31 results about "Pain perception" patented technology

A method of detecting pain in a subject, comprises the steps of generating brain wave data based on brain wave activity of the subject and comparing the brain wave data to reference data to generate result data, the reference data corresponding to at least one of (i) population normative data indicative of brain wave activity of a first plurality of individuals in an absence of pain, (ii) population reference data indicative of brain wave activity of a second plurality of individuals generated in response to pain events inflicted on the second plurality of individuals, (iii) subjective population reference data indicative of brain wave activity of a third plurality of individuals reporting a sensation of pain, and (iv) population of reference data indicative of brain wave activity of a fourth population of individuals following an intervention which has changed a subjective report of pain in combination with determining a presence of pain experienced by the subject as a function of the result data.

A variety of zinc finger proteins (ZFPs) and methods utilizing such proteins are provided for use in treating chronic pain. ZFPs that bind to a target site in genes that are aberrantly expressed in subjects having chronic pain are described. In addition, ZFPs that bind to a target site in genes expressed at normal levels in subjects experiencing chronic pain, modulation of whose expression results in decreased pain perception, are also provided. For example, genes that are over-expressed in the dorsal root ganglia (DRG) of pain patients (e.g., Nav1.8) can be repressed.

The role of the epsilon isozyme of protein kinase C ("PKCepsilon") in pain perception, particularly hyperalgesia, methods of lessening pain through administration of inhibitors of PKCepsilon, methods of identifying compounds that modulate pain, and pharmaceutical compositions comprising an inhibitor of PKCepsilon and PKCepsilon-independent analgesic agent are disclosed.

Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing may be guided or visualized using imaging techniques such as ultrasound imaging or other types of non-invasive imaging techniques.

A variety of zinc finger proteins (ZFPs) and methods utilizing such proteins are provided for use in treating neuropathic pain. ZFPs that bind to a target site in genes that are aberrantly expressed in subjects having neuropathic pain are described. In addition, ZFPs that bind to a target site in genes expressed at normal levels in subjects experiencing neuropathic pain, modulation of whose expression results in decreased pain perception, are also provided. For example, genes that are over-expressed in the dorsal root ganglia (DRG) of pain patients (e.g., VR1, TRKA and / or Nav1.8) can be repressed, whereas genes that are under-expressed in the same populations can be activated.

Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing is employed to identify the scope and severity of chronically painful sensitized tissue areas, and of chronic pain disorders. In other applications, targeted acoustic probing is used to localize nerves and other sensitized tissues for guidance of needles and other delivery devices, and for delivery of anesthetic, analgesic or therapeutic compositions.

The invention discloses diaper rash cream and a preparation method thereof. The diaper rash cream is prepared from the main components of petrolatum, caprylic / capric triglyceride, avocado tree fruit fat, polyglyceryl-4 isostearate, meadowfoam seed oil, gallnut extract, microcrystalline wax, polydimethylsiloxane, Sorbitan olivate, Quaternium-18 Hectorite, propylene glycol, Chrysanthellum indicum extract, sodium dehydroacetate, butanediol, hydrolyzed rice protein, Anthemis nobilis flower extract, radix sophorae extract, fructus cnidii extract, Bisabolol, Ginger Root Extract, Hexyldecanol, Brassinosteroids, N-palmitoyl hydroxyproline cetyl ester, stearic acid, menthol, tocopheryl acetate, perfume, p-hydroxyacetophenone, caprylyl glycol, 1,2-hexanediol, chlorhexidine diacetate, disodium EDTA and water through synergistic interaction in an appropriate ratio by the scientific preparation method, and the produced diaper rash cream has good skin care and skin-firming effect and good affinity,can relieve skin pain, and has good stability.

The role of the epsi isozyme of protein kinase C ("PKCepsi") in pain perception, particularly hyperalgesia, methods of lessening pain through administration of inhibitors of PKCepsi, methods of identifying compounds that modulate pain, and pharmaceutical compositions comprising an inhibitor of PKCepsi and PKCepsi-independent analgesic agent are disclosed.

A method of detecting pain in a subject, comprises the steps of generating brain wave data based on brain wave activity of the subject and comparing the brain wave data to reference data to generate result data, the reference data corresponding to at least one of (i) population normative data indicative of brain wave activity of a first plurality of individuals in an absence of pain, (ii) population reference data indicative of brain wave activity of a second plurality of individuals generated in response to pain events inflicted on the second plurality of individuals, (iii) subjective population reference data indicative of brain wave activity of a third plurality of individuals reporting a sensation of pain, and (iv) population of reference data indicative of brain wave activity of a fourth population of individuals following an intervention which has changed a subjective report of pain in combination with determining a presence of pain experienced by the subject as a function of the result data.

Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing is employed to identify the scope and severity of chronically painful sensitized tissue areas, and of chronic pain disorders. In other applications, targeted acoustic probing is used to localize nerves and other sensitized tissues for guidance of needles and other delivery devices, and for delivery of anesthetic, analgesic or therapeutic compositions.

A Chinese medicine composition for treating knee osteoarthritis and a preparation method thereof. The Chinese medicine composition comprises: by weight, 40 to 50 parts of Unprocessed Semen Strychni, 40 to 50 parts of Unprocessed Radix Aconiti, 30 to 40 parts of Unprocessed Radix Aconiti Kusnezoffii, 35 to 45 parts of Frankincense, 50 to 60 parts of Myrrh and 25 to 35 parts of Angelica sinensis. The Chinese medicine composition provided by the invention has favorable effects of activating blood circulation and arresting pain perception on knee osteoarthritis, and clinical data shows that a recurrence rate of knee osteoarthritis is very low after treatment utilizing the Chinese medicine composition.

The invention discloses a mammary gland imaging device. The device comprises a compressing plate used for compressing the mammary gland, and a control processing part used for controlling the compressing plate to compress the mammary gland, and further comprises a pain perception part used for perceiving physiologic pain information of an examinee and sending the pain information to the control processing part, wherein the control processing part is further used for controlling the compressing plate to compress the mammary gland according to the physiologic pain information. According to the mammary gland imaging device, the compressing operation of the mammary gland compressing plate is controlled by detecting the pain information of the examinee; the compression is continuously applied when a compressing upper limit value is not exceeded, and the pain information of the examinee is detected; and once the examinee is discovered to feel uncomfortable or painful, the situation can be fed back to the control processing part through the pain perception part, and the compression on the mammary gland is stopped, so that the injury caused by the fact that the examinee feels painful or the mammary gland is excessively oppressed can be avoided and a relatively user-friendly and intelligent control effect is achieved.

The invention encompasses a method for treating a disease or condition mediated by the human MRG-X1 receptor, such as nociception, hyperalgesia, allodynia, pain related to central hypersensitivity conditions, somatic pain, visceral pain, acute pain, chronic pain, post-operative pain, headache, inflammatory pain, neurological pain, musculoskeletal pain, cancer related pain or vascular pain, in a human patient in need thereof comprising administering to the patient a therapeutically effective amount of a 3-substituted-2-(diphenylmethy)-1-azabicyclo[2.2.2]octane or a pharmaceutically acceptable salt thereof. The invention is also directed to the use of these compounds as molecular tools to directly explore the role of the MRG-X1 receptor in pain perception.

This invention provides a conjugate comprising Substance P, or an analog thereof, and a protein, such as Saporin, that inhibits protein synthesis.This invention provides a method of reducing the perception of pain by a subject comprising administering to the subject an effective amount of the pharmaceutical composition of the conjugate comprising Substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, so as to reduce the perception of pain by the subject.This invention provides a method of selectively destroying NK-1R-expressing neuronal cells in a subject comprising administering to the subject an effective amount of the conjugate comprising Substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, so as to selectively destroy NK-1R-expressing neuronal cells.Lastly, this invention provides a method for treating a NK-1R-associated disorder in a subject, which comprises administering to the subject an amount of the pharmaceutical composition comprising substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, in an effective amount to treat the disorder associated with the NK-1R.

The invention provides a surgical anesthesia pain perception monitor capable of more accurately testing physiological indexes such as neural activity in the surgical anesthesia process of a patient. The surgical anesthesia pain perception monitor comprises a laser Doppler sensing device (2), an electrocardiogram monitoring device (3), a respiratory monitoring device (4), a pulse monitoring device (5), a peripheral nerve signal monitoring device (6), a central venous blood pressure monitoring device (7), an end-tidal carbon dioxide monitoring device (8), an invasive arterial blood pressure monitoring device (9) and a non-invasive arterial blood pressure monitoring device (10) which are all electrically connected with a central processor (1), and also comprises a power supply used for supplying power to each electric component.

