The present invention describes novel nitrosated and / or nitrosylated α-
adrenergic receptor antagonists, and novel compositions containing at least one nitrosated and / or nitrosylated α-
adrenergic receptor antagonist, and, optionally, one or more compounds that donate, transfer or release
nitric oxide, elevate endogenous levels of
endothelium-derived relaxing factor, stimulate endogenous synthesis of
nitric oxide or are a substrate for
nitric oxide synthase, and / or one or more
vasoactive agents. The present invention also provides novel compositions containing at least one α-
adrenergic receptor antagonist, and one or more compounds that donate, transfer or release nitric
oxide, elevate endogenous levels of
endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric
oxide or is a substrate for
nitric oxide synthase and / or one or more
vasoactive agents. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing benign prostatic
hyperplasia, hypertension, congestive
heart failure, variant (Printzmetal)
angina,
glaucoma, neurodegenerative disorders, vasospastic diseases, cognitive disorders,
urge incontinence, or
overactive bladder, and for reversing the state of
anesthesia.