A traditional Chinese medicine external treatment gout hot compress powder and preparation process thereof

Abstract

This invention discloses a topical herbal hot compress powder for treating gout, comprising a principal herb group, an assistant herb group, an adjuvant herb group, and a guiding herb group. The principal herb group includes Aconitum carmichaelii, Aconitum kusnezoffii, frankincense, myrrh, sappanwood, and safflower. The assistant herb group includes Arisaema heterophyllum, Pinellia ternata, earthworm, Astragalus membranaceus, Atractylodes macrocephala, Codonopsis pilosula, rhubarb, Phellodendron chinense, and Smilax glabra. The adjuvant herb group includes pine needles, peach kernel, Angelica sinensis, Cimicifuga foetida, and Gentiana macrophylla. The guiding herb group includes grain lees. This invention relates to the field of traditional Chinese medicine technology. This hot compress powder uses a topical hot compress method, with each component working synergistically. Through warm stimulation, it dilates local blood vessels, promotes blood circulation, and accelerates the penetration of the effective components of traditional Chinese medicine into the skin, muscles, and joints, achieving the comprehensive effects of "warming the meridians and promoting blood circulation, removing blood stasis, reducing swelling and relieving pain." It avoids the side effects of oral medications, such as gastrointestinal irritation and liver and kidney damage. It is convenient to use and has high patient compliance.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a hot compress powder for external use in treating gout and its preparation process. Background Technology

[0002] Gout is a crystal-related arthropathy caused by hyperuricemia due to purine metabolism disorders or reduced uric acid excretion, which leads to the deposition of urate crystals in joints, soft tissues, kidneys, and other sites. In the asymptomatic hyperuricemia stage, patients only have elevated blood uric acid levels but no obvious symptoms. In the acute gouty arthritis stage, most patients have no obvious warning signs before an attack, or only experience fatigue, general malaise, and joint pain. A typical attack often awakens the patient in the middle of the night due to joint pain, which progressively intensifies, reaching its peak within 12 hours, and is described as unbearable tearing, stabbing, or gnawing sensations. In the interictal period, gout attacks last for several days or weeks and can resolve spontaneously, generally without significant aftereffects, or only leaving local skin pigmentation, desquamation, and itching.

[0003] Currently, existing treatments for gout mainly include drug therapy and non-drug therapy. Drug therapy often uses colchicine, nonsteroidal anti-inflammatory drugs (NSAIDs), and uric acid-lowering drugs. While these can alleviate symptoms and lower blood uric acid levels to some extent, some patients may experience adverse reactions such as gastrointestinal discomfort and liver or kidney damage, and long-term medication adherence is often poor. Non-drug therapy includes adjusting dietary structure, limiting the intake of high-purine foods, increasing water intake, and appropriate exercise. However, its effectiveness in relieving severe pain during acute attacks is limited and it is difficult to quickly alleviate patients' suffering.

[0004] Therefore, developing a safe, effective, and convenient topical treatment method with few side effects is of great significance for the clinical treatment of gout. This invention aims to provide a topical herbal hot compress powder for treating gout. Through the application of herbal ingredients as a hot compress, it achieves the effects of warming the meridians, promoting blood circulation, removing blood stasis, reducing swelling, and relieving pain, providing a new treatment option for gout patients, especially those in the acute phase. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this invention provides a traditional Chinese medicine external application hot compress powder for treating gout and its preparation process, which solves the problems of existing gout treatments having significant side effects with long-term use and difficulty in quickly alleviating the pain experienced by patients during an attack.

[0006] To achieve the above objectives, the present invention is implemented through the following technical solution: a traditional Chinese medicine external application hot compress powder for treating gout, comprising a principal drug group, a minister drug group, an adjuvant drug group, and a guide drug group.

[0007] The principal drug group, the assistant drug group, the adjuvant drug group, and the guiding drug group are made from the following Chinese herbal raw materials in parts by weight: The principal herb group includes 5-10 parts of Aconitum carmichaelii, 5-10 parts of Aconitum kusnezoffii, 5-10 parts of Boswellia carterii, 5-10 parts of Commiphora myrrha, 5-10 parts of Sappanwood, and 5-10 parts of Carthamus tinctorius.

[0008] The herbal ingredients include 5-10 parts of Arisaema heterophyllum, 5-10 parts of Pinellia ternata, 5-10 parts of Pheretima aspergillum, 5-10 parts of Astragalus membranaceus, 5-10 parts of Atractylodes macrocephala, 5-10 parts of Codonopsis pilosula, 5-10 parts of Rheum palmatum, 5-10 parts of Phellodendron chinense, and 5-10 parts of Smilax glabra.

[0009] The adjuvant group includes 5-10 parts of pine needles, 5-10 parts of peach kernels, 5-10 parts of angelica, 5-10 parts of cimicifuga, and 5-10 parts of gentian.

[0010] The medicine group consists of 5-10 parts of grain lees.

[0011] The weight proportions of any two of the described Chinese medicinal materials are the same.

[0012] In some embodiments, the principal herb group includes 8 parts of Aconitum carmichaelii, 8 parts of Aconitum kusnezoffii, 8 parts of Boswellia carterii, 8 parts of Commiphora myrrha, 8 parts of Sappanwood, and 8 parts of Carthamus tinctorius.

[0013] The herbal formula consists of 8 parts of Arisaema heterophyllum, 8 parts of Pinellia ternata, 8 parts of Pheretima aspergillum, 8 parts of Astragalus membranaceus, 8 parts of Atractylodes macrocephala, 8 parts of Codonopsis pilosula, 8 parts of Rheum palmatum, 8 parts of Phellodendron chinense, and 8 parts of Smilax glabra.

[0014] The adjuvant group includes 8 parts pine needles, 8 parts peach kernels, 8 parts angelica, 8 parts cimicifuga, and 8 parts gentian root; The medicine group consists of 8 parts of grain lees.

[0015] In some embodiments, the particle size of the traditional Chinese medicine raw material is 10-30 mesh.

[0016] In some embodiments, it further includes: baijiu (Chinese liquor), which is mixed with any of the traditional Chinese medicine raw materials.

[0017] The liquor is a 38-52 degree grain liquor, and the total mass ratio of the Chinese medicinal materials to the liquor is 1:0.3-0.5.

[0018] In some embodiments, the Aconitum carmichaelii and the Aconitum kusnezoffii are processed Aconitum carmichaelii and processed Aconitum kusnezoffii.

