92results about How to "Reduce the risk of blood clots" patented technology

The invention provides a catheter for optical ablation of tissue in a living body, the catheter including: a distal end; a proximal end; an elongate catheter body coupled between the distal end and the proximal end; a light emission device at the distal end and configured to emit an ablation light having characteristics selected to regulate an optically regulatable transcription control element operably linked to a nucleic acid sequence for a gene product, the expression of which gene product in cells directly or indirectly kills cells; and a projection control mechanism coupled to the light emission device and configured to control an effectively illuminated area where the optically regulatable transcription control element is effectively regulatable by the ablation light projected from the light emission device. Also provided is a system which includes the catheter, and methods to prevent, inhibit or treat AF which employ an expression cassette and / or one or more selected wavelengths of light.

The invention provides a catheter for optical ablation of tissue in a living body, the catheter including: a distal end; a proximal end; an elongate catheter body coupled between the distal end and the proximal end; a light emission device at the distal end and configured to emit an ablation light having characteristics selected to regulate an optically regulatable transcription control element operably linked to a nucleic acid sequence for a gene product, the expression of which gene product in cells directly or indirectly kills cells; and a projection control mechanism coupled to the light emission device and configured to control an effectively illuminated area where the optically regulatable transcription control element is effectively regulatable by the ablation light projected from the light emission device. Also provided is a system which includes the catheter, and methods to prevent, inhibit or treat AF which employ an expression cassette and / or one or more selected wavelengths of light.

The invention provides a device for assisting a heart in functional failure. The device comprises a motor, a coupler, a driving rotor, a driven rotor, a catheter, a driving shaft and a pump, wherein the coupler is detachably jointed with the motor, the driven rotor is arranged in the coupler, the near end of the catheter is connected to the coupler, the driving shaft penetrates through the catheter and is driven by a rotor shaft, and the pump is driven by the driving shaft to pump blood. The driving rotor comprises a first bracket connected to the output shaft of the motor and a driving piece arranged on the first bracket; the driven rotor comprises a rotor shaft and a driven piece arranged on the rotor shaft and coupled with the driving piece. One of the driving piece and the driven piece is a magnetic force providing element, the other is a conductor, and a gap is formed between the driving piece and the driven piece.

The invention discloses a half-blade-rotor-type axial flow blood pump which comprises an inner barrel, a front guide, a rotor and a rear guide. The front guide has three straight blades, the rotor has two rotating blades, the two rotating blades of half-blade structures are distributed on a front half of a hub of the rotor only, and blade tip clearance length of the rotor is reduced by a half; the rear guide has three big rotating blades and three small rotating blades, the big rotating blades and the small rotating blades are distributed at intervals, each big rotating blade is provided with a suspension arm with one-half length, each suspension arm extends into a rotor area to form a suspension arm blade structure, and a runner portion on the outer surface of the rotor is made by smooth date-pit-shaped cubic spline curves. The half-blade-rotor-type axial flow blood pump has the advantages that a whole runner formed by the front guide, the rotor and the rear guide is designed to be of a date-pit-shaped structure, and the smooth cubic spline curves are adopted, so that pressure rise of the blood pump is increased, flow field distribution in the pump is improved, area of a rotating-stilling interface is reduced, and risk of thrombosis at a bearing is lowered.

The invention discloses a low-blood-loss micro axial-flow type artificial heart which comprises a vane wheel, a motor rotor, and a motor stator, wherein the vane wheel is arranged inside the motor rotor in an interference fit and coaxial mode, the vane wheel is placed between an entry guide vane and an exit guide vane, two flow-guiding cones with large ends of 3mm are respectively arranged on an inlet end of the entry guide vane and an outlet end of the exit guide vane, the conical degree of the flow-guide cone is 90 degrees, and the two flow-guiding cones are in symmetrical arrangement. The helical angle of each flow-guiding vane on the entry guide vane gradually reduces from 90 degrees to 30 degrees along the axial direction from the inlet end to the outlet end, and the helical angle of each flow-guiding vane on the exit guide vane 3 gradually increases from 30 degrees to 90 degrees along the axial direction from the inlet end to the outlet end. The vanes on the vane wheel and all the flow-guiding vanes are in the shape of a logarithm helical line. Shaftless drive of the vane wheel reduces thrombus risk, and the micro structure improves the ability to implant. The low-blood-loss micro axial-flow type artificial heart has the advantages of being low in hemolysis, strong in implanting ability, simple in structure, high in reliability and the like.

