Intelligent antibacterial nano-hydrogel bone fracture plate with topological structure and manufacturing method thereof

Abstract

The invention discloses an intelligent antibacterial nano-hydrogel bone fracture plate with a topological structure. The surface of a substrate is coated with composite micelles, wherein each composite micelle comprises a polyethylene glycol-co-acrylic acid microgel core which serves as inner core and an outer layer controlled release shell which is a pH sensitive polymethylacrylic acid microgel layer; the polyethylene glycol-co-acrylic acid microgel core and the pH sensitive polymethylacrylic acid microgel layer form intelligent charge gradient radial distribution; the composite micelle coating forms a topological antibacterial structure surface on stainless steel, titanium metal or titanium alloy bone fracture plate and is loaded with beta-defensin-1-3, lactoferrin 1-11, LL-37, histadine-rich protein analogues, endogenous antimicrobial peptide-1 and artificially synthesized cationic antimicrobial peptides. The intelligent antibacterial nano-hydrogel bone fracture plate with the topological structure is used as an intelligent simulation response mechanism of contact sterilization when the bacteria are generated on the surface of an orthopedic object and serve as a stimulation factor, so that osteoblasts can quickly grow on the surface of the orthopedic object; the bacterial adhesion is reduced; the bacteria are killed by antimicrobial peptide; target points used for controlling the formation of bacterial biofilms can be really restrained in the initial stage, thereby finally reducing the occurrence rate of orthopedic device related infections.

Description

technical field [0001] The invention belongs to surgical medical materials and a manufacturing method thereof, in particular to an antibacterial bone plate with an intelligent nanometer hydrogel topological structure. Background technique [0002] According to the report of AO (Arbeit sgem ein schaft fur Osteosyntheses fragen) / ASIF (Association for the Study of Internal Fixation), the infection rate in open fractures is as high as 3-40%, and the infection rate will increase if internal fixation is used. More than 30%. About 50% of the approximately 2 million nosocomial infection cases in the United States are related to implants every year, which not only consumes a huge social wealth of up to 24 billion US dollars, but also leads to serious consequences including bacterial resistance, amputation, and even the death of 100,000 patients every year. The reason is that the adhesion of bacteria to implant materials to form a complete biofilm is the main pathological basis of "p...

AI Technical Summary

Problems solved by technology

The former, often due to local injury and blood circulation disruption, makes it difficult for the antibiotics in the systemic blood to reach an effective antibacterial concentration in the damaged area; the latter, although a high concentration of antibiotics can be produced locally at the beginning, then declines rapidly and cannot maintain an effective therapeutic concentration

Therefore, it is difficult to produce effective anti-infection effects on the formation and development of ODRI and traumatic osteomyelitis

At present, for bacterial biofilms, methods such as inhibiting the synthesis of polysaccharide matrix and promoting its decomposition, interfering with the density sensing system, adding monoclonal antibodies and improving the surface physical and chemical properties of implants to reduce the adhesion of bacteria to materials and antibiotic coatings, etc. It has been confirmed that the incidence of ODRI can be reduced to a certain extent, but none of them can completely solve the formation of biofilm and the resulting persistent infection

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