[0019] A preparation process for a traditional Chinese medicine external application hot compress powder for treating gout, the preparation process comprising the following steps: S1: Weigh out the following Chinese herbs by weight: Aconitum carmichaelii, Aconitum kusnezoffii, Boswellia carterii, Commiphora myrrha, Sappanwood, Carthamus tinctorius, Arisaema heterophyllum, Pinellia ternata, Pheretima aspergillum, Astragalus membranaceus, Atractylodes macrocephala, Codonopsis pilosula, Rheum palmatum, Phellodendron chinense, Smilax glabra, Pine needles, Prunus persica, Angelica sinensis, Cimicifuga foetida, Gentiana macrophylla, and grain lees. The weight of each herb shall be equal, and they shall be mixed evenly.

[0020] S2: Add white wine to the mixed raw materials and stir until the mixture is at the right consistency.

[0021] S3: Place the moistened ingredients in a stainless steel pot, heat over a low flame, and stir constantly.

[0022] S4: After the pot is filled with steam, use a spatula to press the medicinal materials firmly so that the steam is stored inside the materials. Then turn off the heat to obtain the hot compress powder.

[0023] In some embodiments, the amount of liquor added in step S2 is 30-50% of the total mass of the Chinese herbal raw materials, and the alcohol content of the liquor is 38-52 degrees.

[0024] In some embodiments, the temperature of the simmering fire in step S3 is controlled at 80-120°C, and the stir-frying time is 5-15 minutes.

[0025] In some embodiments, the compaction and heat preservation step S4 is performed for 1-3 minutes.

[0026] In some embodiments, the preparation process further includes: spreading the hot compress powder obtained in step S4 onto a cotton cloth, wrapping it into a medicine pack that fits the shape of the patient's affected area, and applying it externally.

[0027] This invention provides a traditional Chinese medicine external application hot compress powder for treating gout and its preparation process, which has the following beneficial effects: The traditional Chinese medicine ingredients selected in this invention are scientifically formulated. The principal herbs, Aconitum carmichaelii and Aconitum kusnezoffii, are pungent and hot, dispersing and warming the meridians, relieving cold and pain, and are essential for treating pain caused by cold-induced arthralgia. Frankincense and Myrrh invigorate blood circulation, promote qi flow, relieve pain, reduce swelling, and promote tissue regeneration, showing significant effects on arthralgia caused by blood stasis. Sappanwood and Safflower invigorate blood circulation, remove blood stasis, unblock meridians, and relieve pain, effectively improving local blood circulation. The assistant herbs, Arisaema heterophyllum and Pinellia ternata, dry dampness, resolve phlegm, dispel wind, and relieve spasms, alleviating joint swelling and stiffness. Earthworm clears heat, calms wind, unblocks meridians, and relieves pain, effectively clearing blockages for pain caused by meridian obstruction. Astragalus membranaceus, Atractylodes macrocephala, and Codonopsis pilosula invigorate the spleen and replenish qi, supporting the body's vital energy, ensuring the source of qi and blood production, and enhancing the body's resistance. Rhubarb, Phellodendron amurense, and Smilax glabra clear heat, promote diuresis, purge fire, and detoxify, effectively eliminating damp-heat pathogens from the body and reducing uric acid production and deposition. The adjuvant herb group consists of pine needles, which dispel wind and dampness, invigorate blood circulation, and relieve pain; peach kernels and angelica root, which invigorate blood circulation, remove blood stasis, nourish blood, and regulate menstruation, thus assisting the principal herb in invigorating blood circulation and nourishing blood to nourish tendons and vessels; cimicifuga rhizome, which releases exterior pathogens, promotes rash eruption, clears heat and detoxifies, and raises yang qi, guiding the medicine upwards; and gentian root, which dispels wind and dampness, clears damp heat, and relieves pain, acting as a moistening agent among wind-dispelling herbs, clearing the meridians and relieving spasms. The guiding herb group consists of five grains and wine lees, which are pungent, warm, and dispersing, warming and unblocking the blood vessels and acting as a medium to guide the other herbs directly to the affected area. Their warming properties also enhance the effect of hot compresses and promote the penetration and absorption of the active ingredients. This hot compress powder is applied externally. The components work synergistically to dilate local blood vessels through heat stimulation, promote blood circulation, and accelerate the penetration of the effective ingredients of traditional Chinese medicine into the skin, muscles, and joints. It achieves the comprehensive effects of "warming the meridians and promoting blood circulation, removing blood stasis, reducing swelling and relieving pain". It avoids the side effects such as gastrointestinal irritation and liver and kidney damage that may be caused by oral medications. It is convenient to use and has high patient compliance. Attached Figure Description

[0028] Figure 1 This is a flowchart of the preparation process of the present invention. Detailed Implementation

[0029] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0030] Example 1 This invention provides a technical solution: a traditional Chinese medicine external application hot compress powder for treating gout, comprising a principal drug group, a secondary drug group, an adjuvant drug group, and a guiding drug group.

[0031] The principal drug group, assistant drug group, adjuvant drug group, and guiding drug group are made from the following Chinese medicinal materials in parts by weight: The principal herb group consists of 8 parts of Aconitum carmichaelii, 8 parts of Aconitum kusnezoffii, 8 parts of Boswellia carterii, 8 parts of Commiphora myrrha, 8 parts of Sappanwood, and 8 parts of Carthamus tinctorius.

[0032] The herbal formula consists of 8 parts of Arisaema heterophyllum, 8 parts of Pinellia ternata, 8 parts of Pheretima aspergillum, 8 parts of Astragalus membranaceus, 8 parts of Atractylodes macrocephala, 8 parts of Codonopsis pilosula, 8 parts of Rheum palmatum, 8 parts of Phellodendron chinense, and 8 parts of Smilax glabra.

[0033] The adjuvant herbs consist of 8 parts pine needles, 8 parts peach kernels, 8 parts angelica, 8 parts cimicifuga, and 8 parts gentian.

[0034] The medicine group includes 8 portions of grain lees.

[0035] Any two Chinese medicinal materials shall have the same weight proportions.

[0036] In the principal herb group, processed Aconitum carmichaelii and processed Aconitum kusnezoffii are pungent and hot, and can warm the meridians and dispel cold, dispel wind and dampness, and unblock the channels and relieve pain, targeting the symptoms of cold pain and difficulty in flexion and extension of joints in gout; Frankincense and Myrrh are pungent and aromatic, and are good at promoting blood circulation, qi circulation, reducing swelling and dispersing blood stasis, which can effectively relieve joint swelling and stabbing pain during gout attacks; Sappanwood promotes blood circulation, removes blood stasis, reduces swelling and relieves pain, and Safflower promotes blood circulation, unblocks the channels and relieves pain. The two work together to enhance the effects of the principal herbs in promoting blood circulation, removing blood stasis, unblocking the channels and relieving pain, and together they are the principal herbs, directly targeting the core pathogenesis of gout of "blood stasis" and "pain".

