3603results about How to "Inhibition effect" patented technology

Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of an opioid analgesic, an opioid antagonist and one or more pharmaceutically acceptable excipients; the dosage form further including a gelling agent in an effective amount to impart a viscosity unsuitable for administration selected from the group consisting of parenteral and nasal administration to a solubilized mixture formed when the dosage form is crushed and mixed with from about 0.5 to about 10 ml of an aqueous liquid.

A stimulator for stimulating the leg or other parts of the body e.g. the leg in a patient with drop foot is provided, the stimulator being controlled by e.g a foot switch but being reliable in use and therefore commanding acceptance by users. The foot switch has to work in adverse environmental conditions and is subject to repeated use so that its characteristics vary with time. The invention provides a functional electrical stimulator for attachment to the leg that has adaptive characteristics and comprises first and second electrodes for attachment to the leg to apply an electrical stimulus, a foot switch for sensing foot rise or foot strike, a circuit responsive to said foot switch for generating stimulation pulses; and means forming part of said circuit for responding to changes in the resistance characteristics of said switch means by adjusting a corresponding response threshold of said circuit.The invention also provides a two-channel stimulator that offers various possibilities for controlling the signals to be supplied to different muscle groups. For example, means may be provided defining a signal pathway between the first and second channels so that the supply of stimulation pulses in one of said first and second channels can be controlled by the state of switch means associated with the other of said first and second channels. In a further embodiment means defining a signal pathway between the first and second channels is arranged so that the supply of stimulation pulses in one of said first and second channels can be controlled by the state of activity of the other of said first and second channels. In a yet further embodiment the first channel has means arranged to cause the stimulation pulses to time-out after a predetermined period and the second channel having no or disabled timing means so that supply of stimulation pulses is continuous in a predetermined state of limb position responsive switch means associated with that channel. The two-channel stimulator can be used e.g., to treat bilateral dropped foot.

Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.

A method and apparatus for non-invasively determining the blood oxygen saturation level within a subject's tissue is provided that utilizes a near infrared spectrophotometric (NIRS) sensor capable of transmitting a light signal into the tissue of a subject and sensing the light signal once it has passed through the transmitting a light signal into the subject's tissue, wherein the transmitted light signal includes a first wavelength, a second wavelength, and a third wavelength; (2) sensing a first intensity and a second intensity of the light signal, along the first, second, and third wavelengths after the light signal travels through the subject at a first and second predetermined distance; (3) determining an attenuation of the light signal for each of the first, second, and third wavelengths using the sensed first intensity and sensed second intensity of the first, second, and third wavelengths; (4) determining a difference in attenuation of the light signal between the first wavelength and the second wavelength, and between the first wavelength and the third wavelength; and (5) determining the blood oxygen saturation level within the subject's tissue using the difference in attenuation between the first wavelength and the second wavelength, and the difference in attenuation between the first wavelength and the third wavelength.

A highly reliable, high voltage AC/DC LED device with integrated protection mechanism is disclosed. The protection element can be a current-limiting resistor, monolithically integrated on LED chip, or a discrete resistor assembled in the lamp package or submount. The protection elements may also include other parts integrated on a submount.

The invention relates to TGF-β blocking agent-treated HSC compositions and methods comprising the same. The TGF-β blocking agent-treated stem cells are viable for an extended time in culture without replication or differentiation and upon transfer to appropriate conditions are capable of long term hematopoietic reconstitution.

Provided are a magnetic field shield sheet for a wireless charger, which blocks an effect of an alternating-current magnetic field generated when a charger function for a portable mobile terminal device is implemented in a non-contact wireless manner on a main body of the portable mobile terminal device and exhibits excellent electric power transmission efficiency, a method of manufacturing the sheet, and a receiver for the wireless charger by using the sheet. The sheet includes: at least one layer thin magnetic sheet made of an amorphous ribbon separated into a plurality of fine pieces; a protective film that is adhered on one surface of the thin magnetic sheet via a first adhesive layer provided on one side of the protective film; and a double-sided tape that is adhered on the other surface of the thin magnetic sheet via a second adhesive layer provided on one side of the double-sided adhesive tape, wherein gaps among the plurality of fine pieces are filled by some parts of the first and second adhesive layers, to thereby isolate the plurality of fine pieces.

Lift propulsion and stabilizing system and procedure for vertical takeoff and landing aircraft that consists in applying simultaneously and combined as lifters during the initial portion of the climb and at the end of the descent of: a) some fans or electric turbines, EDF, and b) at least one rotor with external blades and/or rotary and/or c) the engine flow directed downwards and/or d) pressure air jets injected on leading edges control fins, and/or e) water jets and/or f) supplemented with aerodynamic lift produced during frontal advance of the aircraft, the stabilization is achieved by the gyroscopic stiffness of the rotor and two or more lifting fans oscillating fins and/or air jets located on two or stabilizers more peripheral points in a plane perpendicular to the vertical axis of the aircraft.

