96 results about "Osteomyelitis" patented technology

The invention discloses a long acting slow-release drug carrier material for therapy and repair of bone disease and preparation method; wherein, the components of the drug carrier material are 4-8 weight account of strontium-doped calcium polyphosphate, 1-3 weight account of chitosan drug-loaded microspheres and 1-3 weight account of chitosan; the preparation method of the compound drug carrier material for therapy of osteomyelitis and other bone diseases is that (1) the chitosan-acetic acid solution is prepared, (2) the strontium-doped calcium polyphosphate powder is put into the chitosan-acetic acid solution and dispersed evenly, (3) the prepared chitosan drug-loaded microspheres is added, (4) the cross-linking agent is added for cross-linking, (5) freezing at temperature of 2-6 DEG C is processed for 12-48 hours, and (6) heating and drying are processed at temperature of 40-100 DEG C. The drug carrier material has the advantages of being applicable to therapy and repair of osteomyelitis and other bone diseases, releasing antibiotic for a long period, bone repair function, good biocompatibility and degradability, and ideal double function of therapy and repair of osteomyelitis and other bone diseases.

The invention relates to a metal bone graft material with a porous structure, and preparation and application thereof. The metal bone graft material is used as a filling material for transplantation after orthopaedic and oral damage and defects. The metal bone graft material contains the following trace elements in the human body by weight: 70.0 to 98.0 of Mg, 0.1 to 10.0% of Si, 0.1 to 10% of Sr and 0.1 to 10.0% of Ca, wherein the trace elements are uniformly distributed in a substrate and a coating. According to the invention, good ossification capability and matching in-vivo absorption capability are obtained by adjusting the contents of components in an alloy, controlling the shape, quantity and distribution of mesophase in metal, changing processing technology and surface coating protection of the alloy and preparing the porous structure; and the metal bone graft material has good biocompatibility and bone conduction capability, is a medical absorbent metal bone graft material with excellent mechanical properties, and is applicable to bone defects caused by wounds, malformation, bone tumors, osteomyelitis and joint displacement in clinical practice to promote bone restoration and applicable as a drug sustained release system.

The present invention relates to a slow-released preparation containing beta-lactamase inhibitor and cephalosporin. Said slow-released preparation can be made into antibiotic slow-released injection or slow-released implant preparation. Said injection is formed from slow-released microsphere and solvent, the slow-released microsphere contains slow-released auxiliary material and beta-lactamase inhibitor with antibacterial effective dose and cephalosporin, the solvent is special one containing suspension adjuvant of carboxymethyl cellulose sodium, etc. and its viscosity is 100 cp-3000 cp (20 deg.C-30 deg.C). The slow-released auxiliary material is selected from EVAc, polylactic acid copolymer, sebacic acid copolymer, albumin glue and gelatin, etc. The slow-released implant preparation is prepared by using slow-released microsphere or adopting melting process. Said invention also provides its application method. and can obtain obvious therapeutic effect for curing various infective diseases.

The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are monoclonal antibody binding portions, recombinant or hybridoma cell lines, pharmaceutical compositions containing the monoclonal antibody or binding portions thereof, and methods of treating 5*. aureus infection and osteomyelitis, and methods for introducing an orthopedic implant into a patient using the monoclonal antibody, binding portion, or pharmaceutical composition of the present invention.

The present invention provides an ointment for external application for curing various burns, scalds, wound ulcera, nonunion of wound and osteomyelitis with the obvious therapeutic effect, and its preparation process includes the following steps: placing 25 Chinese medicinal materials of lonicera flower, rhubarb, coptis root, phellodendron bark, gardenia fruit, Chinese ilex leaf, dried/fresh rehmannia and others as raw material in sesame oil with 360-400 deg.C, deep-frying until scorched, removing residue, adding beesmax to obtain paste-like material, cooling to 60 deg.C, addinkg cutch powder, borneol powder and musk powder, stirring them, high-temp. steam sterilizing and botting so as to obtain the invented ointment which is low in cost, can eliminate wound infection, can promote tissue regeneration, and can make healed wound have no obvious and clear scar.