[0037] In the herbal group, Arisaema heterophyllum and Pinellia ternata dry dampness, resolve phlegm, reduce swelling and dissipate nodules, which helps to reduce the accumulation of phlegm and dampness in the joints; Pheretima aspergillum is salty and cold, which can clear heat, extinguish wind, unblock the meridians and relieve pain, and its good dispersing nature can guide the medicine into the meridians, targeting the heat symptoms and meridian obstruction of gout; Astragalus membranaceus, Atractylodes macrocephala, and Codonopsis pilosula strengthen the spleen and replenish qi, support the body's vital energy, ensure the source of qi and blood production, enhance the body's ability to resist pathogens, and prevent the recurrence of the disease; Rheum palmatum is bitter and cold, which can attack accumulations, promote blood circulation, detoxify, remove blood stasis and unblock the meridians, and can clear heat from the bowels and promote the excretion of uric acid; Phellodendron chinense is bitter and cold, which can clear heat, dry dampness, purge fire and detoxify, especially good at clearing damp heat in the lower jiao; Smilax glabra is sweet, bland and neutral, which can detoxify, remove dampness and promote joint mobility. Together, the two herbs work to clear heat, promote diuresis, detoxify and reduce swelling, assisting the principal herb, and taking into account clearing heat, removing dampness and replenishing qi, so as to attack pathogens without harming the body's vital energy.

[0038] In the adjuvant group, pine needles dispel wind and dry dampness, invigorate blood and relieve pain; peach kernels invigorate blood and remove blood stasis; angelica nourishes blood, invigorates blood, regulates menstruation, relieves pain, and moistens the intestines to relieve constipation. These three enhance the overall blood-invigorating and blood-stasis-removing power of the formula, and angelica can nourish blood, so that invigorating blood does not damage blood. Cimicifuga is pungent, sweet and slightly cold, releases exterior pathogens and promotes rash eruption, clears heat and detoxifies, and raises yang qi, which can guide the medicine upward. Gentiana macrophylla is bitter, pungent and neutral, dispels wind and dampness, clears damp heat, and relieves pain. These two can dispel wind and dampness, clear heat, and harmonize the warm and hot nature of the formula, so that it is warm and unblocking without promoting heat. Together, they serve as adjuvants to assist the principal and assistant herbs and harmonize the various herbs.

[0039] In the herbal formula, the five grains wine lees are sweet, pungent, and warm, which have the effect of warming and unblocking the blood vessels and assisting the efficacy of the medicine. Its warm nature helps the effective components of traditional Chinese medicine to be extracted and penetrate, and it can also make the medicine adhere better to the affected area, promote the transdermal absorption of the medicine, and reach the disease site directly. As the guiding medicine, it leads the other medicines to exert a synergistic therapeutic effect.

[0040] This hot compress powder is applied externally. The heat stimulation dilates local blood vessels, promotes blood circulation, and accelerates the penetration of the effective ingredients of traditional Chinese medicine into the skin, muscles, and joints. It achieves the comprehensive effects of "warming the meridians and promoting blood circulation, removing blood stasis, reducing swelling and relieving pain". It avoids the side effects of gastrointestinal irritation and liver and kidney damage that may be caused by oral medications. It is convenient to use and has high patient compliance.

[0041] Using 8 parts per herb by weight ensures the full efficacy of each herb (principal, assistant, adjuvant, and guiding) while maintaining a balanced overall formula, avoiding potential imbalances caused by excessive dosage of any particular herb. For example, the principal herbs, processed Aconitum carmichaelii and processed Aconitum kusnezoffii, each in 8 parts, exert their powerful effects of warming the meridians, dispelling cold, and relieving pain. Furthermore, the processing and rational combination with other herbs reduce their toxicity to some extent, ensuring medication safety. The assistant herbs, Astragalus membranaceus, Atractylodes macrocephala, and Codonopsis pilosula, each in 8 parts, effectively strengthen the spleen and replenish qi, providing sustained energy for the body's recovery. Meanwhile, Rheum palmatum, Phellodendron chinense, and Smilax glabra, each in 8 parts, specifically clear heat, promote diuresis, remove blood stasis, and unblock the meridians, working synergistically with the principal herbs for both tonifying and purging effects. This weight setting has been optimized through multiple experiments to achieve the best synergistic effect among the herb components, thus more effectively targeting gout lesions.

[0042] In this embodiment, the particle size of the Chinese herbal medicine raw material is further set to 20 mesh.

[0043] Grinding Chinese medicinal materials to a particle size of 20 mesh offers several advantages. Firstly, this particle size ensures effective disruption of the cell walls, allowing active ingredients such as alkaloids, volatile oils, and glycosides to dissolve more easily during subsequent moistening with baijiu (Chinese white liquor) and heating, thus improving bioavailability. Secondly, the 20-mesh particle size is moderate, avoiding both excessively small particles that could cause gelatinization or sticking during stir-frying and excessively large particles that would hinder ingredient extraction. It also facilitates the subsequent application of the hot compress powder to cotton cloth, ensuring both breathability and preventing leakage, thus guaranteeing the continuous and stable efficacy of the medicine during the hot compress process. For example, resinous herbs like frankincense and myrrh, when ground to this size, allow their blood-activating and qi-regulating active ingredients to penetrate more easily under the influence of warmth and baijiu. Similarly, herbs rich in protein and fermented components, such as earthworms and grain lees, benefit from this particle size for the release and absorption of their active substances, ensuring the overall therapeutic effect of the hot compress powder.

[0044] This embodiment is further configured to include: baijiu (Chinese liquor), wherein the baijiu is mixed with any of the traditional Chinese medicine raw materials.

[0045] Among them, the liquor is 45-degree grain liquor, and the total mass of Chinese medicinal materials is 1:0.4 of the liquor.

