40 results about "Neurological pain" patented technology

An apparatus for use in peripheral nerve field stimulation (PNFS) whereby a plurality of curved introducer needles, of varying curvatures, are provided to permit the physician to best locate the region of oligodendrocytes that contain the A Beta fibers by matching the lumbar lordosis. A wing device is also provided that is attachable to the hub of the curved needle introducer which gives the physician better ability to maneuver the needle during insertion as well as permitting tenting of the skin. The invention benefits a large number of painful disorders arising from pathology in the cervical, thoracic, and lumbar spine. In addition, this invention can also help a large number of other conditions including but not limited to failed back surgery syndrome / post-laminectomy pain, occipital / suboccipital headaches, scar pain, post herpetic neuralgia pain, mononeuritis multiplex, and pain following joint surgery (e.g., knee, hip, shoulder).

Described herein are methods of treating neurological injury and conditions, in particular neurological pain. These treatment methods can include the steps of generating a pulsed electromagnetic field from a pulsed electromagnetic field source and applying the pulsed electromagnetic field in proximity to a target region.

An allergy skin test device is disclosed that causes less pain than commonly used devices that include multi-point sharp puncture heads. The allergy skin test device incorporates multiple dull pressure heads distributed amongst the sharp multi-point sharp puncture heads, each dull pressure head activating a neurological pain gate that reduces pain sensation typically caused by the neighboring multi-point head when it engages the skin.

The invention relates to a device for treating a patient for neurological or muscular pain by neurostimulation comprising a pair of electrodes to be applied externally, ie. to the surface of the skin, in the region of the pain and to apply a current of between 0.2 and 12 mA at a frequency of between 1 and 50 Hz, and preferably between 2 and 10 Hz. Optimal results appear to be achieved when the applied current is between 3 and 10 mA. In use at least one of the electrodes, a stimulating electrode is used to accurately locate the pain and during treatment the electrode is applied to the patient's skin as located using mild pressure, while a stimulating pulse is applied as treatment. This action produces a remarkable and unexpected level of pain relief. The invention extends to a method for the treatment of neurological pain using the above parameters and procedure.

The invention relates to medical compress patches, in particular to a medical far infrared hot compress patch for soft tissue repairing and a preparation method thereof. The medical far infrared hot compress patch comprises a non-woven fabric bag, a heating layer arranged at the non-woven fabric bag, and a pressure sensitive adhesive tape used for fixing the non-woven fabric bag; the heating layer is composed of 35-45% of reduced iron powder, 0.1-5% of aluminum powder, 5-15% of far infrared ceramic powder, 10-16% of active carbon, 0.5-2% of polymer water-absorbent resin, 1-6% of sodium chloride and rest of purified water by weight. By means of a thermal therapy and infrared therapy combination mode, the medical far infrared hot compress patch for the soft tissue repairing has physical therapy and therapy effects for the inflammation and indisposition due to rheumatic arthritis, cervical spondylosis, lumbar muscle degeneration, lumbar disc herniation, scapulohumeral periarthritis, soft tissue injury, hyperosteogeny, ischialgia, pain from rheumatism, knee injury, chronic prostatitis, chronic mastitis, hyperplasia of mammary glands, chronic gastroenteritis, chronic gynaecology inflammation, cold in uterus, stomach cold, pain from rheumatism and the like.

Provided is a compound useful as a therapeutic drug for pain and inflammation caused by various pathological conditions such as neuropathic pain and rheumatoid arthritis. The compound of the formula (I) or a salt thereof [wherein R1 is a methyl group or a hydrogen atom, R2 represents a hydrogen atom, an alkyl group, an alkylcarbonyl group or an aryl carbonyl group, A represents a cycloalkyl group, a cycloalkenyl group, an aryl group or a heteroaryl group (each group may be substituted with a substituent selected from the group consisting of alkyl, alkenyl, cycloalkyl and halogen), n and m each represent an integer of 1, 2 or 3, and p represents an integer of 0, 1, 2 or 3].

The invention belongs to the field of Chinese medicaments, and relates to medicinal liquor for treating rheumatism, rheumatoid and pains of neck, shoulders, waist and legs. The medicinal liquor is prepared from prepared monkshood, prepared kusnezoff monkshood root, eucommia bark, safflower, cassia bark, medicinal cyathula root, whole worm, long-noded pit viper, divaricate saposhnikovia root, Chinese angelica, obscured homalomena rhizome, schizonepeta, clematis root, asarum, dipsacus root, pseudo-ginseng and white spirit. The Chinese medicaments and the white spirit with functions of promoting blood circulation are prepared into the medicinal liquor and are mutually supplemented and pressed; the medicinal liquor has the effects of eliminating the pathogenic factor without damaging healthy energy, supporting healthy energy without leaving pathogenic factor, promoting blood circulation to remove blood stasis, promoting blood circulation and regulating vital energy, promoting restoration of consciousness and activating collaterals, dispelling wind and dampness, warming meridians to dissipate cold, decreasing swelling and relieving pain, softening hardness to dissipate stagnation, reinforcing kidney to strengthen yang, alleviating pain and diminishing inflammation, clearing heat and detoxifying, cultivating blood losing muscles and bones of human joints, smoothing blood vessels and meridians and removing pathogenic factors of wind, cold, dampness and heat so as to eliminate various joint pains. The medicinal liquor has a unique curative effect on rheumatism, rheumatoid arthritis, pains of waist and legs, scapulohumeral periarthritis, numbness of limbs, sciatica, hyperostosis, protrusion of intervertebral disc, cervical spondylosis, ankylosing spondylitis, hyperplasia of mammary glands, various pains and chronic and stubborn diseases, crooked mouths and oblique eyes.

The invention relates to a medical patch, and specifically relates to a medical magnetic therapy type hot compressing patch for treating soft tissue pain and a preparation method thereof. The medical magnetic therapy type hot compressing patch comprises a nonwoven fabric bag, a heating magnetic therapy layer arranged at the nonwoven fabric layer, and a pressure sensitive adhesive belt for fixing the nonwoven fabric bag, wherein the heating magnetic therapy layer is prepared from the following raw materials in percentage by weight: 35 to 45% of iron powder reduced, 8 to 12% of permanent magnetic powder,10 to 16% of activated carbon, 0.5 to 2% of super absorbent polymer, 1 to 6% of sodium chloride, and the balance of purified water. According to the medical magnetic therapy type hot compressing patch, the thermal therapy and the magnetic therapy are combined; the medical magnetic therapy type hot compressing patch has the physiotherapy and treatment effects for inflammations and pain caused by rheumatic arthritis, pain in waist and lower extremities, cervical spondylosis, lumbar disc herniation, scapulohumeral periarthritis, soft tissue injury, osteoproliferation, sciatica, pain from rheumatism, knee joint injury, chronic prostatitis, chronic mastitis, hyperplasia of mammary glands, chronic pelvic inflammatory disease, chronic gastroenteritis, chronic gynaecology inflammation, cold in uterus, stomach cold and pain from rheumatism.

An allergy skin test device is disclosed that causes less pain than commonly used devices that include multi-point sharp puncture heads. The allergy skin test device incorporates multiple dull pressure heads distributed amongst the sharp multi-point sharp puncture heads, each dull pressure head activating a neurological pain gate that reduces pain sensation typically caused by the neighboring multi-point head when it engages the skin.

The invention relates to application of 7-O-beta-D-acetylation sugar-coumarin compounds in treating chronic neuropathic pains. The 7-O-beta-D-acetylation sugar-coumarin compounds comprise a pharmaceutically acceptable salt, ester or a solvate thereof, and the application relates to the application of the salt, the ester or the solvate in preparing medicaments for treating the chronic neuropathic pains, wherein a glycosyl part is arbitrary pyranose or furanose, the hydroxy of which is totally acetylated; a representative compound is 7-O-beta-D-acetylation glucose-coumarin; and the structural formula is disclosed in the specification. On a classical sciatic nerve chronic compression injury (CCI) model, through single intragastric administration and continuous intragastric administration for 7 days, the compound shows definite treatment effect of resisting nervous pains. At a dose point appointed by an experiment, the compound can obviously improve the mechanical stimulus pain threshold, the nervous pain resistant efficacy is equivalent to that of Gabapentin which is a contrast medicament, and the duration is superior to that of the Gabapentin. Proved by research results, the compound can be used for treating the chronic neuropathic pains.

The invention encompasses a method for treating a disease or condition mediated by the human MRG-X1 receptor, such as nociception, hyperalgesia, allodynia, pain related to central hypersensitivity conditions, somatic pain, visceral pain, acute pain, chronic pain, post-operative pain, headache, inflammatory pain, neurological pain, musculoskeletal pain, cancer related pain or vascular pain, in a human patient in need thereof comprising administering to the patient a therapeutically effective amount of a 3-substituted-2-(diphenylmethy)-1-azabicyclo[2.2.2]octane or a pharmaceutically acceptable salt thereof. The invention is also directed to the use of these compounds as molecular tools to directly explore the role of the MRG-X1 receptor in pain perception.

The invention relates to a lumbago relieving capsule which can relax tendons and activate collaterals, remove blood stasis, relieve pain, activate blood and remove rheumatism. The lumbago relieving capsule can be applied to rheumatoid arthritis, hypertrophic ixomyelitis, hypertrophic thoracic inflammation, cervical inflammation, sciatica and lumbar muscle strain. Since the lumbago relieving capsule contains toxic kusnezoff monkshood root, carefulness is needed during clinical use. The quality standard of current lumbago relieving capsules cannot totally meet the purpose of drug safety supervision. The lumbago relieving capsule of the invention aims at providing more perfect quality control method from qualitative and rational aspects.

The invention provides an ointment for treating rheumatism. The ointment is prepared from arisaema cum bile, prepared semen strychni, fossil fragment, safflower, frankincense and other raw materials, is quick in response and remarkable in effect when used for treating various old trauma pain, rheumatic arthritis, lumbar strain, sciatica and the like, prevents relapse, and does not have toxic or side effect.

The invention discloses a Mongolian medicament for strengthening muscles and bones, promoting blood circulation and removing blood stasis, diminishing inflammation and easing pain, which is mainly prepared from the following raw materials in part by weight: 300 parts of Arula, 300 parts of Barula, 300 parts of Zhurula, 200 to 500 parts of phellodendron, 100 to 200 parts of clam, 200 to 500 parts of Zhugang, 100 to 300 parts of safflower and 100 to 200 parts of Ximuxing. The Mongolian medicament has the effects of strengthening muscles and bones, promoting blood circulation and removing blood stasis, diminishing inflammation and easing pain, removing dampness and dispelling wind and the like, is mainly used for treating traumatic injury, pain in necks, waists and backs, osteoproliferation, osteoarthritis, rheumatic arthritis, superficial thrombophlebitis, intervertebral disc herniation, ischioneuralgia, gout, femoral head necrosis and the like, and is suitable for various diseases and convenient to popularize and apply.

The present invention discloses an external Chinese ointment for expelling wind, eliminating stasis and relieving pain. The trade name is American Lopseed Pain-relief Paste, suitable for pain and microcirculation barriers caused by rheumatism, rheumatoid arthritis, omarthritis, cervical spondylosis, psoas fatigue, bone hyperplasia, bruises, lumbar disc herniation, waist and leg pain, and sciatica. The American Lopseed Pain-relief Paste has the advantages of good curative effect, long period of medical effect, small toxic side effect, convenient use, safety and effectiveness. The American Lopseed Pain-relief Paste is made of prepared Sichuan aconite root, fangji root, american lopseed, yanhusuo (vinegar), dried ginger, camphora and azone according to a certain weigh proportion.

The invention discloses external medicine for treating herpes zoster and a preparation method thereof. The external medicine is composed of, by weight, 20-30 parts of silkworm excrement, 30-40 parts of realgar (water grinding), 10-20 parts of propolis (30% alcohol extract), 1-10 parts of bee venom (1% alcohol extract), 1-10 parts of camphor, 1-10 parts of menthol, 500-1000 parts of alcohol and 1-5 parts of dimethyl sulfoxide. The external medicine is externally applied on a wound, medication and needling are not needed, and a patient is free of suffering and side effect. The external medicine is quick in pain stopping and good in effect, can realize pain stopping, and 5-7 days are consumed to heal herpes zoster. Almost no one has sequela of nervous pain, so that the 54 is needed is simple to process, lo in cost and convenient to use.

