An external synthetic Chinese medicine composition for treating osteomyelitis, sinus and intractable ulcer and a preparation method thereof

Abstract

The present application relates to the technical field of external use of traditional Chinese medicine, in particular to an external use synthetic traditional Chinese medicine composition for treating osteomyelitis, sinus tract and stubborn ulcer and a preparation method thereof, which comprises, by weight, 10-15 parts of honeysuckle, 10-15 parts of dandelion, 10-12 parts of purple flower ground ivy, 6-10 parts of Chinese cork tree, 6-10 parts of bitter apricot seed, 5-8 parts of red root of sophora, 5-8 parts of Chinese angelica, and 1-4 parts of borneol; the present application is applicable to the infection period and the repair period, realizes the integration of anti-inflammatory, bacteriostasis, muscle regeneration and repair, adopts low-temperature ultrasonic extraction, avoids high-temperature damage to heat-sensitive components, has stronger and more stable efficacy, the formula contains blood-activating and stasis-removing components such as red root of sophora, Chinese angelica, frankincense and myrrh, can promote the penetration of the medicine into deep tissues, has a remarkable effect on the sinus tract and osteomyelitis wound, is a pure traditional Chinese medicine for external use, does not add hormones and antibiotics, is mild in nature, and is suitable for long-term use.

Description

Technical Field

[0001] This invention relates to the field of topical Chinese medicine preparations, specifically to a topical synthetic Chinese medicine composition for treating osteomyelitis, sinus tracts, and intractable ulcers, and its preparation method. Background Technology

[0002] Osteomyelitis, chronic sinus tracts, and refractory skin ulcers are clinically difficult-to-treat wound diseases, characterized by long course, easy recurrence, difficulty in wound healing, and easy secondary infection. Conventional Western medicine treatment mainly involves debridement, antibiotics, and surgical skin grafting, which has drawbacks such as long treatment cycle, high risk of drug resistance, large tissue damage, and easy recurrence after healing.

[0003] While traditional Chinese medicine external therapies possess advantages such as clearing heat and detoxifying, removing necrotic tissue and promoting tissue regeneration, current technologies have significant shortcomings:

[0004] Single formula combination: Most Chinese medicine formulas only focus on clearing heat and detoxifying or promoting tissue regeneration, lacking the synergistic effect of anti-inflammatory and antibacterial + blood circulation and stasis removal + tissue regeneration and repair, and have limited efficacy for deep infections, sinus tracts and intractable ulcers.

[0005] Single and fixed dosage form: Traditional products can only be prepared in a single dosage form, and cannot flexibly select powder, ointment or liquid according to the dryness or wetness of the wound, the degree of infection and the healing stage, resulting in poor clinical adaptability;

[0006] Outdated preparation process: Traditional decoction and grinding processes result in low extraction rate of effective components, many impurities, poor stability, and rapid decline in efficacy, making it difficult to meet the needs of long-term clinical use;

[0007] Insufficient permeability: Ordinary topical preparations have difficulty penetrating the skin surface and deep sinus tract tissues, and have a weak effect on deep infection lesions;

[0008] Low safety and standardization: The lack of unified extraction, purification and formulation processes leads to unstable product quality and a tendency to cause irritation, allergies and other problems.

[0009] Currently, there is a lack of a scientifically formulated, multi-dosage-formula-compatible, technologically advanced, highly permeable, safe and stable topical Chinese medicine composition that can be applied to osteomyelitis, chronic sinus tracts, refractory ulcers, and slow-healing wounds. Therefore, this paper proposes a topical synthetic Chinese medicine composition for the treatment of osteomyelitis, sinus tracts, and refractory ulcers, as well as its preparation method. Summary of the Invention

[0010] In view of this, the present invention provides a topical synthetic traditional Chinese medicine composition for treating osteomyelitis, sinus tracts and refractory ulcers and its preparation method, so as to solve or alleviate the technical problems existing in the prior art, and at least provide a beneficial option.

[0011] The technical solution of the present invention is as follows: a topical synthetic Chinese medicine composition for treating osteomyelitis, sinus tracts and intractable ulcers, comprising, by weight: 10-15 parts of honeysuckle, 10-15 parts of dandelion, 10-12 parts of violet, 6-10 parts of phellodendron bark, 6-10 parts of sophora flavescens, 5-8 parts of red peony root, 5-8 parts of angelica sinensis, and 1-4 parts of borneol.