The invention discloses a compressible valve clamping device. The compressible valve clamping device comprises a base, a sliding block and at least two groups of clamping components, wherein a butt joint part is arranged on the near end side of the base; a center hole penetrating through the sliding block is formed in the center of the sliding block in the axial direction; and the sliding block comprises a first connecting part arranged at the far end, a second connecting part arranged at the near end and a middle part located between the first connecting part and the second connecting part. The first connecting part is connected with the butt joint part, the sliding block can move close to and away from the base in the axial direction of the sliding block; each clamping component group comprises a connecting arm, a first clamping arm and a second clamping arm; the far end of each connecting arm is movably connected with the base, and the near end of each connecting arm is movably connected with one end of the corresponding first clamping arm to form a first included angle; the other end of the first clamping arm is movably connected to the sliding block, one end of the second clamping arm is connected with the other end of the first clamping arm to form a second included angle, and a pull wire penetrates through the other end of the second clamping arm. The valve clamping device can be compressed, and the overall size of a clamping system is greatly reduced.

The invention discloses a stable pharmaceutical composition, which contains (6S)-5-methyl-calcium tetrahydrofolate crystal and / or pharmaceutically acceptable reducing substances, and pharmaceutically acceptable auxiliary materials. Specifically, the reducing substances can protect (6S)-5-methyl-tetrahydrofolic acid and its salt from being oxidized, and can be selected from vitamin C and its salt, isovitamin C and its salt, mercaptoethanol, cysteine, mercaptoethyl sulfonic acid, dithiothreitol, reduced glutathione, and lipoic acid. The stable pharmaceutical composition provided by the invention has good stability during processing and storage, the drug risk caused by degradation can be avoided, and at the same time fast and reliable release of (6S)-5-methyl-tetrahydrofolic acid in the composition can be ensured.

The invention relates to the fields of a medical material and an apparatus thereof, and provides an in-vivo degradable implantable intravascular stent product. The product comprises 1) an in-vivo degradable implantable zinc-based metal material; 2) the intravascular stent product produced by the zinc-based alloy material in the step 1) is in a pipenet structure; 3) a magnesium metal film coating is uniformly distributed and deposed at the surface of the pipenet stent product; and 4) the magnesium film coating is coated with a degradable polymer coating, and the polymer coating can contains therapeutic drugs. The zinc based alloy has the advantages of excellent mechanical properties, strong corrosion controllability, and excellent compatibility. According to the intravascular stent product,surface special arrangement is benefit for keeping a complete initial structure, is benefit for stent endothelialization, reduces an inflammatory reaction, and reduces local inflammation, restenosisand thrombus risk in the stent after stent implantation.

The invention provides a continuous positive pressure remaining needle which comprises a remaining needle body, a catheter and a positive pressure keeping assembly. The remaining needle body is provided with a branch tube, the branch tube is connected with one end of the catheter, the other end of the catheter is connected with the positive pressure keeping assembly, and the positive pressure keeping assembly comprises a silicone tube, a liquid inlet one-way valve, a liquid outlet valve and a connector. The silicone tube has elasticity, the volume of the silicone tube is expanded when the silicone tube is filled with liquid, the silicone tube is connected with the liquid inlet end of the connector through the liquid inlet one-way valve, the silicone tube is connected with the liquid outlet end of the connector through the liquid outlet valve, and the connector is connected with the other end of the catheter at the same time. The continuous positive pressure remaining needle is provided with the positive pressure keeping assembly, when the remaining needle is not used for infusion, trace normal saline can be continuously injected into a blood vessel of a patient, the phenomenon of backflow and solidification of blood in the catheter of the remaining needle is avoided, and therefore the risk of thrombosis in the catheter of the remaining needle is reduced.

