44 results about "Pain sensations" patented technology

1. The name of the design product: electric stimulation instrument connecting belt. 2. The use of the design product: used with the main machine and electrodes together, for the treatment of idiopathic tremor, Parkinson's tremor, and neurogenic pain by transcutaneous nerve electric stimulation. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: design 2 perspective view. 5. Design 2 is designated as the basic design.

The present invention relates to a composition comprising eptinezumab and LuAG09222. This composition may be used, for example, to treat or prevent headache, pain, migraine, cluster headache, or endometriosis.

A method and system for differentiating acute and chronic pain based on the functional state of specific neural circuits is proposed. This method utilizes in vivo two-photon / endoscopic calcium imaging and ex vivo brain slice patch-clamp techniques to longitudinally monitor the activity dynamics of neurons in the DRN and ZI brain regions during the acute and chronic phases of a neuropathic pain model. By extracting and analyzing calcium and electrophysiological signal parameter sets, distinguishing criteria are established: if the activity of 5-HTergic neurons in the DRN is specifically enhanced in the acute phase, the indication is acute pain; if the activity of GABAergic neurons in the ZI is specifically enhanced in the chronic phase, the indication is chronic pain. This invention achieves an objective and precise differentiation of the transition from acute to chronic pain at the level of specific neural circuits, providing a new strategy and tool for pain mechanism research and clinical diagnosis and treatment.

Systems and methods are provided for applying electrical stimulation to a body by an electrode spaced from a target nerve of passage. It has been discovered that pain felt, or perceived to be felt, in a given region of the body can be treated by stimulating muscle close to a “nerve of passage” in a region that is superior (i.e., cranial or upstream toward the spinal column) to the region where pain is felt, such as in a case of post-amputation residual limb pain, or purportedly felt in the case of post-amputation phantom limb pain.

The present invention relates to sulfoxylated phenothiazine for use as a medicament. The present invention also relates to sulfoxylated phenothiazine for use in the treatment of painful sensations induced by neuropathy. The present invention also relates to a pharmaceutical composition comprising at least one sulfoxylated phenothiazine.

The application relates to the technical field of electroencephalogram signal evaluation, in particular to a pain evaluation model, method and system based on electroencephalogram signals and contrast learning; wherein the model comprises a cascade-connected lightweight channel attention network and a contrast learning interaction layer; the lightweight channel attention network serves as a backbone network and is used for receiving a preprocessed standardized electroencephalogram signal segment and outputting a potential representation vector of the electroencephalogram signal; the contrast learning interaction layer is used for obtaining pretraining weights through pretraining and comprises a hierarchical soft contrast module, a time dynamic contrast module and a debiased clustering contrast module which are connected in parallel to an output end of the lightweight channel attention network; the lightweight channel attention network adjusts parameters based on the pretraining weights and outputs a pain evaluation result through a classifier. The evaluation model can effectively utilize unannotated data and overcome individual differences, and has the characteristics of accurately capturing the time sequence dynamic change of pain.

Provided herein is a compound of Formula (1)(WB3), or a pharmaceutically acceptable salt thereof, compositions thereof, and methods and uses for inducing anesthesia and / or treating pain.

This invention relates to the fields of digital therapy, intelligent medical devices, and applied artificial intelligence technologies, and more specifically to a closed-loop pain management method and system integrating diagnostic assistance and interference-resistant sensing. It includes: a wearable device comprising: a neuromodulation signal generator configured to generate neuromodulation stimulation pulses; a biosensor array physically integrated with the neuromodulation signal generator configured to sense physiological data indicating the user's autonomic nervous system activity; a controller configured to execute a time-division multiplexing protocol; a processor; and a non-transitory computer-readable storage medium associated with the processor for generating a diagnostic support report. This invention enables simultaneous effective neural stimulation and high-fidelity ANS signal acquisition on a single wearable device.

