248 results about "Pain sensations" patented technology

A method and apparatus particularly useful for pain control by selectively blocking the propagation of body-generated action potentials travelling through a nerve bundle by using a tripolar electrode device to generate unidirectional action potentials to serve as collision blocks with the body-generated action potentials representing pain sensations in the small-diameter sensory fibers. In the described preferred embodiments there are a plurality of electrode devices spaced along the length of the nerve bundle which are sequentially actuated with delays corresponding to the velocity of propagation of the body-generated action potentials through the large-diameter fibers to produce a "green wave" effect which minimizes undesired anodal blocking of the large-diameter fibers while maximizing the collision blocking of the small-diameter fibers.

Devices, systems and methods are provided for treating pain while minimizing or eliminating possible complications and undesired side effects, particularly the sensation of paresthesia. This is achieved by stimulating in proximity to a dorsal root ganglion with stimulation energy in a manner that will affect pain sensations without generating substantial sensations of paresthesia. In some embodiments, such neurostimulation takes advantage of anatomical features and functions particular to the dorsal root ganglion.

The present invention relates to methods of affecting chronic pain by electrically and / or chemically stimulating target sites of the pain circuitry associated with chronic pain. Such target sites include cerebral target sites, including limbic structures, associated with the emotional and suffering components of chronic pain, as well as deep brain target sites associated with the affective and sensory components of chronic pain. Also provided is a method of affecting chronic pain by stimulating a target site of the pain circuitry associated with chronic pain to stimulate the synthesis or release of endogenous opioids.

Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and / or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.

A method, system, device and an artificial tooth is disclosed for simulating both pain and anesthesia in a model of jaws. The tooth is equipped with sensors and connected to a data processing unit, memory unit and audiovisual display unit. The system is for teaching and practicing in the field of dentistry according to which removing artificial tooth or artificial bone substances by a dental drill, generates signals of pseudo pain with different intensities. Signals are fed to the data processing unit which simulates perception of the simulated pain and accordingly to said audio-visual display unit which simulates reaction to the different intensities of generated pseudo pain signals by playing different sounds which are stored in said memory unit. Furthermore, the system is able to simulate anesthesia by generating block signals as a result of applying different anesthetic techniques by means of a dental syringe connected to the system.

The present invention provides a method for the long-term relief of chronic pain in a subject by activating in the subject an analgesic alpha-adrenergic receptor in the absence of alpha-2A receptor activation over a period of at least three days, such that relief of chronic pain is maintained in the absence of continued activation of said receptor. The analgesic alpha-adrenergic receptor can be, for example, the alpha-2B receptor.

Described herein is a novel fMRI-based neurologic signature that predicts pain. Further described are methods for detecting pain, for diagnosing pain-related neuropathic conditions and for predicting or evaluating efficacy of an analgesic based on the neurologic signature.

The invention relates to a substance for curing or relieving pain, and provides application of a gamma-aminobutyric acid A receptor inverse agonist containing alpha 5 subunits in preparing a drug for preventing and improving or curing the pain and also provides a drug composition containing the substance for curing or relieving the pain.

Novel peripheral antinociceptive compounds are disclosed having a pharmacophore unit that target small-diameter nerve fibers that transmit signals of pain and discomfort from the soma and viscera. By acting on this target, the pharmacophore unit obtunds pain and diminishes hyper-reflexia from organs such as the skin, the respiratory tract, the corpus, the lower urinary tract, and the bowel. The pharmacophore unit is coupled to substituents that facilitate delivery of the pharmacophore to its target.

In general, the invention features methods for identifying therapeutic interventions for functional illnesses, e.g., neuropathic pain or depression, and methods for identifying markers for functional illnesses by employing an acute painful stimulus or other stimulus for a functional illness and measuring levels of CNS activity.

The disclosure describes devices and methods for providing transdermal electrical stimulation therapy to a subject including positioning a stimulator electrode over a glabrous skin surface overlying a palm of the subject and delivering electrical stimulation via a pulse generator transdermally through the glabrous skin surface and to a target nerve or tissue within the hand to stimulate the target nerve or tissue within the hand so that pain felt by the subject is mitigated. The pulses generated during the electrical stimulation therapy may include pulses of two different magnitudes.

