in a mass ratio of 1:10, adjust the temperature to 55°C, reflux and extract for 5 hours, then high-speed centrifuge for 10 minutes, let stand for 1 hour, filter, and obtain a Bletilla striata extract; The Bletilla striata extract is spray dried to obtain a Bletilla striata water extract.

[0049] The preparation method of the modifier is: First, the cocoons are cleaned and then drained for 2 hours; chopping the silkworm cocoons into pieces to obtain silkworm cocoon scraps; The cocoon fragments were mixed with sodium carbonate solution, and then heated to boiling, stirred for 10 minutes, filtered, and the filter residue was washed with 80°C deionized water for 10 minutes, and then dried for 10 minutes. The sodium carbonate solution was used for repeated boiling, filtering, and drying for 3 cycles, and then vacuum dried at 60°C for 14 hours, crushed, and passed through an 80-mesh sieve to obtain.

[0050] The mixing ratio of silkworm cocoon fragments and sodium carbonate solution is 11g:200mL; The mass fraction of the sodium carbonate solution is 0.5%.

[0051] The preparation method of the compression layer material is as follows: First, prepare a 10% methanol solution; Add cotton cellulose to the methanol solution, stir and mix evenly, then add it to the reaction, introduce nitrogen into the reactor, exhaust the air in the reactor, then adjust the temperature to 60°C, keep stirring for 2 hours, then cool to 40°C, continue stirring for 10 minutes, then add acrylic acid, methylenebisacrylamide, sodium acrylate, benzoyl peroxide in sequence, adjust the temperature to 78°C, keep reacting for 4 hours, then filter, wash, and dry to obtain.

[0052] The mixing ratio of cotton cellulose and methanol solution is 33g:250mL; The mixing mass ratio of cotton cellulose, acrylic acid, methylenebisacrylamide, sodium acrylate and benzoyl peroxide is 5.8:10:3:2:0.1. Example 4

[0053] Based on Example 1, the difference from Example 1 is as follows: The material preparation method of the hemostatic layer 4 is as follows: Firstly, a sodium alginate aqueous solution is prepared, and the water extract of Bletilla striata is prepared into a water extract of Bletilla striata; The sodium alginate aqueous solution and the Bletilla striata aqueous solution were uniformly mixed in a volume ratio of 5.8:1 to obtain a mixed solution; Adding a modifier to the mixed solution and stirring for 1 hour, then adding a ferric chloride solution, stirring and mixing for 30 minutes, and then freeze-drying to obtain a pre-gel; Among them, the mass ratio of mixed liquid to modifier is 10:1.4; The volume ratio of the mixed solution to the ferric chloride solution is 1:1.2; Wherein, the concentration of ferric chloride solution is 250mmol / L; The pregel was washed with deionized water until it was colorless, and then freeze-dried for 10 hours to obtain.

[0054] The mass fraction of sodium alginate aqueous solution is 1.6%; The mass fraction of the aqueous solution of the Bletilla striata water extract is 0.25%.

[0055] The preparation method of Bletilla striata water extract is as follows: The rhizome of Bletilla striata is first dried at 60°C for 20 hours, and then crushed to obtain Bletilla striata powder; Mix the Bletilla striata powder and water in a mass ratio of 1:10, adjust the temperature to 55°C, reflux and extract for 5 hours, then high-speed centrifuge for 10 minutes, let stand for 1 hour, filter, and obtain a Bletilla striata extract; The Bletilla striata extract is spray dried to obtain a Bletilla striata water extract.

[0056] The preparation method of the modifier is: First, the cocoons are cleaned and then drained for 2 hours; chopping the silkworm cocoons into pieces to obtain silkworm cocoon scraps; The cocoon fragments were mixed with sodium carbonate solution, and then heated to boiling, stirred for 10 minutes, filtered, and the filter residue was washed with 80°C deionized water for 10 minutes, and then dried for 10 minutes. The sodium carbonate solution was used for repeated boiling, filtering, and drying for 3 cycles, and then vacuum dried at 60°C for 14 hours, crushed, and passed through an 80-mesh sieve to obtain.

[0057] The mixing ratio of silkworm cocoon fragments and sodium carbonate solution is 11g:200mL; The mass fraction of the sodium carbonate solution is 0.5%.

