115 results about "Local pain" patented technology

The invention discloses a medicament formula for relieving pain caused by infusion medicament and preventing phlebitis. The medicament formula can be used for relieving pain caused by intravenous supplementing potassium, infusion mannitol, azithromycin, fructose diphosphate sodium and chemotherapeutic medicaments, and can be used for effectively preventing and treating extravasation phlebitis caused by long-term use of a remaining needle, infusion of vein high-nutrition medicaments, infusion of chemotherapeutic medicaments, infusion extravasation and the like. According to the medicament formula, 20-35ng of anisodamine, 6-13ml of lidocaine, 15-26mg of dexamethasone and 4-6ml of glycerin are arranged in a sterile kidney basin, sterile gauze is coated above a puncture part after being uniformly wetted, and an external preservative film is wound on the gauze. The medicinal formula has the advantages of continually and efficiently relieving local pain caused by infusion medicaments, and effectively preventing and treating local inflammation, swelling pain and stripped cable change caused by infusion.

The invention provides a traditional Chinese medicine capsule for treating scapulohumeral periarthritis. The traditional Chinese medicine capsule for treating the scapulohumeral periarthritis is prepared from the following traditional Chinese medicine raw materials: deer-horn glue, Poria cocos, garden balsam stem, folium artemisiae argyi, parasitic loranthus, turmeric, wild aconite root, frankincense, radix clematidis, notopterygium root, homalomena occulta, ginger, radix aconiti sinensis, cassia twig, lycopodium clavatum, bighead atractylodes rhizome, Suberect Spatholobus Stem, ramulus mori, Schizophragma integrifolium, Angelica sinensis, radix paeoniae alba, asarum, Radix Stephaniae Tetrandrae, radix angelicae pubescentis, erythrina indica lam, pawpaw, camphor, fructus aurantii, Manis pentadactyla, centipede, radix angelicae, liquorice, Radix Puerariae, Codonopsis pilosula and ephedra. The invention aims to provide the traditional Chinese medicine capsule for treating the scapulohumeral periarthritis, which is good in treatment effect, has no side effects and can achieve an effect of treating both symptoms and root causes. The traditional Chinese medicine capsule can be used for effectively tonifying liver and kidney, strengthening tendons and bones, inhibiting osseous degeneration and proliferation, effectively dispelling cold and dampness, resisting inflammations and easing pain and rapidly relieving symptoms, such as local pain and numb caused by inflammations, and thereby, an effect that the scapulohumeral periarthritis does not relapse after being healed, and various abuses and toxic and side effects brought to patients by Western medicines are avoided.

The invention relates to the technical field of pharmaceutical preparations, and provides a preparation method of biodegradable bupivacaine microspheres with high drug loading capacity. Bupivacaine microspheres entrapping free alkali are prepared by utilizing biodegradable high-molecular-weight polylactic acid as a carrier material according to an emulsified solvent evaporation method. The frozen-dried bupivacaine microspheres are dispersed in a medium for injection so as to be subjected to local injection administration, and is used for postoperative analgesia or is used for relieving local pains; the weight ratio of bupivacaine to the carrier material is (75:25) to (85:15), the drug loading capacity of the bupivacaine in the microspheres is not less than 60%, and medicaments can be completely released within 5-7 days.

A transdermal paster for treating acute or chronic local pain is prepared from lidocain hydrochloride and methol. It can be used for the ultrasonic-type, ion leading-in type, electric perforating type, or high-pressure gas type medicine supplying system.

The invention provides a novel anesthetic, which comprises the following components in percentage by weight: 85 to 90 percent of propofol, 4 to 8 percent of datura flower extract, 0.5 to 1 percent of mentholum, 0.5 to 2.5 percent of chamomile, 1 to 3 percent of pseudo-ginseng powder, and 1 to 3 percent of astragalus powder. According to the novel anesthetic, the principle of combining traditional Chinese and western medicine is adopted, the original propofol drug effect can be maintained by propofol serving as a basic drug, datura flower serving as an auxiliary drug, mentholum and chamomile with pain relieving effect, astragalus with blood pressure dual-direction regulating effect and antitetanic pseudo-ginseng, the function of analgesia is increased, and the problem of local side effect caused by local pains when the propofol is used for injecting can be solved; adverse responses of myoclonus, nausea, emesis, respiratory depression which easily occurs and the like happening to partial patients in anaesthesia recovering period can be solved; and the dosage of propofol can be reduced, and the safety is increased.

