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7 results about "Blood type" patented technology

A blood type (also called a blood group) is a classification of blood, based on the presence and absence of antibodies and inherited antigenic substances on the surface of red blood cells (RBCs). These antigens may be proteins, carbohydrates, glycoproteins, or glycolipids, depending on the blood group system. Some of these antigens are also present on the surface of other types of cells of various tissues. Several of these red blood cell surface antigens can stem from one allele (or an alternative version of a gene) and collectively form a blood group system. Blood types are inherited and represent contributions from both parents. A total of 36 human blood group systems and 346 antigens are now recognized by the International Society of Blood Transfusion (ISBT). The two most important blood group systems are ABO and Rh; they determine someone's blood type (A, B, AB and O, with +, − or null denoting RhD status) for suitability in blood transfusion.

Methods for enhancing specificity and sensitivity of group a Streptococcus immunoassay

ActiveUS12663421B2Biological testingDeoxyglucoseBiological organism
The present disclosure provides methods and kits for detecting Group A Streptococcus in biological samples. More particularly, the present disclosure provides methods for enhancing the specificity and sensitivity of Group A Streptococcus immunoassays by including N-propionyl-D-glucosamine, 2-N-butanoyl-D-glucosamide, Bis-(2-(D-2-deoxy-glucosaminyl))-PEG3-amide, m-PEG4-glucosamine, m-PEG6-glucosamine, or m-PEG10-glucosamine. The methods and kits disclosed herein are thus useful for reliable and early diagnosis of streptococcal infections in a subject.
Owner:AUGUSTA SPINCO CORP

A set of amplification primers, an amplification system, an amplification method, a library construction method and a sequencing method for genotyping of human Lewis blood system

PendingCN122279061AGenotypingHaplotype
This invention relates to the fields of molecular diagnostics and gene sequencing technology, specifically to a complete solution for high-precision genotyping of the human Lewis blood group system. The invention provides primer pairs for specifically amplifying long fragments of the Lewis blood group coding genes FUT2 and FUT3, and an optimized single amplification system; a library construction method adapted for nanopore sequencing; and a Lewis (FUT2, FUT3) genotyping method based on long-read data for haplotype analysis. This invention overcomes the detection limitations of conventional techniques, simultaneously acquiring the complete sequence and phase information of key regions of the FUT2 and FUT3 genes through a single amplification system, achieving accurate genotyping of common Lewis blood group phenotypes (Le(a+b−), Le(a−b+), Le(a−b−)) and effective identification of rare variants such as weakly expressed and deleted variants.
Owner:JIANGSU WEIHE BIOTECH

A composite material based on hollow mesoporous carbon spheres loaded with abo blood group monoclonal antibodies

ActiveCN121027542BA AntibodyBiology
This invention discloses a composite material based on hollow mesoporous carbon spheres loaded with ABO blood group monoclonal antibodies, comprising hollow mesoporous carbon spheres and ABO blood group monoclonal antibodies loaded on the hollow mesoporous carbon spheres, wherein the ABO blood group monoclonal antibodies are selected from at least one of type A antibodies and type B antibodies. This invention also discloses a method for preparing the composite material, comprising: modifying the surface of the hollow mesoporous carbon spheres with amino groups; dispersing the spheres in an ABO blood group monoclonal antibody solution; and stirring the reaction. This invention immobilizes ABO blood group monoclonal antibodies on the surface of hollow mesoporous carbon spheres, improving the stability, specificity, and sensitivity of the antibodies, and achieving rapid and accurate ABO blood group identification. This invention also discloses a kit comprising the above-mentioned composite material, and the application of this composite material in ABO blood group detection.
Owner:SHAANXI PROVINCIAL BLOOD CENT

Use of 6-benzylaminopurine and a pharmaceutical containing 6-benzylaminopurine for preventing and / or treating blood type disease of silkworm

This invention discloses the application of 6-benzylaminopurine and drugs containing 6-benzylaminopurine in the prevention and / or treatment of hemorrhagic septicemia in silkworms. Using 6-benzylaminopurine as the core active ingredient, drugs for the prevention and treatment of hemorrhagic septicemia in silkworms can be prepared. Experiments show that when the final concentration of 6-benzylaminopurine reaches 50 μM, it can significantly inhibit the replication of BmNPV, and can still exert an inhibitory effect after the virus has completed cell infection, demonstrating good therapeutic efficacy. This invention provides a new solution for the research and development and production of drugs for hemorrhagic septicemia in silkworms, and has broad application prospects and promotional value.
Owner:JIANGSU UNIV OF SCI & TECH

A kind of amplification primer set, amplification system, amplification method, library construction method and sequencing method for Kidd blood group system genotyping based on long-read nanopore sequencing

PendingCN122279025AGenotypingHaplotype
This invention relates to the fields of molecular diagnostics and gene sequencing technology, specifically to a primer set, amplification system, amplification method, library construction method, and sequencing method for Kidd blood group system genotyping amplification based on long-read nanopore sequencing. This invention provides primers and an optimized amplification system for specifically amplifying long fragments of the Kidd blood group encoding gene SLC14A1; a library construction method adapted for nanopore sequencing; and a SLC14A1 genotyping method based on long-read data for haplotype analysis. This invention overcomes the limitations of conventional techniques that only detect single SNPs, enabling the simultaneous acquisition of the complete sequence and phase information of key regions of the SLC14A1 gene, achieving accurate genotyping of JKA / JKB and effective identification of rare variants such as weakly expressed and deleted variants. This invention provides a powerful molecular tool for clinical transfusion safety assurance, rare blood group bank construction, and genetic research.
Owner:JIANGSU WEIHE BIOTECH