223 results about "Blood type" patented technology

The present invention relates to a microbial composition which is tailored based on the spectrum of microbes found more frequently from the intestine of non-secretor individuals than from the intestine of secretor individuals. The present invention further relates to a method of tailoring a microbial composition based on the spectrum of microbes found more frequently from the intestine of non-secretor individuals than from that of secretor blood group status. The present invention relates to use of the secretor status of an individual as a criterion for microbial supplementation tailored based on the differences in the spectra of microbes found between secretor and non-secretor individuals.

Provided is a microbial composition which is tailored based on the spectrum of microbes found more frequently from the intestine of non-secretor individuals than from the intestine of secretor individuals. Further provided is a method of tailoring a microbial composition based on the spectrum of microbes found more frequently from the intestine of non-secretor individuals than from that of secretor blood group status. Further provided is a use of the secretor status of an individual as a criterion for microbial supplementation tailored based on the differences in the spectra of microbes found between secretor and non-secretor individuals.

The invention discloses a method and device for obtaining chat reply contents. The method comprises the following steps: obtaining basic information of a communication terminal which sends and / or receives a chat initiation sentence, wherein the basic information comprises one or more of the twelve animals, constellations, blood types and color preferences; obtaining a user portrait label corresponding to a preset user portrait entry according to the basic information, wherein the user portrait label is used for carrying out user portraying on the communication terminal; obtaining a chat reply content corresponding to the chat initiation sentence according to the user portrait label. according to the method and device disclosed in the invention, the technical problems that the conventional chat reply content obtaining method in the prior art does not combine the user portrait information of the communication terminal participating in the chat so as to enable the obtained chat reply content to be single and fixed, enable the intelligent degree of the chat to be low and enable the user experience to be bad is solved, different chat reply contents can be obtained according to different user portrait information, and the obtained chat reply contents are fully combined with the user portrait information of the communication terminal, so that relatively high intelligent and individual level are embodied.

Populations of stem cells and methods for their isolation and use are provided. These stem cell populations comprise aldehyde dehydrogenase positive (ALDHbr) cells isolated from bone marrow, and ALDHbr CD105+ cells derived from any stem cell source. These populations may also comprise cells expressing such surface markers as CD34, CD38, CD41, CD45, CD105, CD133, CD135, CD117, and HLA-DR, and / or are substantially free from such cell surface markers as CD3, CD7, CD 10, CD 13, CD 14, C1319, CD33, CD35, CD56, CD 127, CD 138, and glycophorin A. The population may also comprise cells expressing CD90. The stem cell populations of the invention are isolated from a stem cell source such as bone marrow, peripheral blood, umbilical cord blood, and fetal liver. Methods of the invention comprise isolating and purifying stem cell populations from stem cell sources, and methods of using these cells to reconstitute, repair, and regenerate tissues.

The invention relates to a medical record information management method based on the two-dimensional code technology, which comprises the steps of leading personal information (such as name, date of birth, mailing address, telephone number, identity card, number of medical insurance certificate and the like) of patients and pathological information (such as blood type, medical history, allergy drugs and other medical characteristic information) to form two-dimensional codes by utilizing two-dimensional code encoding software, saving as image files and printing on outpatient and emergency medical record manuals. When the patient holds the outpatient and emergency medical record manual printed with the two-dimensional codes to see a doctor in any medical institution, the doctor needs to use a scanning instrument or a camera head to collect the two-dimensional code images on the medical record manual, and then the information of the patient can be displayed through a computer or an intelligent mobile phone equipped with two-dimensional code reading software. Therefore, the method can not only save information inquiry time, but also avoid the embarrassment of inquiring privacy information face to face, facilitate medical diagnosis and information sharing, realize the protection of personal privacy and not increase additional economic burden on the patients.

Simultaneous forward and reverse blood group testing is described using both a visual detection system and a fluorescent based labeling and detection system. Forward and reverse tests could be performed separately, but A and B agglutinates can be detected and discriminated simultaneously.

A system, a device, a method, and a computer program are provided that dispense pharmacy / clinic loaded medications only to a specific patient that has biometric information pre-programmed to a Biometric Electronic Communicating Drug Dispenser (BECDD) device by, e.g., a clinic physician or authorized user. The biometric information may include, e.g., a finger print, a retinal signature, a voice signature, a DNA code, a blood type, or the like.