The invention relates to a pain relieving fitness paste and a production method thereof which are mainly used for providing medication for treating the pain caused by osteomyelitis, arthritis and hyperosteogeny. The pain relieving fitness paste is prepared from 90-120g of radix salviae miltiorrhizae, 90-120g of safflower, 90-120g of caulis spatholobi, 90-120g of fructus gardeniae, 45-65g of radix clematidis, 45-65g of radix angelicae pubescentis, 45-65g of pricklyash peel, 130-165g of borneol, 90-120g of camphora and 90-120g of menthol crystal. The production method comprises the following steps of: grinding the radix salviae miltiorrhizae, safflower, caulis spatholobi, fructus gardeniae, radix clematidis, radix angelicae pubescentis and pricklyash peel into coarse powder; percolating the coarse powder with ethanol; concentrating the percolate into extract; extracting the dregs with gasoline to obtain extraction oil; preparing rubber paste, rosin, zinc oxide, wool fat, yellow vaseline, liquid paraffin, gasoline or SIS, liquid paraffin, glycerol ester of rosin and 2,6-butylated hydroxytoluene into a matrix; adding the extract, extraction oil, borneol, camphora and menthol crystal; and smearing the obtained product on the base cloth, covering with an anti-sticking layer, and slicing. Through the invention, the formula is scientific and reasonable, the active ingredients are maintained to the greatest degree, and the curative effect is improved.

The present invention relates to a slow-released preparation containing beta-lactamase inhibitor. Said slow-released preparation can be made into antibiotic slow-released injection or slow-released implant preparation. Said injection is formed from slow-released microsphere and solvent, said slow-released microsphere contains slow-released auxiliary material and beta-lactamase inhibitor with antibacterial effective dose and penicillin antibiotics, the solvent is special solvent containing suspension adjuvant of carboxymethyl cellulose sodium, etc. its viscosity is 100 cp-3000 cp (20 deg.C-30deg.C); the slow-released auxiliary material is selected from EVAc, polylactic acid copolymer, sebacic acid copolymer, albumin glue and glatin, etc. The slow-released implant preparation is prepared by using slow-released microsphere or adopting melting process. Said invention also provides its application range and can obtain obvious therapeutic effect for curing various infective diseases.

The invention relates to a lignin compound that could prevent yellow staphylococcal bacteria and B type hemolytic streptococcus, and the medicine combination of the compound. The invention of lignin Morgan dandehon herb acid A and Rufescidride has obviously effect restraining yellow staphylococcal and B type hemolytic streptococcus. It is also respected to prevent the diseases caused by them, like boil, blain, toxicity epidermis necrolysis, pneumonia, etc.

The invention relates to a slow-releasing agent of antibiotics containing aminoglycoside, comprising slow-releasing micro-sphere containing slow-releasing findings and aminoglycoside antibiotics, and special dissolvent containing suspending adjuvant agent such as sodium carboxymethyl cellulose with the adhesive degree being 100cp-3000cp (at 20-30 Deg. C). The slow-releasing findings comprises EVAc, polyphenyl, PLA, PLGA, decanedioic acid copolymer, albumen glue and gelatin; the slow-releasing micro-sphere can be produced to slow-releasing implanting agent and unguent agent. When the slow-releasing implanting agent and injection is placed or injected into bacteria, the medicine can be released slowly for more than 5-30 days, and toxicity is dramatically reduced at the same time when effective medicine concentration is got and maintained. The said slow-releasing agent is specially effective for chronic medullitis, bedsore, intractable ulcer on skin, diabetes femoral head necrosis and other abscessus, which are caused by Staphylococcus, Streptococcus, Streptococcus, acne Propionibacteriaceae, Enterobacter, Enterobacter, gonotoxin or parameningococcus.

The invention discloses a process for preparing polyanlydrides, carriers for hydrophilous antiphlogistic drug and antitumor agent by using binary aliphatic acid and dimer acid copolymerization, because the use of diacid with longer carbon chain as monomer, the degradation speed of the polyanlydride material is slow, and the medicinal release cycle is longer, thus is suitable for the local slow release administration treatment for osteomyelitis and solid tumor diseases.

Disclosed is a topical applicated antibiotics slow release agent as a slow release injection or a slow release implantation agent, comprising slow release microspheres and menstruum. Said release microsphere comprises slow release assist materials and antibiotics, and said menstruum is a special menstruum comprising suspending agents of sodium carboxymethylcellulose, etc, with a viscosity of 100cp-3000cp(at 20-30 DEG C). Said slow release assist materials are selected from the group of EVAc, polifeprosan, PLA, PLGA, sebacic acid copolymer, albumen glue, gelatin, and etc. Said slow release implantation agent is prepared with slow release microspheres or by melt method, etc. The disclosed slow release agent can release drugs for 10 days by topical applicated or injected at a focus, decreasing whole body toxicity obviously while obtaining and sustaining effective topical drug concentration at the focus.