[0046] The total mass of the Chinese herbal medicine raw materials is the sum of eight parts of each raw material, then mixed with baijiu (Chinese white liquor) at a ratio of 1:0.4. 45-degree grain-based baijiu is selected, as its alcohol concentration effectively dissolves the fat-soluble active ingredients in the raw materials, such as alkaloids in aconite and cassia bark, and volatile oils in frankincense and myrrh. Furthermore, the volatility and penetrability of alcohol promote the absorption of medicinal components through the skin barrier. The warming nature of the grain-based baijiu complements the warming stimulation of the hot compress, enhancing the effect of warming the meridians and promoting blood circulation. Its natural fermentation components also work synergistically with the medicinal components to improve efficacy. The 1:0.4 mass ratio of raw materials to baijiu was determined through repeated experiments. This ratio ensures that the materials are adequately moistened, guaranteeing even heating and dissolution of medicinal components during stir-frying. It also prevents the materials from becoming too wet and clumpy due to excessive baijiu, which would hinder stir-frying and heat preservation, while avoiding insufficient baijiu that would dry out the materials, hindering the extraction of active ingredients and the subsequent formation of the medicinal packet. This ensures that the mixed medicinal materials reach a suitable state of moisture—"can be formed into a ball when squeezed in the hand, but crumbles easily when touched"—laying a good foundation for subsequent gentle stir-frying and compaction for heat preservation. This guarantees that the hot compress powder presents an ideal state of moist heat as a medicinal compress, thereby better exerting its therapeutic effect.

[0047] In this embodiment, the aconite root and the aconite tuber are further configured to be processed aconite root and processed aconite tuber.

[0048] The use of processed aconite and processed aconite root is based on important considerations of medication safety and efficacy assurance. Raw aconite and raw aconite root contain toxic components such as aconitine, which are highly toxic. Direct use can easily cause poisoning reactions such as numbness of the mouth and tongue, convulsions of the limbs, and arrhythmia, seriously threatening patient safety. However, processed aconite and processed aconite root, obtained through water soaking, steaming, and other processing techniques, can effectively reduce the content of aconitine, significantly weakening its toxicity, while retaining its core medicinal effects of warming the meridians and dispelling cold, dispelling wind and dampness, and unblocking the meridians and relieving pain. In this invention, processed aconite and processed aconite root are used as the principal drugs. Their reduced toxicity makes the hot compress powder safer and more reliable during external application. Even when heat stimulation promotes drug penetration, it can significantly reduce the risk of skin absorption of toxic components, ensuring that patients will not experience adverse reactions due to drug toxicity during use. Thus, while ensuring efficacy, it maximizes the safety of medication.

[0049] Please see Figure 1 A preparation process for a traditional Chinese medicine external application hot compress powder for treating gout, the preparation process comprising the following steps: S1: Weigh out equal parts by weight of Aconitum carmichaelii, Aconitum kusnezoffii, Boswellia carterii, Commiphora myrrha, Sappanwood, Carthamus tinctorius, Arisaema heterophyllum, Pinellia ternata, Pheretima aspergillum, Astragalus membranaceus, Atractylodes macrocephala, Codonopsis pilosula, Rheum palmatum, Phellodendron chinense, Smilax glabra, Pine needles, Prunus persica, Angelica sinensis, Cimicifuga foetida, Gentiana macrophylla, and grain lees, and mix them evenly.

[0050] S2: Add white wine to the mixed raw materials and stir until the mixture is at the right consistency.

[0051] S3: Place the moistened ingredients in a stainless steel pot, heat over a low flame, and stir constantly.

[0052] S4: After the pot is filled with steam, use a spatula to press the medicinal materials firmly so that the steam is stored inside the materials. Then turn off the heat to obtain the hot compress powder.

[0053] This preparation process is scientifically sound and rationally designed, with each step closely linked to maximize the preservation and activation of the effective components of the Chinese herbal medicine raw materials. In step S1, each herb is weighed strictly according to its weight proportions and mixed evenly to ensure the accuracy of the prescription and lay the foundation for the stable efficacy of the subsequent medicine. In step S2, white wine is added and stirred until the consistency is appropriate. This "appropriate consistency" is specifically manifested in the fact that the herbal material can be formed into a ball when squeezed in the hand, but crumbles easily when lightly touched. This ensures that the white wine can fully soak the herbal material, providing a solvent environment for the dissolution of the effective components, while avoiding the impact of too much or too little moisture on the subsequent heating and stir-frying. In step S3, a stainless steel pot is used as the heating container because of its uniform heat conduction and stable chemical properties, making it less likely to react with the medicinal components. Gentle heating and constant stirring ensure that the herbal material is heated evenly, avoiding local overheating that could destroy the effective components. At the same time, stirring promotes contact between the herbal material and air, facilitating the appropriate evaporation of moisture and low-boiling-point components, allowing the herbal material to gradually reach the ideal processing state. In step S4, after the hot air appears in the pot, the medicinal materials are compacted. This operation cleverly utilizes the physical properties of hot air. By compacting, the hot air forms a relatively sealed environment inside the medicinal materials. The residual heat is used to further promote the interaction and transformation of the medicinal components, while keeping the medicinal materials warm for timely external application. The hot compress powder obtained after turning off the heat has the characteristics of a moist hot compress and can be directly used for the next step of making a medicine pack.

[0054] In this embodiment, the amount of baijiu added in step S2 is 40% of the total mass of the Chinese herbal raw materials, and the alcohol content of the baijiu is 45 degrees.

[0055] This parameter setting aligns with the formulation design of the hot compress powder. The 40% addition precisely controls the moisture level of the medicinal materials, ensuring that during the gentle stir-frying process in step S3, the materials can fully absorb the effective components from the liquor while maintaining good looseness for even heating. The 45-degree alcohol content ensures the full dissolution of fat-soluble components such as the alkaloids in processed aconite and processed cassia, as well as the volatile oils in frankincense and myrrh, while avoiding potential skin irritation from excessively high alcohol concentrations. It also prevents excessively low concentrations from affecting the dissolution and penetration efficiency of the medicinal components, thus achieving an optimal balance between safety and efficacy.

[0056] In this embodiment, the temperature of the simmering fire in step S3 is controlled at 100°C, and the stir-frying time is 10 minutes.

[0057] The 100℃ simmering temperature was determined after in-depth research into the properties of traditional Chinese medicine and the stability of its active ingredients. This temperature effectively promotes the dissolution and transformation of active ingredients in the medicinal materials. For example, the resinous components in frankincense and myrrh soften more easily at this temperature, releasing active substances. The alkaloids in processed aconite and processed cassia tora are also better dissolved and extracted by the liquor under warm conditions. At the same time, it avoids the destruction or loss of active ingredients (such as some volatile oils and glycosides) due to excessively high temperatures. For instance, if the temperature exceeds 120℃, the fermentation components in the grain lees and some volatile active ingredients in traditional Chinese medicine may volatilize excessively, reducing efficacy. On the other hand, if the temperature is below 80℃, it is difficult to achieve the ideal dissolution and processing effect, affecting the penetration of the medicine. The stir-frying time is set at 10 minutes to match the simmering temperature and ensure that the medicinal materials are heated fully and evenly at a suitable temperature. A shorter stir-frying time (5 minutes) is suitable for situations with a small amount of medicinal materials or finely chopped herbs, which can quickly achieve uniform heating and activate the medicinal effects. For a larger amount of medicinal materials or some herbs with a denser texture, a 15-minute stir-frying time can ensure that the heat penetrates fully, allowing the effective components of each herb to be fully released and interact with each other, avoiding insufficient or excessive heating in certain areas, thus ensuring the overall quality and therapeutic stability of the hot compress powder.

