12results about How to "Reduce hemolysis" patented technology

The utility model discloses a medical blood flow guiding and distributing device which comprises a flow guiding plate and a distributing plate which are mutually buckled in a sealing mode, a cavity for containing blood is formed between the flow guiding plate and the distributing plate, the flow guiding plate is provided with an inlet, an outlet and an exhaust hole which are both communicated with the cavity, and the exhaust hole is provided with a waterproof breathable film. A plurality of distribution holes communicated with the cavity are formed in the distribution plate, a flow guide groove is formed in the side face, located in the cavity, of the flow guide plate, one end of the flow guide groove starts from the end, located in the cavity, of the inlet and outlet, and the other end of the flow guide groove extends in the direction away from the inlet and outlet. The utility model aims to provide the medical blood diversion and distribution device which can be mounted at a blood inlet and a blood outlet of a blood treatment device, so that the blood can obtain a better blood treatment effect, the speed of the blood flowing out of the treatment device is more uniform and stable, turbulence is not easy to generate, and hemolysis and thrombus are reduced.

The invention relates to the field of medicines, and provides a tevirimat composition as well as a preparation method and application thereof. The composition contains tevirimat serving as an active component, cyclodextrin serving as an inclusion agent, meglumine serving as a solubilizer and an alkaline additive in a weight ratio of 1: (15-30): (0.05-0.2): (0.1-0.2). Wherein the solubility of the active ingredient tevirimat can be greatly improved through the matching and combined use of the three auxiliary materials including the inclusion agent, the solubilizer and the alkaline additive. Compared with the prior art, the dosage of each auxiliary material in the composition can meet the specified limit in related laws and regulations, the allergy risk, the hemolysis risk and the stimulation risk are low, and the preparation safety is better. The composition provided by the invention is simple and feasible in preparation method, more stable in preparation finished product quality and more convenient to apply. The composition can be used for treating or preventing virus infection and related diseases caused by orthopoxvirus.

The application discloses a kind of tangential magnetization rotor integrated shaftless impeller's magnetic suspension artificial heart pump structure, including impeller and several equidistantly connected independent blades of equal size and material in rotor inside, the blade is located in rotor center, but not connected on main shaft, realize the integration of impeller and rotor and the shaftless of impeller, improve traditional central shaft driven impeller to four peripheral driving type.Blade equidistantly connects in rotor shield sleeve inside, realizes shaftless, to be integrated with rotor in one body.The application adopts above-mentioned tangential magnetization rotor integrated shaftless impeller's magnetic suspension artificial heart pump structure and can reduce motor volume, easy to transplant;Meanwhile, the integrated structure can prevent blood from flowing through motor air gap to the maximum, to reduce the situation of hemolysis and thrombosis.

The invention provides a self-lubricating anticoagulant surface coating and a preparation method and application thereof, and the self-lubricating anticoagulant surface coating (SLACS) composed of dimethyl siloxane gel and dimethyl siloxane (S-PDMS) gel is prepared on a rough substrate through physical adhesion and chemical bonding. Under the action of the lubricating layer, plasma protein and blood cells are difficult to adhere to and activate on the surface of the SLACS. The SLACS shows strong blood adhesion resistance and is beneficial to high-level blood compatibility of the SLACS. The coating of the ECMO centrifugal pump head is improved through SLACS, the feasibility of the ECMO centrifugal pump head serving as a novel centrifugal pump head is further verified through static experiments, computer simulation and dynamic experiments, and a new choice is provided for safe medical treatment in the future.

The invention discloses a magnetic levitation pump with a symmetrical hollow thin-wall structure and a control method thereof.The magnetic levitation pump with the symmetrical hollow thin-wall structure comprises a shell, magnetic levitation blades and a magnetic levitation driving assembly, the shell comprises an upper pump shell and a lower pump shell connected with the upper pump shell in a sealed mode, and the magnetic levitation blades are arranged in the shell; the magnetic suspension blades are provided with symmetrical cavities, the positions, located between the cavities, of the magnetic suspension blades are provided with liquid inlet hollow channels, the positions, located on the outer sides of the cavities, of the magnetic suspension blades and the inner wall of the lower pump shell form thin-wall channels communicating with the liquid inlet hollow channels, and the magnetic suspension driving assembly is used for controlling and driving the magnetic suspension blades to rotate in the shell. The flow channel design of the pump is optimized, the microcontroller is used for controlling radial and axial stator currents in real time, high-speed rotation and suspension of rotor blades can be achieved, the turbulence effect when blood flows through can be greatly inhibited, eddy currents and local high-shear areas can be reduced, the fluid dynamic characteristics are improved, and hemolysis is reduced.

The application relates to a microfluidic device, a support and a plasma separation method for whole blood filtration, comprising a body, a filtration mechanism arranged in the body and a collection tank in communication with the filtration mechanism, the filtration mechanism is used for filtering red blood cells, and the collection tank is used for collecting plasma; the application further comprises a driving mechanism used for driving a sample in the body to move from a side where the filtration mechanism is located to a side where the collection tank is located. The driving mechanism can improve the flow speed of the sample, thereby improving the whole blood filtration speed, shortening the whole blood separation time and reducing the possibility of hemolysis. The microfluidic device provided by the embodiment can obtain plasma without a centrifuge, has a small device volume and is easy to operate.

