24 results about "Osteomyelitis" patented technology

Described herein are methods and compositions for using microbial agents (probiotics) and agents that promote growth of certain microbes (prebiotics) for management (including prevention and treatment) of musculoskeletal disorders, including osteoporosis, osteopenia, Paget's disease, stunting, osteoarthritis, osteomyelitis, and delayed or non-union fractures. Also described herein are methods and compositions for using probiotics and prebiotics for management of inflammation, and symptoms of menopause.

The invention discloses a manganese-based layered hydroxide modified by gold nanoparticles and a preparation method thereof, and relates to the technical field of drug synthesis, and the key points of the technical scheme are as follows: the layered morphology of Mn-LDH is observed on the manganese-based layered hydroxide in a transmission electron microscope, and spherical AuNPs dispersed on the surface and edge of a laminate have a uniform particle size and a uniform particle size. EDS energy spectrum analysis finds that gold, manganese, magnesium, aluminum and carbon elements exist, the hydrated particle size is 312 nm, and the dispersity is good. The material can initiate an excellent photo-thermal effect under the irradiation of 808nm near-infrared light to generate active oxygen and hydroxyl radicals to destroy bacterial cell walls and cell membranes, and the antibacterial effect can reach 99%. In addition, the material can stimulate a local active immune function, promote T cell infiltration and realize active immune sterilization. The nano material shows a remarkable anti-infection effect in an in-vitro antibacterial experiment and an in-vivo osteomyelitis animal model experiment, and a new insight is provided for treating osteomyelitis caused by methicillin-resistant staphylococcus aureus.

The present application relates to the technical field of medical devices, mainly applied to patients with diabetic foot ulcers or osteomyelitis. Specifically, it is a kind of flushing drainage device, including support frame, the front bottom of support frame is provided with flushing drainage part, flushing drainage part includes two drainage components, the inner wall of two drainage components is provided with positioning assembly. The present application is provided with support frame and flushing drainage part, which realizes the significant improvement of the efficiency and safety of the operation of flushing and drainage of the deep cavity of the patient's bone, which is due to a carefully designed mechanical linkage structure. The structure can automatically complete the extension action of the spray pipe during the preparation stage of flushing, and ensure that the protection plate is quickly and stably closed, which not only ensures the accuracy of the flushing process, but also greatly reduces the risk of secondary injury to the patient during operation. Moreover, through the independent operation and cooperative mechanism of the left and right drainage components, the left component focuses on accurate flushing of the lesion area, and the right component is committed to efficient drainage.

This application provides an application of a Raman spectroscopy biomarker combination in the preparation of diagnostic products for diabetic foot osteomyelitis, belonging to the field of biomedical detection technology. The biomarker combination includes a first type of characteristic spectrum showing a significant increase in intensity or intensity ratio in positive samples of diabetic foot osteomyelitis compared to negative samples, and a second type of characteristic spectrum showing a significant decrease in intensity; specifically involving 1070 cm⁻¹. ‑1 With 1450 cm ‑1 The strength ratio, (851+873+917) cm ‑1 Region and 1656 cm ‑1 The strength ratio, and 960 cm ‑1 1001 cm ‑1 1103 cm ‑1 1450 cm ‑1 1590 cm ‑1 1656 cm ‑1 The intensity of multiple characteristic wavelengths was measured. The diagnostic model constructed based on this combination demonstrated good discrimination performance in testing. The method provided in this application has the advantages of being rapid and low-cost, offering a new solution for the early screening and auxiliary diagnosis of diabetic foot osteomyelitis.

Compositions for identifying a pathogenic bacterial infection include a mannitol compound with one or more substituents including radioisotopes. These radiopharmaceuticals, such as a positron-emitting mannitol analogue, [18F]fluoromannitol ([18F]FMtl), are rapidly taken up by gram-positive and gram-negative bacteria such as E. coli, S. aureus, A. baumannii, S. epidermis, P. mirabilis, S. enterica, K. pneumonia, E. faecium, E. cloacae, and M. marinum, but not non-active infection sites such as sterile inflammatory sites, cancer sites, etc. Administration of these radiopharmaceuticals to and subsequent imaging of patients, e.g., via positron emission tomography (PET), enables detection of deep-seated and difficult to manage bacterial infections, such as osteomyelitis and prosthetic joint infection, or in patients with sickle cell disease. [18F]FMtl injection detects and differentiates infection rapidly. The radiolabeled mannitol compounds can be produced via nucleophilic substitution reactions that are deployable on commercially available synthesizers, facilitating straightforward and wide accessibility, and counteracting unnecessary antibiotic use.

