7 results about "Free hemoglobin" patented technology

The invention relates to the technical field of blood detection, and particularly discloses a spectrum detection method, system, device, equipment and medium for detecting the free hemoglobin content of a plasma braid, and the method comprises the following steps: taking out a to-be-detected sample of the plasma braid to obtain an original optical measurement object to obtain the to-be-detected sample; performing multi-wavelength alternate irradiation on the to-be-detected sample and collecting continuous time sequence photoelectric response to obtain an original time sequence signal set; obtaining an absorbance set; a normalized absorption characteristic subjected to scattering and temperature dual compensation is obtained; obtaining an initial free hemoglobin concentration estimated value; the final free hemoglobin concentration and a judgment result are obtained; by directly detecting the separated plasma tube braid, the sealing performance and safety of the main blood bag are not influenced at all, and the pollution risk caused by puncture sampling is thoroughly avoided. The method is objective and accurate, results are quantified, manual subjective errors are thoroughly eliminated by adopting a spectral analysis technology, and particularly, judgment on critical value samples is extremely accurate.

The application belongs to the technical field of medical equipment, and provides a blood treatment system including a blood treatment assembly, an optical detection assembly and a control module. The blood treatment assembly uses a treatment liquid to treat blood of a target object to obtain waste liquid and treated blood, and the treated blood is transfused back to the target object. The optical detection assembly generates irradiation light of at least three wavelengths, wherein the irradiation light of the first wavelength is used for detecting bilirubin or free hemoglobin, the irradiation light of the second wavelength is used for detecting intracellular hemoglobin, and the irradiation light of the third wavelength is used for detecting the waste liquid. The optical detection assembly collects light information of emergent light of the at least three wavelengths. The control module obtains light change information corresponding to the at least three wavelengths according to the light information of the emergent light of the at least three wavelengths and the light information of the irradiation light of the at least three wavelengths. Whether the light change information corresponding to the at least three wavelengths satisfies a preset alarm condition is judged to determine whether to perform a hemolysis alarm or a blood leakage alarm, so that detection is distinguished.

The invention discloses a blood hemolysis detection kit and a detection method, and the kit comprises a hemoglobin cracking reagent which is used for destroying hemoglobin to release internal iron ions and / or ferrous ions; and the iron ion fluorescent probe is used for detecting the iron ion concentration in combination with fluorescence detection. The invention provides a strategy different from conventional hemolysis detection: the hemolysis degree is indirectly judged by detecting the content of Fe, specifically, the erythrocyte releases free hemoglobin after hemolysis, and the hemoglobin contains specific iron; based on the principle, hemoglobin is destroyed and cracked to release internal Fe and / or Fe, then a self-made iron ion fluorescent probe is adopted, and a fluorescence measurement means is combined, so that the iron ion concentration can be detected, and the hemolysis degree of the blood to be detected is judged, namely the higher the iron ion concentration is, the more serious the hemolysis is.

The invention provides a double-position centrifugal plasma purification system, and belongs to the technical field of plasma purification. Comprising a plasma collection system, a plasma adsorption system and a liquid feedback system, the plasma collection system and the liquid feedback system are both connected with a blood supplier to form a blood closed-loop conveying loop, and the plasma adsorption system is connected with the plasma collection system and the liquid feedback system; the plasma collecting system comprises two centrifugal machines and further comprises a back-flushing cleaning system, and the two centrifugal machines are alternately connected with the plasma collecting system and the back-flushing cleaning system through a first control valve and a second control valve. The centrifugal machine after each round of blood separation is flushed through the backflushing cleaning system, blood residues in a container of the centrifugal machine are avoided, free hemoglobin rising caused by long-time centrifugation of blood components is avoided, and the effect of improving the safety and reliability of the blood purification process is achieved.

Chromatographic assay devices for detecting the presence of free hemoglobin in a liquid biological sample are disclosed. The device comprises a sample application pad and a chromatographic detection pad, wherein the sample application pad is formed of two layers of material. Medical diagnostics devices for use with the chromatographic assay devices are also disclosed, as well as kits and methods of using the chromatographic assay device and / or medical diagnostics device.

An apparatus comprises a barrel and a colorimetric assay assembly. The barrel has a sidewall defining a portion of a colorimetric chamber that is in fluid communication with an internal chamber defined by an inner surface. The colorimetric assay assembly, housed in the colorimetric chamber, comprises a sample application pad to receive a fluid sample and a colorimetric detection pad to visualize a presence of free hemoglobin. The sample application pad is formed of a prefiltration layer and a filtration layer. The prefiltration layer comprises a distal surface having a first wetting property and a hydrophilic receiving surface having a second wetting property less than the first wetting property and is configured to receive the fluid sample and convey at least a portion of the fluid sample to the filtration layer. The filtration layer is porous to plasma and the free hemoglobin and not porous to red blood cells.

There is presented an apparatus (100) for automatically measuring an analyte concentration in a liquid sample (102) comprising the analyte and cell-free hemoglobin and for automatically determining a cell-free hemoglobin interference criticality, said apparatus comprising one or more sensors (104) for measuring the analyte concentration in the liquid sample, and a cell-free hemoglobin concentration in the liquid sample, and further comprising a data processing device (106) comprising a processor configured to determine the cell-free hemoglobin interference criticality based on the cell-free hemoglobin concentration, and the analyte concentration, and output a signal (108) indicative of the cell-free hemoglobin interference criticality at least in case the cell-free hemoglobin interference criticality is within a predetermined range.