The invention discloses an intelligent health service system based on health big data. The system comprises an acquisition module and a system data center. The acquisition module acquires human body physique data and is connected with the system data center through the Internet for data return. The human body physique data comprises ages, blood types, health check reports, medical reports, medication records, familial inheritance, work pressure, dietary habits, sleep habits, sleep quality, motion mass, mood swing, air quality, weather conditions, temperature and humidity and noise indexes. The system data center provides customized intelligent health services including health tracking, health monitoring, health records, health consultants, health reminding, health evaluation, health common sense and health consultation for users according to the big data analysis technology and in combination with health management specialized knowledge and medical service resources. By means of the technical scheme, the health status and living quality of residents are improved, and the medical healthcare cost is reduced.

A blood type detection card filling machine comprises a rotary disc mechanism, an automatic card feeding structure, a liquid filling mechanism, a powder filling mechanism and a heat-seal mechanism, wherein the automatic card feeding structure, the liquid filling mechanism, the powder filling mechanism and the heat-seal mechanism serve as a filling and sealing mechanism. The rotary disc mechanism comprises a rotary disc, a photoelectric sensor, a rotary disc stepping motor and a clamping groove. The automatic card feeding mechanism, the liquid filling mechanism, the powder filling mechanism and the heat-seal mechanism are sequentially arranged around a rotary disc in a 90-degree spacing manner. The automatic card feeding mechanism comprises a card feeding stepping motor, card feeding guide rails, a card push air cylinder, a card push sliding block, a card push guide rail, a card containing card row, a card push initial position sensor, a locating blocking piece, a card push locating sensor, a card push finial point position sensor and a card push synchronizing belt. The liquid filling mechanism comprises a liquid filling support, a liquid filling motor, a liquid filling lead screw, a stroke switch, an upper needle plate, liquid filling syringe needles, a lower needle plate, needle holes and a liquid filling air cylinder. The powder filling mechanism comprises a powder filling support, a lifting air cylinder, a powder push air cylinder, a powder containing tank, a powder storage hole plate, a powder falling hole plate and a powder filling hopper. The heat-seal mechanism comprises a card feeding module, a heat-seal module and a paper feeding module.

The invention discloses an individual recognition system based on next generation sequencing and a kit and application of the kit. The individual recognition system comprises a primer sequence designed at 112 STR sites and 318 SNP sites, wherein the 112 STR sites include 53 autosome STR sites, 23 X chromosome STR sites, 35 Y chromosome STR sites and a gender determination site AMEL; the 318 SNP sites include 186 autosome SNP sites, 69 X chromosome SNP sites, 57 Y chromosome SNP sites and 6 blood group phenotype related SNP sites. The individual recognition system can obtain second-generation or three-generation genetic marker information on autosome, X chromosome and Y chromosome at the same time only through once amplification; thus, operation steps are reduced, experiment time is shortened, and the individual recognition system is suitable for DNA genotype detection of people in different countries and different areas all over the world.

The invention discloses an ABO, RhD blood typing reagent card, a preparation method thereof and an antibody diluting solution adopted in the preparation method. In the preparation method, the pH value of a system is maintained by virtue of a sodium phosphate buffer system, tween 80 is added, the component of a gel preservation solution is removed, and proper lubrication capability can be obtained when erythrocyte passes through the gap of gel, so that unaggregated erythrocytes have the capability of passing through gaps of gel particles, and aggregated erythrocytes cannot pass; nonspecific adsorption of the gel is eliminated by adding bovine serum albumin to protect the titer of the antibody; microbial contamination is reduced by adopting sodium azide, the preservation period of the product is prolonged, and blood typing error caused by microbial contamination is eliminated; and the gel is screened in the preparation process, and the gel raw material which is obtained by virtue of screening is required to be swelled, wet heat sterilization and cleaning, so that microbes contained in the gel are eliminated, the components of the gel preservation solution and broken gel particles are eliminated, and the product quality is greatly improved.

