256 results about "Pain sensations" patented technology

An assessment apparatus and method for objective pain assessment are provided, wherein the apparatus includes a processor comprising a frequency-domain transformation module, a frequency-band segmentation module, a first assessment submodule, and a second assessment submodule. The frequency-domain transformation module generates a global time-frequency feature matrix, which is segmented by the frequency-band segmentation module in a frequency domain into five frequency bands associated with pain perception. The first assessment submodule extracts last time step features and an adjacency matrix from the time-frequency feature matrix and generates a first feature vector representing global association patterns among electrodes used for acquiring EEG signals. The second assessment submodule generates a second feature vector with local spatiotemporal dynamic features of EEG signals, concatenates it with the first feature vector to form a fused feature vector, computes its class probability distribution, normalizes it, and generates an objective pain quantification indicator corresponding to the EEG signals.

In the herpes zoster neuralgia chronic detection and AI identification model training method and system, information of a detector is collected, and the information of the detector comprises age, gender and herpes zoster definite diagnosis time; collecting detection information of a detector, wherein the detection information comprises a ratio of IL18 to IL18BP; pain information of the detected person is collected; the pain information of the detector comprises pain intensity and attack frequency; the pain information of the detected person is marked, marked information is obtained, and the marked information comprises acute pain, chronic pain and the risk degree of converting the acute pain into the chronic pain; performing AI training according to the detector information, the detection information and the annotation information, and obtaining a herpes zoster neuropathic pain AI feature data set after the AI training; the herpes zoster neuralgia AI feature data set is used for detecting the possibility that the herpes zoster neuralgia of the testee is converted from acute pain to chronic pain in combination with AI software. And diagnosis and treatment basis information from a brand new perspective is provided for the post-herpes zoster neuralgia.

The invention provides a nerve electrical stimulation method, device and system based on electroencephalogram signals, and the method comprises the steps: obtaining pain related features in real time, the pain related features comprising electroencephalogram index features and heart rate variability features; generating a comprehensive pain score value in real time based on the pain related characteristics, and generating an electrical stimulation parameter in real time based on a target difference value between the comprehensive pain score value and the baseline score value; the vagus nerve of the patient is electrically stimulated based on the electrical stimulation parameters. The problem that in the prior art, due to immobilization of electrical stimulation parameters, dynamic adjustment cannot be conducted according to real-time neural activity of a patient, and therefore the treatment effect is affected is solved.

The invention provides an analgesia feedback and control method and system based on multi-modal data, electronic equipment and a storage medium, and relates to the technical field of analgesia feedback and control. The method related to the technology comprises the following steps: acquiring pain associated data based on a multi-mode sensor and an emotion perception assembly; generating a comprehensive pain index based on the pain sense associated data, and matching an analgesia scheme based on the comprehensive pain index; or directly outputting an analgesia scheme based on the pain associated data; and performing analgesia control based on the analgesia scheme. According to the analgesia feedback and control technology, data, such as electroencephalogram, voice emotion and environment, associated with pain sense are integrated, the limitation of a single signal is broken through, and analgesia feedback and control are more accurate and intelligent.

The invention relates to the technical field of medical health data information decoding analysis and processing, and particularly discloses a dynamic pain nerve decoding and intervention system based on a prefrontal lobe time sequence characteristic window, which comprises a signal acquisition module, a dynamic window control module, a phase prediction module, an intervention execution module and an event driving controller. The dynamic window control module intelligently adjusts the duration of a signal analysis window through real-time calculation of the energy ratio of a # imgabs 0 # frequency band to a # imgabs 1 # frequency band, and accurately locks a transient characteristic window in a pain outbreak period; the phase prediction module realizes millisecond-level synchronization of stimulation pulse and a rising edge of action potential of a neural cluster based on a two-factor mapping mechanism of an individualized conduction velocity level and an oscillation frequency; the event-driven controller reduces the power consumption to a wearable device level while maintaining 10 ms-level real-time response through a dynamic resource allocation strategy.

The present disclosure is directed to a system and method for selectively and reversibly modulating targeted neural and non-neural tissue of a nervous system for the treatment of pain. An electrical stimulation is delivered to the treatment site that selectively and reversibly modulates the targeted neural- and non-neural tissue of the nervous structure, inhibiting pain while preserving other sensory and motor function, and proprioception.

The invention discloses an intelligent analysis system and method for rehabilitation treatment of lumbar intervertebral disc herniation, and relates to the field of intelligent analysis. Abstract clinical information amounts such as lesion part features, pain perception description and movement function requirements are converted into high-dimensional vectors by adopting a semantic coding technology based on deep learning; the system can more accurately understand and simulate the condition of a patient in a multi-dimensional space, further, a dynamic mapping mechanism between a rehabilitation starting point and a target is established to capture non-linear correlation between the current state of the patient and an ideal rehabilitation target, and intelligent derivation of a rehabilitation path is achieved based on the non-linear correlation. Through the dynamic analysis of the multi-dimensional information of the patient, the system can better understand the unique demand of each patient, the matching precision of the rehabilitation treatment scheme is improved, and the treatment is more personalized and effective.

