143results about How to "Reduce hemolysis" patented technology

A rotary blood pump is provided which includes a pump housing and a rotor mounted for rotation with the housing. The rotor has an impeller. A rotor motor is provided including a plurality of permanent magnets carried by the impeller. A first motor stator is positioned on one side of the impeller and a second motor stator is positioned on an opposite side of the impeller. The motor stators each include a plurality of electrically conductive coils and pole pieces located within the housing. A plurality of wedge-shaped hydrodynamic thrust bearings are located outside of the axis of the rotor. During rotation of the impeller, the hydrodynamic bearings are separated from the housing by a fluid film and are not in direct mechanical contact with the housing.

A sulfoalkyl ether-alkyl ether cyclodextrin (SAE-AE-CD) derivative is provided. The SAE-AE-CD possesses advantages over known SAE-CD and AE-CD derivatives as well as over the parent cyclodextrin by being more water soluble and less membrane disturbing. The SAE-AE-CD includes at least one sulfoalkyl ether group and at least one alkyl ether group even though the degree of substitution for the functional groups can be different. The SAE functional group can be present in molar excess over the AE functional group and vice versa. The total degree of substitution of the cyclodextrin, with respect to both functional groups, can be varied such that a minority or a majority of the hydroxyl moieties of the CD are derivatized. The SAE-AE-CD derivative can be used to solubilize compounds with insufficient water solubility. In some cases, they also stabilize compounds in solution against degradation or to solubilize degradation products formed during degradation. In addition, SAE-AE-CD can also be used for other purposes such as osmotic agents, agents used to mask the taste of problematic drugs. Surprisingly, while AE-CDs are known to be toxic by being membrane disturbing, SAE-AE-CDs are less membrane disturbing and therefore have greater safety.

A red blood cell storage composition includes a composition of red blood cells and biochemistry altering reagents, the biochemistry altering reagents being present at a concentration so as to reduce the percent hemolysis of the red blood cells during the freeze-thaw cycle below that of the percent hemolysis of the red blood cells in the absence the biochemistry altering reagents. The red blood cell storage composition preferably includes reagents selected from: modifiers of glycolytic/metabolic components, modifiers of antioxidant potential, effectors of intracellular ionic distribution, modifiers of membrane fluidity, modifiers of cytoskeletal structure, effectors of the cyclooxygenase second messenger pathway, effectors of the lipoxygenase second messenger pathway, effectors of the hexose monophosphate second messenger pathway, effectors of the phosphorylation second messenger pathway, modifiers of specific messenger molecules, and combinations thereof.

An apparatus and methods for enhanced plasmapheresis comprising a filter membrane under an orbital motion or movement that has optimal local shear forces and maximum plasma flow output. The methods for biological separation and therapies comprise platelet collection, viral particle removal, cell washing and processing for stem cell selection, bone marrow purging, red blood cell collection, auto-transfusion, auto-immune disease treatment, selective macro-molecule removal, toxin removal, LDL removal, extracorporeal plasma delipidation, and the like.

There is provided a non-contact, passively suspended blood pump that includes (a) a housing; (b) a pump rotor within the housing, wherein the pump rotor has a first end and a second end, and an axis of rotation; (c) a first axial thrust bearing across a first axial gap, between the first end and the housing, that axially suspends the first end; (d) a second axial thrust bearing across a second axial gap, between the second end and the housing, that axially suspends the second end; (e) a first radial hydrodynamic bearing that radially suspends the first end; and (f) a second radial hydrodynamic bearing that radially suspends the second end. Determining pump differential pressure by monitoring rotor axial position allows automatic physiologic control.

A cannulation system for cardiac support uses an inner cannula disposed within an outer cannula. The outer cannula includes a fluid inlet for placement within the right atrium of a heart. The inner cannula includes a fluid inlet extending through the fluid inlet of the outer cannula and the atrial septum for placement within at least one of the left atrium and left ventricle of the heart. The cannulation system also employs a pumping assembly coupled to the inner and outer cannulas to withdraw blood from the right atrium for delivery to the pulmonary artery to provide right heart support, or to withdraw blood from at least one of the left atrium and left ventricle for delivery into the aorta to provide left heart support, or both.

The invention relates to an apparatus system and methods for treatment of virus-infected or pathogen-loaded human blood components separated from normal components comprising a separation apparatus and treatment apparatus system that inactivate pathogens in an extracorporeal blood system.

The invention relates to an embedded micro streamline axial flow blood pump, which can be used for assisting blood circulation of failed heart. The blood pump comprises a pump body arranged in a sleeve body and a driving device arranged outside the pump body, wherein the pump body comprises the sleeve body, a front guide vane, a rotor and a back guide vane; the hubs of the front guide vane, a rotor and the back guide vane are designed integrally in an integral streamline form; and the front half part of the rotor is provided with an inductive blade. The blood pump can reduce the on-way pressure loss of the blood in the flow channel of the blood pump, improve efficiency and reduce hemolysis; and can promote the circumferential speed of the blood after entering into a rotor area due to the inductive blade arranged on the front half part of the rotor, and avoids the occurrence of vacuole phenomenon.

Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorders.