The invention relates to the technical field of biomedicine, and discloses an experimental method for treating osteomyelitis by using human umbilical cord mesenchymal stem cells. The method aims at solving the problems that an existing osteomyelitis experimental model is disjointed from clinical pathological characteristics, the activity loss of mesenchymal stem cells in an infection environment is large, a combined intervention scheme lacks pathological suitability, and an evaluation system is single. The method comprises the following steps: firstly, constructing a clinical adaptive model by combining pathogenic bacterium injection with immunosuppression and ischemia induction, then carrying out anti-oxidation and targeted colonization double pretreatment on MSC, then implementing stepped combined intervention according to the requirements of acute-stage bacterium control and chronic-stage repair, and comprehensively evaluating through infection control, immune balance and bone repair multi-dimensional indexes, so as to obtain a bone repair model. The constructed model is closer to clinical pathological characteristics, the MSC activity and colonization ability are stable, the intervention scheme collaboration is high, the evaluation result is comprehensive and reliable, a standardized tool can be provided for preclinical research of osteomyelitis treatment schemes, and the conversion guidance value of the experimental result is improved.

The present application relates to the technical field of external use of traditional Chinese medicine, in particular to an external use synthetic traditional Chinese medicine composition for treating osteomyelitis, sinus tract and stubborn ulcer and a preparation method thereof, which comprises, by weight, 10-15 parts of honeysuckle, 10-15 parts of dandelion, 10-12 parts of purple flower ground ivy, 6-10 parts of Chinese cork tree, 6-10 parts of bitter apricot seed, 5-8 parts of red root of sophora, 5-8 parts of Chinese angelica, and 1-4 parts of borneol; the present application is applicable to the infection period and the repair period, realizes the integration of anti-inflammatory, bacteriostasis, muscle regeneration and repair, adopts low-temperature ultrasonic extraction, avoids high-temperature damage to heat-sensitive components, has stronger and more stable efficacy, the formula contains blood-activating and stasis-removing components such as red root of sophora, Chinese angelica, frankincense and myrrh, can promote the penetration of the medicine into deep tissues, has a remarkable effect on the sinus tract and osteomyelitis wound, is a pure traditional Chinese medicine for external use, does not add hormones and antibiotics, is mild in nature, and is suitable for long-term use.

Systems, devices and methods for controlled intramedullary delivery of light (frequencies from about 380 nm to about 500 nm) to treat tissue or bones disorders, including osteomyelitis, by a flexible fiber are provided, where the light is delivered in a circumferential fashion around the fiber, and where the energy delivered from the fiber is of a similar average intensity at the front end and back end of the fiber, and in between. The methods and systems deliver intramedullary light to the canal over long lengths via a minimally invasive pathway to a bone. The methods and systems deliver and maintain a light delivery system within the canal of the bone to provide single or multiple doses of light to kill, eliminate, remove or reduce bacteria, viruses, fungus and pathogens, without removal of the light fiber system, thereby providing single or multiple treatments.

The invention discloses a perfusate suspension device with dual-redundancy pressure protection, relates to the technical field of lavage after tibial osteomyelitis in the children orthopedics department, and aims to solve the problem that an existing perfusate suspension device is difficult to operate in lavage after tibial osteomyelitis in children. The technical problems that in the prior art, a dynamic pressure protection mechanism matched with child bone growth is lacked, interference of temperature on pressure monitoring is not eliminated, redundant protection is not achieved, and bone wall damage or incomplete lavage is likely to happen are solved, and the device comprises a hanging assembly used for bearing a perfusate container; the perfusion assembly comprises a perfusion pipeline and a lavage needle, and the two ends of the perfusion pipeline are connected with an outlet of the perfusate container and the lavage needle respectively; and the dual-redundancy pressure monitoring module comprises two independent pressure acquisition paths which are used for respectively acquiring the pressure in the marrow cavity and the pressure in the perfusion pipeline, and the two acquisition paths are synchronously connected to the temperature compensation unit. The device has the advantages that accurate pressure monitoring and dynamic threshold adjustment are achieved, and the child lavage safety and effect are guaranteed.

