The invention discloses a
solid dispersion body of a
berberine-
phospholipid complex and a preparation method thereof and belongs to the field of pharmaceuticals. The lipid
solubility of
berberine is low, the absorbing capability of a permeable membrane is poor, and the
berberine is a substrate of P-
glycoprotein (P-gp) and is expelled by epithelial cells on the
stomach and intestine to result in the extremely low oral
bioavailability, so that an
effective method needs to be adopted to improve the lipid
solubility of the berberine, meanwhile, the expelling of P-
glycoprotein is inhibited, and further the
drug absorption is promoted. The
solid dispersion body of the berberine-
phospholipid complex disclosed by the invention consists of berberine,
phospholipid,
vitamin E
polyethylene glycol
succinic acid ester and
silicon dioxide in a certain weight ratio, and has the advantages that the lipid
solubility of the berberine is improved, the expelling of P-
glycoprotein is inhibited, the
drug is promoted to be absorbed by the
gastrointestinal tract, the
bioavailability is improved, the stability and the flowability are good, the preparation method is simple and convenient, and the great industry prospect is provided.