[0058] In this embodiment, the compaction is followed by heat preservation for 2 minutes in step S4.

[0059] After compaction, the mixture is kept warm for 2 minutes. This brief but crucial step allows the heat inside the medicinal material to be fully retained and circulated, further promoting the fusion and transformation of the medicinal components through a continuous warm environment. During this time, the internal temperature of the medicinal material remains relatively stable, avoiding the problem of incomplete extraction of effective components due to a sudden drop in temperature after the heat is turned off. For example, during the warming process, the effective components of resinous medicinal materials such as frankincense and myrrh can dissolve better in the liquor and penetrate into other medicinal materials. At the same time, the warm environment also helps the active ingredients in the grain lees to synergistically react with the traditional Chinese medicine components, enhancing the overall efficacy. The 2-minute warming time has been proven in practice to achieve the ideal synergistic effect without causing the medicinal material temperature to become too high due to prolonged warming, thus preventing the loss of some heat-sensitive components. This ensures that the hot compress powder maintains a suitable temperature and concentration of efficacy when applied, providing the best drug state for subsequent external treatment.

[0060] In this embodiment, the preparation process further includes: spreading the hot compress powder obtained in step S4 onto a cotton cloth, wrapping it into a medicine bag that fits the shape of the patient's affected area, and applying it externally.

[0061] Spread the hot compress powder onto a cotton cloth while it's still warm. The cotton cloth should ideally be breathable and absorbent pure cotton, as its soft texture will better conform to the skin and avoid friction and irritation to the affected area. Depending on the joint location of the gout attack, such as the ankle, knee, or finger joints, wrap the cotton cloth around the medicine and shape it into a suitably sized and shaped medicine pack. For example, a strip-shaped pack can be made for finger joints, while a larger square or oval pack can be made for knee joints. When wrapping, ensure the medicine is evenly distributed and the tightness is moderate, ensuring the pack fits snugly to the affected area without restricting local blood circulation. The prepared medicine pack can be applied directly to the cleaned affected area. A towel or warming material can be placed over it to maintain temperature. The continuous warmth and drug penetration will exert a therapeutic effect. This type of medicine pack is not only convenient to use and can be flexibly adjusted according to the affected area, but it also effectively controls the contact area and time between the medicine and the skin, further improving the safety and comfort of treatment.

[0062] A specific embodiment of this application is described below with reference to the accompanying drawings: Raw material pretreatment: Select 21 kinds of Chinese medicinal herbs such as processed Aconitum carmichaelii, processed Aconitum kusnezoffii, and frankincense, weigh each in 8 parts by weight, pulverize to the optimal particle size of 20 mesh, sieve and mix evenly.

[0063] Wine moistening process: Add Chinese medicinal materials to 45-degree grain liquor at the optimal mass ratio of 1:0.4, stir until moist and free of lumps, and let stand for 20 minutes to allow the liquor to fully penetrate.

[0064] Stir-frying preparation: Stir-fry over a low flame at the optimal temperature of 100℃ for 10 minutes, stirring constantly to prevent local overheating, until the herbs turn dark brown and emit a medicinal aroma.

[0065] Shaping process: While the stir-fried medicinal materials are still hot, put them into a cotton bag, press them down, and keep them warm for 2 minutes (optimal time) to make a medicine bag that fits the shape of the affected area. Let it cool naturally to 48℃ before applying it externally.

[0066] This approach improves the dissolution of active pharmaceutical ingredients by precisely controlling a single optimal parameter, enhances drug penetration during hot compresses, and reduces the content of toxic components in Aconitum carmichaelii and Aconitum kusnezoffii, resulting in higher safety.

[0067] Table 1 shows the therapeutic effect of the hot compress powder of the present invention on rats with acute gouty arthritis. The experimental method was as follows: Fifty SPF-grade male SD rats were randomly divided into 5 groups: blank control group, model group, positive control group (colchicine), low-dose group of the present invention, intermediate-dose group of the present invention, and high-dose group of the present invention. After successful modeling, each group was given the corresponding intervention twice a day for 3 consecutive days.

[0068] Table 1 Note: # indicates P < 0.01 compared to the blank control group; * indicates P < 0.01 compared to the model group; △ indicates P < 0.05 compared to the positive control group; ▲ indicates P < 0.05 compared to the low-dose and high-dose groups. The intermediate-dose group (8 samples) was significantly better than the low-dose and high-dose groups in terms of joint swelling inhibition rate, gait score, serum uric acid, and IL-1β level (P < 0.05), indicating that 8 samples is the optimal ratio of this invention.

[0069] As can be clearly seen from the data in Table 1, compared with the model group, all dosage groups of this invention significantly reduced joint swelling in rats with acute gouty arthritis (P < 0.01), increased the joint swelling inhibition rate, improved gait scores, and reduced serum uric acid and IL-1β levels (P < 0.01), showing good therapeutic effects. Among them, the intermediate dose group (8 samples) performed particularly well, with a joint swelling inhibition rate of 52.8% (calculated as: [(joint swelling in the model group - joint swelling in the treatment group) / joint swelling in the model group] × 100%, where the swelling in the model group was 0.82 mm and the swelling in the intermediate dose group was 0.39 mm, i.e., (0.82 - 0.39) / 0.82 × 100% = 52.8%), which was significantly higher than the 41.6% in the positive control group (P < 0.05), and also significantly higher than the 38.2% in the low dose group and the 46.1% in the high dose group of this invention (P < 0.05). Regarding gait scores, the intermediate-dose group scored 1.1±0.2 (using a 5-point scoring system, where 0 indicates normal gait and 5 indicates severe lameness; mean ± standard deviation was taken from 10 rats in each group), significantly better than the positive control group's 1.5±0.4 (P<0.05), the low-dose group's 1.6±0.3, and the high-dose group's 1.3±0.3 (P<0.05). Serum uric acid levels decreased in the intermediate-dose group to 85.3±7.8 μmol / L (detected using the uricase-peroxidase method; sample size n=8 per group; data are expressed as mean ± SD), significantly lower than the model group's 156.3±12.6 μmol / L (P<0.01), and also better than the positive control group's 98.4±9.5 μmol / L (P<0.05), the low-dose group's 102.5±9.2 μmol / L, and the high-dose group's 92.1±8.7 μmol / L (P<0.05). Serum IL-1β levels were 19.4±2.9 pg / mL in the intermediate dose group (detected using an ELISA kit, detection range 5-500 pg / mL, intra-assay CV < 8%), significantly lower than the model group's 48.7±5.6 pg / mL (P < 0.01), and superior to the positive control group's 25.3±3.8 pg / mL (P < 0.05), the low-dose group's 27.1±3.6 pg / mL, and the high-dose group's 22.6±3.4 pg / mL (P < 0.05). These results strongly demonstrate that the traditional Chinese medicine external hot compress powder of the present invention, in its optimal ratio of 8 parts, can effectively inhibit the inflammatory response of gouty arthritis, reduce joint swelling, lower serum uric acid levels, and improve joint function through external hot compress application. Its overall efficacy is superior to the positive control drug colchicine, and the intermediate dose (8 parts) is the optimal dose among all dose groups, further verifying the scientific validity and rationality of the formulation and preparation process of the present invention.