The invention relates to an ABO / RhD blood typing detection reagent card and preparation of the ABO / RhD blood typing detection reagent card. The ABO / RhD blood typing detection reagent card is characterized in that the detection reagent card is provided with 8 micro-column gel tubes, wherein one micro-column gel tube contains gel and an anti-A monoclonal antibody of IgM property, one micro-column gel tube contains gel and an anti-B monoclonal antibody of IgM property, one micro-column gel tube contains gel and an anti-D RhD blood type monoclonal antibody of IgM property, and the rest five gel tubes contain gel suspending medium buffer solutions and gels.

The invention provides a blood type distinguishing method based on a blood type card. The blood type distinguishing method based on the blood type card comprises the following steps: according to positioning characteristics of micro column tubes in the blood type card, calculating to obtain a coordinate position where column gel in each micro column tube in the blood type card is located, partitioning a gel column graph of each tube, and carrying out gray value statistics on all regions in each column body and comparing, so that negative and positive characteristic of reaction in each column body and reaction intensity characteristic can be obtained. By combining the negative and positive characteristics of each tube corresponding to a sample and reaction intensity reference values, a final blood type result of the sample can be obtained, manual operation is reduced, and efficiency can be improved.

A system, a device, a method, and a computer program are provided that dispense pharmacy / clinic loaded medications only to a specific patient that has biometric information pre-programmed to a Biometric Electronic Communicating Drug Dispenser (BECDD) device by, e.g., a clinic physician or authorized user. The biometric information may include, e.g., a finger print, a retinal signature, a voice signature, a DNA code, a blood type, or the like.

This invention relates to one ABO blood reverse shape agent, which is based on the a's liquid and adopts the improved buffer system, that is from single citrate buffer system into citrate and phosphate double buffer system to better keep the system PH value stable, wherein, the invention adds gland purine as nutrient to make the erythrocyte keep bright color during abundant oxygen process; the anti-erosion system not adopting any chemical antigen to avoid impacting the oxygen content to make the red cell dark; adding EDTA sodium salt to prevent blood-stop cell hemolytic phenomenon.

The invention provides an automatic blood group serology detection method and an automatic detection system for realizing the method. The method provided by the invention is convenient and effective, controllably improves the suspension effect of micro liquid and satisfies the operation requirements of blood immune reaction, so that results are more reliable and accurate; an adopted test tube luminous flux detection method is the obtained most widely-used method, can quickly judge experimental results and is high in accuracy rate, high in detection rate of weak agglutination and better in sensitivity. The detection system provided by the invention can quickly judge the experimental results through close cooperation of all parts and is high in accuracy rate, high in detection rate of weak agglutination and better in sensitivity; particularly, a bead adding device obtains a good effect and is high in degree of automation, accurate and quick in bead adding action, so that the vibration intensity of an existing oscillating mechanism is greatly reduced, the suspension effect of the micro liquid is improved, and the operation requirements of the blood immune reaction is satisfied.

An antigen-dependent negative selection blood cell separation method is described. Rare circulating epithelial cells can be separated from blood by depleting erythrocytes from a blood sample. Erythrocytes are depleted by agglutination. The new method comprises the use of an agglutinating agent, such as an anti-glycophorin A or glycophorin B antibody, as glycophorin A or B are present on erythrocytes and not on the desired epithelial cells. With regular mixing, desired rare circulating epithelial cells do not become entrapped in the red cell agglutinate.

A system for monitoring blood groups and for detecting immunohematological reactions uses a detection device consisting of a quartz crystal microbalance (QCM), a device able to measure very small variations in mass (down to fractions of a nanogram).

A blood analysis apparatus configured such that a nozzle sucks a predetermined amount of a blood specimen in a specimen container, and dispenses the specimen to each blood cell counting part which obtains count data, and a control part processes the count data to perform blood analysis. In this apparatus, two or more blood cell counting parts (basophil counting part, LMNE counting part, red blood cell counting part, white blood cell counting part) are constituted to obtain the count data of the same particular blood cell type (white blood cells), and the control part calculates the ratio or number of the existing blood cell from each count data, and judges whether the amount of the blood specimen sucked in the nozzle is normal or insufficient by comparing respective calculation results to determine whether they are within the predetermined allowable ranges.

Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs). More particularly, disclosed are a variety of antigen specific polypeptides, including soluble, monoclonal, and multivalent forms, as well as methods of using the polypeptides, antibodies that bind the antigen specific polypeptides, and nucleic acids, vectors and expression systems that encode the polypeptides. Antigen specific polypeptides that selectively bind pathogens, like anthrax, and carbohydrates, like blood group determinants, are specifically disclosed.

The invention relates to an affinity chromatography matrix, as a gel, comprising polymeric particles on which at least one oligosaccharide corresponding to a blood group A epitope and / or blood group B is grafted, via a spacer, characterized in that the density of oligosaccharides is comprised between 0.2 and 0.7 mg / ml of matrix. The invention also relates to the uses of this matrix for preparing concentrates of immunoglobulins for therapeutic use.

The invention discloses an agent adding device for an analyzer. The agent adding device comprises an agent adding base, wherein a rotating base is mounted on the agent adding base; a vertical agent adding rotating shaft which can rotate by self is mounted on the rotating base; a moving base which can move up and down along the agent adding rotating shaft is mounted on the agent adding rotating shaft; a transverse beam which can move horizontally along the moving base is mounted on the moving base; an injection pump is mounted on the transverse beam; one end of the injection pump is communicated with a needle tube. The agent adding device is simple in structure, small in size, low in cost and flexible in sample taking and addition and movement. A full-automatic blood type analyzer comprises a working table, wherein the agent adding device is mounted on the working table. The full-automatic blood type analyzer is simple in structure, small in size and low in cost; in operation, a sample adding device and the agent adding device are operated independently without mutual influence, the sample treatment time can be shortened, and the working efficiency can be improved.

The invention discloses a broad-spectrum contact type hemostatic medical fungicide and a preparation method thereof. The fungicide comprises the following components in percentage by weight: 5 to 15 percent of povidone iodine, 3 to 10 percent of chitosan, 3 to 10 percent of petroleum jelly for medical purposes, 1 to 5 percent of nonoxinol, and the balance of purified water. After the fungicide is contacted with a wound surface or an affected part, the fungicide can depolymerize and release the contained iodine to achieve the function of sterilization. The product is the broad-spectrum powerful disinfectant, has strong killing effect on viruses, bacteria, fungi and mycoticspore, not only has long constant acting time, but also has small irritation to human skin, greatly reduces pains unbearable for ordinary people, and simultaneously has the function of hemostasis. The fungicide is applicable to skin and mucousmembrane infection, can be directly used for disinfecting graze, and is safe and convenient to use.

The invention discloses an alpha-galactosidase and an expression and purification method thereof. The alpha-galactosidase is expressed by SEQ ID NO:1 in a sequence table, is obtained by encoding a recombinant genome DNA sequence SEQ ID NO:3 of bacteroides fragilis (Bacteroides fragilis) ATCC25285 and is a protein with effect of converting a red cell blood group of the human body from B-type into O-type and from AB-type into A-type. The alpha-galactosidase of the invention has the advantages of wide application, simple and convenient expression and purification method, low cost, important clinical and scientific research significance and wide market prospect.

The invention aims to provide a single-nucleotide polymorphism locus for detecting A-type variant, inducing acute hemolytic transfusion reaction, of an ABO blood-group system. The single-nucleotide polymorphism locus refers to the 689th basic group counted from an initiation codon in an A-type variant gene coding area. The single-nucleotide polymorphism locus has the advantages that new application of an A-type variant gene is provided, an effective way to fast gene diagnosis, gene screening and genetic counselling for induced acute intravascular hemolytic transfusion reaction is provided, and according to application effects, the single-nucleotide polymorphism locus of the gene and a detect primer can be applied to fast A-type variant gene mutation locus detection for peripheral blood of a clinical patient.

The invention discloses a combined detection card for blood screening, which includes a card base and a card cover fastened on the card base. The card base is provided with a plurality of card slots parallel to each other; the multiple card slots are divided into sequentially Multiple groups are arranged, and each group of card slots corresponds to the infectious disease detection area, blood type detection area, hemoglobin detection area and alanine aminotransferase detection area in sequence, and each card slot is equipped with a test strip matching its detection area; The card cover is sequentially provided with an observation window, a sampling hole and an auxiliary liquid hole at the positions corresponding to the test strips in the infectious disease detection area on the deck; There are sampling holes and auxiliary liquid holes in sequence on the position; the card cover is opened with a sampling hole at the position corresponding to the test strip in the hemoglobin detection area; the card cover is at the position corresponding to the test strip in the alanine aminotransferase detection area There are observation windows and sample injection holes on the top. The invention can realize the detection of multiple items in one card and can ensure the accuracy of detection.