At least three component, body-implantable, absorbable, biocompatible, putty, and non-putty pain-relieving compositions for use in surgery comprising in intimate admixture: an analgesic having local pain-relieving activity for internal relief of pain, a finely powdered bulking material, preferably less than 50 microns, e.g. the metal salts of fatty acid, hydroxyapatite, DBM, polyglycolide, polylactide, polycaprolactones, absorbable glasses, gelatin, collagens, mono, and polysaccharides starches.

An organic liquid capable of solubilizing, dispensing or suspending the analgesic, such as esters of monohydric alcohols with aliphatic monocarboxylic acids; C₂-C₁₈ monohydric alcohols with polycarboxylic acids; C₈-C₃₀ monohydric alcohols; tocopherol and esters thereof with mono or polycarboxylic acids; free carboxylic acids such as oleic, capric, and lauric; dialkyl ethers and ketones; polyhydroxy compounds and esters and ethers thereof; random or block copolymers of ethylene oxide and propylene oxide.

The invention discloses a medical painless chest drainage pipe. The medical painless chest drainage pipe comprises a drainage pipe body, a membranous anther sac, an infusion tube and a connector thereof and a marker line, wherein the drainage pipe body is sleeved with the membranous anther sac of a special structure, and the infusion tube and the connector thereof are connected with the anther sac. In the practical application process of the drainage pipe, the anther sac structure is left in a muscle nerve tissue area under human skin, meanwhile, local anesthetic is injected to the anther sac through the infusion tube with a microsyringe, by means of the anther sac of the special structure, the local anesthetic is overflowed into soft tissue under skin, nerve endings are narcotized, and the effect of local analgesia is achieved. After a cardiac and thoracic surgery or an abdominal surgery is conducted, by means of the cooperation of the painless chest drainage pipe, the muscle nerve tissue of the drainage area is subjected to local anaesthesia, and the local pain on account of the drainage pipe of a patient can be reduced.

The invention relates to a preparation method of pharmaceutical preparation and injection of exenatide acetate. The exenatide acetate pharmaceutical preparation is a stable liquid formulation appliedto a plurality of dosing manners. Per 100ml of the pharmaceutical preparation contains at least the exenatide acetate of 0.005-0.4g, preservative of 0.1-0.75g, appropriate amount of buffer and isotonic agent, wherein the preservative is chosen from one or two of chlorobutanol and phenethyl alcohol, with pH value of the pharmaceutical preparation being 3.0-7.0. The preparation method has the following steps: dissolving auxiliary materials of the preservative, the isotonic agent and the buffer according to prescription amount by using water for injection, and immigrating the dissolving solutioninto batching pot; taking the auxiliary solution or the water for injection to dissolve the exenatide acetate; and replenishing the water for injection to total volume and uniformly stirring; filtering the pharmaceutical preparation for degerming by using filter membrane of 0.22mu m to produce the exenatide acetate injection. The invention has the advantages that the preservative of chlorobutanolhas the dual effects of bacteriostasis and local pain relieving; and the exenatide acetate completes the stability examination of high temperature, hard light, long-term experiment and speed-up experiment, thus having stable quality and fitting for long-term storage.

The invention discloses an external preparation of a lidocaine-prilocaine medicinal composition. The content of the lidocaine-prilocaine medicinal composition is 1%-10%. The external preparation comprises a patch containing lidocaine-prilocaine oily eutectic, a non-hydrophilic matrix material and pharmaceutically acceptable external preparation auxiliary materials, and a gel patch containing lidocaine-prilocaine O/W microemulsion, a hydrophilic gel matrix material and pharmaceutically acceptable external preparation auxiliary materials. The patch and the gel patch can be used for local superficial anesthesia or relieving local pains such as post-injection pain, post-puncture pain, pain caused by intravenous injection, postherpetic neuralgia, touch pain caused by herpes zoster and protrusion of intervertebral disc. The external preparation and the application have the advantages that the lidocaine-prilocaine eutectic is taken as an active ingredient, so that the percutaneous penetrationrate and the absorption degree of lidocaine and prilocaine can be obviously improved, the beneficial effects of synergy are produced, meanwhile, the occurrence rate of toxic and side effects of the lidocaine and the prilocaine is reduced, and a new choice is provided for analgesia and anesthesia requirements of patients and medical staff.

