Method for measuring content of free hemoglobin in blood bag based on multi-position transmission spectra

A technology of transmission spectroscopy and hemoglobin, which is applied in the field of stoichiometry for concentration analysis of complex spectral solutions, can solve problems such as inability to meet, and achieve the effect of suppressing influence and improving analysis accuracy.

Inactive Publication Date: 2017-12-01
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Among the existing technologies, the more mature technology is to detect the content of free hemoglobin in the blood bag through chemical testing, which has the outstanding advantage of high accuracy, but the chemical testing method needs to open the blood bag to take out samples for testing, which cannot meet the requirements of rapid , non-contact and non-pollution requirements, due to its non-contact and non-pollution characteristics, spectral detection is also possible to detect free hemoglobin in blood bags

Method used

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  • Method for measuring content of free hemoglobin in blood bag based on multi-position transmission spectra
  • Method for measuring content of free hemoglobin in blood bag based on multi-position transmission spectra
  • Method for measuring content of free hemoglobin in blood bag based on multi-position transmission spectra

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Embodiment 1

[0050] In the method for measuring free hemoglobin content in a blood bag by multi-position transmission spectroscopy provided by the embodiment of the present invention, the devices used are such as figure 1 As shown, it includes: a light source 1 , a blood bag 3 , a displacement platform 4 and a spectrum receiving device 5 .

[0051] Wherein, ensure that the light outlet of the light source 1 and the incident slit of the spectrum receiving device 5 are close to the blood bag 3, the light source 1 transmits the blood sample in the blood bag 3 at the first position a, and the spectrum receiving device 5 collects the transmission spectrum. Then the light source 1 is controlled by the displacement platform 4 to move to the second position b, the spectrum receiving device 5 collects the transmission spectrum at this position, the light source 1 is controlled by the displacement platform 4 to move to the position n, and the spectrum receiving device 5 collects the transmission spec...

Embodiment 2

[0060] The difference between the embodiment of the present invention and embodiment 1 is only that the light source 1 and the moving mode of the spectrum receiving device 5 are different, see the following description for details:

[0061] see figure 2 , ensure that the light outlet of the light source 1 and the incident slit of the spectrum receiving device 5 are close to the blood bag 3, the light source 1 transmits the blood sample in the blood bag 3, and the spectrum receiving device 5 collects the transmission spectrum at the first position a . Then the spectrum receiving device 5 is controlled by the displacement platform 4 to move to the second position b, and the transmission spectrum at the second position b is collected; the spectrum receiving device 5 is controlled to move to the position n by the displacement platform 4, and the transmission spectrum at the position n is collected .

[0062] Wherein, the subsequent steps of normalization, establishment of a mat...

Embodiment 3

[0066] In actual implementation, due to the limitation of the space structure, it may occur that the light source 1 and the spectrum receiving device 5 cannot be close to the blood bag 3. At this time, an optical fiber can be respectively arranged at the light source 1 and the spectrum receiving device 5 as the incident optical fiber 2 and outgoing fiber 6.

[0067] see image 3 , the light source 1 transmits the blood sample in the blood bag 3 through the incident optical fiber 2, and the transmission spectrum is collected by the spectrum receiving device 5 through the outgoing optical fiber 6, the incident optical fiber 2 and the outgoing optical fiber 6 are respectively close to the blood bag 3, and the position a is the incident optical fiber 2, the spectrum receiving device 5 collects the transmission spectrum at this position; then the incident optical fiber 2 is controlled by the displacement platform 4 to move to the second position b, and the spectrum receiving device...

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Abstract

The invention discloses a method for measuring the content of free hemoglobin in a blood bag based on multi-position transmission spectra. The method comprises the steps that the emergent light outlet of a light source and the incident slit of a spectrum receiving device both cling to the blood bag, the light source carries out transmission on a blood sample, a displacement platform controls the light source to move to a plurality of positions for transmission of the blood sample, and the spectrum receiving device acquires transmission spectra; and the transmission spectra acquired at the plurality of positions are subjected to normalization, and a mathematical model is constructed on the basis of the normalized transmission spectra and chemical examination data; the transmission spectra of an unknown blood sample at a plurality of positions are acquired and are separately normalized and then substituted into the mathematical model for calculation so as to obtain the content of free hemoglobin. The method provided by the invention improves the information amounts of all the components in blood, suppresses influence caused by the scattering of blood, and improves the analysis precision of the free hemoglobin content.

Description

technical field [0001] The invention relates to the field of concentration analysis stoichiometry of spectrally complex solutions, in particular to a method for measuring free hemoglobin content in blood bags by multi-position transmission spectroscopy. Background technique [0002] Among the existing technologies, the more mature technology is to detect the content of free hemoglobin in the blood bag through chemical testing, which has the outstanding advantage of high accuracy, but the chemical testing method needs to open the blood bag to take out samples for testing, which cannot meet the requirements of rapid , Non-contact and non-pollution requirements, due to its non-contact and non-pollution characteristics, spectral detection may also realize the detection of free hemoglobin in blood bags. Due to the complexity of blood components, it has strong scattering and its transmission spectrum is nonlinear. To solve this problem, this method proposes a multi-position transm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/31
Inventor 林凌张梦秋甄建芸王玉宇王艳军张盛昭李刚
Owner TIANJIN UNIV
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