Pharmaceutical compositions for intravenous administration comprising the compound of Formula I

or pharmaceutically acceptable salts, hydrates or prodrugs thereof are described herein. Methods of preparing the pharmaceutical compositions and methods for treating nausea and/or emesis with the pharmaceutical compositions are also described herein.

An implantable cardiovascular blood pump system is provided, suitable for use as a left ventricular assist device (LVAD) system, having an implantable cardiovascular pump, an extracorporeal battery and a controller coupled to the implantable pump, and a programmer selectively periodically coupled to the controller to configure and adjust operating parameters of the implantable cardiovascular pump. The implantable cardiovascular blood pump includes a coaxial inflow cannula and outflow cannula in fluid communication with one another and with a pumping mechanism. The pumping mechanism may be a vibrating membrane pump which may include a flexible membrane coupled to an electromagnetic actuator assembly that causes wavelike undulations to propagate along the flexible membrane to propel blood through the implantable cardiovascular pump. The implantable cardiovascular pump may be programmed to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while avoiding thrombus formation, hemolysis and/or platelet activation.

The invention provides a preparation method and activity detection for antibacterial peptides. In the preparation method, series of antibacterial peptides which contain a few amino acid residues are prepared by using a helical wheel model of a protein; and antibacterial activity, hemolytic activity, cytotoxicity and the like of the series of the antibacterial peptides are detected. The four obtained antibacterial peptides have obvious bacteriostatic activity; and the two antibacterial peptides which contain a plurality of valines have no hemolytic activity and less cytotoxicity, wherein in particular the antibacterial peptides which contain three glycines, five arginines and eight valines have the greatest potential. The preparation method and the activity detection have important theoretical and practical significance for further explaining the action mechanism of the antibacterial peptides, designing the antibacterial peptides reasonably and the like.

The invention discloses a half-blade-rotor-type axial flow blood pump which comprises an inner barrel, a front guide, a rotor and a rear guide. The front guide has three straight blades, the rotor has two rotating blades, the two rotating blades of half-blade structures are distributed on a front half of a hub of the rotor only, and blade tip clearance length of the rotor is reduced by a half; the rear guide has three big rotating blades and three small rotating blades, the big rotating blades and the small rotating blades are distributed at intervals, each big rotating blade is provided with a suspension arm with one-half length, each suspension arm extends into a rotor area to form a suspension arm blade structure, and a runner portion on the outer surface of the rotor is made by smooth date-pit-shaped cubic spline curves. The half-blade-rotor-type axial flow blood pump has the advantages that a whole runner formed by the front guide, the rotor and the rear guide is designed to be of a date-pit-shaped structure, and the smooth cubic spline curves are adopted, so that pressure rise of the blood pump is increased, flow field distribution in the pump is improved, area of a rotating-stilling interface is reduced, and risk of thrombosis at a bearing is lowered.

The invention relates to an apparatus system and methods for treatment of virus-infected or pathogen-loaded human blood components separated from normal components comprising a separation apparatus and treatment apparatus system that inactivate pathogens in an extracorporeal body fluid system.

The invention relates to a red cell storage solution and a preparation method thereof. The storage solution comprises a buffering system, a nutritional system, an osmotic pressure system and an anticorrosion system, wherein the anticorrosion system comprises the following components according to mass concentration: 0.2-1g/L of chloramphenicol, 0.1-0.6g/L of neomycin sulfate, and 0.1-0.5g/L of gentamicin. Through mutual concurrent effects of the buffering system, the nutritional system, the anticorrosion system and the osmotic pressure system of the red cell storage solution provided by the invention, long storage cycle of the red cell storage solution is ensured, at the end of the sixth month of the storage, that red cell suspension free hemoglobin concentration still conforms to national standard is detected, and the hemolysis ratio at the end of the storage is smaller than 0.8 percent of the total of red cells; the red cell storage solution provided by the invention can ensure relatively strong antigenic activity and stability of the red cells.

The invention relates to a blood pump auxiliary device, in particular to an artificial heart auxiliary device which uses external magnetic field for driving a magnetic bearing to support an embeddable conical spiral impeller rotor, belonging to the field of biomedical engineering technique; the blood pump is arranged in an alternating magnetic field and comprises a small end shell (1) which is connected with a blood vessel, a large end shell (4) and a middle shell (3); the large end and the small end of the middle shell (3) are respectively connected with the small end shell (1) and the large end shell (4) hermetically; the small end shell (1) and the large end shell (4) are internally and fixedly provided with a small end guide wheel (2) and a large end guide wheel (6) with impellers on the external surface thereof respectively; the impeller rotor (5) is arranged in a space which is formed by the middle shell (3), the small end guide wheel (2) and the large end guide wheel (6); the impeller rotor (5) is internally provided with a shaft (11); a permanent magnetic strip (12) is fixedly arranged between the impeller rotor (5) and the shaft (11); and clearances are arranged between the impeller rotor (5) and the small end guide wheel (2) and the large end guide wheel (6). The blood pump auxiliary device effectively solves a series of technical problems such as sealing infection and biocompatibility and the like, which are caused by leads passing through skins and can not be overcome by traditional blood pumps.