1 results about "Cationic Antimicrobial Peptides" patented technology

This invention discloses a cell membrane-modified inflammatory-responsive release nanoparticle, its preparation method, and its applications. The nanoparticles use a polylactic-co-glycolic acid (PLA) core, and their surface is modified with an immune cell membrane. The PLA is loaded with an antibacterial drug and modified with a positively charged material and a responsive switch. The immune cell membrane is obtained by isolating immune cells pre-stimulated by pathogens. The nanoparticles prepared by this invention possess the function of rapidly releasing drugs targeting homologous bacteria and sites of inflammation. During systemic circulation, they tend to target sites of inflammation caused by bacterial infection, rapidly releasing the drug under the action of the highly expressed MMP-3 enzyme at the site of inflammation, achieving efficient delivery of antibacterial drugs. This invention has shown good therapeutic effects in a mouse model of bacterial infection, providing not only an effective means for the in vivo delivery of cationic antimicrobial peptides but also a promising therapeutic strategy against Gram-negative bacterial infections.