The invention discloses a stable pharmaceutical composition. The stable pharmaceutical composition contains (6S)-5-methyl-calcium tetrahydrofolate crystal and / or pharmacologically acceptable reducingsubstances as well as pharmacologically acceptable auxiliaries, wherein the reducing substances can protect (6S)-5-methyl-tetrahydrofolic acid and a salt thereof from being oxidized, and are selectedfrom vitamin C and a salt thereof, iso-vitamin C and a salt thereof, mercaptoethanol, cysteine, mercaptoethyl sulfoacid, dithiothreitol, reduced glutathione and thioctic acid. The stable pharmaceutical composition provided by the invention has good stability during processing and storage, avoids drug use risk caused by degradation, and ensures quick and reliable release of (6S)-5-methyl-tetrahydrofolic acid in the composition.

The invention provides a myocardial patch with a microneedle. The myocardial patch comprises a myocardial patch body and the microneedle; the myocardial patch body is of a porous structure; the myocardial patch body has anatomical morphology adaptability; the microneedle sequentially comprises a needle root, a needle body and a needle tip from the near end to the far end, wherein the needle body is located between the needle root and the needle tip; the needle root is provided with a stop structure; an anchoring structure is arranged on the needle body and / or the needle tip; when the myocardial patch makes contact with target tissue of a heart, part or all of the needle body and the anchoring structure on the microneedle pierce into the target tissue along with the needle tip to implement minimally invasive or damage-free anchoring; the myocardial patch body, the stop structure and the anchoring structure cooperate with each other, so that the myocardial patch body and the target tissue are attached and relatively fixed; and the myocardial patch body can be implanted into a target position through a blood vessel or an endoscope by means of a delivery system, thus implementing a minimally invasive implantation operation.

The invention discloses a medical polyurethane catheter composed of blended materials of polyurethane comprising 20% of barium sulfate and polyurethane comprising 40% of barium sulfate. The polyurethane materials with different barium sulfate contents are mixed according to different ratios. With the method provided by the invention, prior defects such as catheter hardness and elasticity can both be solved. Bending is prevented during catheterization, and the catheter has the advantages of good elasticity and pressure resistance. When catheter body is softened, the catheter is prevented from being flattened.

The invention discloses a drug balloon which comprises a balloon body, the outer surface of the balloon body is coated with a drug coating, the drug coating comprises a first component and a second component, the first component comprises polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), a photoinitiator and a first solvent, and the second component comprises a second solvent and a third solvent. The second component comprises a cell proliferation inhibition drug, a drug carrier and a second solvent; the cell proliferation inhibition drug is one or more of rapamycin, rapamycin and derivatives thereof, paclitaxel and derivatives thereof, the drug carrier is one or more of amphipathic high-molecular compounds, the balloon has the advantages of being good in balloon lubricity, low in drug delivery loss rate, high in bioavailability and the like, and compared with other similar products, the balloon has the advantages of being good in balloon lubricity, low in drug delivery loss rate, high in bioavailability and the like. The medicine is more suitable for patients with intracranial atherosclerosis with high intracranial blood vessel tortuosity degree and small narrow blood vessel diameter, and has a remarkable curative effect.

The invention relates to an absorbable iron-based instrument which comprises an iron-based matrix, a zinc-containing protective layer, a corrosion promoting layer and a drug controlled release layer, the iron-based matrix is provided with an outer wall, an inner wall and a side wall, the zinc-containing protective layer at least covers the outer wall and the inner wall of the iron-based matrix, the corrosion promoting layer completely covers the zinc-containing protective layer, the drug controlled release layer at least partially covers the corrosion promoting layer, both the corrosion promoting layer and the drug controlled release layer contain degradable polymers, the weight-average molecular weight of the degradable polymer in the corrosion promoting layer is greater than that of the degradable polymer in the drug controlled release layer, and a thickness ratio of a portion of the zinc-containing protective layer located on the inner wall to a portion of the corrosion promoting layer located on the inner wall is greater than a thickness ratio of a portion of the zinc-containing protective layer located on the outer wall to a portion of the corrosion promoting layer located on the outer wall. The corrosion behavior of the absorbable iron-based instrument meets the clinical use requirement, and the adverse histological reaction is less or not generated.