The invention discloses a tetrodotoxin compound preparation which comprises the following components: tetrodotoxin, lidocaine, puerarin and an excipient. The invention also discloses use of the tetrodotoxin compound preparation in the preparation of a medicament for treating neuropathic pain, wherein the neuropathic pain is diabetic peripheral neuropathic pain or neuropathic injury pain. The novel tetrodotoxin compound preparation provided by the invention is used for treating diabetic peripheral neuropathic pain and neuropathic injury pain, and has advantages of small toxic side effect, good analgesic effect and the like.

Compositions comprising Cannabidiol in combination with non-steroidal anti-inflammatory drugs (NSAIDs) are provided for treating conditions such as sciatica and other nerve pain.

This present invention relates to novel compounds, of the formula (I), isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1;VR1;TRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, inflammatory disease of the joints, neuropathies, HIV-related neuropathy, nerve injury, neurodegeneration, stroke, urinary bladder hypersensitivity including urinary incontinence, cystitis, stomach duodenal ulcer, irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), fecal urgency, gastro-esophageal reflux disease (GERD), Crohn's disease, asthma, chronic obstructive pulmonary disease, cough, neurotic / allergic / inflammatory skin disease, psoriasis, pruritus, prurigo, irritation of skin, eye or mucous membrane, hyperacusis, tinnitus, vestibular hypersensitivity, episodic vertigo, cardiac diseases such as myocardial ischemia, hair growth-related disorders such as effluvium, alopecia, rhinitis and pancreatitis.

The invention relates to application of 2-fluroin-beta-D-glycoside compounds with a compound of the following formula as the ligand in preparing medicaments for treating neuropathic pain, , wherein the glycosyl part is any of pyranose or furanose, with the representative compound of 2-fluroin-beta-D-galactopyranoside which has the structural formula shown in the specification. The compound shows specific effect in treating neuropathic pain by single gastric infusion and continuous gastric infusion on a traditional sciatic nerve chronic compression injury model (CCI).

The invention discloses a liquid medicine for relieving hand joint pain and a preparation method thereof. The liquid medicine comprises the following components in parts by weight, 2-3 parts of raw pinellia ternata, 3-4 parts of radix aconiti, 3-4 parts of aconitum kusnezoffii, 3-4 parts of aconitum carmichaeli, 3-4 parts of safflower, 3-4 parts of asarum, 3 parts of angelica sinensis, 3 parts ofligusticum wallichii, 2-3 parts of croton root; 3-4 parts of sichuan pepper, 3-4 parts of ground beeltle; 5-6 parts of pseudo-ginseng root, 3-4 parts of radix clematidis, 3-4 parts of hematoxylon, 3 parts of dictamnus dasycarpus, 3-4 parts of pomegranate rind, 3 parts of hippocampus, 2 parts of centipede, and 2 parts of dragon's blood. The liquid medicine has rapid pain relieving and treating effects on various pains such as rheumatic bone diseases, and is widely applied to rheumatic and rheumatoid arthralgia, hyperostosis pain, muscle soreness, fracture pain, postoperative pain, prosopalgia,sciatica, headache, scaffold numbness, gout pain, various neck-shoulder and lumbocrural pains, traumatic injury pain, arthralgia and myalgia and neuropathic pain.

The invention discloses a pharmaceutical composition for treating rheumatic arthralgia and a preparation method thereof. The pharmaceutical composition adopts garden balsam stem, common monkshood mother root and garter snake for dispelling pathogenic wind, removing dampness, warming channels, dispelling cold and relieving pain; adopts cuttlebone and leech for invigorating pulse, removing stasis, activating collaterals and dredging meridian passage; and adopts clematis root, obscured homalomena rhizome and natural copper for strengthening tendons and bones, removing dampness, dredging channels and relieving pain, thereby having the effects of dispelling pathogenic wind, removing dampness, warming channels, dispelling cold, promoting blood circulation, removing blood stasis, strengthening tendons and bones, dredging channels, relieving pain and the like for treating arthritis, cervical spondylosis, intervertebral disc herniation, neuropathic pain, bone hyperplasia and the like.

