Red cell storage solution and preparation method thereof

A technology for preserving liquid and red blood cells, applied in the field of biomedicine, can solve the problems of shortened validity period, increased cost, long transportation period, antigen stability and activity, etc., to ensure the pH value environment, stabilize the pH value environment, and avoid aggregation and adhesion. Effect

Inactive Publication Date: 2017-04-19
北京乐普诊断科技股份有限公司
View PDF3 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no unified maintenance system in China, and the red blood cell processing technology is not correspondingly perfect, which makes it difficult to guarantee the preservation of red blood cells in vitro
In foreign countries, Alfred's solution with a pH value of 6.8±0.2 is used as the red blood cell preservation s

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Red cell storage solution and preparation method thereof
  • Red cell storage solution and preparation method thereof
  • Red cell storage solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The erythrocyte preservation solution contains the following components by mass concentration:

[0047]

[0048] The preparation method of erythrocyte preservation solution, comprises the following steps:

[0049] Add HEPES and NaCl according to the formula, adjust the pH to 7.3, then add the rest of the ingredients, adjust the pH to 7.3 after dissolving.

Embodiment 2

[0051] The erythrocyte preservation solution contains the following components by mass concentration:

[0052]

[0053]

[0054] The preparation method of erythrocyte preservation solution, comprises the following steps:

[0055] Add HEPES and NaCl according to the formula, adjust the pH to 7, then add the rest of the ingredients, adjust the pH to 7 after dissolving.

Embodiment 3

[0057] The erythrocyte preservation solution contains the following components by mass concentration:

[0058]

[0059] The preparation method of erythrocyte preservation solution, comprises the following steps:

[0060] Add HEPES and NaCl according to the formula, adjust the pH to 7.5, then add the rest of the components, adjust the pH to 7.5 after dissolving.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a red cell storage solution and a preparation method thereof. The storage solution comprises a buffering system, a nutritional system, an osmotic pressure system and an anticorrosion system, wherein the anticorrosion system comprises the following components according to mass concentration: 0.2-1g/L of chloramphenicol, 0.1-0.6g/L of neomycin sulfate, and 0.1-0.5g/L of gentamicin. Through mutual concurrent effects of the buffering system, the nutritional system, the anticorrosion system and the osmotic pressure system of the red cell storage solution provided by the invention, long storage cycle of the red cell storage solution is ensured, at the end of the sixth month of the storage, that red cell suspension free hemoglobin concentration still conforms to national standard is detected, and the hemolysis ratio at the end of the storage is smaller than 0.8 percent of the total of red cells; the red cell storage solution provided by the invention can ensure relatively strong antigenic activity and stability of the red cells.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the technical field of blood transfusion testing, in particular to a red blood cell preservation solution and a preparation method thereof. Background technique [0002] With the gradual increase of medical technology, that is, people's safety awareness, blood preservation before blood transfusion is more and more used in the treatment of some large diseases. Accurate blood type testing before blood transfusion is the premise of safe blood transfusion in medical treatment. Blood transfusion has healed countless lives as a treatment method, but blood transfusion may also lead to serious adverse reactions of blood transfusion, even life-threatening. Immediate hemolytic transfusion reactions are common in ABO incompatible blood transfusions, so the accurate determination of ABO blood type is very important. ABO blood group positive typing test is particularly prone to false positive or f...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A01N1/02
Inventor 王占伟魏明明陈江莎杨洋邱笑违
Owner 北京乐普诊断科技股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap