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External preparation of lidocaine-prilocaine medicinal composition and application thereof

A technology for external preparations and prilocaine, which is applied in the direction of drug combinations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of cumbersome operation and clothing erasure, and achieve good safety, Reduce the incidence rate and reduce the effect of toxic and side effects

Pending Publication Date: 2021-03-05
CHANGSHA JINGYI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the above-mentioned gel and cream are used, they cannot stay for a long time and are easily wiped off by clothes; if they are packaged, the operation will be cumbersome
In summary, there are still certain defects in the preparation of lidocaine-prilocaine pharmaceutical composition at present.

Method used

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  • External preparation of lidocaine-prilocaine medicinal composition and application thereof
  • External preparation of lidocaine-prilocaine medicinal composition and application thereof
  • External preparation of lidocaine-prilocaine medicinal composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1: lidocaine-prilocaine patch (solvent base)

[0059] Prescription composition:

[0060]

[0061] Preparation process: Take lidocaine and prilocaine in the prescribed amount into a container, heat to 40-50°C, stir and mix until they are completely melted, forming a transparent oily eutectic liquid. Take the prescribed amount of DURO-TAK 180-129A, kaolin, tocopherol, propylene glycol, methyl p-hydroxybenzoate and lidocaine-prilocaine oily eutectic into a mixing container, stir and mix evenly to obtain a drug-containing layer. The drug-containing layer is evenly coated on the polyethylene terephthalate PET film, laminated with non-woven fabric, and cut into the required size to obtain the lidocaine-prilocaine patch.

Embodiment 2

[0062] Embodiment 2: lidocaine-prilocaine patch (hot-melt matrix)

[0063] Prescription composition:

[0064]

[0065] Preparation process: Take lidocaine and prilocaine in the prescribed amount into a container, heat to 40-50°C, stir and mix until they are completely melted, forming a transparent oily eutectic liquid. Take the prescribed amount of SIS D1163P, terpene resin, liquid paraffin, dibutyl hydroxytoluene, kaolin, propylene glycol and methyl p-hydroxybenzoate, heat to 150°C to melt and mix well. Subsequently, the lidocaine-prilocaine oily co-melt is added into a mixing container, stirred and mixed evenly to obtain a drug-containing layer. The drug-containing layer is evenly coated on the polyethylene terephthalate PET film, laminated with non-woven fabric, and cut into the required size to obtain the lidocaine-prilocaine patch.

Embodiment 3

[0066] Embodiment 3: lidocaine-prilocaine gel plaster

[0067] Prescription composition:

[0068]

[0069] Preparation process: Take lidocaine and prilocaine in the prescribed amount into a container, heat to 40-50°C, stir and mix until they are completely melted, forming a transparent oily eutectic liquid. Put polysorbate 80, lidocaine-prilocaine co-melt and appropriate amount of purified water in a mixing container, stir homogeneously to emulsify, and prepare an O / W emulsion.

[0070] Dissolve the prescribed amount of sodium polyacrylate NP-700 and polyvinyl alcohol in purified water, fully mix aluminum glycerol, propylene glycol, kaolin, glycerin, and methyl p-hydroxybenzoate, and then add it to the above purified aqueous solution to cross-link to form a gel. Gel base. Then add the O / W type emulsion into the gel matrix, stir and mix evenly to obtain the drug-containing layer. The drug-containing layer is uniformly coated on a polyethylene terephthalate PET film, and l...

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Abstract

The invention discloses an external preparation of a lidocaine-prilocaine medicinal composition. The content of the lidocaine-prilocaine medicinal composition is 1%-10%. The external preparation comprises a patch containing lidocaine-prilocaine oily eutectic, a non-hydrophilic matrix material and pharmaceutically acceptable external preparation auxiliary materials, and a gel patch containing lidocaine-prilocaine O / W microemulsion, a hydrophilic gel matrix material and pharmaceutically acceptable external preparation auxiliary materials. The patch and the gel patch can be used for local superficial anesthesia or relieving local pains such as post-injection pain, post-puncture pain, pain caused by intravenous injection, postherpetic neuralgia, touch pain caused by herpes zoster and protrusion of intervertebral disc. The external preparation and the application have the advantages that the lidocaine-prilocaine eutectic is taken as an active ingredient, so that the percutaneous penetrationrate and the absorption degree of lidocaine and prilocaine can be obviously improved, the beneficial effects of synergy are produced, meanwhile, the occurrence rate of toxic and side effects of the lidocaine and the prilocaine is reduced, and a new choice is provided for analgesia and anesthesia requirements of patients and medical staff.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an external preparation of a lidocaine-prilocaine pharmaceutical composition and an application thereof. Background technique [0002] Pain is a defining feature of many disease diagnoses and is an unpleasant sensation and experience. When the intensity of external stimuli reaches the threshold, nociceptive sensory fibers will be activated to generate nerve impulses, which are transmitted to the spinal cord and central nervous system through afferent nerves to produce reflex responses and pain sensations. Common types of pain include protective pain caused by acupuncture, high temperature, extrusion, etc., inflammatory pain and neuropathic pain. Pain can last for hours, days or even years, which not only reduces the quality of life of patients, but also seriously affects their mental and physical health. [0003] Pain relief methods mainly include oral analgesics and ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/167A61K47/32A61K47/26A61K47/10A61P23/02
CPCA61K9/7061A61K31/167A61K47/26A61K47/10A61P23/02A61K2300/00
Inventor 张海龙黄雅倩
Owner CHANGSHA JINGYI PHARM TECH CO LTD
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