[0058] The preparation method of the compression layer material is as follows: First, prepare a 10% methanol solution; Add cotton cellulose to the methanol solution, stir and mix evenly, then add it to the reaction, introduce nitrogen into the reactor, exhaust the air in the reactor, then adjust the temperature to 60°C, keep stirring for 2 hours, then cool to 40°C, continue stirring for 10 minutes, then add acrylic acid, methylenebisacrylamide, sodium acrylate, benzoyl peroxide in sequence, adjust the temperature to 78°C, keep reacting for 4 hours, then filter, wash, and dry to obtain.

[0059] The mixing ratio of cotton cellulose and methanol solution is 30-35g:250mL; The mixing mass ratio of cotton cellulose, acrylic acid, methylenebisacrylamide, sodium acrylate and benzoyl peroxide is 5.7:10:3:2:0.1. Example 5

[0060] Based on Example 1, the difference from Example 1 is as follows: The material preparation method of the hemostatic layer 4 is as follows: Firstly, a sodium alginate aqueous solution is prepared, and the water extract of Bletilla striata is prepared into a water extract of Bletilla striata; The sodium alginate aqueous solution and the Bletilla striata aqueous solution were uniformly mixed in a volume ratio of 6:1 to obtain a mixed solution; Adding a modifier to the mixed solution and stirring for 1 hour, then adding a ferric chloride solution, stirring and mixing for 30 minutes, and then freeze-drying to obtain a pre-gel; Among them, the mass ratio of the mixed liquid to the modifier is 10:1.5; The volume ratio of the mixed solution to the ferric chloride solution is 1:1.2; Wherein, the concentration of ferric chloride solution is 250mmol / L; The pregel was washed with deionized water until it was colorless, and then freeze-dried for 10 hours to obtain.

[0061] The mass fraction of sodium alginate aqueous solution is 1.8%; The mass fraction of the aqueous solution of the Bletilla striata water extract is 0.3%.

[0062] The preparation method of Bletilla striata water extract is as follows: The rhizome of Bletilla striata is first dried at 60°C for 20 hours, and then crushed to obtain Bletilla striata powder; Mix the Bletilla striata powder and water in a mass ratio of 1:10, adjust the temperature to 55°C, reflux and extract for 5 hours, then high-speed centrifuge for 10 minutes, let stand for 1 hour, filter, and obtain a Bletilla striata extract; The Bletilla striata extract is spray dried to obtain a Bletilla striata water extract.

[0063] The preparation method of the modifier is: First, the cocoons are cleaned and then drained for 2 hours; chopping the silkworm cocoons into pieces to obtain silkworm cocoon scraps; The cocoon fragments were mixed with sodium carbonate solution, and then heated to boiling, stirred for 10 minutes, filtered, and the filter residue was washed with 80°C deionized water for 10 minutes, and then dried for 10 minutes. The sodium carbonate solution was used for repeated boiling, filtering, and drying for 3 cycles, and then vacuum dried at 60°C for 14 hours, crushed, and passed through an 80-mesh sieve to obtain.

[0064] The mixing ratio of silkworm cocoon fragments and sodium carbonate solution is 12g:200mL; The mass fraction of the sodium carbonate solution is 0.5%.

[0065] The preparation method of the compression layer material is as follows: First, prepare a 10% methanol solution; Add cotton cellulose to the methanol solution, stir and mix evenly, then add it to the reaction, introduce nitrogen into the reactor, exhaust the air in the reactor, then adjust the temperature to 60°C, keep stirring for 2 hours, then cool to 40°C, continue stirring for 10 minutes, then add acrylic acid, methylenebisacrylamide, sodium acrylate, benzoyl peroxide in sequence, adjust the temperature to 78°C, keep reacting for 4 hours, then filter, wash, and dry to obtain.

[0066] The mixing ratio of cotton cellulose and methanol solution is 35g:250mL; The mixing mass ratio of cotton cellulose, acrylic acid, methylenebisacrylamide, sodium acrylate and benzoyl peroxide is 6:10:3:2:0.1.

[0067] Comparative Example 1: The difference from Example 1 is that no compression layer is added, and the rest of the technical solutions remain unchanged.

[0068] Comparative Example 2: The difference from Example 1 is that no modifier is added when preparing the hemostatic layer material, and the rest of the technical solutions remain unchanged.

[0069] Comparative Example 3: The difference from the embodiment is that when preparing the hemostatic layer material, no water extract is added, and the rest of the technical scheme remains unchanged test: Cytotoxicity assay Referring to the prior art: the biosafety of the hemostatic layer material in the embodiment was evaluated by the CCK8 method.