[0012] More preferably, the composition has the effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, removing necrotic tissue and promoting tissue regeneration, and promoting wound healing. It is used for external care of osteomyelitis, chronic sinus tracts, intractable ulcers, and wounds that do not heal for a long time.

[0013] Further preferred products are topical preparations, for external use only, and strictly prohibited from oral administration. Dosage forms include powders, ointments, and liquids.

[0014] A method for preparing a topical synthetic traditional Chinese medicine composition for treating osteomyelitis, sinus tracts, and refractory ulcers includes the following steps:

[0015] (1) Raw material screening, cleaning, and low-temperature drying;

[0016] (2) Coarsely crushed and soaked;

[0017] (3) Low-temperature ultrasonic-assisted water extraction;

[0018] (4) Filtration and centrifugation purification;

[0019] (5) Concentrate under reduced pressure to form a thick extract;

[0020] (6) Prepare powder, ointment, and liquid formulations respectively;

[0021] (7) Inspection and packaging.

[0022] Further preferred methods include extraction at a temperature ≤60℃, ultrasonic-assisted extraction, and concentration of the extract into a thick paste after centrifugal purification.

[0023] A further preferred embodiment is that the aqueous preparation steps are: dissolving the thick extract, adjusting the pH value, adding borneol ethanol solution, fine filtration, sterilization, and filling.

[0024] A further preferred method is to prepare the powder as follows: vacuum drying of the thick extract, ultra-fine pulverization, mixing with borneol powder, sieving, and sterilization.

[0025] A further preferred method is to prepare the ointment by emulsifying and mixing the thick extract with a pharmaceutical matrix, cooling and adding borneol, vacuum degassing, and filling.

[0026] The embodiments of the present invention have the following advantages due to the adoption of the above technical solutions:

[0027] This invention is applicable to the infection and recovery stages, achieving integrated anti-inflammatory, antibacterial, tissue regeneration, and repair effects. It uses low-temperature ultrasonic extraction to avoid high-temperature damage to heat-sensitive components, resulting in stronger and more stable efficacy. The formula contains blood-activating and stasis-removing ingredients such as red peony root, angelica, frankincense, and myrrh, which can promote drug penetration into deep tissues and have significant effects on sinus tracts and osteomyelitis wounds. It is a pure Chinese herbal external application, without added hormones or antibiotics, and is mild in nature, suitable for long-term use.

[0028] The above overview is for illustrative purposes only and is not intended to be limiting in any way. In addition to the illustrative aspects, embodiments, and features described above, further aspects, embodiments, and features of the invention will become readily apparent from the accompanying drawings and the following detailed description. Attached Figure Description

[0029] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0030] Figure 1 This is a flowchart of the preparation process of the present invention. Detailed Implementation

[0031] In the following description, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments can be modified in various ways without departing from the spirit or scope of the invention. Therefore, the drawings and description are considered to be exemplary in nature and not restrictive.

[0032] The embodiments of the present invention will now be described in detail with reference to the accompanying drawings.

[0033] like Figure 1 As shown, this embodiment of the invention provides a topical synthetic Chinese medicine composition for treating osteomyelitis, sinus tracts, and intractable ulcers, comprising, by weight: 10-15 parts honeysuckle, 10-15 parts dandelion, 10-12 parts violet, 6-10 parts phellodendron bark, 6-10 parts sophora flavescens, 5-8 parts red peony root, 5-8 parts angelica sinensis, and 1-4 parts borneol.

[0034] In one embodiment, the composition has the effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, removing necrotic tissue and promoting tissue regeneration, and promoting wound healing. It is used for external care of osteomyelitis, chronic sinus tracts, intractable ulcers, and wounds that do not heal for a long time.

[0035] In one embodiment, the product is a topical preparation, for external use only, and is strictly prohibited from oral administration. The dosage form includes powder, ointment, and liquid.