The invention discloses a medical massager which comprises heaters, massage wheels, a body, storage batteries, a motor, a controller, a temperature control button, a motor rotating speed and rotating direction control button, an ultraviolet lamp tube switch, a fixed rod, an ultraviolet lamp tube, a movable joint and a movable rod. The motor is arranged at the middle end of an inner cavity of the body. The storage batteries are arranged on the two sides of the outer surface of the motor. The motor is in transmission connection with the massage wheels through rotating shafts. The heaters are arranged on the upper surface of the body. The controller is arranged at the lower end of the outer surface of the body. The controller comprises the temperature control button, the motor rotating speed and rotating direction control button and the ultraviolet lamp tube switch. The fixed rod is arranged at the middle end of the bottom of the outer surface of the body. The ultraviolet lamp tube is embedded on the outer surface of the fixed rod. According to the medical massager, due to the combined action of the massage wheels and the heaters, local pain of a body is effectively relieved, and body health is benefited.

The invention discloses a preparation method of Chinese medicinal lotion for treating chronic ulcer of shank with phlegm turbidity and obstruction syndrome, falling into the technical field of Chinese medicine preparation method. At present, antibiotics and sulfonamides such as piperacillin are normally adopted for treating chronic ulcer of shank with phlegm turbidity and obstruction syndrome: intramuscular injection occasionally causes local pain, while rapid intravenous injection may lead to temporary nausea, chest distress, cough, fever, etc. The composition is prepared from 25 medicinal materials including Bulbus Allii Macrostemi, Semen Citri Reticulatae, Pericarpium Citri Tangerinae, Fructus Citri Sinensis, Semen Aesculi, tobacco, Fructus Citri, Rhizoma Cyperi, Cortex Magnolia Officinalis, Semen Litchi, Fructus Litchi, Cacumen Securinegae Suffruticosae, Radix Schefflerae Arboricolae, Radix Alangii, Caulis Sinomenii, Caulis Piperis Futokadsurae, Caulis Trachelospermi, Caulis Aristolochiae, Herba Erodii Seu Geranii, Semen Persicae, Carthami Flos, Salviae Miltiorrhizae Radix, Cortex Moutan, Fructus Trichosanthis and Radix Glycyrrhizae by soaking in water, decocting with slow fire, and collecting decoction. The composition has small side and toxic effects, short treatment course, high curative rate, and avoids adverse effects of western medicines.

The invention discloses a taekwondo scoring protector auxiliary wearing device and a using method thereof. The invention belongs to the technical field of taekwondo protectors. According to the invention, based on a conventional electronic protector,a force digestion layer is innovatively introduced; when facing the striking force of an opponent, the striking action and the striking force are effectively and accurately recognized; meanwhile, the striking force is buffered and converted; different magnetic fields are opened in a targeted manner by utilizing the repeated action of the ball-likemagnetic isolation cover; therefore, the magnetic attraction effect of the magnet blocks on the magnetic massage balls is started; the magnetic massage beads are forced to cling to the skin of the user for back-and-forth extrusion massage; the device assists a user in promoting blood circulation to remove blood stasis, promoting local tissue blood circulation, improving body resistance and repairing capacity, relieving local pain and preventing the user from being injured by strike force and avoiding the interferences on the subsequent competitive state, the user can be effectively protected,and meanwhile the competitive level of the user can be greatly improved.

The invention relates to a pharmaceutical composition of injection cefodizime sodium and lidocaine hydrochloride injection and in particular relates to combined application package. The pharmaceutical composition includes injection cefodizime sodium and lidocaine hydrochloride injection. During a using process, the injection cefodizime sodium is dissolved in 1% of lidocaine hydrochloride injection, so that intramuscular injection is carried out. The pharmaceutical composition not only has the broad-spectrum antibacterial action, but also can be used for relieving local pains caused by injection cefodizime sodium.

The invention discloses a traditional Chinese medicine composition for treating a bone fracture. The composition is prepared from the following 23 traditional Chinese medicines: tinospora sinensis merr, heterosmilax japonica, smalt, pegia sarmentosa, flemingia philippinensis, gynostemma pentaphylla, aituoduo (Chinese character), herba periliae, asclepiadaceae tylophora koi, sinoadina racemosa, herba chloranthi serrate, clerodendrum serratum var amplexifolium, rhinacanthus nasutus, blumea balsamifera, sambucus chinensis, girardinia diversifolia, red elecampane, ardisia mamillata hance, uncaria rhynchophylla, rhizoma smilacis glabrae, tongking pepper, drynaria total flavonoids and epipremnum pinnatum. The traditional Chinese medicine composition works together to achieve the efficacies of promoting reunion of fractured bones, promoting blood circulation to remove blood stasis, relieving swelling and pain, soothing the channels and activating collaterals, has significant curative effects on treatment of the bone fracture, and can also be applied to soft tissue injuries, ligament and joint strain injuries caused by falling, hitting, touching, knocking and the like; and the symptoms such as local pain, tumidness, dysfunction, black and blue subcutaneous addiction spots or hematoma of patients are removed.

