73 results about "Aminoquinoline" patented technology

The invention discloses 7-aminobenzopyrone or 7-aminoquinolinone compounds and application thereof, the structural general formula of the compounds is as shown in formula (I), and the compounds are compounds with androgen receptor antagonistic activity. The compound provided by the invention has relatively high activity of antagonizing androgen receptor transcription, shows relatively good biological activity at molecular level, cellular level and animal level, and has relatively good safety. Therefore, the compound can be used as an androgen receptor antagonist in preparation of drugs for treating androgen receptor mediated diseases, including but not limited to prostate cancer, metastatic prostate cancer, castration-resistant prostate cancer, breast cancer, ovarian cancer, androgen-derived alopecia and acne. The side effect of systemic androgen antagonism caused by systemic distribution can be avoided, and a safer and more targeted treatment choice is provided for patients.

Methods and compositions for treating or preventing non-viral tick-borne diseases and symptoms thereof by administering a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed. Kits including a means for testing for a non-viral tick-borne disease and / or symptoms thereof and a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed.

The invention relates to a cyclic ether modified 3-cyano-4-arylaminoquinoline derivative and a preparation method and application thereof, the cyclic ether modified 3-cyano-4-arylaminoquinoline derivative is a compound as shown in a formula I or pharmaceutically acceptable salt thereof, tests prove that the cyclic ether modified 3-cyano-4-arylaminoquinoline derivative has good in-vitro antitumor activity, and a basis is provided for further research and development of antitumor drugs. # imgabs0 #

The invention relates to the technical field of corrosion inhibitors, and discloses a preparation method and application of a water-soluble quinoline quaternary ammonium salt corrosion inhibitor, 2, 2-dimethylolpropionic acid, 4-formylbenzoyl chloride, 6-aminoquinoline and a dibromoalkane compound are subjected to esterification, Schiff base condensation and quaternization reaction, and the polymer-based water-soluble quinoline quaternary ammonium salt corrosion inhibitor is obtained. The corrosion inhibitor has hydrophilic carboxyl and quaternary ammonium salt groups, so that the corrosion inhibitor is endowed with good water solubility, and the slow release performance of the corrosion inhibitor is favorably improved. The quinoline quaternary ammonium salt corrosion inhibitor contains a Schiff base group, has stronger coordination capacity with the surface of a steel sheet than that of a traditional quinoline quaternary ammonium salt corrosion inhibitor, can form a continuous multi-layer compact polymer film layer on the surface of the steel sheet, effectively inhibits the contact between a hydrochloric acid corrosion medium and the surface of the steel sheet, and shows higher corrosion prevention and inhibition performance.

This invention relates to a method for preparing and applying an acidic medium-based iron ion recognition indicator. The indicator contains an aminoquinoline structure and a sulfosalicylic acid structure. It exhibits excellent dual colorimetric and fluorescence responses to ferric ions. When the sample contains Fe... 3+ At that time, Fe 3+ It can undergo complexation reactions with the -NH-CO-, -OH, and quinoline-N groups in the indicator, changing the solution from colorless to brown. This allows for qualitative analysis of iron ions by naked-eye observation. Simultaneously, the fluorescence weakens, and the fluorescence intensity is similar to that of Fe. 3+ The content exhibits a good linear relationship, reaching the nanomolar level, enabling quantitative detection of iron ions and Fe. 3+ It has extremely excellent selectivity, and can identify and detect iron ions not only in normal environments, but also accurately identify iron ions under extreme conditions of strong acidity. It is stable, can be used in acidic media, and has strong anti-interference ability.

The invention discloses an application of a serum meso-diaminopimelic acid detection method based on liquid chromatography-mass spectrometry or a detection product in sepsis, and relates to the technical field of biological detection. The detection method comprises the following steps: serum sample treatment, derivatization of 6-aminoquinoline-N-hydrogen succinimide carbamate, chromatographic separation and mass spectrometric detection. The detection kit comprises a meso-DAP standard substance, a Lys (Lys-d4) internal standard substance, a borate buffer solution and 6-aminoquinoline-N-succinimide methyl ester. The diagnosis efficacy AUC of meso-DAP is equal to 0.835, compared with a PCT detection method, the meso-DAP has better supplementary diagnosis efficacy, and compared with levo-DAP and dextro-DAP and total DAP, the sepsis diagnosis efficacy of meso-DAP is greatly improved. In addition, the method provided by the invention can also monitor the illness state to a certain extent, and also has a certain indication effect on prognosis.