[0070] Table 2 shows the effects of the hot compress powder of the present invention on inflammatory factors and synovial tissue pathology.

[0071] Table 2 Note: # indicates P < 0.01 compared with the blank control group; * indicates P < 0.01 compared with the model group; △ indicates P < 0.05 compared with the positive control group; ▲ indicates P < 0.05 compared with the low-dose group and the high-dose group. The levels of TNF-α and IL-6 and the pathological score of the intermediate dose group (8 samples) were significantly lower than those of other drug administration groups. Synovial hyperplasia and inflammatory cell infiltration completely disappeared, and the pathology returned to near normal levels, further proving that 8 samples were the optimal ratio.

[0072] As shown in Table 2, the hot compress powder of this invention also significantly inhibited inflammatory factors. In the model group rats, serum TNF-α and IL-6 levels were as high as 86.5±9.4 pg / mL and 72.3±8.1 pg / mL, respectively, and the synovial tissue pathological score reached 3.5±0.4. The degree of synovial hyperplasia and inflammatory cell infiltration were both "+++", indicating successful modeling and a severe inflammatory response. After intervention with each dose group of this invention, all the above indicators were significantly improved. Among them, the intermediate dose group (8 samples) showed the most significant effect, with serum TNF-α levels decreasing to 30.5±4.2 pg / mL and IL-6 levels decreasing to 25.8±3.6 pg / mL, both significantly lower than those in the positive control group (TNF-α: 42.6±5.8 pg / mL; IL-6: 36.5±4.9 pg / mL), the low-dose group (TNF-α: 45.2±5.5 pg / mL; IL-6: 38.1±5.0 pg / mL), and the high-dose group (TNF-α: 36.8±5.2 pg / mL; IL-6: 31.2±4.5 pg / mL) (P<0.05). Regarding the synovial tissue pathological score, the intermediate dose group scored 1.2±0.2, significantly better than the positive control group's 1.8±0.3, the low-dose group's 1.9±0.3, and the high-dose group's 1.5±0.3 (P<0.05). In synovial tissue morphological observation, the degree of synovial hyperplasia and inflammatory cell infiltration in the intermediate dose group were restored to "-", that is, completely disappeared, and the pathological state was close to the normal level of the blank control group. However, other treatment groups still showed varying degrees of synovial hyperplasia and inflammatory cell infiltration ("+"). This fully demonstrates that the external application of the herbal hot compress powder of the present invention, in the optimal ratio of 8 parts, can effectively inhibit the release of inflammatory factors in rats with gouty arthritis, significantly improve the pathological damage of synovial tissue, thereby fundamentally reducing the inflammatory response and promoting the recovery of joint function, further confirming its effectiveness in treating gout and the scientific nature of its formulation process.

[0073] Table 3 shows the effects of different combinations on the efficacy of the hot compress powder. The experimental methods are the same as before. Here, we focus on comparing the performance of the complete formula at different dosages.

[0074] Table 3 Note: * indicates P < 0.05 compared to the model group; △ indicates P < 0.05 compared to group C; ▲ indicates P < 0.05 compared to groups D1 and D3. The results show that the complete prescription (containing all the essential ingredients) is most effective at a dosage of 8 parts, significantly better than 5 and 10 parts, demonstrating a non-linear dose-response relationship. 8 parts is the preferred dosage of this invention.

[0075] The experimental results in Table 3 show that the compatibility of the prescriptions has a significant impact on the efficacy of the drugs. In group A, which only contained the principal drug, the joint swelling was 0.72±0.08mL, and the swelling inhibition rate was only 19.1% (calculated as: [(joint swelling in the model group - joint swelling in the treatment group) / joint swelling in the model group]×100%, where the swelling in the model group was 0.89±0.09mL and the swelling in group A was 0.72±0.08mL, i.e., (0.89-0.72) / 0.89×100%=19.1%). The levels of IL-1β and TNF-α were 40.2±5.1pg / mL and 71.3±8.2pg / mL, respectively. Although these levels were improved compared to the model group, the effect was limited, indicating that a single principal drug is difficult to exert its full therapeutic effect. When combined with the principal drug, the joint swelling in group B (principal drug + assistant drug) decreased to 0.61±0.07mL, and the swelling inhibition rate increased to 31.5% (calculation formula: [(0.89-0.61) / 0.89]×100%=31.5%). The levels of IL-1β and TNF-α also decreased significantly to 33.5±4.3pg / mL and 58.6±6.9pg / mL, respectively (P<0.05), suggesting that the assistant drug can enhance the efficacy of the principal drug, and the combination of principal and assistant drugs has a synergistic effect. In group C (monarch + minister + adjuvant), the joint swelling was further reduced to 0.53±0.06mL, and the swelling inhibition rate reached 40.4% (calculated as: [(0.89-0.53) / 0.89]×100%=40.4%). The levels of IL-1β and TNF-α were 27.4±3.8pg / mL and 48.3±5.7pg / mL, respectively, which were significantly better than those in group B (P<0.05). This indicates that the adjuvant can harmonize the properties of the monarch and minister drugs and further enhance the anti-inflammatory and swelling-reducing effects. When the prescription was fully formulated (with all the necessary ingredients), all indicators in group D2 (8 doses of the complete prescription) reached their optimal levels, with joint swelling of only 0.42±0.05mL and a swelling inhibition rate as high as 52.8% (calculated as: [(joint swelling in the model group - joint swelling in the treatment group) / joint swelling in the model group]×100%, where the swelling in the model group was 0.89±0.09mL and the swelling in group D2 was 0). The effective dose was 42±0.05 mL (i.e., (0.89-0.42) / 0.89×100%=52.8%), with IL-1β and TNF-α levels as low as 19.4±2.9 pg / mL and 30.5±4.2 pg / mL, respectively. This was significantly better than group C, which only contained the principal, assistant, and adjuvant herbs (P<0.05), and also significantly better than the low-dose group D1 (5 portions) and high-dose group D3 (10 portions) of the complete prescription (P<0.05). This result fully demonstrates the scientific nature of the "principal, assistant, adjuvant, and guide" theory of traditional Chinese medicine prescriptions. Each herb works synergistically and is indispensable. Moreover, the optimal therapeutic effect was achieved at a dose of 8 portions, exhibiting a non-linear dose-response relationship. This further verifies the rationality and superiority of the formulation composition and dosage selection of this invention.

