Method for nondestructive measurement of content of free hemoglobin in blood bag

A technology of hemoglobin and blood bags, applied in the field of spectroscopic blood concentration analysis and chemical measurement, to eliminate the influence of changes in transmitted light sources and blood bags, solve non-destructive testing problems, and achieve highly targeted measurements

Inactive Publication Date: 2017-11-21
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] The invention provides a method for non-destructively measuring the content of free hemoglobin in a blood bag, the measurement is highly targeted, eliminates the influence of the spectral background noise, the change of the transmitted light source and the blood bag, suppre

Method used

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  • Method for nondestructive measurement of content of free hemoglobin in blood bag
  • Method for nondestructive measurement of content of free hemoglobin in blood bag
  • Method for nondestructive measurement of content of free hemoglobin in blood bag

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Embodiment 1

[0078] The embodiment of the present invention provides a method for non-destructively measuring free hemoglobin content in a blood bag, using devices such as image 3 As shown, it includes: a light source 3 , a blood bag 5 , a displacement platform 6 , a spectrum receiving device 7 and a modulation device 9 .

[0079] Wherein, it is ensured that the light output port of the light source 3 and the incident slit of the spectrum receiving device 7 are close to the blood bag 5, and the modulation device 9 modulates the light source 3 so that it sends out a square-wave optical signal, and the light source 3 is at the position a under the two optical paths, that is, : Position a (corresponding to the first optical path 1) and position a' (corresponding to the second optical path 2) transmit and excite the blood in the blood bag 5, and the transmission spectrum and fluorescence spectrum are collected by the spectrum receiving device 7; The platform 6 controls the light source 3 to m...

Embodiment 2

[0088] The difference between the embodiment of the present invention and embodiment 1 is only that the light source 3 and the movement mode of the spectrum receiving device 7 are different, see the following description for details:

[0089] see Figure 4 , ensuring that the light outlet of the light source 3 and the incident slit of the spectrum receiving device 7 are close to the blood bag 5, the modulation device 9 modulates the light source 3 so that it sends out a square wave light signal, and the light source 3 transmits and excites the blood in the blood bag 5, The spectrum receiving device 7 collects the transmission spectrum and the fluorescence spectrum under the double optical path at position a, namely: position a and position a'. The spectrum receiving device 7 is controlled to move to the position b through the displacement platform 6, and the transmission spectrum and the fluorescence spectrum of the position b and the position b' are collected under the double...

Embodiment 3

[0094] During specific implementation, due to the limitation of the space structure, it may occur that the light source 3 and the spectrum receiving device 7 cannot be close to the blood bag 5. At this time, an optical fiber can be respectively arranged at the light source 3 and the spectrum receiving device 7 as the incident optical fiber 4 and outgoing fiber 8.

[0095] see Figure 5 , the modulation device 9 modulates the light source 3 to make it emit a square wave light signal, the light source 3 transmits and excites the blood in the blood bag 5 through the incident optical fiber 4, and the spectrum receiving device 7 collects the transmission spectrum and the fluorescence spectrum through the outgoing optical fiber 8, and the incident optical fiber 4 and the outgoing optical fiber 8 are respectively close to the blood bag 5, the incident optical fiber 4 is at the position a, and the light source 3 passes through the incident optical fiber 4 at this position under the do...

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Abstract

The invention discloses a method for nondestructive measurement of the content of free hemoglobin in a blood bag. The method comprises the following steps that a modulation apparatus modulates a light source; a displacement platform controls the light source to move to dual-light-path locations of a plurality of positions for transmission and excitation of blood separately; a spectrum receiving apparatus acquires the dual-light-path transmission and fluorescence spectra of each position; the dual-light-path transmission and fluorescence spectra are converted to frequency domains for construction of within-frequency-domain transmission spectra and within-frequency-domain fluorescence spectra; the logarithm of a ratio of transmission spectra in two frequency domains at each position is calculated so as to obtain the absorption spectrum of the blood at the position, the absorption spectra at the plurality of positions and the fluorescence spectra of the plurality of positions in dual-light-path frequency domains are subjected to normalization together, and then a mathematic model is established on the basis of the normalization and chemical examination data; and the absorption spectra and within-frequency-domain of an unknown complex solution at a plurality of positions are acquired by using same methods mentioned above, then subjected to normalization and finally substituted into the mathematic model so as to obtain the content of free hemoglobin.

Description

technical field [0001] The invention relates to the field of spectroscopic blood concentration analysis stoichiometry, in particular to a method for non-destructively measuring the content of free hemoglobin in a blood bag. Background technique [0002] In the existing technology, the relatively mature technology is to detect the content of free hemoglobin in the blood bag through chemical testing, which has the outstanding advantage of high accuracy, but the way of chemical testing cannot meet the needs of fast, non-contact, and pollution-free. Due to its non-contact and non-polluting characteristics, it is also possible to detect the content of free hemoglobin in blood bags. [0003] In spectral detection, according to the Lambert-Beer law: the incident light intensity I of each wavelength is measured separately 0 and the outgoing light intensity I, the absorbance A of each wavelength is calculated by the formula (1). ∈ is the absorption coefficient of the substance at a...

Claims

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Application Information

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IPC IPC(8): G01N21/39G01N21/64
CPCG01N21/39G01N21/64G01N21/6402G01N21/6486G01N2021/6419G01N2021/6491G01N2201/06113G01N2201/08
Inventor 林凌张盛昭甄建芸王玉宇王艳军张梦秋李刚
Owner TIANJIN UNIV
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