Neuromodulation devices and methods of their use are described in which a therapeutic device is configured to generate a treatment for treating pain such as the reduction of the symptoms of chronic and acute pain as well as for treating other conditions. The neuromodulation device generates an output electrical signal in the form of pulses with a fast rise-time spike waveform followed by a longer-duration, lower amplitude primary phase waveform. The output signal includes a broad range of frequency components, with time constants tuned so as to interact with specific cell membrane or cellular components. The output signal may be conducted to the patient via electrodes. The pulses are triggered at variable intervals which prevent habituation.

The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator.

This present invention relates to not only providing the conventional support for upper and lower back under normal circumstances of a proper sitting position, it even provides a self-adjusting experience and improved degree of lumbar support whenever a relaxed lean-backward seating posture is taken. This Self-Adjusting Cushion has executed without any compromise of losing the expected level of contoured support for the spine to be in proper alignment. Thus relieving and alleviating any possible fatigue or pain due to improper sitting position.Portable, Inflatable and Self-Adjusting Cushion for Upper and Lower Back Support is a sealed support device, which is configured and designed with a semi-oval shape structure to provide the contoured lumbar support. It is characterized with the following major components:1. 3 rectangular-shaped slip-sheets of different breadths (depth) but of same length are attached horizontally and parallel to one another. They are configured to be at different heights of the cushion. They are hidden within the sealed support device to form 3 open compartments. During the self-adjusting phenomena, these 3 sheets will prevent the sealed support device from being over-expanded beyond its maximum depth to avoid creation of any discomfort to user when more than necessary volume of air is pumped into the sealed support device. In addition, these 3 sheets together will yield the desired semi-oval shaped cushion to provide support for the lumbar region.2. A safety air valve that allows user to manually adjust the degree of firmness for desired comfort by pumping air into or releasing air from the sealed cushion.3. Two adjustable elastic straps with buckles—allow the cushion to be either fixed onto any sizes of seat or to the different sizes of waistline of users.

Methods for treating atrial arrhythmias can involve configuring an implantable arrhythmia treatment device. A device can be configured after implantation when the patient is fully conscious and after any pain suppression medication has worn off. The device is caused to apply a phased unpinning far field therapy to the patient in response to detection of an arrhythmia via a far field configuration of electrodes. An indication of a pain sensation of the patient and the effectiveness of the treatment in response to the therapy can then be received. In response, at least one of a set of therapy parameters is adjusted and the steps are repeated until it is determined that an effective treatment is provide at a pain sensation that is tolerable to the patient. The device is then programmed to automatically treat arrhythmias detected in the patient with the determined set of therapy parameters.

The present invention concerns the novel use of compounds of the Formula I: for treating allodynia as major and unique pain symptom independent of the nature of an underlying disease, but that is often related to neuropathic pain or other different types of chronic or phantom pain.

Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.

The invention discloses a cold / hot pain stimulation system, which mainly solves the problem that the laser stimulation equipment in the prior art cannot refrigerate and is complex in operation and high in cost in a nuclear magnetic environment. The cold / hot pain stimulation system comprises a cold / hot stimulation head (1), a protective net (2), a heat radiation water tank (3), a water pump (4), a water storage tank (5), an embedded type control module (6) and an upper computer, wherein the cold / hot stimulation head (1), the heat radiation water tank (3), the water pump (4) and the water storage tank (5) are connected with each other in sequence to form a water circulation system through water pipes; the cold / hot stimulation head (1) is connected with the upper computer (7) through the embedded type control module (6); the embedded type control module (6) controls the cold / hot stimulation head (1) to stimulate human skin according to the stimulation temperature set by the upper computer; and the actual stimulation temperature and pain sensation scores are transmitted to the upper computer (7) for storage and display through the embedded type control module (6). The cold / hot pain stimulation system disclosed by the invention is easy in operation and safe in use, and can be used for studying the pain sensation and evaluating pain relieving effect in a nuclear magnetic environment.