The invention relates to a quinoline hydrazone compound containing a hydrazone structure as well as a preparation method and application of the quinoline hydrazone compound, and relates to the technical field of chemical engineering and pesticides. According to the invention, 5-aminoquinoline is used as a raw material to synthesize a series of quinoline hydrazone compounds containing a hydrazone structure; the prepared compound can effectively prevent and treat plant fungal diseases including cucumber gray mold, potato late blight, sclerotinia rot of colza, tomato gray mold, wheat scab, rice blast, kiwi fruit phomopsis and rice sheath blight disease.

The invention discloses a method for preparing a 4-amino-2-quinolinone compound through visible light catalysis of cyclization of 1, 6-alkene nitrile, which comprises the following steps: mixing a copper-based photosensitizer, a 1, 6-alkene nitrile compound as shown in a formula I, amine and a solvent in an inert atmosphere, reacting for 12-48 hours at 15-35 DEG C under illumination, and post-treating the reaction liquid to obtain the 4-amino-2-quinolinone compound as shown in a formula II, the method is mild, efficient, green and suitable for large-scale production; # imgabs0 #

The present invention belongs to the technical field of fluorescence detection, and in particular relates to a method for detecting hypochlorite (ClO ‑ ) and phosgene (COCl2) fluorescent probes and their preparation methods and applications. The probe is 7-(diethylamino)-2-oxy-1,2-dihydroquinoline-3-formaldehyde oxime (abbreviated as DOQC). 3-Formyl-7-diethylaminoquinoline-2( 1H )-ketone, hydroxylamine hydrochloride, solvent, and acid binding agent were added to the reaction bottle, stirred, and heated until the reaction was completed. The reaction progress was monitored by thin layer chromatography, and the fluorescent probe DOQC was obtained after filtration and purification. ‑ After the reaction of COCl2 and probe DOQC, the fluorescence color and intensity of the solution changed. This change has the characteristics of high selectivity and high sensitivity. ‑ , COCl2 rapid practical detection has improved new methods and application prospects.

To provide a rubber composition for sidewall that has superior ozone resistance and maintains high levels of elongation at break (EB) and tensile strength (TB) after aging, even in the absence of the antioxidant 6PPD.SOLUTION: A rubber composition comprising a rubber component and an aminoquinoline-based antioxidant represented by the following general formula (1). [In formula (1), A is a single bond or a double bond; R11 and R12 are each independently hydrogen, a C1-C12 alkyl group, a C3-C6 cycloalkyl group, or a phenyl group; R13 to R19 are each independently hydrogen or a C1-C12 alkyl group].SELECTED DRAWING: None

Disclosed is a catalyst composition containing a phosphine-imino-quinoline ligand and a transition metal complex having a phosphine-imino-quinoline ligand. These catalyst compositions are useful in ethylene oligomerization processes to produce 1-hexene and 1-octene.

The invention belongs to the technical field of health, clinical and medical related detection, and relates to a liquid chromatography-mass spectrometry detection kit and a detection method for serum seleno-amino acid labeled on the basis of a mass spectrometry probe. The detection kit comprises a mass spectrum probe solution, a protein precipitant solution and a buffering agent solution, the mass spectrum probe is 6-aminoquinolyl-N-hydroxysuccinimido carbamic acid ester, and the mass spectrum probe is 2-aminoquinolyl-N- The buffer solution contains a seleno-amino acid isotope internal standard. According to the kit, a mass spectrum probe is used for labeling, a serum sample is subjected to protein precipitation and then mixed with the mass spectrum probe at room temperature, and simultaneous high-flux accurate quantification of multiple seleno-amino acids can be directly achieved through liquid chromatography-tandem mass spectrometry in a conventional reversed-phase chromatography mode. The 6-aminoquinolyl-N-hydroxysuccinimido carbamate mass spectrum probe adopted in the kit disclosed by the invention has the advantages of high reaction activity, convenience in operation, high sensitivity and the like.

The present invention discloses a zinc ion fluorescent probe based on 8-aminoquinoline, its preparation method and application. The zinc ion fluorescent probe based on 8-aminoquinoline has the following structural formula. The present invention uses 8-aminoquinoline as a matrix, introduces an acetylamino group at position 2 and reacts with salicylaldehyde at position 8 to design and synthesize a highly selective zinc ion fluorescent probe. 2+ The fluorescent probe APYQ is not interfered by other metal ions, and its synthesis steps are simple and the purification process is easy. The fluorescent probe of the present invention has excellent detection limit (1.87nM) and response time (5s). These two indicators are better than other Zn 2+ The fluorescent probe of the present invention can be used to detect Zn with naked eyes in ethanol / HEPES buffer solution and on test paper. 2+ , can also be used to detect Zn in Hela cells 2+ Fluorescence imaging has good application prospects.