The present invention provides compositions, and methods for local administration of certain peptides or combination with certain small molecules that produce analgesia and anti-inflammation in a mammal. Exemplary polypeptides provide peripheral analgesia and anti-inflammation when administered via local topical, subcutaneous, intradermal, or intranasal administration, to provide analgesia and anti-inflammation. Through antagonism of peripheral CGRP receptors alone, or in combination with inhibition of sensory sodium channels or anti-inflammation, the compositions of the invention provide local therapeutic pain relief with minimal undesired systemic side effects in a subject. Also provided are improved peptide delivery techniques including microneedle unit dose administering apparatus and methods. Also provided are hydrogel formulations for sustained local delivery to a subject of one or more of the compositions according to the invention in a therapeutically effective amount, thereby providing local pain relief and/or reducing associated inflammation.

The invention discloses a Chinese medicinal ethosome gel patch for treating herpes zoster. The Chinese medicinal ethosome gel patch is characterized in that a therapeutic ingredient of the patch is a Chinese medicinal composition, wherein emulsion type polyacrylate is used as a pressure sensitive adhesive; the Chinese medicinal composition consists of the following materials in percentage by weight: 30 percent of liquoric root ethosome, 60 percent of water mixed decoction of gentian, white paeony root, Chinese thorowax root, angelica, root of rehmannia, szechuan lovage rhizome and szechwan chinaberry fruit, 2 percent of polyvinyl alcohol, 1 percent of gardenia, 3 percent of frankincense, 1 percent of indigo naturalis and 3 percent of borneol. The pharmacodynamics study of the patch shows that the patch has a good therapeutic effect on the early-to-mid herpes zoster and especially has better effects of shortening the course of disease, promoting deflorescence and relieving local pain. The patch is easy in medication and convenient to use, has a good therapeutic effect, quick response, strong analgesic action but no adverse reaction, and brings good social benefit and economic benefit after development and application.

The invention provides a piroxicam gel preparation and a preparation method of the piroxicam gel preparation. The gel preparation comprises the following components in percentages by weight: 0.1-1% of piroxicam, 0.3-1.2% of Carbomer 940, 0.1-1% of tromethamine, 1-10% of ethanol, 6-15% of propylene glycol, 0.6-1.5% polyethylene glycol 400, 0.006-0.015%Edetate Disodium, and 1.2-2.1% of triethanolamine. Piroxicam is dissolved by using tromethamine to solve the problem that tromethamine is difficult to dissolve in water, the penetrability of piroxicam to the skin is improved, the absorption rate of piroxicam through the skin is increased, the curative effect is obviously improved by local topical administration for curing the local pain, and a novel administration method for the patients is also provided. The gel preparation is semi-solid gel having good transdermal absorption property; the piroxicam is completely dissolved and dispersed in the gel preparation, thereby facilitating the pain relief for the patient. The preparation process is simple, and the preparation is stable and reliable in quality.

The invention relates to GLP-1 (Glucagon-like peptide-1) injection, comprising GLP-1, an isotonic agent, a buffer agent, a preservative and a solvent, wherein the GLP-1 is an effective ingredient, theisotonic agent is one, or a combination, of mannitol, sorbitol, inositol, glycerol, xylitol, and polyethylene glycol, the buffer agent is one, or a combination, of an acetate, a phosphate, a citrateand a glutamate, the preservative is one, or a combination, of chlorobutanol and phenethyl alcohol, the solvent is injection water, and the GLP-1 injection has pH of 4.0-6.0. The GLP-1 injection preparation prepared according to the invention is tested to meet the related specifications in terms of traits, identification, related matters, contents and other indexes. The preservative polyethylene glycol can inhibit bacteria and provide local pain relief, and the GLP-1 injection is better than proprietary prescriptions, and has the advantages of good quality stability and suitability for long-term storage.