The invention relates to a rhesus monkey erythrocyte adsorber, belonging to the field of medicine science. According to the rhesus monkey erythrocyte adsorber, rhesus monkey erythrocytes replace human Rh positive O erythrocytes, the rhesus monkey erythrocytes are washed by 4 DEG C normal saline and 37 DEG C normal saline, so that immune antibodies or natural antibody attaching to the surfaces of the erythrocytes can be removed, after antigenicity detection, cell sediment is added into a cylindrical adsorber made of a material with high biocompatibility till 4 / 5 of the volume is occupied, then 3.5% of mannitol erythrocyte preserving fluid is added, so that the concentration of the erythrocyte achieves 80%, shaking is carried out gently for uniform mixing, the opening is sealed, and the product is stored at 4 DEG C for regular use, wherein a screen is arranged at the opening of a purifier, so that a line of defense for preventing cell debris from being filtered out is formed, after the plasma is filtered, Rh antibodies are combined with Rh positive rhesus monkey erythrocytes to form a fixed compound, the broken erythrocyte debris and the macromolecular compound combined with the broken erythrocyte debris are blocked by the screen of the purifier, and the plasma with morbid substance removed is filtered by the purifier and then conveyed back, so that the purpose of treating blood-group-incompatible haemolytic diseases is achieved by eliminating Rh antibodies of the plasma.

The invention discloses a reagent card for detecting human ABO / RHD blood-grouping and a detection method using the same. The reagent card comprises a lower casing and an upper casing, wherein, three parallel grooves are formed in the lower casing; three substrates are arranged in the three grooves respectively; mats and reaction films are stuck on the three substrates; one end of the mat is in mutual lap joint with the reaction film; an anti-A detection line and a control line are arranged on the first reaction film; an anti-B detection line and a control line are arranged on the second reaction film; an anti-RHD detection line and a control line are arranged on the third reaction film; three liquid-dripping openings and three blood-dripping openings corresponding to the three mats are sequentially arranged on the upper casing; three inspection windows corresponding to the three detection lines and the three control lines are formed on the upper casing; and the blood-dripping openings are positioned between the liquid-dripping openings and the inspection windows. The detection method comprises the following steps: blood-dripping, liquid-dripping, erythrocyte migration and chromatography and result observation, therefore, the invention has the advantages of shorter detection time, higher detection accuracy, lower cost and more convenient detection and observation.

The invention relates to an RHD838>A allele and a detection method thereof, and belongs to the field of analysis and detection technologies in molecular biology. A primer sequence which can amplify a target part including a mutant gene sequence is designed by a PCR-specific primer technology, and PCR amplification selectively and specially aiming at the specific RHD838>A allele is performed on the zone of the target part including the mutant gene sequence by virtue of a gene amplification method. According to the detection method, the gene level is detected by virtue of a molecular biological method which can be used for greatly improving the sensitivity and specificity of the detection and is simple, convenient and rapid. Since different nationalities have difference in the RHD gene, the detection method is designed specially aiming at the RHD838>A allele according to the RHD genetic molecule background of Chinese on the basis of relative researches. The RHD838>A allele and the detection method thereof have significant clinical meaning in overcoming the shortage of the serological technique, and also have wide scientific research and application value.

The invention aims at providing an SNP mark applied to detecting an RhD variation phenotype. The SNP mark is that a 739th basic group from an initiation codon in an RHD gene encoding area mutates, G is mutated into C, a 247th amino acid is changed, and protein conformation is changed. According to the SNP mark disclosed by the invention, an SNP locus is obtained through detecting and screening, so that an effective path to perform RhD blood type gene diagnosis is provided; an application effect shows that an SNP locus and a detection primer of a gene disclosed by the invention can be effectively applied to clinical patients and blood station blood donators to quickly detect RHD genes.