The invention provides a recurrence risk assessment method for treating osteomyelitis through an induced membrane technology, and belongs to the technical field of disease assessment. The method comprises the steps of S1, multi-center data and queue design; s2, two high-annuity radiologists sketch ICCgt layer by layer by adopting a blind method; if 0.80, the ROI is locked; a difference gt; when 0.80, third-person arbitration is introduced; s3, high-dimensional feature extraction and refining; s4, machine learning modeling is carried out; and S5, interpretable output is carried out. According to the method, the scoring objectivity and consistency are remarkably improved; the change of the internal microstructure of the induction film is quantified in vivo and noninvasively for the first time; individualized operation opportunity adjustment can be achieved through longitudinal monitoring, and a result can be explained and can directly guide treatment decisions.

The invention discloses an intramedullary nail capable of slowly releasing antibiotics. The intramedullary nail comprises an intramedullary nail body, a medicine cavity is formed in a rod body of the intramedullary nail body, a plurality of microspheres are put into the medicine cavity, the antibiotics are wrapped in the microspheres, and a plurality of releasing micropores are formed in the rod body, corresponding to the medicine cavity, of the intramedullary nail body. According to the intramedullary nail, the microspheres sealed with antibiotics can be put into the intramedullary nail, the antibiotics can be slowly released through the release micropores, the anti-infection effect on osteomyelitis and local infection patients can be achieved, the microspheres do not need to be taken out in a short time, the pain of the patients is relieved, and the intramedullary nail has the advantages of being simple in structure, convenient to use, low in cost and the like.

The invention provides a composite scaffold material and a preparation method and application thereof, and relates to the technical field of composites.The preparation method comprises the steps that ferric chloride hexahydrate and anhydrous sodium acetate are added into ethylene glycol for a reaction, and Fe3O4 nanoparticles are obtained; potassium ferricyanide and a dispersion medium are added into a hydrochloric acid solution to be dissolved, then Fe3O4 nanoparticles are added for a reaction, and a Fe3O4 / PB heterojunction is obtained; the preparation method comprises the following steps: mixing and grinding a Fe3O4 / PB heterojunction and poly-L-lactic acid, and carrying out laser printing to form the PLLA-Fe3O4 / PB microwave antibacterial composite scaffold material. PLLA is taken as a carrier, the Fe3O4 / PB heterostructure scaffold material is loaded, the microwave absorption performance is enhanced through a magnetic-dielectric synergistic effect, under microwave irradiation, by virtue of a dual mechanism of interface polarization and dipole polarization, the composite scaffold material is prepared into the PLLA-Fe3O4 / PB microwave antibacterial composite scaffold material, and the composite scaffold material is prepared into the PLLA-Fe3O4 / PB microwave antibacterial composite scaffold material. Microwave thermal therapy and microwave power are synchronously realized, and the microwave thermal therapy and the microwave power synergistically show an efficient antibacterial effect on the osteomyelitis infected by the staphylococcus aureus.

The invention relates to the technical field of biomedical materials, in particular to carbon dot hydrogel with antibacterial, anti-inflammatory and osteogenesis promoting functions as well as a preparation method and application of the carbon dot hydrogel. The preparation method comprises the following steps: performing hydrothermal reaction on o-phenylenediamine, caffeic acid and selenium tetrachloride to prepare selenium-doped carbon dots Cat-SeCD; phenylboronic acid functionalized sodium alginate PBA-SA and a catechol structure on the surface of the Cat-SeCD are cross-linked through a dynamic covalent bond to form gel. According to the application, the carbon dots can be used as active centers and cross-linking points, and on-demand release of the Cat-SeCD can be realized in an acidic or high oxidative stress microenvironment of an osteomyelitis focus. The Cat-SeCD integrates multiple functions of broad-spectrum antibiosis, free radical scavenging, bone marrow mesenchymal stem cell osteogenic differentiation promotion and the like, realizes three-in-one synergistic intervention of sterilization, anti-inflammation and osteogenesis promotion, and has excellent biocompatibility and clinical application potential.