A hydroalcoholic gel composition is disclosed for alleviating symptoms of psoriasis or arthritis, such as pain resulting from arthritic diseases and / or psoriatric arthritis and / or neurological pain, such as pain resulting from sclerosis, e.g. multiple sclerosis in a subject. Such a composition may comprise, inter alia, 0.1-20% cannabidiol, a skin penetration enhancer, ethanol, and one or more thickeners and / or gelling agents.

The invention discloses application of sodium phenylbutyrate and metabolites thereof in preparation of a medicine for preventing or treating chemotherapy-induced peripheral neuropathic pain. Animal experiments prove that the sodium phenylbutyrate has a remarkable analgesic effect on paclitaxel-induced peripheral neuropathic pain of a mouse, the mechanical pain foot retraction threshold value of the mouse can be obviously increased, the photo-thermal pain foot retraction incubation period of the mouse is obviously prolonged, and the condition of demyelination of medullary nerve fibres in sciatic nerves of the mouse caused by paclitaxel is improved. The sodium phenylbutyrate can be used for preparing the medicine for preventing or treating chemotherapy-induced peripheral neuropathic pain, has no obvious toxic or side effect, and has a good application prospect.

The present invention features inhibitors of nitric oxide synthase (NOS), particularly those inhibitors that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isozymes, the NOS inhibitors of the present invention, which Useful, alone or in combination with other pharmaceutically active agents, for the treatment or prevention of conditions such as: e.g. stroke, reperfusion injury, neurodegenerative disease, head trauma, CABG, migraine headache with aura and without aura, with allodynia of migraine, central post-stroke pain (CPSP), neuropathic pain, or chronic pain.

The invention relates to application of combination of imrecoxib and tramadol in preparation of a medicine for treating pain. Specifically, the invention relates to application of combination of irecoxib and tramadol or pharmaceutical salts of irecoxib and tramadol in preparation of a medicine for treating pain. Specific pain may be selected from acute pain, chronic pain, neuropathic pain, nociceptive pain, slight and severe to moderate pain, hyperalgesia, pain associated with central sensitization, allodynia or cancer pain, including diabetic neuropathy and osteoarthritis, and also includingrheumatoid arthritis, ankylosing spondylitis, sciatica and frozen shoulders.

The invention discloses medicine for treating sciatica and a preparation method thereof. The preparation method includes: using costus root, asarum, pangolin scale, dried radix rehmanniae, cortex lycii, radix rehmanniaepreparata, paenoiae alba, prepared liquorice, angelica sinensis, radix cyathulae, stir-fried radix aconiti, gentianamacrophylla, myrrh, radix astragali, red peony root, bighead atractylodes rhizome, angelica pubescens, cassia twig, poriacocos, rhizomachuanxiong, radix dipsaci and radix codonopsis as raw materials, and soaking the medicinal raw materials into Baijiu for 13-18 days to obtain the medicine. The medicine has the effects of eliminating cold to stop pain and promoting blood circulation to remove meridian obstruction and is capable of radically treating the sciatica, good in curative effect, capable of treating both the root causes and symptoms, and capable of relieving the physical and mental pain of patients and lowering the economic burden of the patients. 85 clinical cases using the medicine show that the total effective rate of the medicine is 100%.

The invention relates to application of 4-formylphenyl-beta-D-glucoside compounds in treating chronic neuropathic pains, which uses a compound of the formula (disclosed in the specification) as a ligand, wherein a glycosyl part is arbitrary pyranose or furanose; the 4-formylphenyl-beta-D-glucoside compounds comprise a pharmaceutically acceptable salt, ester and a solvate, and the application relates to the application the salt, the ester and the solvate in preparing medicaments for treating the neuropathic pains; a representative compound is 4-formylphenyl-beta-D-xyloside; and the structural formula is disclosed in the specification. On a classical sciatic nerve chronic compression injury (CCI) model, through single intragastric administration and continuous intragastric administration for 7 days, the compound shows definite treatment effect on resisting nervous pains. At a dose point appointed by an experiment, the compound can obviously improve the mechanical stimulus pain threshold, the nervous pain resistant efficacy is equivalent to that of Gabapentin which is a contrast medicament, and the duration is superior to that of the Gabapentin. Proved by research results, the compound can be used for treating the chronic neuropathic pains.