This invention is a game platform for the assessment and/or treatment of disorders of binocular vision, such as amblyopia. The game content is devised to maximize the possible therapeutic effects by leveraging advanced research in opthalmology, as well as advanced display technology to render images independently to each eye. In particular, the game content engages both eyes at different levels of difficulty, forcing an amblyopic eye to work harder to regain its performance in the visual system. The invention herein described provides a mobile device, capable of interaction with an eye care specialist, for the assessment/treatment of binocular vision using innovative mechanisms for ensuring proper use thereof.

The present invention provides a method for forming a metal-oxide-semiconductor (MOS) device and the structure thereof. The method includes at least the steps of forming a silicon germanium layer by the first selective epitaxy growth process and forming a cap layer on the silicon germanium layer by the second selective epitaxy growth process. Hence, the undesirable effects caused by ion implantation can be mitigated.

A radio base station includes multiple antennas associated with a cell. Multiple mobile radios are selected to receive transmissions over a shared radio channel during a predetermined time interval. Information is transmitted over the shared radio channel to multiple mobile radios in the cell during the predetermined time interval using multiple antenna beams. As a result, interference from the transmission appears as white additive Gaussian noise in time and in space in the cell. A “flashlight effect” caused by a single beam transmission over the shared channel during a predetermined time interval that would normally detrimentally impact mobile channel quality detection is avoided. Other methods for avoiding the flashlight effect are described.

A method for producing a three-dimensionally shaped object, includes the steps of: (i) forming a solidified layer by irradiating a light beam on a specified portion of a powder layer placed on a shaping table to sinter or melt the specified portion; (ii) forming another solidified layer by placing a new powder layer on the solidified layer thus obtained, and irradiating the light beam on a specified portion of the new powder layer to sinter or melt the specified portion of the new powder layer; and (iii) repeating the step (ii) to produce a three-dimensionally shaped object. When performing the steps (i) to (iii) within a chamber, at least a part of an ambient gas in the chamber is exhausted from the chamber through a gas passage of a shaping tank.

A flip-chip semiconductor package structure and a package substrate applicable thereto are disclosed. The package substrate includes a body having at least a chip-attach area disposed thereon; a plurality of solder pads disposed in the chip-attach area and arranged at different intervals; and a fluid-disturbing portion disposed in the chip-attach area at a position where the solder pads are loosely arranged. A flip-chip semiconductor chip is mounted on the solder pads via conductive bumps and an underfill material is filled between the package substrate and the flip-chip semiconductor chip, the underfill material encapsulating the conductive bumps and the fluid-disturbing portion. By protrudingly disposing the fluid-disturbing portion at a position where the conductive bumps are loosely arranged, that is, the conductive bumps having bigger intervals therebetween, gap between the package substrate and the flip-chip semiconductor chip can be reduced so as to increase capillary attraction generated by capillary phenomenon, thereby balancing flow rate of the underfill material between the conductive bumps that are arranged at different intervals and thus avoiding problems of void formation, subsequent popcorn effect or delamination as encountered in the prior art.

An automated microscope and computer system captures a set of images for a capture area in a plurality of focal planes. The images can then be integrated into composite images for browsing to simulate viewing an item, such as a biological sample, under a microscope. A corrective filter can be constructed from the images to avoid an effect called “tiling.” Before capture, variable focal plane error can be avoided by collecting z locations for a set of points in the capture area. During image browsing, entire composite images can be loaded into memory in compressed form. Compressed image portions can be pre-decompressed to avoid delay as a browsing user navigates throughout the composite images. Pre-decompression can be done by a thread separate from the thread performing navigation operations.

Sirtuin modulators, particularly sirtuin activators, are useful in treating vision impairment. In general, the sirtuin modulators inhibit the progression of vision impairment resulting from various eye disorders. The invention also includes pharmaceutically acceptable formulations of sirtuin modulators, particular ophthalmically acceptable formulations.

A shield electrode is provided in parallel with a sensor electrode. A detecting circuit detects a capacitance formed thereby around the sensor electrode. A capacitance-voltage conversion circuit converts the capacitance into a voltage by repeating a predetermined sequence. A shield electrode drive unit switches an electric state of the shield electrode in synchronization with the predetermined sequence. The shield electrode drive unit switches an electric state of the shield electrode in accordance with an electric state of the sensor electrode.

Sirtuin modulators, particularly sirtuin activators, are useful in treating vision impairment. In general, the sirtuin modulators inhibit the progression of vision impairment resulting from various eye disorders. The invention also includes pharmaceutically acceptable formulations of sirtuin modulators, particular ophthalmically acceptable formulations.

The antenna matching circuit control device with an antenna body includes a sensing module, a processing module, a power adjusting module and a frequency adjusting module. The sensing module senses an object that approaches the antenna body and outputs a sensing signal accordingly. The processing module is coupled to the sensing module and outputs a first control signal and a second control signal according to the sensing signal. The power adjusting module is coupled to the processing module and controls a power amplifier to couple with one of a plurality of first matching circuits according to the first control signal. The frequency adjusting module is coupled to the antenna body and the power adjusting module. The frequency adjusting module controls one of a plurality of second matching circuits to couple with one of the first matching circuits according to the second control signal.