The invention discloses a periosteum distraction device. The periosteum distraction device comprises a distraction plate, at least one barrier plate, a distraction screw and a steel needle. A threaded hole and a cylindrical fixing hole I are formed in the center of the distraction plate; the blocking plate is located below the stretching plate, and a center hole and a second cylindrical fixing hole are formed in the center of the blocking plate. The distraction screw is a hollow screw and is used for being screwed into the threaded hole along the steel needle; and the steel needle is used for penetrating through the central hole and drilling into sclerotin to be fixed. The diameter of the center hole is smaller than the outer diameter of the distraction screw, and a steel needle can pass through the center hole. The blocking plate is arranged below the distraction plate, the distraction screws are effectively prevented from penetrating into bone cortex in the distraction process, the risks of bone destruction, fracture and osteomyelitis are reduced, meanwhile, local pain in the distraction process is relieved, and the periosteum distraction device is suitable for periosteum distraction treatment of osteoporosis patients.

The invention is applicable to the technical field of biological medicine, and provides application of hesperidin in preparation of a medicine for treating staphylococcus aureus osteomyelitis, hesperidin serves as a novel medicine for inhibiting staphylococcus aureus virulence regulatory factors, and activates Nrf2 / SLC7A11 / GPX4 signal channels in osteoblasts by inhibiting activity of the staphylococcus aureus virulence regulatory factors AgrA and SarA, so that the activity of the staphylococcus aureus virulence regulatory factors AgrA and SarA is inhibited, and the activity of the staphylococcus aureus virulence regulatory factors AgrA and SarA is inhibited. The composition can inhibit osteoblast ferroptosis, alleviate inhibition of staphylococcus aureus on cell viability, differentiation and mineralization of osteoblasts, reduce cortical bone destruction and bone mass loss of mice with staphylococcus aureus osteomyelitis, and has a good protection effect on staphylococcus aureus osteomyelitis.

The invention relates to the technical field of medical detection and diagnosis, in particular to a diabetic foot wound infection severity and osteomyelitis risk combined assessment method and system based on image recognition. The method comprises the following steps: acquiring a wound image and a patient context, and performing white balance correction, color card reference calibration and quality screening to obtain a quality passing image; performing instance segmentation and semantic segmentation through the image based on the quality, generating a wound mask, a contour and a tissue category mask, and performing area and color texture statistics to construct a candidate index structure; feature aggregation, double-task reasoning and hierarchical calibration are executed, and a joint evaluation structure is generated; and finally, performing thermodynamic diagram rendering, evidence fragment extraction and report generation to obtain a configuration updating parameter structure. According to the invention, multi-modal data fusion and automatic decision-making of wound assessment are realized, and the accuracy, interpretability and clinical applicability of the assessment result are improved.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of a bone marrow focus targeting traditional Chinese medicine sustained release preparation. The traditional Chinese medicine sustained release preparation for targeting the bone marrow focus comprises the following raw materials in parts by mass: 15-25 parts of oldenlandia diffusa, 5-15 parts of sculellaria barbata, 20-30 parts of astragalus membranaceus, 10-20 parts of dandelion, 5-12 parts of herba violae, 5-15 parts of gynura bicolor, 1-3 parts of sodium alginate, 1-3 parts of hyperbranched polylysine, 1-2 parts of poloxamer, 1-5 parts of a polylactic acid-glycolic acid copolymer and 5-15 parts of a calcium chloride solution. And 5-10 parts of polyvinyl alcohol. The sustained and controllable release of the traditional Chinese medicine components in the osteomyelitis focus part is realized, the long-acting anti-infection and bone repair promoting potential is achieved, and the preparation method is simple and suitable for large-scale popularization and application.

The application provides a composite bone repair scaffold, a preparation method thereof and application thereof in preparation of a product for treating radiation osteomyelitis, and belongs to the technical field of biomedical materials. The composite bone repair scaffold comprises a three-dimensional porous scaffold matrix, a bacteriostatic agent and functionalized microspheres; the three-dimensional porous scaffold matrix is a gelatin-sodium alginate oxide double-network hydrogel; and the functionalized microspheres are microspheres loaded with eucommia extract and radix astragali extract. The composite bone repair scaffold provided by the application has good pore size, porosity and mechanical properties, and has good degradation performance, water absorption performance and bacteriostatic performance, and has good biocompatibility, can be used for preparing a product for treating radiation osteomyelitis, and has a wide application prospect.