A system and method for measuring an infant's pain intensity is presented. The method for assessing an infant's pain intensity based on facial expressions is comprised of three main stages: detection of an infant's face in video sequence followed by preprocessing operations including face alignment; expression segmentation; and expression recognition or classification. Also presented is a multimodal system for assessing an infant's pain intensity using the following classifiers: facial expression classifier; vital sign classifier; crying recognition classifier; body motion classifier and state of arousal classifier. Each classifier generates an individual score, all of which are normalized and weighed to generate a total pain score that indicates pain intensity.

A combination comprising as components (a) the compound 3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol, and (b) one or more non-steroidal anti-inflammatory drugs (NSAIDs); a pharmaceutical salt comprising said components; a compound derived from said components; a pharmaceutical formulation and a dosage form comprising said combination, salt, or compound; as well as a method of treating pain, e.g. chronic or acute pain, in a mammal characterized in that components (a) and (b) are administered simultaneously or sequentially to a mammal, wherein component (a) may be administered before or after component (b) and wherein components (a) or (b) are administered to the mammal either via the same or a different pathway of administration.

The present disclosure is directed to a system and method for selectively and reversibly modulating targeted neural and non-neural tissue of a nervous system for the treatment of pain. An electrical stimulation is delivered to the treatment site that selectively and reversibly modulates the targeted neural- and non-neural tissue of the nervous structure, inhibiting pain while preserving other sensory and motor function, and proprioception.

The exemplified systems and methods facilitate a nerve conduction block at a target nerve using electrical stimulation applied from one or more electrodes located on a percutaneous lead that are placed in parallel, or substantially in parallel, and without direct contact, to a long axis of the peripheral nerve over an overlapping nerve region of greater than about 3 millimeters. The exemplified system and method can be further configured to block nerve condition without eliciting onset activity and co-excitation of non-targeted structures. The exemplified method and system can be performed using conventional percutaneous leads, though an improved percutaneous lead design is disclosed herein. In an aspect, an introducer is disclosed that facilitates accurate and consistent insertion of the percutaneous lead to the specified or intended position relative to the target nerve. In another aspect, a treatment kit comprising the various system components to treat pain is disclosed.

This invention relates to aryl or heteroaryl amido alkane derivatives of formula (I) in which Ar1 and Ar2 independently represent phenyl or a 5 or 6-membered heteroaromatic ring, R6 represents carboxyl or tetrazolyl, and the remaining variables are as defined in the text and claims, which are useful as an active ingredient of pharmaceutical preparations. The aryl or heteroaryl amido alkanes of the present invention have PGI2 antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with PGI2 activity. Such diseases include urological diseases or disorder as follows: bladder outlet obstruction, overactive bladder, urinary incontinence, detrusor hyper-reflexia, detrusor instability, reduced bladder capacity, frequency of micturition, urge incontinence, stress incontinence, bladder hyperreactivity, benighn prostatic hypertrophy (BPH), prostatitis, urinary frequency, nocturia, urinary urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostatodynia, cystitis, or idiophatic bladder hypersensitivity. The compounds of the present invention are also useful for treatment of pain including, but not limited to inflammatory pain, neuropathic pain, acute pain, chronic pain, dental pain, premenstrual pain, visceral pain, headaches, and the like; hypotension;hemophilia and hemorrhage; and inflammation, since the diseases also relate to PGI2.

The inventive method for processing an RR series comprises a plurality of (RR) samples representing time intervals (dti) between two successive heart beats or the inverse (1 / dti) of said time intervals consists in selecting (N) (RRi) samples in a main time window having a predetermined length (n), in cutting said main window into (m) subwindows (Fj), in calculating an intermediate parameter (A1) for each subwindow (Fj) on the basis of the (RRi) samples contained in the subwindow (Fj) and in calculating a final parameter as a function of the intermediate parameters (Aj).The invention is used for analysing a cardiac rhythm variability, in particular for assessing a patient's pain or stress.