The present invention provides an organic-inorganic self-solidified composite bone graft formed by a hydration bridge formation of a multi-trace element organic compound and an inorganic compound. Themulti-trace element organic compound is prepared by using a solution method, inorganic salts with different metastable-state structures are prepared by a heat treatment, the two materials are mixed and ground to form micro-nano powder, the micro-nano powder is mixed with water-containing solidified liquid to form a bridge structure by diffusion and a hydrated crystalline water structure by self-solidification, and thus a stable bone repair material is formed. The prepared bone graft can be shaped at will and has high strength, can provide various essential elements for bone tissue repair, hasgood biological properties, has a degradation rate consistent with a bone formation cycle, and finally can be completely absorbed by tissues to substitutably form new bones and obtains any desired compressive strengths and degradation cycles according to needs to adjust raw material composition ratios, and can be used as the repair material for bone defects caused by trauma, deformity, bone tumors, osteomyelitis or joint replacement, etc. clinically.

The invention discloses a flavonoid glycoside and medical salt and application to prevent Micrococcus pyogenes and beta hemolytic streptococcus, which is characterized by the following: preventing pustule, toxic epidermal decay, acute myocarditis, cystitis, cervicitis and tumour of neutral nerve system; fitting for treating prostatitis, pneumococcus, medullitis and knuckle disease.

The invention relates to a slow-releasing agent or rslow-releasing implanting agent containing antibiotics. The injection comprises slow-releasing micro-sphere and dissolvent. The slow-releasing micro-sphere contains slow-releasing findings and antibiotics, and dissolvent contains suspending adjuvant agent such as sodium carboxymethyl cellulose with the adhesive degree being 100cp-3000cp (at 20-30 Deg. C). The slow-releasing findings comprises EVAc, polyphenyl, PLA, PLGA, decanedioic acid copolymer, albumen glue and gelatin; the slow-releasing implanting agent is prepared with slow-releasing micro-sphere or through other methods. When said antibiotics is placed or injected into bacteria, the medicine can be released slowly for more than 10 days, and toxicity is dramatically reduced at the same time when effective medicine concentration is got and maintained. The said slow-releasing agent is specially effective for chronic medullitis, bedsore, intractable ulcer on skin, diabetes femoral head necrosis and other abscessus, which are caused by Staphylococcus, Streptococcus, Streptococcus, acne Propionibacteriaceae, Enterobacter, Enterobacter, gonotoxin or parameningococcus.

The invention relates to an anti-tuberculosis Chinese medicine, a special adjuvant medicine and a preparation method thereof. Pharmaceutically-effective raw materials of the anti-tuberculosis Chinese medicine comprise blister beetle, drgon's bone, oyster, chicken gizzard-membrane, pumice and egg white of 10 eggs (yolk removed). The adjuvant medicine is water soaking liquid or water decoction of one or more selected from milkvetch root, licorice root, ginseng, radix codonopsis, milkvetch root, red jujube and wine-processed twotoothed achyranthes root. The medicine has the effects of removing blood stagnation and eliminating pathogenic accumulation, and is mainly used to treat pulmonary tuberculosis, tuberculous pleurisy, pyogenic osteomyelitis, bone tuberculosis, tuberculosis of thoracic and lumbar vertebra, lymphoid tuberculosis, tuberculous peritonitis, silicosis complicated with tuberculosis, and acute lymphadenitis.

The invention discloses a composite hydrogel for promoting osteomyelitis healing, and a preparation method of the composite hydrogel comprises the following steps: mixing a mixed solution A containingcarboxymethyl chitosan and hyaluronic acid with a mixed solution B containing antibiotics and bone morphogenetic protein sustained-release microspheres, adding a crosslinking agent, and crosslinkingto obtain the composite hydrogel. The composite hydrogel disclosed by the invention is of a uniform porous reticular structure, can effectively promote wound healing, and has good bionic performance,biocompatibility, mechanical property and degradability. Moreover, the composite hydrogel disclosed by the invention can continuously release antibacterial antibiotics for a long time and induce bonemorphogenetic protein formed by new bones, infection can be effectively controlled, bone regeneration can be effectively promoted under the condition that no extra operation is conducted, the operation frequency is reduced, the treatment period is shortened, the physical and economic burdens of a patient are relieved, and the composite hydrogel has a good application prospect in osteomyelitis treatment.