The invention relates to chemistry and pharmacology, specifically to a synthetic biologically active substance—7,9-dibromo-2,4-dioxo-1,2,3,4-tetrahydrochromeno[2,3-d]-pyrimidinium-10 acetate or succinate formula 1:1Where X−═CH3COO− or HOOCCH2CH2COO−,as well as its tautomeric, hydrated forms, solvate, complex compounds, adducts and salt forms, possessing antimicrobial activity, and the ability to penetrate bacterial biofilms. The compound is intended for the treatment of bacterial infections of the oropharynx, skin, and mucous membranes, urinary system, implants, respiratory system, gastrointestinal tract. osteomyelitis, sepsis, nosocomial and wound infections.

The invention relates to a preparation method of Cu-EGC (copper-epigallocatechin) nanoparticles loaded by selenium-doped carbon dots. The nanoparticles prepared by the invention can simultaneously remove drug-resistant bacteria at an infected part, relieve inflammatory response, regulate an oxidative stress microenvironment and effectively induce osteogenic differentiation of bone marrow mesenchymal stem cells, so that bone tissue repair is accelerated, and a new solution is provided for clinical treatment of osteomyelitis.

The application discloses a research method for tumor cell influence mechanism of monocyte remodeling based on bone marrow inflammatory microenvironment, and relates to the technical field of tumor treatment; and comprises the following steps: S1, providing bone marrow plasma from a classic myeloproliferative neoplasm patient; S2, placing primary CD14+ monocytes from a healthy donor in an in-vitro culture system containing the bone marrow plasma, inducing phenotype remodeling of the monocytes, and obtaining the remodeling monocytes. The application establishes CD163+CD206+ double-positive remodeling monocytes as a new target for MPN treatment; through comparison experiments of direct co-culture and indirect co-culture by Transwell, it is confirmed that the promotion effect of the remodeling monocytes on HEL cell proliferation strictly depends on physical contact between cells, rather than soluble secreted factors; and the application provides a theoretical basis for developing new antibody drugs or small molecule inhibitors for blocking cell-cell interaction.

The application provides a clinical decision method and device for osteomyelitis and an electronic device. The method comprises obtaining medical record text data, wound image data and medical image data of a patient; inputting the medical image data into a corresponding image recognition model to obtain the bone state of the patient; inputting the wound image data into a corresponding wound recognition model to obtain the wound state of the patient; evaluating the patient based on the medical record text data, the bone state and the wound state to determine whether the patient has osteomyelitis; if the patient has osteomyelitis, evaluating the patient based on the medical record text data, the bone state and the wound state to stage the osteomyelitis of the patient; classifying the osteomyelitis of the patient based on the medical record text data, the medical image data and the wound state of the patient; and outputting a treatment suggestion based on the osteomyelitis judgment result, the osteomyelitis staging result and the osteomyelitis classification result of the patient. The application can reduce the misdiagnosis rate of osteomyelitis.

The utility model provides a bone fracture internal fixture scrap collecting device which comprises a first connecting rod, a second connecting rod, a rotating shaft, a first collecting part and a second collecting part, and the first connecting rod and the second connecting rod are located on the same horizontal plane and rotatably connected together through the rotating shaft. The first collecting part and the second collecting part are installed at one end of the first connecting rod and one end of the second connecting rod respectively, and the first collecting part and the second collecting part can be driven by the first connecting rod and the second connecting rod to be combined to form a scrap collecting groove. According to the metal scrap collecting device, all metal scraps can be collected, it is guaranteed that all the metal scraps do not make contact with a wound, and therefore relevant complications such as wound infection, osteomyelitis and wound non-healing caused by metal scrap residues and the fact that the metal scraps make contact with the wound are avoided.

The application provides application of ipomoea nil exocyst in preparation of a medicine for preventing, alleviating or treating osteomyelitis. The application creatively finds that the ipomoea nil exocyst can significantly inhibit the expression of macrophage pyroptosis markers GSDMD-NT and Caspase-1, promote the expression of osteogenesis markers RUNX2 and OPN, and mediate immune regulation to achieve the treatment of osteomyelitis. The ipomoea nil exocyst is loaded in a three-dimensional cross-linked skeleton formed by oxidized dextran, aminopolysaccharide and gelatin, has better mass transfer delivery effect, and significantly improves the treatment effect on osteomyelitis.