6results about How to "Reduce hemolysis" patented technology

The invention relates to the field of medicines, and provides a tevirimat composition as well as a preparation method and application thereof. The composition contains tevirimat serving as an active component, cyclodextrin serving as an inclusion agent, meglumine serving as a solubilizer and an alkaline additive in a weight ratio of 1: (15-30): (0.05-0.2): (0.1-0.2). Wherein the solubility of the active ingredient tevirimat can be greatly improved through the matching and combined use of the three auxiliary materials including the inclusion agent, the solubilizer and the alkaline additive. Compared with the prior art, the dosage of each auxiliary material in the composition can meet the specified limit in related laws and regulations, the allergy risk, the hemolysis risk and the stimulation risk are low, and the preparation safety is better. The composition provided by the invention is simple and feasible in preparation method, more stable in preparation finished product quality and more convenient to apply. The composition can be used for treating or preventing virus infection and related diseases caused by orthopoxvirus.

The application discloses a kind of tangential magnetization rotor integrated shaftless impeller's magnetic suspension artificial heart pump structure, including impeller and several equidistantly connected independent blades of equal size and material in rotor inside, the blade is located in rotor center, but not connected on main shaft, realize the integration of impeller and rotor and the shaftless of impeller, improve traditional central shaft driven impeller to four peripheral driving type.Blade equidistantly connects in rotor shield sleeve inside, realizes shaftless, to be integrated with rotor in one body.The application adopts above-mentioned tangential magnetization rotor integrated shaftless impeller's magnetic suspension artificial heart pump structure and can reduce motor volume, easy to transplant;Meanwhile, the integrated structure can prevent blood from flowing through motor air gap to the maximum, to reduce the situation of hemolysis and thrombosis.

The application relates to a microfluidic device, a support and a plasma separation method for whole blood filtration, comprising a body, a filtration mechanism arranged in the body and a collection tank in communication with the filtration mechanism, the filtration mechanism is used for filtering red blood cells, and the collection tank is used for collecting plasma; the application further comprises a driving mechanism used for driving a sample in the body to move from a side where the filtration mechanism is located to a side where the collection tank is located. The driving mechanism can improve the flow speed of the sample, thereby improving the whole blood filtration speed, shortening the whole blood separation time and reducing the possibility of hemolysis. The microfluidic device provided by the embodiment can obtain plasma without a centrifuge, has a small device volume and is easy to operate.

The present invention provides a method for preparing a sterilized composition for stabilizing extracellular nucleic acids. Also provided are sterilizable compositions, wherein the compositions in sterilized form are suitable for stabilizing extracellular nucleic acid populations of biological samples. Other useful methods, devices, kits and uses are also provided. Other sterilizable and sterilized compositions described herein are also suitable for stabilizing intracellular nucleic acids (e.g., intracellular DNA such as genomic DNA and / or intracellular RNA) and cell characteristics, such as cell surface proteins and / or cell morphology.

The application discloses a centrifugal blood pump with constant rotating speed and output pulsating flow, which is characterized by the following technical scheme: a steering gear assembly is arranged in the pump body, an impeller is arranged in the inner cavity of the pump shell, a bevel gear I is arranged at the root of the blade uniformly arranged on the circumference of the impeller, and a driving motor II is used for driving the impeller to rotate; a driving motor I is used for driving the steering gear assembly to work, the steering gear assembly comprises a box body, two output inner gear rings with opposite rotating directions which can rotate axially in the box body, and an input inner gear ring; a steering gear is arranged in the middle of the box body, the steering gear is sleeved on the rotating main shaft of the impeller, one end of the steering gear is engaged with the bevel gear I through the bevel gear II in the impeller, and the straight gear at the other end is connected with an alternate steering mechanism so that the deflection angle of the blade is changed alternately, the rotating range of the blade angle is adjusted by the independent motor driving the related gear mechanism, the blade can be effectively and reliably driven to perform high-frequency angle adjustment, and the blood flow output by the blood pump can meet the pulsating demand of human body under the condition that the rotating speed is constant.