A visual synthesis-based virtual or augmented reality pain treatment apparatus and device. In the apparatus, an interaction control unit generates a pain stimulation scheme matching a current patient to be treated and sends the pain stimulation scheme to a data processing unit. The data processing unit, on the basis of the received pain stimulation scheme, generates a virtual reality environment and a virtual stimulation source visible to the patient in the virtual reality environment. A display unit displays the virtual reality environment and the virtual stimulation source to said patient. The data processing unit, on the basis of a pain category to be induced, determines a stimulation target of a limb and parameters of the virtual stimulation source. The display unit drives the virtual stimulation source to implement a visual approaching motion to the stimulation target of the patient so as to achieve non-real stimulation. The somatosensory system of the patient is activated by means of a vision-nerve coupling mechanism to induce the patient to feel a tactile sensation, a thermal sensation, and / or a cold sensation at the stimulation target and in a nearby area thereof, thereby achieving neuromodulation therapy of a pain pathway.

The invention relates to the field of medical auxiliary diagnosis, in particular to an intelligent child pain assessment system based on AI facial expression analysis, a facial detection module obtains a child facial image, and performs three-stage cascade detection by using a multi-task cascade convolutional neural network model to obtain facial key point pixel coordinate information; the key point positioning module carries out noise filtering processing on the coordinate information to obtain more accurate face key point coordinate information, the information is transmitted to the key point thermodynamic diagram representation module, and the key point thermodynamic diagram representation module generates a face key point thermodynamic diagram representing the degree of pains of children in combination with the face key point coordinate information and a thermodynamic diagram mechanism. The child pain intelligent evaluation module evaluates the degree of pain of the child based on the thermodynamic diagrams and obtains an evaluation result, and finally, the pain evaluation result visualization module visualizes the evaluation result, and the accuracy of pain characterization is improved through high-precision face detection and key point thermodynamic diagram technology, so that the accuracy of pain characterization is improved. And an effective method is provided for evaluating the pains of children.

The treatment system includes a limb sleeve containing a heating subsystem, a pressure subsystem, and a vibration subsystem. The heating subsystem provides controlled cyclic heating to the limb, leading to dilation of the microvasculature and improved blood flow to nerve receptors. The pressure subsystem provides progressively staged, cyclic pressure to the limb, thereby improving blood circulation to the limb, reducing edema buildup, and flushing waste out the lymphatic system. The vibration subsystem provides controlled vibrotactile sensation to the limb to promote neuronal stimulation and decrease pain sensation. The treatment system allows for a multi-faceted approach in disease stabilization and assistive, personalized treatment for peripheral neuropathy.

A method for assessing pain experienced by a patient (3) comprises: receiving a sensor signal (8) which has been generated in a sequence of epochs (10) by a sensor (2) configured for measuring a physical activity of the patient (3), wherein each epoch (10) comprises a sequence of measurement periods (11), wherein the sensor signal (8) has been generated in each measurement period (11); determining a signal intensity value (12) for each measurement period (11) from the sensor signal (8); classifying the signal intensity values (12) of each epoch (10) with different physical activity classes (13a, 13b, 13c, 13d) to obtain a classification result (15) for the epoch (10); and determining a behavior assessment score (16) indicative of the pain experienced by the patient (3) from the classification results (15) of different epochs (10).

The invention relates to the technical field of signal analysis, in particular to an acute pain assessment method and system based on an EDA signal, and the method comprises the following steps: collecting a skin electrical activity EDA signal of a subject; calculating an individual time-varying sympathetic nerve activity TVSymp curve; the method comprises the following steps: constructing a priori knowledge base containing a standardized pain response sympathetic nerve SpainSymp template; inputting the EDA signal and the individual TVSymp curve into a PCVAE model, fusing features and decoupling the features into pain common features and individual specific features; carrying out pain intensity classification, and reconstructing and generating a standardized SpainSymp curve of which individual specific characteristics are removed; and outputting the pain intensity classification result and the dynamic change trend of the standardized SpainSymp curve in real time. By adopting the method, the pain-induced physiological reaction and individual baseline variation can be effectively decoupled and separated from the mixed EDA signal, the interference of individual difference is avoided, and the method has the characteristics of high accuracy and strong real-time performance.

Presented herein are devices and systems as well as the methods of using the same for the purpose of reducing and / or ameliorating the sensation of pain, specifically, chronic pain. Particularly, in one aspect, the devices, systems, and their methods of use disclosed herein are effective for reducing peripheral nerve pain, such as resulting from traumatic nerve injury and other types of nerve damage.

The present invention relates to a drug injection multi-needle of which the surface to come into contact with the skin provides either a cooling or warming sensation so that pain can be reduced and, simultaneously, a hemostatic effect can be increased and, specifically, comprises: an injection part to which a drug syringe for storing a drug is coupled and into which the drug is injected by means of pressure; a needle coupling part which is coupled to the front surface of the injection part and to which a plurality of needles to penetrate the skin are coupled; a suction part into which the needle coupling part is inserted and which suctions air at a position coming into contact with the skin; and a temperature-regulating part which is formed on the front surface of the suction part and which regulates the temperature.

The present invention relates to nicotinamide mononucleotide, its pharmaceutically acceptable precursors, its pharmaceutically acceptable derivatives or its pharmaceutically acceptable salts for use in the prevention and / or treatment of pain, in particular nociceptive pain, and the invention also relates to compositions containing them.

The present invention relates to a sustained-release injectable composition containing dutasteride. Compared with the conventional Avodart (registered trademark) taken once a day, even if the dosage of dutasteride is the same as or less than that of Avodart, it is possible to show a sustained release effect of dutasteride for 3 months or more, and a long-term drug-taking effect can be shown by a single injection. In addition, it can show a therapeutic effect on benign prostatic hyperplasia, prostate cancer, and hair loss continuously for 3 months or more. The microparticles contained in the sustained-release injectable composition have a constant average diameter, can regulate the release of the drug, and maintain a constant effective drug concentration, and can reduce the foreign body sensation and pain when administered to patients as an injection.

The present invention relates to modulators of TNF signalling for use in treating and / or preventing acute pain. In particular, a modulator of TNF signalling may be a tumour necrosis factor receptor 2 (TNFR2) agonist comprising (i) a TNFR2 binding domain comprising three TNF homology domains (THD) that specifically bind to TNFR2; and (ii) an Fc domain. The present invention further relates to combinations of a TNFR2 agonist and an inhibitor of tumour necrosis factor receptor 1 (TNFR1) signalling.

Systems and methods of applying electrical stimulation to achieve sustained relief of chronic pain that comprise a coiled wire percutaneous lead configured for insertion into a portion of a body that is proximal to a region of pain and an electrode formed integrally on the coiled wire percutaneous lead, wherein the electrode is configured to be positioned inside the body and at a therapeutically effective distance from a portion of at least one peripheral nerve that innervates the region of pain. The systems and method may also include an electrical stimulation device operatively coupled to the lead to apply electrical stimulation through the at least one electrode to at least one peripheral nerve that innervates the region of pain, to activate target peripheral nerve fibers while preventing activation of non-target peripheral nerve fibers and avoiding changing or blocking neural activity in off-target peripheral nerve fibers in the at least one peripheral nerve to create comfortable sensations in the region of pain and produce pain relief by modulating central nervous system plasticity associated with the pain.

The invention discloses a closed-loop analgesia method and system for regulating and controlling a secondary sensory cortex based on primary sensory cortex neural activity feedback. The system comprises a signal acquisition module used for acquiring neuron activity signals in the S1 region, a pain judgment module used for analyzing the signals and judging the pain state, a feedback control module used for generating stimulation control signals, and a stimulation execution module used for applying adjustable nerve regulation stimulation to the S2 region. According to the method, a specific pain nerve signal of S1 is monitored in real time and serves as a closed-loop feedback source, intervention on S2 is dynamically controlled, stimulation parameters are automatically started and optimized only when pain is detected, stimulation is automatically weakened or stopped after the pain fades away, and therefore self-adaptive, on-demand and accurate intelligent analgesia is achieved. According to the invention, accurate pain determination is realized by using a specific signal at the upstream of a pain pathway, personalized, efficient and low-energy-consumption intelligent analgesia is realized through closed-loop control, and a brand new solution is provided for chronic pain treatment.

1. The name of the design product: electric stimulation instrument connecting belt. 2. The use of the design product: used with the main machine and electrodes together, for the treatment of idiopathic tremor, Parkinson's tremor, and neurogenic pain by transcutaneous nerve electric stimulation. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: design 2 perspective view. 5. Design 2 is designated as the basic design.

The invention discloses a painless non-intrusive simulation acupuncture therapy VR (virtual reality) system integrating multi-sensory stimulation and personalized adaptation, which comprises an intelligent treatment scheme management module, a processing control module, a multi-sensory stimulation module, a dynamic acupuncture point adaptation module and an audio guide module, the system fundamentally avoids safety risks such as acupuncture pain, subcutaneous hemorrhage and local infection, eliminates treatment fear of people sensitive to the pain, improves user acceptance and long-term treatment compliance, and compared with traditional invasive acupuncture, the system does not need a strict disinfection process and whole-course operation monitoring of professional doctors, and is convenient to use and popularize. Potential safety hazards in the treatment process are reduced, the device is more suitable for being used in diversified scenes such as homes and grassroots, and the strict dependence of traditional acupuncture on the treatment environment and professional resources is broken through.

