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Method for measuring content of free hemoglobin in blood bag by multiple-position modulated light source

A technique for modulating light source and hemoglobin, which is applied in the measurement of color/spectral characteristics, etc., to achieve the effects of improving analysis accuracy, eliminating spectral background noise, and suppressing influence

Inactive Publication Date: 2017-11-17
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complexity of blood components, it has strong scattering, its transmission spectrum is nonlinear, and the traditional transmission spectrum cannot completely eliminate the influence of spectral background noise. To solve this problem, this method proposes a multi-position modulated light source to measure blood Method for free hemoglobin content in bags

Method used

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  • Method for measuring content of free hemoglobin in blood bag by multiple-position modulated light source
  • Method for measuring content of free hemoglobin in blood bag by multiple-position modulated light source
  • Method for measuring content of free hemoglobin in blood bag by multiple-position modulated light source

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Embodiment 1

[0055] The embodiment of the present invention provides a method for measuring free hemoglobin content in a blood bag with a multi-position modulated light source. The devices used are such as figure 2 As shown, it includes: a light source 1 , a blood bag 3 , a displacement platform 4 , a spectrum receiving device 5 and a modulation device 7 .

[0056] Wherein, ensure that the light outlet of the light source 1 and the incident slit of the spectrum receiving device 5 are close to the blood bag 3, the modulation device 7 modulates the light source 1 so that it sends out a square wave light signal, and the light source 1 faces the inside of the blood bag 3 at the first position a. The blood sample is transmitted, and the transmission spectrum is collected by the spectrum receiving device 5 . Then the light source 1 is controlled by the displacement platform 4 to move to the second position b, the spectrum receiving device 5 collects the transmission spectrum at this position, t...

Embodiment 2

[0065] The difference between the embodiment of the present invention and embodiment 1 is only that the light source 1 and the moving mode of the spectrum receiving device 5 are different, see the following description for details:

[0066] see image 3 To ensure that the light outlet of the light source 1 and the incident slit of the spectrum receiving device 5 are close to the blood bag 3, the modulation device 7 modulates the light source 1 so that it sends out a square wave light signal, the light source 1 transmits the blood sample in the blood bag 3, and the The spectrum receiving device 5 collects the transmission spectrum at the first position a. Then the spectrum receiving device 5 is controlled by the displacement platform 4 to move to the second position b, and the transmission spectrum at the second position b is collected; the spectrum receiving device 5 is controlled to move to the position n by the displacement platform 4, and the transmission spectrum at the po...

Embodiment 3

[0071] In actual implementation, due to the limitation of the space structure, it may occur that the light source 1 and the spectrum receiving device 5 cannot be close to the blood bag 3. At this time, an optical fiber can be respectively arranged at the light source 1 and the spectrum receiving device 5 as the incident optical fiber 2 and outgoing fiber 6.

[0072] see Figure 4 The modulation device 7 modulates the light source 1 so that it sends out a square-wave optical signal. The light source 1 transmits the blood sample in the blood bag 3 through the incident optical fiber 2. The spectrum receiving device 5 collects the transmission spectrum through the outgoing optical fiber 6. The incident optical fiber 2 and the outgoing optical fiber 6 respectively close to the blood bag 3, the position a is the first position of the incident optical fiber 2, and the spectrum receiving device 5 collects the transmission spectrum at this position; then the incident optical fiber 2 is...

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Abstract

The invention discloses a method for measuring the content of free hemoglobin in a blood bag by a multiple-position modulated light source. The method comprises the following steps: modulating a light source by a modulation device, allowing the light exit port of the light source and the entrance slit of a spectrum receiving device to cling to the blood bag, controlling the light source to move to multiple positions by a displacement platform in order to transmit a blood sample, and acquiring the transmission spectrum by the spectrum receiving device; transforming the time sequence of every wavelength in the acquired transmission spectrum into a frequency domain, constructing a transmission spectrum in the frequency domain based on the fundamental wave component of every wavelength, carrying out normalization processing, comparing the obtained result with existing chemical analysis results, and establishing a mathematical model; and acquiring the transmission spectrum in the frequency domain of an unknown blood sample through using above steps, normalizing the obtained transmission spectrum, and substituting the normalization result into the mathematical model in order to obtain the content of the free hemoglobin. The method eliminates the influences brought by spectral background noises and scattering, increases the information content of all components in the blood, and improves the precision of the free hemoglobin content analysis.

Description

technical field [0001] The invention relates to the field of chemical metering for concentration analysis of complex spectral solutions, in particular to a method for measuring free hemoglobin content in blood bags by modulating light sources at multiple positions. Background technique [0002] Among the existing technologies, the more mature technology is to detect the content of free hemoglobin in the blood bag through chemical testing, which has the outstanding advantage of high accuracy, but the chemical testing method needs to open the blood bag to take out samples for testing, which cannot meet the requirements of rapid , Non-contact and pollution-free requirements. [0003] Due to its non-contact and pollution-free characteristics, spectral detection is also possible to detect free hemoglobin in blood bags. Due to the complexity of blood components, it has strong scattering, its transmission spectrum is nonlinear, and the traditional transmission spectrum cannot comp...

Claims

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Application Information

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IPC IPC(8): G01N21/25
Inventor 林凌张梦秋甄建芸王玉宇王艳军张盛昭李刚
Owner TIANJIN UNIV
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