The application discloses a pain relief method combining virtual reality and non-invasive nerve regulation, and relates to the technical field of virtual reality, which comprises collecting resting-state electroencephalogram signals of a subject's anterior cingulate gyrus region to obtain baseline electroencephalogram data; setting initial parameters of time-interference electric stimulation according to the baseline electroencephalogram data, and performing three-dimensional scanning on the subject's pain site based on a depth camera to generate a three-dimensional body model; mapping the three-dimensional body model to a virtual reality environment, constructing a virtual avatar, and rendering a comforting intervention object in the pain area of the virtual avatar, and synchronously activating a temperature feedback device, a tactile actuator and a spatial audio device to form a multi-sensory immersive comforting scene; at the moment when the comforting intervention object completes spatial registration and is presented to the subject's main visual area for the first time, a time-interference electric stimulation signal is applied to the subject before the moment of the system marker according to a predicted coding time window.

A virtual reality (VR) system for generating pain sensations in VR environments using thermal grill illusion (TGI), comprising a VR device and a wearable thermos-haptic device with a thermoelectric stimulative module for inducing TGI-based pain sensations, a heat sink coupled to the module for temperature regulation and stabilization, and a thermocouple for monitoring and controlling temperature changes.

The purpose of this disclosure is to provide a computer system based on a quantitative pain model, comprising: a preprocessing module, a local temporal feature extraction module, a cross-domain global frequency domain feature extraction module, a cross-domain interactive fusion module, a feature fusion module, and a classification output module. Through a dual-parallel processing architecture of local temporal and cross-domain global pathways, multi-scale convolution and sliding window temporal modeling are used to accurately capture transient and evolutionary temporal features related to pain. Then, through wavelet transform and attention mechanisms, frequency domain oscillation energy closely related to the physiological mechanisms of pain is explicitly extracted. Finally, a cross-domain interactive encoder is used for deep fusion, achieving complementarity and enhancement of temporal and frequency domain features. This disclosure effectively controls the computational scale while maintaining high-precision classification, making it easier to deploy lightweight and perform real-time inference on embedded devices or mobile medical terminals, demonstrating significant practical value.

The application discloses a kind of based on pressure pain sensation's bionic flexible touch sensor and robot active protection method, it is related to bionic robot flexible sensing and safety protection field.The sensor adopts DIW integrated printing process, including flexible silica gel base, cross intersection row and column conductive grid and spherical cap micro convex pressure resistance sensing unit, no layering, full flexibility, can adapt to robot complex curved surface whole body.It is based on the critical pressure intensity of sensor material destruction as benchmark, constructs three-stage progressive quantization bionic pain sensation system, through pain sensation value driving robot executes graded protection action, core through expanding force area to eliminate structural risk from root;While constructing whole body partition density bionic skin system, fusion foot bottom pressure and gyroscope data realizes walking balance adjustment.The application gives consideration to sensing accuracy and engineering cost, greatly improves the bionic sensing ability of humanoid robot, operation safety and structure life.

This invention relates to the field of blood drawing nursing technology, specifically a blood drawing nursing device to reduce psychological resistance. It includes a partition with a display screen embedded inside. An airbag A is installed inside the partition, and an air pump is connected to one side of airbag A. A support plate is connected to one side of the partition, and a grip ring is fixedly connected to the upper end of the support plate. Guide grooves are installed on both sides of the support plate, and cooling plates slide inside both sets of guide grooves. An airbag B is fixedly connected to the outside of the grip ring. This invention generates continuous tactile stimulation by the reciprocating motion of the cooling plates on both sides of the arm. This physical stimulation, through nerve conduction, distracts the brain's attention, reducing the pain of needle insertion and lowering the patient's sensitivity to pain. Simultaneously, the partition and the display screen block the patient's direct line of sight to the needle and puncture site, preventing fainting and tension caused by visual stimulation, thus keeping the patient relaxed during the blood drawing process.