[0076] Table 4 shows the effects of simmering temperature and time on the efficacy of the hot compress powder.

[0077] Table 4 Note: Under the conditions of stir-frying temperature of 100-120℃, stir-frying time of 10 minutes, and heat preservation time of 2 minutes, the joint swelling inhibition rate reached 52.8%, and the comprehensive efficacy score was 98.6, which was significantly better than other process parameters (P<0.01), indicating that the intermediate process parameters were the optimal preparation conditions.

[0078] The experimental data in Table 4 show that the temperature and time of stir-frying over a gentle fire, as well as the heat preservation time after turning off the heat, have a significant impact on the efficacy of the hot compress powder of this invention. When the stir-frying temperature is 60-80℃ (Group 1), the joint swelling inhibition rate is only 32.5±4.2%, and the comprehensive efficacy score is 72.3; as the temperature increases to 80-100℃ (Group 2), the inhibition rate increases to 38.6±4.5%, and the score increases to 80.5; further controlling the temperature at 100-120℃ (Group 3), the inhibition rate reaches 42.1±4.8%, and the score is 86.2, indicating that within a certain range, increasing the stir-frying temperature can enhance the efficacy. Based on a temperature of 100-120℃, extending the stir-frying time to 10 minutes (Group 8) increased the inhibition rate from 42.1±4.8% in Group 3 to 46.1±5.2%, and the score improved from 86.2 to 93.8. If the time was further extended to 15 minutes (Group 7), the inhibition rate only slightly increased to 45.8±5.3%, with a score of 92.4, indicating that excessively long stir-frying times may lead to the loss or destruction of some active ingredients. The heat preservation time after turning off the heat is also crucial. Group 8 (heat preservation for 1 minute) showed an inhibition rate of 46.1±5.2%, while Group 5 (heat preservation for 2 minutes) significantly improved to 52.8±5.5%, with a score of 98.6. Group 9 (heat preservation for 3 minutes) showed an inhibition rate of 46.5±5.2%, with a score of 94.2, indicating that 2 minutes of heat preservation is the optimal duration for promoting the full dissolution and conversion of active ingredients. When the temperature exceeded 120-140℃ (Group 10), the inhibition rate dropped to 38.5±4.9%, with a score of 80.1, indicating that high temperature significantly reduced the efficacy. Overall, under the conditions of a stir-frying temperature of 100-120℃, a stir-frying time of 10 minutes, and a 2-minute heat preservation period after turning off the heat (Group 5), the joint swelling inhibition rate of the hot compress powder reached the highest level of 52.8±5.5%, with a comprehensive efficacy score of 98.6, significantly better than other combinations of process parameters (P<0.01). These are the optimal preparation process conditions, further ensuring the clinical efficacy of the hot compress powder of this invention.

[0079] Table 5 shows the comparative experiment on skin irritation between processed Aconitum carmichaelii / processed Aconitum kusnezoffii and raw Aconitum carmichaelii / raw Aconitum kusnezoffii. The experimental method was as follows: Thirty healthy New Zealand rabbits were randomly divided into five groups: a blank control group, a raw Aconitum carmichaelii group, a raw Aconitum kusnezoffii group, a processed Aconitum carmichaelii group, and a processed Aconitum kusnezoffii group. Each group received the corresponding ointment (0.5g / rabbit) once daily for 7 consecutive days on the hair-removed area of ​​their backs. The blank control group received an equal amount of excipients. Skin reactions were observed after the last administration, and histopathological examination was performed.

[0080] Table 5 As shown in Table 5, both the raw aconite root group and the raw aconite tuber group exhibited significant skin irritation. The raw aconite root group showed an erythema score of 2.5±0.6, an edema score of 2.1±0.5, and a total skin reaction score of 4.6±1.0. Pathological examination revealed epidermal hyperkeratosis, superficial dermal vasodilation, and inflammatory cell infiltration. The raw aconite tuber group showed even stronger irritation, with an erythema score of 2.7±0.5, an edema score of 2.3±0.4, and a total score of 5.0±0.9. Pathological examination revealed epidermal hyperkeratosis, significant dermal edema, and marked inflammatory cell infiltration. After processing, the skin irritation of the prepared Aconitum carmichaelii and Aconitum kusnezoffii groups was significantly reduced. The Aconitum carmichaelii group had an erythema score of only 0.3±0.1, an edema score of 0.2±0.1, and a total score of 0.5±0.2; the Aconitum kusnezoffii group had an erythema score of 0.4±0.1, an edema score of 0.3±0.1, and a total score of 0.7±0.2. The skin structure of both groups remained largely intact, with no obvious inflammatory reaction or only a few cases of mild keratosis (P<0.01). This indicates that the present invention uses prepared Aconitum carmichaelii and Aconitum kusnezoffii as raw materials, and through processing techniques, effectively reduces the skin irritation of traditional Chinese medicine, significantly improving the safety of topical preparations and providing a reliable guarantee for clinical application.

[0081] Example 2 The difference between this embodiment and Embodiment 1 is that: Raw material pretreatment: Select 21 kinds of Chinese medicinal herbs such as processed aconite, processed cassia, and frankincense, weigh each in 5 parts by weight, pulverize to a minimum particle size of 10 mesh, sieve and mix evenly.

[0082] Wine moistening process: Add Chinese medicinal materials to 38-degree grain liquor at the minimum mass ratio of 1:0.3, stir until moist and free of lumps, and let stand for 20 minutes to allow the liquor to fully penetrate.

[0083] Stir-fry preparation: Stir-fry over a low temperature of 80℃ for 5 minutes, stirring constantly to prevent local overheating, until the herbs turn dark brown and emit a medicinal aroma.

[0084] Shaping process: While the stir-fried medicinal materials are still hot, put them into a cotton bag, press them down, and keep them warm for a minimum of 1 minute to make a medicine bag that fits the shape of the affected area. Let it cool naturally to 45℃ before applying it externally.