[0070] First, L929 cells were seeded into 96-well plates at a density of 5,000 cells per well, and then DMEM complete medium was added and placed in a constant temperature incubator with φ(CO2)=5% for 24 h. After the cells adhered to the wall and grew, the old medium was removed and the plates were washed twice with PBS. Then, a suspension of the hemostatic layer material in the example sample prepared with DMEM complete medium containing 0.5 g / L was added, and the culture was continued for 24 h. After removing the old medium, the plates were washed twice with PBS to remove free substances. Then, 100 μL of cell culture medium containing CCK8 (φ=10%) was added to each well. After culturing in the dark for 1 h, 90 μL of the culture supernatant was taken into another 96-well plate, and the absorbance (OD) of each well at a wavelength of 450 nm was detected using an enzyme marker.

[0071] The cell viability (Cv) was calculated as follows: Cv=(OD sample— OD blank ) / (OD control— OD blank )×100%; Each group was tested 6 times and the average value was taken. The results are shown in Table 1: Cell survival rate% Example 1 99.9 Example 2 99.9 Example 3 99.9 Example 4 99.9 Example 5 99.9 It can be seen from Table 1 that the hemostatic layer material prepared by the present invention has high biological safety.

[0072] The liquid absorption properties of the samples of the embodiments and comparative examples were measured by the front-to-back specific gravity method.

[0073] The sample preparation method is: using the embodiment and comparative example samples of the same shape and size, a certain amount of PBS buffer solution is prepared to simulate the body fluid environment. The test conditions are: the dried embodiment and comparative example samples are accurately weighed, and the mass is recorded as M1, and then immersed in the prepared PBS buffer solution, and the embodiment and comparative example samples are taken out after absorbing the liquid to saturation, and the excess water on the surface of the embodiment and comparative example samples is removed with filter paper, and weighed again, and the mass is recorded as M2.

[0074] The liquid absorption rate of the examples and comparative examples was calculated using the following formula: W = (M2-M1) / M1×100%; Where: M1 is the mass of the samples of the embodiment and the comparative example in a dry state, in g; M2 is the mass of the example and comparative example samples after liquid absorption, in g.

[0075] There are 5 samples in each group, and the results are averaged: Liquid absorption rate% Example 1 435 Example 2 446 Example 3 451 Example 4 440 Example 5 443 Comparative Example 1 401 Comparative Example 2 412 It can be seen from Table 2 that the absorbent hemostatic dressing prepared by the present invention has a high liquid absorption performance.

[0076] Hemostasis experiment The samples of the embodiment and the comparative example were subjected to a hemostatic test: the hemostatic performance of the samples was tested by a BALB / c mouse needle-pricking experiment.

[0077] The mice were randomly divided into 9 groups, with 3 BALB / c mice in each group. The hair on the same part of the back of the BALB / c mice was shaved, and then the same depth of acupuncture was performed with a sterilized needle of the same specification. Then, the wound was immediately covered with a commercially available band-aid, the embodiment and the comparative example samples, and the blood loss and hemostasis time of each mouse were recorded to evaluate the hemostatic ability of the embodiment and the comparative example samples: Blood loss / ml Hemostasis time / s Example 1 0.33 135 Example 2 0.36 137 Example 3 0.32 131 Example 4 0.35 136 Example 5 0.38 139 Comparative Example 1 0.72 168 Comparative Example 3 0.47 146 Control group 1.82 215 Control group: conventional commercially available Band-Aid purchased from Band-Aid; It can be seen from Table 3 that the hemostatic dressing prepared by the present invention has an excellent hemostatic effect and can shorten the hemostatic time. Example 6