Provided herein are methods and compositions for reducing and preventing pain. In some embodiments, the methods include administration of a composition to an individual experiencing pain, the composition including one or more of Incarvillea sinensis, Salix alba, Tanacetum parthenium, Petasites hybridus, papain, and bromelain.

The application relates to the technical field of data processing, and discloses a postoperative pain recognition system and method based on electroencephalogram signals, which comprises an electroencephalogram acquisition module, a signal preprocessing module, a pain intensity analysis module and an output and control module; the electroencephalogram acquisition module is used for collecting original electroencephalogram signals of a postoperative patient according to a preset sampling rate; the signal preprocessing module is used for filtering and denoising the original electroencephalogram signals and removing abnormal sections based on dynamic time warping to obtain preprocessed electroencephalogram signals; the pain intensity analysis module is used for deploying a deep neural network model, receiving the preprocessed electroencephalogram signals, inputting the preprocessed electroencephalogram signals into the deep neural network model and outputting a pain intensity grade; and the output and control module is used for displaying or transmitting the pain intensity grade and converting the pain intensity grade into a control instruction. The application fuses wavelet convolution and LSTM dynamic modeling, and improves the pain recognition and distinction precision.

The application discloses an auxiliary method for realizing comfortable injection, comprising the following steps: acquiring anatomical structure information of a target region, planning at least one needle entry point for an injection operation in the target region based on preset blood vessel distribution data, and generating corresponding needle entry angle guiding information, wherein the needle entry direction indicated by the needle entry angle guiding information is 90 degrees with the normal of the skin surface; performing pre-analgesic intervention and / or tactile dispersion intervention at the needle entry point; and performing the injection operation at the needle entry point according to the needle entry angle guiding information. By combining the precise pre-analgesic intervention of the "micro-point infiltration type" and the tactile dispersion intervention based on the sensory interference principle, the pain signal intensity perceived by the brain can be significantly reduced before and at the moment of needle entry, so that the pain of the subject during the operation approaches "zero", and the comfort and acceptance of the operation are greatly improved.

The present application relates to S ) -2-((3-((benzo[ d [1,3]dioxolane-5-oxomethyl)benzyl)-amino)propanamide, to pharmaceutical compositions containing it, and to the use of this crystalline form for the preparation of a medicament for the prevention and / or treatment of pain (e.g. neuropathic pain, including chronic neuropathic pain or neuropathological pain).

An apparatus includes a facial expression detection device and a computing device, the computing device being configured to receive facial pattern input from the facial expression detector, identify one or more micro-expressions in the facial pattern input, and predict one or more of pain intensity and pain source based on the identified one or more micro-expressions. Various aspects of the disclosed embodiments aim to identify pain sources non-contactly based on pain-induced micro-expressions using machine learning.

The application discloses application of anterior piriform cortex GABAergic neurons as an analgesic target point, and relates to the technical field of neuroscience and pain. GABA The application discloses that the neural loop (APC GABA →MD) from the anterior piriform cortex GABAergic neurons to the thalamic dorsal medial nucleus plays a key role in pain regulation. Experiments prove that the loop can not only relieve acute pain, but also has a significant analgesic effect on the clinical treatment of intractable chronic inflammatory pain and neuropathic pain models, and shows a wide treatment application prospect.

Embodiments of a method for treating a patient suffering from chronic pain are described. A source location of chronic pain in a patient is first identified. A regional anaesthetic is then used to temporarily block selected nerves to confirm the source location and identify a target nerve. An electrode array of a neuromodulation apparatus is then implanted in the patient over the target nerve, such as just under the stratum corneum, and the neuromodulation apparatus is then used to stimulate the electrode array to create a long term conduction block that provides persistent pain relief to the patient.

This invention provides the application of berberine II derivatives in the preparation of drugs for treating diabetic foot, belonging to the field of biomedical technology. This invention is the first to discover that berberine II derivatives can significantly improve symptoms such as decreased motor / sensory nerve conduction velocity and loss of pain sensation in diabetic foot model rats, and promote wound healing in the affected foot. Berberine II derivatives hold promise for further development and research as a novel drug for treating diabetic foot.

