The invention discloses a drug balloon which comprises a balloon body, the outer surface of the balloon body is coated with a drug coating, the drug coating comprises a first component and a second component, the first component comprises polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), a photoinitiator and a first solvent, and the second component comprises a second solvent and a third solvent. The second component comprises a cell proliferation inhibition drug, a drug carrier and a second solvent; the cell proliferation inhibition drug is one or more of rapamycin, rapamycin and derivatives thereof, paclitaxel and derivatives thereof, the drug carrier is one or more of amphipathic high-molecular compounds, the balloon has the advantages of being good in balloon lubricity, low in drug delivery loss rate, high in bioavailability and the like, and compared with other similar products, the balloon has the advantages of being good in balloon lubricity, low in drug delivery loss rate, high in bioavailability and the like. The medicine is more suitable for patients with intracranial atherosclerosis with high intracranial blood vessel tortuosity degree and small narrow blood vessel diameter, and has a remarkable curative effect.