The invention relates to a novel compound and a preparation method thereof, in particular to a polysubstituted indeno [1, 2-c] aminoquinoline derivative as well as a synthesis method and application thereof. The invention relates to a novel polysubstituted indeno [1, 2-c] aminoquinoline derivative which is prepared by taking substituted isatin, substituted phenylacetic acid and various amine compounds as raw materials through four-step conventional chemical reaction and simple post-treatment operation. Research finds that the novel polysubstituted indeno [1, 2-c] aminoquinoline derivative has good anti-tumor activity and can be applied to research and development of anti-tumor drugs. The synthesis method of the polysubstituted indeno [1, 2-c] aminoquinoline derivative has the advantages of cheap and easily available raw materials, simple and safe treatment operation after reaction and the like, and the developed brand new indeno [1, 2-c] aminoquinoline derivative is expected to be developed into an important lead compound of antitumor drugs.

The present invention relates to compounds that have activity as cluster of differentiation 38 (CD38) inhibitors, compositions of such compounds, and methods using such compounds for preventing or treating diseases and disorders such as, for example, diseases and disorders of metabolism.

The present disclosure provides a compound represented by formula (I): wherein R1a, R1b, R2a, R2b, R2c, R3a, R3b, R3c, R3d, R3e, R3f, and R3g are as defined in the specification, or a salt, solvate, or stereoisomer thereof. The present disclosure also provides compositions, vulcanized elastomer articles, lubricant compositions, combustible fuel compositions, and fuel additive compositions comprising the compounds disclosed herein. The present disclosure also provides methods for making the compositions and vulcanized elastomeric articles described herein. The present disclosure also provides a method for retreading a tire using the composition described herein. The present disclosure also provides kits comprising the compositions described herein. (I)

The invention relates to the technical field of anticorrosive coatings, in particular to a weather-resistant anticorrosive coating for protecting a metal tank body and a preparation method of the weather-resistant anticorrosive coating. Comprising 100 parts of quick-hardening sulphoaluminate cement, 40-55 parts of slaked lime, 50-65 parts of fly ash, 60-80 parts of quartz powder, 10-20 parts of reinforced fibers, 5-10 parts of an air entraining agent, 10-20 parts of a foam stabilizer, 60-80 parts of waterborne epoxy resin, 3-5 parts of a polycarboxylic acid high-performance water reducing agent, 4-8 parts of calcium formate, 65-85 parts of water, 15-25 parts of a quinoline-containing POSS derivative, 1-2 parts of a curing agent and 0.5-1 part of a silane coupling agent. The quinoline-containing POSS derivative is prepared from octacarboxyl POSS and 3, 4-diaminoquinoline through a reaction of octacarboxyl POSS and 3, 4-diaminoquinoline. According to the preparation method, octacarboxyl POSS and 3, 4-diaminoquinoline are subjected to acylation reaction for the first time to prepare the quinoline-containing POSS derivative with a cage-shaped POSS inner core and quinolyl rigid outer arm structure, the quinoline-containing POSS derivative is used as an anti-corrosion synergist to be applied to a coating, and the weather resistance and corrosion resistance of the coating are improved through triple mechanisms of physical barrier, chemical passivation and microbial inhibition.

The present invention discloses a method for asymmetric aryl alkylation reaction of three-component non-activated olefins catalyzed by nickel. Non-activated olefins using 8-aminoquinoline as a directing group are coordinated with a nickel catalyst, and the target product is obtained with a high yield under the regulation of a specific chiral ligand and the enantioselectivity is as high as 96.5:3.5. The whole method is simple, easy and safe, and a multi-component asymmetric coupling reaction of non-activated olefins with halogenated aromatics and halogenated alkanes is achieved in one step. Under optimized reaction conditions, the yield of the target product after separation can be as high as 85%, which is a general, efficient, economical and environmentally friendly method for constructing carbon-carbon bonds.