The invention discloses a drug for oral local anesthesia of a pregnant woman and a preparation method thereof. The drug is prepared from herba asari, sculellaria barbata, liquorice, fructus forsythiae, folium et cacumen murrayae, acutangular anisodus roots, flos daturae, fructus cnidii, rhizoma cyperi, cacumen biotae, hemp fimble leaves, common nandina fruit, mint, rhizoma ligustici, greater celandine herbs, pseudobulb of fimbriate calanthe, flos magnoliae, cryptotaenia japonica hassk, roots of featherycleft horsegentian, radix angelicae pubescentis, juniper berries, lemongrass herbs, plantainlily-leaved onion herbs, drooping stringbush flower roots and bark, stramonium leaves and halimasch. The drug for the oral local anesthesia of the pregnant woman and the preparation method thereof have the advantages that the drug is used for the oral local anesthesia of the pregnant woman, the anesthetic effect is good, oral treatment is conducted after anesthesia, the painful feeling does not exist, side effects on a patient do not exist, the safety is greatly improved, and a fetus is not affected.

The state of general anesthesia (GA) is essential to many surgical and medical procedures. This state is characterized by loss of consciousness, deep analgesia and suppression of movements. GA is rarely achieved with a single drug, usually requiring the combination of various pharmacological agents. Each drug can interact with one or more molecular targets affecting neuronal excitability and synaptic transmission in multiple regions of the CNS. Agonists of the μ-opioid receptor are commonly used in GA to cause analgesia, but not to induce or maintain loss of consciousness or movement suppression. Additionally, agonists of the μ-opioid receptor can cause serious unwanted side effects, e.g. respiratory depression. The present invention provides alternative combination products based on K-opioid receptor agonists. These combination products unexpectedly induced loss of consciousness, and were able to achieve and maintain GA. Furthermore, the combination products suppressed pain perception without the need of a μ-opioid receptor agonist. The combination of Salvinorin A, a selective κ-opioid receptor agonist, with Diazepam or Medetomidine surprisingly led to rapid consciousness, deep analgesia and movement suppression. This combination was found to effectively induce and maintain a state of general anesthesia.

The present disclosure provides compositions suitable for oral use to relieve pain associated with teething in infants and young children. The compositions include a cooling agent in a base formulation that is configured for application to the gums and surrounding tissue and can remain in place for a time sufficient to relive painful sensations, including those arising from teething. The present disclosure further provides methods for relieving pain and / or discomfort in an infant or young child, such as pain and / or discomfort associated with teething.

The invention provides a toilet aid system and method for muscle injury patients. The system comprises a support base disposed on the ground on the periphery of a pedestal pan, a foot separating mechanism disposed at the front end of the pedestal pan, a buttock support mechanism arranged on the support base, a trousers wearing and taking off mechanism arranged on the buttock support mechanism, a back support mechanism disposed on the support base and matched with the buttock support mechanism, a height recognition mechanism disposed on the back support mechanism and a control mechanism arranged on the support base and used for controlling the foot separating mechanism, the buttock support mechanism, the back support mechanism, the trousers wearing and taking off mechanism and the height recognition mechanism. By means of the system, the pain of the patients caused by movement of muscles in the squatting process can be reduced when the patient go to the toilet; at the same time, adjustment can be performed according to the height and the size of the patients to avoid the fact that the patients have poor experience due to different heights. In addition, the system can help the patients to wear and take off the trousers and avoid the muscle pain caused by wearing and taking off of the trousers.

This invention, in one aspect, relates generally to methods for optically modulating pain in animals and human. The invention provides method for the use of opsin for modulating pain, wherein optical stimulation of specific neurons and / or other cells in targeted regions of the nervous system sensitized by opsin, using genetic technologies, leads to significant reduction of pain perception to noxious stimuli. Further, the invention provides a method for inhibition of pain without use of exogenous opsin, wherein visual stimulation of eye (having endogenous opsin) is carried out. The invention also includes device(s) for controlled modulation neural and / or cellular activities in brain, eye and peripheral nervous system in order to treat different forms of chronic pain.

The invention discloses a floor capable of preventing injury during tumbling, which comprises a surface layer, a dispersion layer assembly, floor bodies and a bottom layer, and the bottom layer is laid below the plurality of floor bodies; in order to prevent a user from directly contacting the floor body after falling down, the surface layer and the dispersion layer assembly are mounted on the floor body, the surface layer is integrally laid on the dispersion layer assembly, the hardness of the whole surface layer is moderate, and the walking stability can be improved; when the surface layer is subjected to impact force, the surface layer plays a role in partial buffering at first, then the impact force is conducted to the dispersion layer assembly, the dispersion layer assembly can play a role in partial buffering of the impact force, and then the impact force is conducted to the floor body to frequently buffer the impact force, so that a user is prevented from being injured when falling down on the floor; meanwhile, through the design of the surface layer assembly and the dispersion layer assembly, the pain feeling of a user is further reduced, and the user can conveniently and safely use the floor.