The invention discloses isolation liquid. The isolation liquid comprises normal saline, lidocaine or pharmaceutical salts thereof and epinephrine or pharmaceutical salts thereof. The invention further provides a method for preparing the isolation liquid with the lidocaine or the pharmaceutical salts thereof and the epinephrine or the pharmaceutical salts thereof. The isolation liquid and the method have the advantages that the isolation liquid can be injected into front and back envelopes of thyroids and dangerous trigona in thyroid thermal ablation surgery, accordingly, important tissue structures of recurrent laryngeal nerves, superior laryngeal nerves, oesophagi, tracheas and the like can be sufficiently isolated and protected, and the purposes of realizing definite local pain relieving effects and effectively controlling bleeding around the envelopes of the thyroids during isolation can be achieved; the isolation liquid is viscous and fluidic and is convenient to inject into the front and back envelopes of the thyroids and the dangerous trigona, the staying time of the isolation liquid in tissues can be prolonged owing to the viscosity of the isolation liquid, and repeated isolation liquid injection operation can be omitted; the isolation liquid is difficult to diffuse in the tissues, and accordingly the surgery can be facilitated; the method is easy to implement, and clinical operation requirements can be met.

The invention discloses a bone setting agent which has functions of tonifying kidney and regenerating bone marrow and is capable of accelerating fracture healing. The bone setting agent is prepared from active pharmaceutical ingredients in parts by weight as follows: 45-55 g of native copper, 12-18 g of davallia mariesii, 10-15 g of dipsacaceae, 10-15 g of cuscuta, 10-15 g of schisandra chinensis, 12-18 g of cyathula officinalis, 12-18 g of salvia miltiorrhiza, 12-18 g of caulis spatholobi, 12-18 g of ground beetles, 10-15 g of frankincense, 10-15 g of myrrh, 10-15 g of carthamus tinctorius, 10-15 g of angelica sinensis, 25-35 g of astragalus, 12-18 g of radix paeoniae alba, 10-15 g of alisma plantago-aquatica, 10-15 g of a hiraute shiny bugleweed herb, 10-15 g of pubescent angelica root, 10-15 g of ligusticum wallichii and 8-10 g of liquorice. The active pharmaceutical ingredients are decocted in water for oral dose; the agent treats both symptoms and root causes through synergistic effect of the traditional Chinese medicine through reasonable compatibility, can promote callus growth through adjustment and reinforcement of liver and kidney, improve the activity of osteoblasts, increase the quantity of the osteoblasts, promote calcification of the bone matrix and accelerate callus transformation, can further relieve local pain, and has more advantages than pure compounds and biological agents.

The invention discloses a multifunctional facial cold and hot compress bag. The bag comprises a cold and hot compress bag body, eye through holes are formed in the surface of the cold and hot compressbag body, a nasal through hole is formed in the portion, located below the eye through holes, of the surface of the cold and hot compress bag body, and a breathing through hole is formed in the portion, located below the nasal through hole, in the surface of the cold and hot compress bag body; a first polymer gel bag is fixedly connected to the portion, located above the eye through holes, in thecold and hot compress bag body, and a second polymer gel bag is fixedly connected to the portion, located at the left side of the nasal through hole, in the cold and hot compress bag body. The multifunctional facial cold and hot compress bag meets the cold compress demands of various patients in the ophthalmology department, the otolaryngology department, the stomatology department, the maxillofacial surgery department and the like, the work efficiency of nurses is improved, the comfort degree of the patients is increased, local pain and bleeding are reduced, the doctor seeing experience of the patients is improved, and the problems are solved that conventional ice bags are large in size, hard in texture and poor in fitness and cannot achieve a good cold compress effect, and the discomfort degree of local bleeding and seepage cannot be reduced.

The invention discloses a traditional Chinese medicine composition for preventing and treating bone joint pain and a drug bag and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition for preventing and treating the bone joint pain comprises the following raw materials: safflower, camphor, common clubmoss herb, mulberry twig, cassia twig, garden balsam stem and the like. The traditional Chinese medicine composition disclosed by the invention has the advantages that proved by the results of years of clinic tests of applicant, the traditional Chinese medicine composition is capable of effectively treating the diseases such as waist and knee joint pain, numbness of limbs, shoulder and back pain, elbow pain, gynecological lumbago, exercise sprain and the like caused by rheumatism, osteoarthritis and the like and has a good treatment effect on joint local pain caused by lumbar intervertebral disc protrusion, sciatica, stroke, fracture sequelae and the like. In addition, the drug bag has good disease preventing and treating effects on sportsmen, field workers and freezer operating personnel.