[0078] A production device for an adsorption-type hemostatic dressing, comprising a connecting frame 42, a guide input structure 43, a negative pressure fan 44, a protection plate frame 45, a cutting and separating structure 5, a synchronous belt 6 and an extrusion and bonding structure 7, wherein the side end of the connecting frame 42 is fixedly connected with the protection plate frame 45, the negative pressure fan 44 is installed on the protection plate frame 45, the lower center of the protection plate frame 45 is provided with an extrusion and bonding structure 7, the side end of the extrusion and bonding structure 7 is fixedly connected with the cutting and separating structure 5, and the cutting and separating structure 5 and the extrusion and bonding structure 7 are connected by a synchronous belt 6, and the center of the connecting frame 42 is fixedly provided with the guide input structure 43; The guide input structure 43 includes a storage roller 8, a rotating rod 9, a first motor 10, a side frame 11, a guide pipe 12 and a negative pressure adsorption seat 13. The negative pressure adsorption seat 13 is provided with a guide roller 14. The rear end of the negative pressure adsorption seat 13 is connected to the guide pipe 12. The side frame 11 is rotatably connected to the guide roller 14. The side frame 11 is fixedly connected to the negative pressure adsorption seat 13. The rear end of the side frame 11 is installed with a first motor 10, and the first motor 10 is driven and connected to the storage roller 8 through the rotating rod 9.

[0079] The extrusion laminating structure 7 comprises a matching guide roller 15, a second motor 16, a mounting plate 17, a third motor 18, a first extrusion roller 19, a transmission toothed disc 20, a rotating eccentric wheel 21 and a smoothing control component 22. The second motor 16 is mounted at the rear end of the mounting plate 17, the matching guide roller 15 is drivingly connected to the second motor 16, the smoothing control component 22 is mounted at the middle of the mounting plate 17, the third motor 18 is mounted at the front end of the mounting plate 17, the third motor 18 is drivingly connected to the first extrusion roller 19, the side end of the first extrusion roller 19 is fixedly connected to the transmission toothed disc 20, the side end of the transmission toothed disc 20 is fixedly connected to the rotating eccentric wheel 21, and the rotating eccentric wheel 21 is in contact with the smoothing control component 22; The straightening control component 22 includes a first contact roller 23, a second contact roller 24, a connecting disk 25, a limit seat 26, a positioning rod seat 27, a first return spring seat 28, a swing rod 29, a second return spring seat 30 and a connecting wheel seat 31. The side end of the second return spring seat 30 is connected to the limit seat 26, and the second return spring seat 30 is connected to the connecting disk 25. The upper end of the connecting disk 25 is rotatably connected to the first contact roller 23, and the lower end of the connecting disk 25 is rotatably connected to the second contact roller 24. The upper end side of the connecting disk 25 is fixedly connected to the connecting wheel seat 31. The connecting wheel seat 31 is connected to the connecting wheel seat 31. 1 contacts with the swing rod 29, the swing rod 29 is elastically connected to the positioning rod seat 27 through the first return spring seat 28, the limit seat 26 is fixed to the mounting plate 17, the positioning rod seat 27 is fixed on the mounting plate 17, the rotating eccentric wheel 21 rotates through the transmission gear plate 20, and the rotating eccentric wheel 21 contacts with one end of the swing rod 29 to press the swing rod 29, and the other end of the swing rod 29 contacts with the connecting wheel seat 31, driving the first contact roller 23, the second contact roller 24, and the connecting plate 25 to rotate and adjust, and the connecting wheel seat 31 is relatively rotated and contacted with the swing rod 29.

[0080] The cutting and separation structure 5 includes a collecting roller 32, a base frame 33, a rotating docking plate 34, a first cutting component 35, a second cutting component 36 and a second squeezing roller 37. The upper end of the base frame 33 is rotatably connected to the collecting roller 32, the rear end of the base frame 33 is rotatably connected to the second cutting component 36, the lower end of the second cutting component 36 is meshingly connected to the first cutting component 35, the side end of the first cutting component 35 is fixedly connected to the rotating docking plate 34, and the end of the base frame 33 facing away from the collecting roller 32 is rotatably connected to the second squeezing roller 37.

[0081] The second cutting component 36 includes a longitudinal cutting knife 46, a transverse cutting knife 38, a rotating control roller 39, a docking shaft 40 and a cooperative toothed disk 41. The side end of the docking shaft 40 is fixedly connected to the rotating control roller 39, the transverse cutting knife 38 and the longitudinal cutting knife 46 are fixedly connected to the rotating control roller 39, and the side end of the rotating control roller 39 is fixedly connected to the cooperative toothed disk 41.

[0082] The cross-cutting knife 38 and the rotating control roller 39 are used for block cutting work, and the docking shaft 40 rotates on the base frame 33, the first cutting component 35 and the second cutting component 36 are meshed and connected through the cooperative toothed disc 41, and the rotating docking disc 34 is driven by the synchronous belt 6.