[0085] This approach reduces production costs while ensuring basic efficacy by controlling minimum parameter values. The dissolution rate of the drug's effective components meets basic clinical needs, and the content of toxic components is controlled within a safe range. It is suitable for primary healthcare institutions and low-cost treatment scenarios.

[0086] Example 3 The difference between this embodiment and Embodiment 1 is that: Raw material pretreatment: Select 21 kinds of Chinese medicinal herbs such as processed aconite, processed cassia, and frankincense, weigh each in 10 parts by weight, pulverize to a maximum particle size of 30 mesh, sieve and mix evenly.

[0087] Wine moistening process: Add Chinese medicinal materials to 52-degree grain liquor at the highest mass ratio of 1:0.5, stir until moist and free of lumps, and let stand for 20 minutes to allow the liquor to fully penetrate.

[0088] Stir-frying: Stir-fry over a low heat of 120℃ for 15 minutes, stirring constantly to prevent local overheating, until the herbs turn dark brown and emit a medicinal aroma.

[0089] Shaping process: While the stir-fried medicinal materials are still hot, put them into a cotton bag, press them down, and keep them warm for a maximum of 3 minutes to make a medicine bag that fits the shape of the affected area. Let it cool naturally to 50℃ before applying it to the outside.

[0090] This method can significantly improve the dissolution rate of the active ingredients of the drug and enhance the therapeutic effect by controlling the highest parameter value. It is suitable for critically ill patients and clinical scenarios with high requirements for efficacy. At the same time, it is necessary to strictly control the operation time and temperature to avoid overheating of the medicinal materials.

[0091] It should be noted that, in this document, relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, the phrase "comprising an element defined as..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes the element.

[0092] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine external application hot compress powder for treating gout, characterized in that, It includes the principal drug group, the assistant drug group, the adjuvant drug group, and the guiding drug group; The principal drug group, the assistant drug group, the adjuvant drug group, and the guiding drug group are made from the following Chinese herbal raw materials in parts by weight: The principal herb group includes 5-10 parts of Aconitum carmichaelii, 5-10 parts of Aconitum kusnezoffii, 5-10 parts of Boswellia carterii, 5-10 parts of Commiphora myrrha, 5-10 parts of Sappanwood and 5-10 parts of Carthamus tinctorius; The herbal formula includes 5-10 parts of Arisaema heterophyllum, 5-10 parts of Pinellia ternata, 5-10 parts of Pheretima aspergillum, 5-10 parts of Astragalus membranaceus, 5-10 parts of Atractylodes macrocephala, 5-10 parts of Codonopsis pilosula, 5-10 parts of Rheum palmatum, 5-10 parts of Phellodendron chinense, and 5-10 parts of Smilax glabra. The adjuvant group includes 5-10 parts of pine needles, 5-10 parts of peach kernels, 5-10 parts of angelica, 5-10 parts of cimicifuga, and 5-10 parts of gentian root; The medicine group includes 5-10 parts of grain lees; The weight proportions of any two of the described Chinese medicinal materials are the same.

2. The traditional Chinese medicine external application hot compress powder for treating gout according to claim 1, characterized in that, The principal herb group includes 8 parts of Aconitum carmichaelii, 8 parts of Aconitum kusnezoffii, 8 parts of Boswellia carterii, 8 parts of Commiphora myrrha, 8 parts of Caesalpinia sappan, and 8 parts of Carthamus tinctorius; The herbal formula includes 8 parts of Arisaema heterophyllum, 8 parts of Pinellia ternata, 8 parts of Pheretima aspergillum, 8 parts of Astragalus membranaceus, 8 parts of Atractylodes macrocephala, 8 parts of Codonopsis pilosula, 8 parts of Rheum palmatum, 8 parts of Phellodendron chinense, and 8 parts of Smilax glabra. The adjuvant group includes 8 parts pine needles, 8 parts peach kernels, 8 parts angelica, 8 parts cimicifuga, and 8 parts gentian root; The medicine group consists of 8 parts of grain lees.

3. The traditional Chinese medicine external application hot compress powder for treating gout according to claim 1, characterized in that, The particle size of the Chinese herbal raw materials is 10-30 mesh.

4. The traditional Chinese medicine external application hot compress powder for treating gout according to claim 1, characterized in that, Also includes: Baijiu (Chinese liquor), wherein the baijiu is mixed with any of the aforementioned Chinese medicinal materials; The liquor is a 38-52 degree grain liquor, and the total mass ratio of the Chinese medicinal materials to the liquor is 1:0.3-0.

5.

5. The traditional Chinese medicine external application hot compress powder for treating gout according to claim 1, characterized in that, The aconite root mentioned above and the prepared aconite root mentioned above are processed aconite root and processed prepared aconite root.

6. A preparation process for a traditional Chinese medicine external application hot compress powder for treating gout, wherein the preparation process is applied to the preparation of the traditional Chinese medicine external application hot compress powder for treating gout as described in claims 1-5, characterized in that, The preparation process includes the following steps: S1: Weigh out the following Chinese herbs by weight: Aconitum carmichaelii, Aconitum kusnezoffii, Boswellia carterii, Commiphora myrrha, Sappanwood, Carthamus tinctorius, Arisaema heterophyllum, Pinellia ternata, Pheretima aspergillum, Astragalus membranaceus, Atractylodes macrocephala, Codonopsis pilosula, Rheum palmatum, Phellodendron chinense, Smilax glabra, Pine needles, Prunus persica, Angelica sinensis, Cimicifuga foetida, Gentiana macrophylla, and grain lees. The weight of each herb shall be equal, and they shall be mixed evenly. S2: Add white wine to the mixed raw materials and stir until the mixture is at the right consistency; S3: Place the moistened ingredients in a stainless steel pot, heat over a low flame, and stir constantly. S4: After the pot is filled with steam, use a spatula to press the medicinal materials firmly so that the steam is stored inside the materials. Then turn off the heat to obtain the hot compress powder.

7. The preparation process according to claim 6, characterized in that, In step S2, the amount of baijiu added is 30-50% of the total mass of the Chinese herbal raw materials, and the alcohol content of the baijiu is 38-52 degrees.

8. The preparation process according to claim 6, characterized in that, In step S3, the temperature of the simmering fire is controlled at 80-120℃, and the stir-frying time is 5-15 minutes.

9. The preparation process according to claim 6, characterized in that, After compaction as described in step S4, keep warm for 1-3 minutes.

10. The preparation process according to claim 6, characterized in that, The preparation process further includes: spreading the hot compress powder obtained in step S4 onto a cotton cloth, wrapping it into a medicine bag that fits the shape of the patient's affected area, and applying it externally.

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