The invention discloses a membrane type oxygenator with a biocompatible coating. The oxygenator comprises a hollow fiber membrane type oxygenation unit and heat exchange units, wherein a plurality ofoxygenation units are arranged in the oxygenator at equal intervals; each heat exchange unit surrounds the outer periphery of the corresponding oxygenation unit; and moreover, the oxygenator further comprises the biocompatible coating which coats the surface of the hollow fiber membrane. The coating of the surface of the hollow fiber membrane is modified to improve the biocompatibility of contactbetween the fiber membrane and blood, the risk of formation of thrombi is reduced, the blood cardiopulmonary bypass of the oxygenator is reduced, meanwhile, the problem that the temperature of blood is reduced in an oxygenation process of the oxygenator is solved, over-high temperature gradient in a blood flowing process is improved, blood gas exchange efficiency is improved, the performance of the oxygenator is further improved, and demands of people are met.

The invention relates to an injectable dextran hydrogel microsphere filling agent and a preparation method thereof, and the preparation method of the injectable dextran hydrogel microsphere filling agent comprises the following steps: chemically modifying dextran to obtain polymerizable dextran, and further preparing dextran hydrogel microspheres through polymerization reaction crosslinking. And finally, uniformly mixing with an aqueous solution for injection, and fully swelling to obtain the injectable dextran hydrogel microsphere filler. The invention also provides the injectable dextran hydrogel microsphere filling agent prepared by the preparation method of the injectable dextran hydrogel microsphere filling agent. The preparation method of the injectable dextran hydrogel microspheres, disclosed by the invention, has the advantages of simple preparation method, mild conditions, few cross-linking agent residues and suitability for large-scale production, and the obtained injectable dextran hydrogel microsphere filler can realize long-acting filling and is suitable for various human body soft tissue filling occasions.

The invention relates to a diaphragm pump head. The diaphragm pump head comprises a shell and a diaphragm fixedly arranged in the shell. A pressure inlet and outlet is formed in the portion, corresponding to one side of the diaphragm, of the shell, a blood inlet and outlet is formed in the portion, corresponding to the other side of the diaphragm, of the shell, one end of the blood inlet and outlet is communicated with the shell, and the other end of the blood inlet and outlet is simultaneously communicated with a blood inflow pipe and a blood outflow pipe. Through the structural arrangement, thrombi can be effectively avoided, the service life is prolonged, and use cost is reduced.

The invention relates to a device promoting venous return of lower limbs of a patient. The device comprises a pressure resistance housing in the shape of a sleeve, an omega-shaped sac body and an airtight mechanism, wherein the pressure resistance housing consists of two hinged U-shaped modules; the omega-shaped sac body is adhered to the pressure resistance housing; an inlet and an outlet are respectively formed in positions adjacent to two ends of the sac body; the airtight mechanism comprises two sealing strips, two omega-shaped inserting rings and two elastic rings which can tightly sleevelegs. The device disclosed by the invention is especially applied to a patient being not smooth in venous return of lower limbs and staying in the bed for a long term; after the device sleeves the legs of the patient, a sealed space is formed between the whole device and the legs; and gas or liquid is inflated and deflated, so that the sac body is inflated or contracted, positive pressure stimulation and negative pressure stimulation can be performed on the legs, and the application is safe and comfortable.

The invention discloses an adenovirus vector for specifically inhibiting proliferation and migration of smooth muscle cells and application of the adenovirus vector. Target genes and miRNA regulatory sequences are inserted at multiple clone sites of the adenovirus vector. After atherosclerosis disease interventional therapy, a main principle of restenosis lies in that the smooth muscle cells migrate to an intima and perform pathological proliferation. The adenovirus vector disclosed by the invention is applied, so that the movement of the proliferation, the migration and the like of the smooth muscle cells can be well restrained, and restenosis can be avoided. The adenovirus vector is adjusted and controlled based on miRNA, so that the purpose of specifically inhibiting proliferation and the migration of vascular smooth muscle cells can be realized, and influence on vascular endothelial cells is little. Therefore, the repair of endothelium is not influenced, so that the risk of thrombosis is reduced, and the use of antiplatelets and bleeding can be reduced; the effect of interventional treatment of the atherosclerosis diseases can be improved.