[0083] When in use, in order to carry out the lamination production of the adhesive layer 1 and the release paper layer 2, this equipment is used, wherein the connecting frame 42 is fixed to the protective plate frame 45, which can play a fixed support function, and at the same time the negative pressure fan 44 adopts negative pressure adsorption treatment, which can perform internal extraction work to keep the internal environment stable, and the overall structure is provided with a glass layer for internal and external separation work, the adhesive layer 1 and the release paper layer 2 are respectively transmitted through the upper and lower rotating rods 9, and the first motor 10 is driven at this time, and the storage roller 8 is driven to rotate through the rotating rod 9, so that the adhesive layer 1 and the release paper layer 2 are transmitted, and the adhesive layer 1 and the release paper layer 2 arrive at the guide roller 14 at the side end position, and continue to guide and transmit, and the negative pressure adsorption seat 13 and the guide pipe 12 are connected, so that the adsorption work can be carried out. The adhesive layer 1 and the release paper layer 2 are more closely attached to the guide roller 14. After that, the adhesive layer 1 and the release paper layer 2 reach the position of the matching guide roller 15. At this time, the second motor 16 is driven to drive the adhesive layer 1 and the release paper layer 2 to be transmitted. At the same time, the adhesive layer 1 and the release paper layer 2 reach the position of the smoothing control component 22. At this time, the third motor 18 is driven to drive the first squeezing roller 19, the transmission gear plate 20, and the rotating eccentric wheel 21 to rotate. The rotation of the first squeezing roller 19 facilitates the subsequent squeezing and laminating of the adhesive layer 1 and the release paper layer 2. At the same time, the rotation of the transmission gear plate 20 makes the upper and lower first squeezing rollers 19 rotate in opposite directions. The rotating eccentric wheel 21 is arranged at the eccentric position of the side end of the transmission gear plate 20, which can smooth the swing rod 29 in the control component 22. The swing rod 29 is extruded, and the swing rod 29 swings through the positioning rod seat 27 and the first return spring seat 28. The upper end can fit with the connecting wheel seat 31, driving the connecting wheel seat 31 to rotate. The connecting wheel seat 31 is connected to the first contact roller 23, driving the first contact roller 23 and the second contact roller 24, and the connecting plate 25 to rotate on the limit seat 26. Due to the reciprocating rotation of the rotating eccentric wheel 21, the swing rod 29 can move continuously. At the same time, the swing rod 29 can be reset with the positioning rod seat 27 through the first return spring seat 28, thereby realizing reciprocating swing, so that the first contact roller 23 and the second contact roller 24 also swing back and forth, acting on the adhesive layer 1 and the release paper layer 2, so that the adhesive layer 1 and the release paper layer 2 can be periodically transmitted and adjusted to reduce The stress generated by the transmission of the adhesive layer 1 and the release paper layer 2 makes the transmission of the adhesive layer 1 and the release paper layer 2 more uniform. Then, the adhesive layer 1 and the release paper layer 2 are extruded and laminated at the position of the first squeezing roller 19, and then reach the position of the second squeezing roller 37 for secondary lamination. Then, they are guided to reach the center of the second cutting component 36 and the first cutting component 35. A wheel body is provided on the side of the lower end transmission gear disk 20. The wheel body can drive the rotating docking disk 34 to rotate through the synchronous belt 6, so that the first cutting component 35 rotates. At the same time, the first cutting component 35 and the second cutting component 36 are meshed and connected through the cooperative gear disk 41, driving the rotating control roller 39 and the docking shaft 40 to rotate. At this time, the cross-cutting knife 38 and the longitudinal cutting knife 46 rotate accordingly.Carry out the slitting process of the adhesive layer 1 and the release paper layer 2, and complete the molding production of the adhesive layer 1 and the release paper layer 2.

[0084] The above are only preferred embodiments of the present invention, but the present invention is not limited to the scope of implementation shown. Any changes made according to the concept of the present invention, or modifications to equivalent embodiments with equivalent changes, which still do not exceed the spirit covered by the specification, should be within the protection scope of the present invention.

