The invention discloses an intelligent vehicle control method and system based on fatigue monitoring. The method comprises the steps that after physiological signals of a driver are collected, in the vehicle driving process, the fatigue degree of the driver is judged according to the physiological signals of the driver, if it is mild fatigue, the driver is prompted, and if it is severe fatigue, the driver is prompted, at the same time, the driving assisting function is started and a hazard warning lamp is turned on, so that a safety assurance is effectively provided for persons in a vehicle during the period from the fatigue state to the wide-awake state of the driver; and when the vehicle stops, the quality signals of air in the vehicle are collected, the personal safety degree of the driver is judged according to the physiological signals of the driver and the quality signals of air in the vehicle, if hazard exists, the driver is prompted, and if it is dangerous, the driver is prompted, and at the same time, vehicle windows are opened, so that the persons in the vehicle are prevented from being harmed by harmful gas and the safety assurance is effectively provided for the persons having a rest in the vehicle.