Polyglycol modified antimicrobial peptide and uses thereof

A polyethylene glycol and antibacterial peptide technology, applied in the field of modification of peptides, can solve the problems such as the reduction of antibacterial activity of antibacterial peptides
CN101429233AInactive Publication Date: 2009-05-13NANKAI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANKAI UNIV
Publication Date
2009-05-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a series of polyethylene glycol modified cationic antibacterial peptide with different molecular weight. The modified antibacterial peptide is self-assembled into a nanometer micelle in an aqueous medium. The formation of the micelle can play a role in protecting the antibacterial peptide and weakening the degradation effect of protease on the antibacterial peptide, and simultaneously improves the stability and antibacterial activity of polypeptide in serum. In addition, the modification of polyethylene glycol obviously reduces the hemolytic toxic side effects of the antibacterial peptide.
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Description

technical field

[0001] The present invention relates to the modification of polypeptides, specifically polyethylene glycol-modified cationic antimicrobial peptides. The polyethylene glycol-modified cationic antimicrobial peptides are self-assembled in aqueous media to form antimicrobial peptides as cores and polyethylene glycol as shells. bundle, thereby reducing the degradation of antimicrobial peptides by proteases. Background technique

[0002] In recent years, cationic antimicrobial peptides and their analogues have attracted great attention as a new generation of antibiotics against drug-resistant bacteria. Especially with the widespread use of traditional antibiotics, bacteria have gradually developed resistance to them, forcing people to constantly search for new antibiotics, cationic antimicrobial peptides are not easy to develop resistance to them due to the unique antibacterial mechanism of bacteria (M .Zasloff, Nature, 2002, 415, 389-395) and has received extensi...

Claims

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