Claims

1. An adsorption hemostatic dressing, characterized in that: It is composed of an adhesive layer, a compression layer, a hemostatic layer, and a release paper layer in sequence; Wherein, the adhesive layer is rectangular; The compression layer is arranged at the center of the adhesive layer; The hemostatic layer is arranged on the surface of the compression layer and completely wraps the compression layer, and the hemostatic layer is connected to the adhesive layer at the same time; The hemostatic layer is square or circular; The compression layer is circular; The area of ​​the hemostatic layer is larger than the area of ​​the compression layer; The adhesive layer is provided with an adhesive on its surface; The adhesive layer and the release paper layer can be aligned and bonded together flatly.

2. The absorbent hemostatic patch according to claim 1, characterized in that: The adhesive layer material is spunlace nonwoven fabric.

3. The absorbent hemostatic patch according to claim 2, characterized in that: The preparation method of the hemostatic layer material is as follows: Firstly, a sodium alginate aqueous solution is prepared, and the water extract of Bletilla striata is prepared into a water extract of Bletilla striata; The sodium alginate aqueous solution and the Bletilla striata aqueous solution are uniformly mixed in a volume ratio of 5-6:1 to obtain a mixed solution; Adding a modifier to the mixed solution and stirring for 1 hour, then adding a ferric chloride solution, stirring and mixing for 30 minutes, and then freeze-drying to obtain a pre-gel; Wherein, the mass ratio of the mixed liquid to the modifier is 10:1-1.5; The volume ratio of the mixed solution to the ferric chloride solution is 1:1.2; Wherein, the concentration of ferric chloride solution is 250mmol / L; The pregel was washed with deionized water until it was colorless, and then freeze-dried for 10 hours to obtain; The mass fraction of the sodium alginate aqueous solution is 1.5-1.8%; The mass fraction of the aqueous solution of the Bletilla striata water extract is 0.2-0.3%.

4. The absorbent hemostatic dressing according to claim 3, characterized in that: The preparation method of the Bletilla striata water extract is: The rhizome of Bletilla striata is first dried at 60°C for 20 hours, and then crushed to obtain Bletilla striata powder; Mix the Bletilla striata powder and water in a mass ratio of 1:10, adjust the temperature to 55°C, reflux and extract for 5 hours, then high-speed centrifuge for 10 minutes, let stand for 1 hour, filter, and obtain a Bletilla striata extract; spray drying the Bletilla striata extract to obtain a Bletilla striata water extract; The preparation method of the modifier is: First, the cocoons are cleaned and then drained for 2 hours; chopping the silk cocoons to obtain silk cocoon scraps; The cocoon fragments were mixed with sodium carbonate solution, and then heated to boiling, stirred for 10 minutes, filtered, and the filter residue was washed with 80°C deionized water for 10 minutes, and then dried for 10 minutes. The sodium carbonate solution was used for repeated boiling, filtering, and drying for 3 cycles, and then vacuum dried at 60°C for 14 hours, crushed, and passed through an 80-mesh sieve to obtain.

5. The absorbent hemostatic patch according to claim 4, characterized in that: The mixing ratio of the silkworm cocoon fragments and the sodium carbonate solution is 10-12 g: 200 mL; The mass fraction of the sodium carbonate solution is 0.5%; The method for preparing the compression layer material is as follows: First, prepare a 10% methanol solution; Add cotton cellulose to the methanol solution, stir and mix evenly, then add it to the reaction, introduce nitrogen into the reactor, exhaust the air in the reactor, then adjust the temperature to 60°C, keep stirring for 2 hours, then cool to 40°C, continue stirring for 10 minutes, then add acrylic acid, methylenebisacrylamide, sodium acrylate, and initiator in sequence, adjust the temperature to 78°C, keep reacting for 4 hours, then filter, wash, and dry to obtain; The mixing ratio of the cotton cellulose and the methanol solution is 30-35 g: 250 mL; The mass ratio of cotton cellulose, acrylic acid, methylene bisacrylamide, sodium acrylate and initiator is 5-6:10:3:2:0.1; The initiator is benzoyl peroxide; The adhesive is a medical pressure-sensitive adhesive.