[0036] A method for preparing a topical synthetic traditional Chinese medicine composition for treating osteomyelitis, sinus tracts, and refractory ulcers includes the following steps:

[0037] (1) Raw material screening, cleaning, and low-temperature drying;

[0038] (2) Coarsely crushed and soaked;

[0039] (3) Low-temperature ultrasonic-assisted water extraction;

[0040] (4) Filtration and centrifugation purification;

[0041] (5) Concentrate under reduced pressure to form a thick extract;

[0042] (6) Prepare powder, ointment, and liquid formulations respectively;

[0043] (7) Inspection and packaging.

[0044] In one embodiment, the extraction temperature is ≤60℃, ultrasonic-assisted extraction is used, and the extract is concentrated into a thick extract after centrifugation purification.

[0045] In one embodiment, the aqueous preparation steps are: dissolving the thick extract, adjusting the pH value, adding borneol ethanol solution, fine filtration, sterilization, and filling.

[0046] In one embodiment, the powder preparation steps are: vacuum drying of the thick extract, ultra-fine pulverization, mixing with borneol powder, sieving, and sterilization.

[0047] In one embodiment, the ointment preparation steps are as follows: emulsifying and mixing the thick extract with a pharmaceutical matrix, cooling and adding borneol, vacuum degassing, and filling.

[0048] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person skilled in the art can easily conceive of various variations or substitutions within the technical scope disclosed in the present invention, and these should all be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A topical synthetic traditional Chinese medicine composition for treating osteomyelitis, sinus tracts, and refractory ulcers, characterized in that: The ingredients, by weight, are: honeysuckle 10-15 parts, dandelion 10-15 parts, violet 10-12 parts, phellodendron bark 6-10 parts, sophora flavescens 6-10 parts, red peony root 5-8 parts, angelica sinensis 5-8 parts, and borneol 1-4 parts.

2. The topical synthetic traditional Chinese medicine composition for treating osteomyelitis, sinus tracts, and refractory ulcers according to claim 1, characterized in that: The composition has the effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, removing necrotic tissue and promoting tissue regeneration, and promoting wound healing. It is used for external care of osteomyelitis, chronic sinus tract, intractable ulcers, and wounds that do not heal for a long time.

3. The topical synthetic traditional Chinese medicine composition for treating osteomyelitis, sinus tracts, and refractory ulcers according to claim 1, characterized in that: This product is for external use only and is strictly prohibited from being taken orally. Dosage forms include powder, ointment, and liquid.

4. A method for preparing a topical synthetic traditional Chinese medicine composition for treating osteomyelitis, sinus tracts, and refractory ulcers, in conjunction with the topical synthetic traditional Chinese medicine composition for treating osteomyelitis, sinus tracts, and refractory ulcers as described in any one of claims 1-3, characterized in that: Includes the following steps: (1) Raw material screening, cleaning, and low-temperature drying; (2) Coarsely crushed and soaked; (3) Low-temperature ultrasonic-assisted water extraction; (4) Filtration and centrifugation purification; (5) Concentrate under reduced pressure to form a thick extract; (6) Prepare powder, ointment, and liquid formulations respectively; (7) Inspection and packaging.

5. The topical synthetic traditional Chinese medicine composition for treating osteomyelitis, sinus tracts, and refractory ulcers according to claim 4, and its preparation method, characterized in that: The extraction temperature is ≤60℃, and ultrasonic-assisted extraction is used. The extract is purified by centrifugation and then concentrated into a thick extract.

6. The topical synthetic traditional Chinese medicine composition for treating osteomyelitis, sinus tracts, and refractory ulcers according to claim 4, and its preparation method, characterized in that: The preparation steps for the aqueous solution are as follows: dissolving the thick extract, adjusting the pH value, adding borneol ethanol solution, fine filtration, sterilization, and filling.

7. The topical synthetic traditional Chinese medicine composition for treating osteomyelitis, sinus tracts, and refractory ulcers according to claim 4, and its preparation method, characterized in that: The powder preparation steps are as follows: vacuum drying of thick extract, ultra-fine pulverization, mixing with borneol fine powder, sieving, and sterilization.

8. The topical synthetic traditional Chinese medicine composition for treating osteomyelitis, sinus tracts, and refractory ulcers according to claim 4, and its preparation method, characterized in that: The ointment preparation steps are as follows: emulsify and mix the thick extract with the pharmaceutical matrix, add borneol after cooling, degas under vacuum, and fill.

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