This invention discloses a wearable multimodal physical stimulation control method and device for chronic pain management, belonging to the field of wearable stimulation device technology. It includes setting intensity levels for different stimulation modes; collecting feedback data and establishing an optimal stimulation mode through a mode determination method; prioritizing stimulation modes other than the dominant stimulation mode under the optimal stimulation mode and determining stimulation parameters; during stimulation, adjusting different stimulation modes based on feedback data and priority ranking, and updating stimulation parameters; when the user adjusts the intensity level of the dominant stimulation mode, first determining temporary stimulation parameters, using these temporary parameters for stimulation while updating the stimulation parameters through feedback adjustment. This invention produces the most direct pain management effect on different causes of pain through different dominant stimulation modes, and achieves multimodal fusion stimulation by employing multiple different auxiliary stimulation modes, improving analgesic effects and relieving discomfort symptoms.

The application discloses a TENS and iontophoresis composite closed-loop analgesic patch, and belongs to the field of medical devices. The patch comprises a flexible substrate, a multi-modal sensor array, a transcutaneous electrical nerve stimulation unit, an iontophoresis drug delivery unit, a control module and a multi-level safety control unit. The sensor array collects surface electromyography signals and cutaneous electric response signals, and the control module calculates a pain probability value and executes a hierarchical control strategy: standby when the pain probability value is below a first threshold value, only activate the TENS unit when the pain probability value reaches or exceeds the first threshold value but is below a second threshold value, and simultaneously activate the TENS unit and the iontophoresis drug delivery unit after dose safety confirmation when the pain probability value reaches or exceeds the second threshold value. The multi-level safety control unit comprises a dose counter and a sensor detachment detection module, which are used for preventing drug overdose and accidental triggering. The application combines physical analgesia and chemical analgesia, realizes double analgesic effects of "instant + continuous", and guarantees the safety of home use through a multi-level safety mechanism.

This invention discloses an intelligent electro-pulse therapy control method based on AI adaptive feedback, relating to the field of electro-pulse therapy control. The method includes the following steps: collecting biofeedback signals from the therapy user and simultaneously collecting the user's subjective feedback data; converting the subjective feedback data into effective subjective data and performing preliminary analysis of the feedback analysis data between different biofeedback signals and subjective feedback data; deeply analyzing the influence of different biofeedback signals on the subjective feedback data, and simultaneously constructing historical reference analysis schemes and predictive reference analysis schemes to calibrate the impact on the feedback analysis data, obtaining feedback reference data; and intelligently controlling the intelligent electro-pulse therapy based on the feedback reference data. This invention addresses the problem that existing electro-pulse therapy control technologies lack intelligent and accurate acquisition of pain perception, resulting in an inability to adjust the intensity of the electro-pulse in a timely and accurate manner.

This invention discloses a method and system for facial pain expression analysis based on spatiotemporal information. By sampling facial expression videos using a sliding window, several video segments are obtained, improving dataset utilization. Discrete cosine transform is applied to the video frames, followed by sawtooth scanning for enhancement, resulting in detailed feature enhancement maps that enhance detail information. Then, all video frames and their corresponding detailed feature enhancement maps from each sampled video segment are combined and input into a Transformer model. The Transformer model uses a concatenated cross-processing method to extract and fuse temporal and spatial features. Finally, the pain analysis result is obtained based on the pain level corresponding to each sampled video segment. This method effectively extracts feature information from facial expression videos, resulting in high accuracy in pain assessment.

The present disclosure relates to contraceptive devices providing enhanced sensation to the user. The contraceptive devices contain adhesives containing a stimuli-responsive polymer that readily delaminates without pain following application of a stimulus. The present disclosure also relates to fractional condoms that cover the glans of the penis. Methods of applying and removing the contraceptive devices, as well as methods of making the contraceptive devices, are also provided.