This invention regarding touch therapy has been around for centuries, and continues to evolve into various models and styles. This therapy has been practiced by various groups and is believed to reduce muscle pain, relieve stress, and provide relaxation. One touch therapy that is part of sensory integration is deep touch pressure therapy. By applying deep pressure to the body of an individual experiencing anxiety disorders, the body will feel embraced and the user will feel calmer. Current deep touch pressure therapy devices still have limitations in mobility and flexibility, so further design studies are needed to support the invention of flexible therapy devices. This invention is a vest-shaped therapy device that uses a strap tightening mechanism to provide a pressure sensation to the user.The simple shape of the vest can be a solution to the need for a therapy tool that is easy to carry and apply.

The present disclosure relates to methods of treating nerve injuries. In particular, the present disclosure relates to methods of repairing severed peripheral nerves in a subject as well as reducing pain and increasing protective sensation.

The present invention relates to a composition comprising eptinezumab and LuAG09222. This composition may be used, for example, to treat or prevent headache, pain, migraine, cluster headache, or endometriosis.

The utility model provides a limb circumference measuring device, which relates to the technical field of medical instruments and comprises a positioning cover, two sides of the positioning cover are respectively connected with a measuring scale through a flexible connecting piece, each measuring scale comprises a shell and two measuring tapes arranged in the shell, two openings are oppositely arranged on the shell, and the measuring tapes are arranged on the two openings. And the measuring ends of the two measuring tapes can be drawn out respectively. According to the utility model, the measuring ruler with the two measuring tapes is arranged, so that the measuring ends of the two measuring tapes can be respectively drawn out from the openings at the two ends to carry out two-section measurement, and compared with the mode of measuring around the limb by one circle in the prior art, the limb circumference can be measured only by simply rotating the limb without lifting the limb away from the bed surface when the limb circumference is actually measured; the limb pain of a patient can be relieved.

The invention includes a group of devices allowing people to indicate when and where they experience pain or discomfort, and a system and method for using this information to improve clinical medical care. The user can indicate, with the user's finger, tongue, or in other ways, where on the user's body, or in the user's mouth, the user is experiencing pain, and the pain's intensity. Some versions of the invention include models of parts or all of a person's body, so the user can show where, and how much, pain is being experienced. The invention also includes a group of programs and databases for monitoring the pain users experience and for drawing conclusions about modifying medical and dental procedures to reduce pain that patients experience. The invention can also be used to monitor other sensations such as “itchiness”.

To properly provide, when haptic sensation with electric stimulus is provided, the haptic sensation without causing pain.SOLUTION: A haptic feedback device includes: a waveform processing unit 12 which processes haptic signals generated from haptic vibration sampled at a predetermined frequency to form pulse voltages of a predetermined short intervals, for each sampling signal; and a pulse application unit 22 which applies the pulse voltages of the predetermined short intervals obtained in the waveform processing unit 12 to electrodes 23a, 23b, 23c that are brought into contact with skin. Accordingly, haptic sensation can be provided to a fingertip, or the like, properly without causing pain.SELECTED DRAWING: Figure 1

A method and system for differentiating acute and chronic pain based on the functional state of specific neural circuits is proposed. This method utilizes in vivo two-photon / endoscopic calcium imaging and ex vivo brain slice patch-clamp techniques to longitudinally monitor the activity dynamics of neurons in the DRN and ZI brain regions during the acute and chronic phases of a neuropathic pain model. By extracting and analyzing calcium and electrophysiological signal parameter sets, distinguishing criteria are established: if the activity of 5-HTergic neurons in the DRN is specifically enhanced in the acute phase, the indication is acute pain; if the activity of GABAergic neurons in the ZI is specifically enhanced in the chronic phase, the indication is chronic pain. This invention achieves an objective and precise differentiation of the transition from acute to chronic pain at the level of specific neural circuits, providing a new strategy and tool for pain mechanism research and clinical diagnosis and treatment.

The invention relates to bromhexine or a salt thereof for treating acute or chronic pain in a patient. In particular, the invention relates to bromhexine or a salt thereof for use in treating nociceptive pain, neuropathic pain and or dysfunctional pain. The invention further relates to a topical pharmaceutical composition comprising bromhexine or a salt thereof and to a composition or a topical pharmaceutical composition comprising bromhexine or a salt thereof for treating acute or chronic pain.