6. A production device for an adsorption hemostatic patch, using the adsorption hemostatic patch as claimed in claim 5, characterized in that: The invention comprises a connecting frame (42), a guide input structure (43), a negative pressure fan (44), a protection plate frame (45), a cutting and separating structure (5), a synchronous belt (6) and an extrusion bonding structure (7), wherein the side end of the connecting frame (42) is fixedly connected to the protection plate frame (45), the negative pressure fan (44) is installed on the protection plate frame (45), the extrusion bonding structure (7) is provided at the center of the lower part of the protection plate frame (45), the side end of the extrusion bonding structure (7) is fixedly connected to the cutting and separating structure (5), and the cutting and separating structure (5) and the extrusion bonding structure (7) are connected by a synchronous belt (6), and the center of the connecting frame (42) is fixedly provided with the guide input structure (43); The guide input structure (43) comprises a storage roller (8), a rotating rod (9), a first motor (10), a side frame (11), a guide pipe (12) and a negative pressure adsorption seat (13); the negative pressure adsorption seat (13) is provided with a guide roller (14); the rear end of the negative pressure adsorption seat (13) is connected to the guide pipe (12); the side frame (11) is rotatably connected to the guide roller (14); the side frame (11) is fixedly connected to the negative pressure adsorption seat (13); the rear end of the side frame (11) is equipped with a first motor (10); the first motor (10) is connected to the storage roller (8) through the driving of the rotating rod (9).

7. The production device of the adsorption hemostatic patch according to claim 6, characterized in that: The extrusion laminating structure (7) comprises a matching guide roller (15), a second motor (16), a mounting plate (17), a third motor (18), a first extrusion roller (19), a transmission toothed disc (20), a rotating eccentric wheel (21) and a smoothing control component (22); the second motor (16) is mounted at the rear end of the mounting plate (17); the matching guide roller (15) is drivingly connected to the second motor (16); the smoothing control component (22) is mounted at the middle of the mounting plate (17); the third motor (18) is drivingly connected to the first extrusion roller (19); the side end of the first extrusion roller (19) is fixedly connected to the transmission toothed disc (20); the side end of the transmission toothed disc (20) is fixedly connected to the rotating eccentric wheel (21), and the rotating eccentric wheel (21) is in contact with the smoothing control component (22); The smoothing control component (22) comprises a first contact roller (23), a second contact roller (24), a connecting disk (25), a limit seat (26), a positioning rod seat (27), a first return spring seat (28), a swing rod (29), a second return spring seat (30) and a connecting wheel seat (31); a side end of the second return spring seat (30) is connected to the limit seat (26), and the second return spring seat (30) is connected to the connecting disk (25); the upper end of the connecting disk (25) is rotatably connected to the first contact roller (23); the lower end of the connecting disk (25) is rotatably connected to the second contact roller (24); the upper end side of the connecting disk (25) is fixedly connected to the connecting wheel seat (31); the connecting wheel seat The first contact roller (23), the second contact roller (24), and the connecting plate (25) are connected to the first contact roller (23), the second contact roller (24), and the connecting plate (25), and the connecting wheel seat (31) are connected to the first contact roller (23), the second contact roller (24), and the connecting plate (25), and the first contact roller (23), the second contact roller (24), and the connecting plate (25 ...

8. The production device of the adsorption hemostatic dressing according to claim 7, characterized in that: The cutting and separating structure (5) comprises a collecting roller (32), a base frame (33), a rotating docking plate (34), a first cutting component (35), a second cutting component (36) and a second squeezing roller (37); the upper end of the base frame (33) is rotatably connected to the collecting roller (32); the rear end of the base frame (33) is rotatably connected to the second cutting component (36); the lower end of the second cutting component (36) is meshingly connected to the first cutting component (35); the side end of the first cutting component (35) is fixedly connected to the rotating docking plate (34); and the end of the base frame (33) facing away from the collecting roller (32) is rotatably connected to the second squeezing roller (37).

9. The production device of the adsorption hemostatic dressing according to claim 8, characterized in that: The second cutting component (36) comprises a longitudinal cutting knife (46), a transverse cutting knife (38), a rotation control roller (39), a docking shaft (40) and a cooperative toothed disc (41); the side end of the docking shaft (40) is fixedly connected to the rotation control roller (39); the transverse cutting knife (38) and the longitudinal cutting knife (46) are fixedly connected to the rotation control roller (39); and the side end of the rotation control roller (39) is fixedly connected to the cooperative toothed disc (41).

10. The production device of the adsorption hemostatic dressing according to claim 9, characterized in that: The cross-cutting knife (38) and the rotating control roller (39) are used for block cutting, and the docking shaft (40) rotates on the base frame (33). The first cutting component (35) and the second cutting component (36) are meshed and connected via a cooperative toothed disc (41), and the rotating docking disc (34) is driven by a synchronous belt (6).

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