The invention relates to a traditional Chinese medicine composition for treating bone tuberculosis and osteomyelitis. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 28-32 parts of earthworm, 28-32 parts of Astragalus root, 14-16 parts of Codonopsis pilosula, 14-16 parts of Angelica sinensis, 14-16 parts of pangolin, 8-12 parts of white paeony root, 14-16 parts of bighead atractylodes rhizome, 8-12 parts of spina gleditsiae, 8-12 parts of liquorice, 14-16 parts of prepared rhizome of rehmannia, 28-32 parts of rhizoma alismatis and 8-12 parts of Poria cocos. The traditional Chinese medicine composition disclosed by the invention is an oral medicine preparation form of each conventional traditional Chinese medicine containing a medicinal auxiliary material or not, preferably a powder preparation or a capsule preparation. The traditional Chinese medicine composition disclosed by the invention has obvious curative effects on the tuberculosis and the osteomyelitis, which are caused by various reasons; and compared with the existing traditional Chinese medicine prescription, the traditional Chinese medicine composition has the advantages of quick effect, short course of treatment and no toxic side effects.

The invention discloses a traditional Chinese medicine for treating acute purulent osteomyelitis and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine comprises the following traditional Chinese medicine raw materials: kudzuvine root, dark plum, radices trichosanthis, membranous milkvetch root, gypsum rubrum, rhizoma anemarrhenae, dayflower, cape jasmine fruit, baical skullcap root, garden burnet, Stachys kouyangensis, giant knotweed, Chinese fever vine, Begonia bretschneideriana Hemsl, Pittosporum sahnianum Gowda, coptis, gentian, Thalictrum petaloideum, RhizomaParidis, Sargentodoxa cuneata, radix tinosporae, potentilla discolor, figwort, Callicarpa bodinieri Levl, Carpesium abrotanoides, panax notoginseng, Agrimonia pilosa Ledeb, turmeric and Liquidambar formosana Hance. The invention has the benefits that the traditional Chinese medicine has the effects of clearing heat-toxin, replenishing and cooling blood, and relieving pain, has a short course of treatment without recurrence after cure, can improve immunity of the human body, is convenient in manufacturing technology, low in toxic or side effects, is easy to manufacture, and is low in cost.

The invention discloses a traditional Chinese medicine for treating osteomyelitis and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine comprises the following components in parts by weight: 1-3 parts of calculus bovis, 5-7 parts of centipede, 8-10 parts of typhonium giganteum, 4-6 parts of akebia trifoliata koidz, 10-12 parts of impatiens balsamina, 7-9 parts of peony, 10-15 parts of poria, 10-12 parts of myrrh, 5-7 parts of sangusis draconis, 9-11 parts of viola inconspicua, 1-3 parts of semen cuscutae, 3-5 parts of panax notoginseng, 8-10 parts of styphnolobium japonicum, 10-12 parts of mulberry branch, 2-5 parts of herba epimedii, 6-8 parts of ligusticum wallichii, 1-3 parts of manis pentadactyla, 9-11 parts of rhizoma acori graminei, 10-20 parts of peppermint leaf, 5-7 parts of phryma leptostachya, 3-5 parts of panax quinquefolium, 7-9 parts of radix achyranthis bidentatae and 8-10 parts of hypericum japonicum. Partial hydropathic compress is carried out to the wound surface of osteomyelitis by the traditional Chinese medicine for detoxifying and tonifying qi, removing slough and promoting growth of tissue regeneration and tonifying vital energy, so that the immunity of a human body is improved, and disease resistance of the human body to external evil and poison is enhanced. The traditional Chinese medicine has advantages of good treatment effect, short course of treatment and small pain of patients.

The invention discloses a method for fixing open bone defect by negative-pressure closed irrigation and autograft. The method comprises the following steps of washing a wounded limb three times by using a sterile brush after anesthesia on a patient is successful; washing a wound surface and the periphery of the wound surface by using III-type entoiodine liquid and normal saline sequentially; sterilizing and paving a drape; performing debridement and probing; removing polluted, necrotic and deactivated tissues; striking off polluted tissues of capitula and medullary space; reserving free bone blocks; irrigating a wound again by using III-type entoiodine and normal saline; paving a drape again; resetting the free bone blocks; fixing the free bone blocks by selecting a steel plate, intramedullary nails or an external fixing rack; covering anadesma and soft tissues surrounding a bone planting area by using negative-pressure closed irrigation dressings; detaching a negative-pressure closed irrigation and perfusion device; probing the wound surface; selectively performing negative-pressure closed irrigation and skin flap transfer surgery or skin-grafting and negative-pressure closed irrigation surgery on the granulation wound surface again; and closing the wound surface. By using the method, infection, osteomyelitis, delayed union and bone ununion can be effectively prevented, the level of the clinical medical science is improved, and the therapeutic cost is reduced.