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Method for measuring content of free hemoglobin in blood bag by dual-light path modulated light source

A technology for modulating light source and hemoglobin, which is applied in color/spectral characteristic measurement, measuring device, material analysis through optical means, etc. It can solve the problem that it is difficult to ensure that the position of the sample and the neutral attenuator are consistent, and it is difficult to find the neutral attenuator and other problems, to achieve the effect of solving non-destructive testing problems, eliminating the influence of spectral background noise, and strong operability

Inactive Publication Date: 2017-09-15
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] It is difficult to find exactly the same neutral attenuator in different occasions, and it is difficult to ensure that the position of the sample and the neutral attenuator are consistent

Method used

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  • Method for measuring content of free hemoglobin in blood bag by dual-light path modulated light source
  • Method for measuring content of free hemoglobin in blood bag by dual-light path modulated light source
  • Method for measuring content of free hemoglobin in blood bag by dual-light path modulated light source

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Embodiment 1

[0072] The embodiment of the present invention provides a method for measuring the content of free hemoglobin in a blood bag with a dual optical path modulation light source. The devices used are such as image 3 As shown, it includes: a light source 3 , a blood bag 5 , a displacement platform 6 , a spectrum receiving device 7 and a modulation device 9 .

[0073] Wherein, ensure that the light output port of the light source 3 and the incident slit of the spectrum receiving device 7 are close to the blood bag 5 and coaxial, the modulation device 9 modulates the light source 3 so that it sends out a square wave light signal, and the light source 3 is at the first position a (corresponding to the first light Process 1) transmits the blood sample in the blood bag 5, and the transmission spectrum is collected by the spectrum receiving device 7. Then, the displacement platform 6 controls the light source to move to the second position b (corresponding to the second optical path 2) ...

Embodiment 2

[0082] The difference between the embodiment of the present invention and embodiment 1 is only that the light source 3 and the movement mode of the spectrum receiving device 7 are different, see the following description for details:

[0083] see Figure 4 To ensure that the light outlet of the light source 3 and the incident slit of the spectrum receiving device 7 are close to the blood bag 5 and coaxial, the modulation device 9 modulates the light source 3 so that it sends out a square wave light signal, and the light source 3 transmits the blood sample in the blood bag 5, The transmission spectrum is acquired by the spectral receiving device 7 at the first position a. Then, under the premise of ensuring that the light outlet of the light source 3 is coaxial with the incident slit of the spectrum receiving device 7, the displacement platform 6 controls the spectrum receiving device 7 to move to the second position b, and collects the transmission spectrum at the second posit...

Embodiment 3

[0088] The difference between the embodiment of the present invention and embodiment 1 is only that the light source 3 and the moving direction of the spectrum receiving device 7 are different, see the following description for details:

[0089] see Figure 5 , ensure that the light source 3 and the spectrum receiving device 7 are close to the blood bag 5 and ensure that the light outlet of the light source 3 is coaxial with the incident slit of the spectrum receiving device 7, and the modulating device 9 modulates the light source 3 so that it sends out a square wave optical signal, at the first position a The blood sample in the blood bag 5 is transmitted by the light source 3, and the transmission spectrum is collected by the spectrum receiving device 7 at the first position a', and then the displacement platform 6 is used to ensure that the light output port of the light source 3 and the light spectrum receiving device 7 incident narrow On the premise that the slits are co...

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Abstract

The invention discloses a method for measuring the content of free hemoglobin in a blood bag by a dual-light path modulated light source. The method comprises the following steps: modulating a light source by a modulation device, allowing the light exit port of the light source and the entrance slit of a spectrum receiving device to be close to and coaxial with a packaging bag, allowing the light source to transmit a blood sample, and acquiring the transmission spectrum by the spectrum receiving device; controlling the light source to move by a displacement platform on the premise of guaranteeing that the light exit port of the light source is coaxial with the entrance slit of the spectrum receiving device, and acquiring the transmission spectrum by the spectrum receiving device; transforming the time sequence of every wavelength in the acquired transmission spectrum into a frequency domain, constructing a transmission spectrum in the frequency domains based on the fundamental wave component of every wavelength, carrying out logarithm calculation on the light intensity ratio at every wavelength of the transmission spectrum in the constructed two frequency domains to obtain absorption spectra, carrying out normalization processing, comparing the obtained result with existing chemical analysis results, and establishing a mathematical model; and acquiring the absorption spectrum of unknown blood through using above steps, normalizing the absorption spectrum, and substituting the obtained normalization result into the to the mathematical model in order to obtain the content of the free hemoglobin.

Description

technical field [0001] The invention relates to the field of concentration analysis stoichiometry of spectrally complex solutions, in particular to a method for measuring the content of free hemoglobin in a blood bag by modulating a light source with two optical paths. Background technique [0002] In the existing technology, the relatively mature technology is to detect the content of free hemoglobin in the blood bag through chemical testing, which has the outstanding advantage of high accuracy, but the way of chemical testing cannot meet the needs of fast, non-contact, and pollution-free. Due to its non-contact and non-polluting characteristics, it is also possible to detect the content of free hemoglobin in blood bags. [0003] In spectral detection, according to the Lambert-Beer law: the incident light intensity I of each wavelength is measured separately 0 and the outgoing light intensity I, the absorbance A of each wavelength is calculated by the formula (1). ∈ is th...

Claims

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Application Information

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IPC IPC(8): G01N21/31
CPCG01N21/3151
Inventor 林凌王艳军罗永顺张梦秋甄建芸王玉宇李刚
Owner TIANJIN UNIV
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