The invention discloses a heart valve tether and a heart valve assembly with the same. One end of the heart valve tether is connected with a heart valve implanted into a heart, the other end of the heart valve tether is fixed outside the heart, the heart valve tether is made of an elastic material, and the strain of the elastic material is 6%-12% within the stress range not larger than 20 N. The heart valve tether can adapt to elastic connection required by heart beating, can apply fixed tension to the heart valve according to the change of the length of the tether, prevent the heart valve from falling into the atrium, can adapt to tension with different magnitudes in the heart beating process, and prevent damage to the heart due to the fact that the tension is too large.

The invention relates to a medicine eluting instrument and a manufacturing method thereof. The medicine eluting instrument comprises a basal body and a medicine carrying layer, wherein the basal bodycomprises an outer surface, side surfaces and an inner surface; the medicine carrying layer contains a medicine carrier and an active medicine; the outer surface, the side surfaces and the inner surface of the basal body are covered by the medicine carrying layer; and the active medicine is only distributed on at least a part of regions covering the outer surface and the side surfaces, of the medicine carrying layer, in the thickness direction of the at least a part of the regions, the concentration of the active medicine on one side adjacent to the basal body is greater than that of the active medicine on one side away from the basal body, and the region in the inner surface of the basal body, of the medicine carrying layer does not contain the active medicine. Through the adoption of themedicine eluting instrument disclosed by the invention, the release period of the active medicine is long, and the risk of generating thrombosis is low.

The invention relates to a locally-enhanced textile-based valve leaflet for an artificial heart valve and application of the valve leaflet. The valve leaflet comprises an attachment edge, an abdomen, a joint and a free edge; the valve leaflet is a woven jacquard fabric which is formed at one time; the local enhancement means that the tightness and / or thickness of a local area on the valve leaflet are / is greater than those of a non-local area on the valve leaflet; the local area comprises one or more of an attachment edge area, a joint area, a free edge area and an abdomen part area; and the abdomen part area refers to a plurality of line-shaped areas distributed in the abdomen area by taking the radial center line of the valve leaflet as a symmetry axis. According to the locally-enhanced textile-based valve leaflet for the artificial heart valve, integrated forming and multi-dimensional arbitrary regulation and control can be achieved, the tear resistance and hemodynamic performance of the valve leaflet are improved, the stress concentration phenomenon is reduced, and the long-term durability is improved.

The invention belongs to the field of medical apparatus and instruments, and specifically relates to a covered stent. The covered stent has a proximal great curvature side and a proximal lesser curvature side; the covered stent includes a main support, an inner layer covering film arranged on the inner side of the main support and an outer layer covering film arranged on the outer side of the main support; the main support includes multiple wave circles spaced in an axial direction, and wave peaks and wave troughs in alternate arrangement are formed on the wave circles; and the outer layer covering film is provided with first openings, and the first openings makes at least one wave trough, located on the proximal great curvature side or close to the proximal great curvature side, exposed to the outside. According to the covered stent of embodiment, the exposed wave troughs are easy to hang on vascular walls, therefore the effects of preventing the covered stent from dislocating can be achieved; and the wave peaks and wave troughs located on the proximal lesser curvature side maintain to be covered by the outer layer covering film, thus, the covering film in the cavity of the stent and wave circle stacking states are along the direction of blood flow, and the risks of thrombosis can be reduced.

The invention provides a conveyor and a medical device. The medical device comprises the conveyor, and the conveyor comprises a tube assembly and a rear release assembly, the tube assembly comprises an inner tube and an outer tube, the outer tube sleeves the inner tube, the outer tube can move in the axial direction of the inner tube, and the space between the inner tube and the outer tube is used for loading a medical implant; the rear release assembly comprises a fixing part and a connecting mechanism; the fixing part is connected to the inner tube and located on the far end side of the medical implant; and at least part of the structure of the connecting mechanism is used for being detachably connected to the fixing part, and the connecting mechanism is further used for being detachably connected with the medical implant. The medical device can improve the positioning accuracy of the medical implant.