Provided are methods for reversing the effects of agents used for muscular immobilization and / or loss of consciousness and / or loss of pain perception. The method comprises administering a composition comprising acyclic CB[n]-type compounds to an individual in need of reversal of the effects of neuromuscular blocking agents and / or anesthetic agents such that the effects of the agent(s) are partially fully reversed.

Presented herein are devices and systems as well as the methods of using the same for the purpose of reducing and / or ameliorating the sensation of pain, specifically, chronic pain. Particularly, in one aspect, the devices, systems, and their methods of use disclosed herein are effective for reducing peripheral nerve pain, such as resulting from traumatic nerve injury and other types of nerve damage.

Methods of utilizing a gene related to pain perception, herein dubbed HSN2, or its encoded protein, dubbed herein “sensorin,” for the screening and identification of agents for the treatment of pain, neuropathy and related disorders, especially small organic compounds, as well as methods of using these compounds to treat or otherwise ameliorate pain, neuropathy and related disorders in human patients. Novel polypeptides and polynucleotides, along with their nucleotide and amino acid sequences, are also disclosed.

The invention discloses a cold / hot pain stimulation system, which mainly solves the problem that the laser stimulation equipment in the prior art cannot refrigerate and is complex in operation and high in cost in a nuclear magnetic environment. The cold / hot pain stimulation system comprises a cold / hot stimulation head (1), a protective net (2), a heat radiation water tank (3), a water pump (4), a water storage tank (5), an embedded type control module (6) and an upper computer, wherein the cold / hot stimulation head (1), the heat radiation water tank (3), the water pump (4) and the water storage tank (5) are connected with each other in sequence to form a water circulation system through water pipes; the cold / hot stimulation head (1) is connected with the upper computer (7) through the embedded type control module (6); the embedded type control module (6) controls the cold / hot stimulation head (1) to stimulate human skin according to the stimulation temperature set by the upper computer; and the actual stimulation temperature and pain sensation scores are transmitted to the upper computer (7) for storage and display through the embedded type control module (6). The cold / hot pain stimulation system disclosed by the invention is easy in operation and safe in use, and can be used for studying the pain sensation and evaluating pain relieving effect in a nuclear magnetic environment.

The invention provides an electronic pain comparison recorder, relates to the field of medical instruments, and aims to solve the problems that no monitoring equipment capable of effectively monitoring parameters of human pain exists at present, medical staff can only infer the pain intensity of a patient through experience and professional knowledge according to the description or various physiological responses of the patient, undeniably, the majority of medical staff can make accurate judgments under most conditions, but a very few of the judgments are inaccurate to cause misdiagnosis or medical negligence. In order to solve the problem, the invention provides an electronic pain comparison recorder. The electronic pain comparison recorder is convenient to use, low in cost and capable of visualizing and digitizing the pain feeling of the patient and recording pain data. The technical scheme is as follows: the electronic pain comparison recorder comprises a discharge electrode, a conductive plate, a linear switch, a controller, a power supply, a battery and a display, wherein the controller is a central processing unit and is connected with the discharge electrode, the conductive plate, the linear switch, the power supply, the battery and the display.

The invention discloses a body position pad for interventional operation, which comprises a bearing wood plate; a large protrusion is connected to the outer wall of the top of the bearing wood plate; a small protrusion is connected to the outer wall of the tail of the bearing wood plate; a rubber pad is connected to the upper portion of the bearing wood plate; and a semicircular rubber block is arranged at the top of the rubber pad. According to the invention, a limb on the operation side can be effectively lifted up before an operation; disinfection is completed in cooperation with a doctor; the difficulty of hanging the limb of a patient is relieved; random swinging is achieved; the comfort level of the patient is improved; the working efficiency is improved; the invention pays more attention to intraoperative changes of the patient; safety in the operation is guaranteed; time waste caused by manual body position swinging of nursing personnel and non-standardization of personnel operation are reduced; the swelling, numbness and pain feelings of surgical limbs of the patient can be relieved; and the surgical nursing quality of the patient is effectively improved.

The invention discloses application of a targeting small molecule capable of acting on a classical pain receptor TRPV1 channel in preparation of a medicine for preventing and / or treating pain. The small molecule has a delay effect on opening of a TRPV1 channel caused by capsaicin, the pain feeling of a mouse is remarkably relieved on the premise of not interfering the body temperature maintenance and body temperature regulation functions of the mouse, the analgesic effect is rapid, remarkable and lasting, and a new development strategy is provided for a TRPV1 channel targeted analgesic drug.