The present invention provides a method for preparing a sterilized composition for stabilizing extracellular nucleic acids. Also provided are sterilizable compositions, wherein the compositions in sterilized form are suitable for stabilizing extracellular nucleic acid populations of biological samples. Other useful methods, devices, kits and uses are also provided. Other sterilizable and sterilized compositions described herein are also suitable for stabilizing intracellular nucleic acids (e.g., intracellular DNA such as genomic DNA and / or intracellular RNA) and cell characteristics, such as cell surface proteins and / or cell morphology.

The invention discloses a catheter device for circulation assistance and a circulation assistance system. The catheter device comprises a catheter body, a far-end one-way valve and a near-end one-way valve which are distributed at intervals are arranged on the catheter body, the far-end one-way valve is closer to the tail end of the catheter body than the near-end one-way valve, and the rotating opening and closing directions of valve blades of the far-end one-way valve and the near-end one-way valve are opposite; in a suction state, valve blades of the far-end one-way valve and the near-end one-way valve are driven by negative pressure in the catheter body to inwards close a flow channel, so that a valve port of the near-end one-way valve is communicated with an inner cavity of the catheter body to form a suction channel; in the liquid injection state, the valve leaves of the far-end one-way valve and the near-end one-way valve are driven by positive pressure in the catheter body to outwards close valve ports of the valve leaves and open flow channels of the valve leaves, and the catheter body is made to be through in the injection direction. Through the design of the integrated catheter structure and the double-valve structure, the double-valve structure of the ventricle and the active ejection process are simulated, electrocardio gating triggering is not needed, and implantation operation and use are easy.

The present invention provides an extracorporeal magnetic suspension centrifugal blood pump with a central magnetic pole structure, wherein the pump head includes an impeller and a pump casing, the lower bottom plate of the cylindrical chamber at the lower part of the pump casing is concave to form a central cylindrical shell, and the lower bottom plate outside the corresponding pump casing forms a central tube cavity; the blades in the impeller are fixed on the base, the base is a cylindrical shell, a pipe section is arranged inside it, and the permanent magnet is fixed in the annular chamber between the pipe section and the shell; the impeller is sleeved on the central cylindrical shell; there is a W-shaped secondary flow channel between the impeller base and the cylindrical chamber of the pump casing and between the pipe section and the central cylindrical shell; the magnetic suspension device is below the pump casing, and the stator soft iron in the magnetic suspension element includes a central columnar soft iron, and the central tube cavity of the pump casing is inserted on the central columnar soft iron to form a central magnetic pole. The centrifugal blood pump can reduce thrombosis and hemolysis, and improve the stability and operation efficiency of the pump.

The invention relates to the technical field of red blood cell preservation, and discloses a supercooling preservation method capable of preserving functional integrity of red blood cells for a long time, which comprises the following steps: step 1, fixing a PVC blood bag on a hard substrate; 2, storing 100-200ml of red blood cells in the PVC blood bag, and sealing the top of the liquid level of the red blood cells with an incompatible oil phase; 3, the PVA blood bag in the step 2 is subjected to supercooling storage. According to the invention, the PVC blood bag is combined with the paraffin oil for sealing, so that the crystallization freezing point is reduced, the storage condition is stabilized, and 100ml of red blood cells are successfully preserved at the temperature of-8 DEG C for 63 days. Tests on the preserved erythrocytes find that the method of the scheme significantly reduces hemolysis, metabolism and oxidative stress, and maintains the integrity and functionality of erythrocyte membranes. The method is expected to obviously promote the progress of red blood cell preservation technology and standard and improve the medical level of blood transfusion.

The application discloses a centrifugal blood pump with constant rotating speed and output pulsating flow, which is characterized by the following technical scheme: a steering gear assembly is arranged in the pump body, an impeller is arranged in the inner cavity of the pump shell, a bevel gear I is arranged at the root of the blade uniformly arranged on the circumference of the impeller, and a driving motor II is used for driving the impeller to rotate; a driving motor I is used for driving the steering gear assembly to work, the steering gear assembly comprises a box body, two output inner gear rings with opposite rotating directions which can rotate axially in the box body, and an input inner gear ring; a steering gear is arranged in the middle of the box body, the steering gear is sleeved on the rotating main shaft of the impeller, one end of the steering gear is engaged with the bevel gear I through the bevel gear II in the impeller, and the straight gear at the other end is connected with an alternate steering mechanism so that the deflection angle of the blade is changed alternately, the rotating range of the blade angle is adjusted by the independent motor driving the related gear mechanism, the blade can be effectively and reliably driven to perform high-frequency angle adjustment, and the blood flow output by the blood pump can meet the pulsating demand of human body under the condition that the rotating speed is constant.