The invention discloses a rapid blood vessel anastomosis device. The rapid blood vessel anastomosis device comprises a first end sleeve, a second end sleeve, a nail hammer and a handheld suturing nail percussion assembly, wherein the first end sleeve and the second end sleeve are coaxially arranged in an end-to-end opening and closing mode. The first end sleeve comprises a nail bin and the nail hammer, the nail bin is provided with a plurality of nail bin holes which are through along the axial direction and used for containing suturing nails, and suturing nail pushing pieces at one end of the nail hammer are used for being inserted into the nail bin holes in a one-to-one correspondence and matched mode from one end of the nail hammer; the second end sleeve is provided with a plurality of nail anvils; and the handheld suturing nail percussion assembly is used for being connected with the nail hammer of the first end sleeve and the second end sleeve, and clamping force is applied by holding the handheld suturing nail percussion assembly by a hand, so that the suturing nails in the corresponding nail bin holes are pushed out by the suturing nail pushing pieces of the nail hammer, and blood vessel suturing is conducted under the cooperation of the nail anvils. The rapid blood vessel anastomosis device can be used for conveniently and rapidly connecting blood vessels in a narrow in-vivo space during organ transplantation, the blood vessel anastomosis quality is high, the activity of an organ after transplantation can be improved, and the risk of transplantation complications is lowered.

The invention relates to an intravenous injection lipid emulsion having anti-inflammatory and anti-thrombosis functions as well as a preparation method and an application thereof. The lipid emulsion consists of anti-inflammatory lipid, lipid having an anti-platelet aggregation function, an emulsifier, polyhydric alcohol and other pharmaceutical accessories, wherein the anti-inflammatory lipid is lipid which can form timnodonic acid or butyric acid through metabolism in vivo; and the lipid having an anti-platelet aggregation function is lipid which can form docosapentaenoic acid through metabolism in vivo. On one hand, the lipid emulsion disclosed by the invention can effectively relieve inflammatory reaction in patients, and can significantly reduce platelet aggregation and reduce the risk of high-risk thrombosis on the other hand. In addition, by virtue of reasonable lipid composition, the lipid emulsion can improve metabolism rate of fatty acid lipid and accelerate energy supply.

The present invention relates to a device and a method for supporting a human being, preferably a newborn, in particular an extremely premature infant between the 21 / 0 and 28 / 0 week of pregnancy (SSW), comprising at least one through-flow system (21), comprising a number of fluid-permeable elements (22) and connecting elements (26, 28) for the connection to an umbilical arterial catheter (30) and an umbilical venous catheter (32) of the newborn and a through-flow lumen (20) for passing modified amniotic fluid enriched with oxygen or a oxygen-containing gas mixture through the fluid-permeable elements (22), and at least one connection (12) for introducing the modified amniotic fluid enriched with oxygen or an oxygen-containing gas mixture into the through-flow system (21), wherein the through-flow system (21) is configured in such a way that the amniotic fluid modified with oxygen or an oxygen-containing gas mixture is guided through the fluid-permeable elements (22) of the through-flow system (21) while the foetal blood is passed along the outer side of the fluid-permeable elements (22), but directed past the through-flow lumen, whereby a gas exchange occurs.

The invention relates to a chondroitin sulfate modified collagen / polycaprolactone vascular repair scaffold and a preparation method and application thereof. According to the invention, coupling between chondroitin sulfate and collagen is realized by adopting a reductive amination method with a relatively mild reaction process, the chondroitin sulfate modified collagen obtained by chemical coupling is used as a base material of the scaffold, polycaprolactone is used as a mechanical reinforcing material, and the chondroitin sulfate modified collagen / polycaprolactone vascular repair scaffold is prepared by an electrostatic spinning method. The vascular repair scaffold has a good antithrombotic effect, can realize rapid endothelialization, is expected to be used as a vascular repair scaffold material, is applied to transplantation, repair and regeneration of small blood vessels, and is used for treating cardiovascular diseases which seriously threaten human health.