The invention relates to a near-infrared ratiometric fluorescent probe for mercury ions of targeted mitochondria as well as preparation and application of the near-infrared ratiometric fluorescent probe. According to the preparation method of the fluorescent probe, (E)-4-(2-(7-(diethylamino)-2-oxo-2H-chromene-3-yl) vinyl)-1-(4-((diphenylselenophosphoryl) oxy) benzyl) is obtained by taking (E)-7-diethylamino-3-(4-quinolyl) vinyl coumarin, diphenylselenophosphoryl and p-hydroxybenzyl as fluorophore, recognition group and connecting arm respectively, and (E)-4-(2-(7-(diethylamino)-2-oxo-2H-chromene-3-yl) vinyl)-1-(4-((diphenylselenophosphoryl) oxy) benzyl) quinoline-1-bromide, namely a compound 1; according to the application of the fluorescent probe, mercury ions are detected by utilizing the change of the fluorescence intensity ratio F721nm / F578nm at two different emission wavelengths, and the fluorescent probe is used for targeted imaging of mercury ions and mitochondria in living cells. The fluorescent probe is simple to prepare, and has the advantages of good selectivity, high sensitivity, high response speed and the like in a coexistence system of mercury ions and other metal ions.

The present invention belongs to the technical field of synthesis of small molecule compounds containing 4-aminoquinoline, and specifically relates to a method for preparing 4-aminoquinoline derivatives by coordinated catalytic oxidative aromatization of palladium and copper, which is applied to the synthesis of small molecule compounds containing 4-aminoquinoline and the synthesis of the core skeleton of antimalarial drugs. The present invention uses palladium acetate and copper acetate as catalysts, 4,4'-dimethoxybipyridine and the like as ligands, and oxygen as a green oxidant, and amination dehydrogenation aromatization occurs under the action of acid to prepare 4-aminoquinoline derivatives.

The present invention discloses the use of 2-aminoquinoline in the preparation of a drug for inhibiting Salmonella typhimurium. The present invention inhibits the expression of QS-related genes and virulence genes and the formation of biofilms by binding 2-aminoquinoline to an LsrB protein, thereby reducing the pathogenicity of Salmonella typhimurium. 2-aminoquinoline can also inhibit the invasion and adhesion capabilities of Salmonella typhimurium to cells. Therefore, 2-aminoquinoline can be used in the preparation of a drug for inhibiting Salmonella typhimurium.

The present invention addresses the problem of providing a rubber composition with which it is possible to suppress the occurrence of cracks while also improving fuel efficiency. As a means for solving said problem, this rubber composition is characterized by including: a diene rubber (A); a heterocyclic compound (B) having at least one heterocycle selected from the group consisting of a pyrimidine ring, a pyridazine ring, a pyrazine ring, a triazine ring, and a tetrazine ring; and an anti-aging agent (C). The rubber composition is also characterized in that the anti-aging agent (C) includes at least one selected from the group consisting of phenylenediamine-based anti-aging agents (C1-1) represented by a specific structural formula and aminoquinoline-based anti-aging agents (C1-2) represented by a specific structural formula.

The present invention addresses the problem of providing a rubber composition having excellent wear resistance, mechanical strength before and after thermal degradation, and ozone resistance. As a means for solving said problem, this rubber composition is characterized by including a rubber component (A), syndiotactic 1,2-polybutadiene (B), an anti-aging agent (C), and an organic peroxide (D), wherein the anti-aging agent (C) includes at least one selected from the group consisting of phenylenediamine-based anti-aging agents (C1-I) represented by general formula (1-I) and aminoquinoline-based anti-aging agents (C1-II) represented by general formula (1-II).

This invention relates to the field of pharmaceutical biotechnology, providing the application of aminoquinoline compounds (such as hydroxychloroquine and chloroquine) in the preparation of drugs for treating hyperparathyroidism. These compounds restore the expression of calcium-sensitive receptors (CaSRs) on the cell membrane surface by inhibiting the lysosomal degradation pathway of CaSRs in parathyroid cells. Experiments have confirmed that 4-aminoquinoline compounds, used alone or in combination with calcimimetics (such as cinacalcet), significantly reduce serum PTH and calcium levels in a model of refractory secondary hyperparathyroidism (SHPT) and inhibit glandular hyperplasia. In particular, the combination therapy regimen exhibits a significant synergistic effect, effectively reversing calcimimetics resistance. This invention is the first to discover a novel use for the antimalarial / antirheumatic drug hydroxychloroquine in the treatment of hyperparathyroidism, realizing a new use for an existing drug; and providing a safe and effective new drug treatment strategy for clinically refractory SHPT.

Disclosed are methods and compositions for treating or preventing non-viral tick-borne diseases and symptoms thereof by administering a long half-life 8-aminoquinoline such as tafenoquine. The present invention discloses a kit, including a device for detecting non-viral tick-borne diseases and / or symptoms thereof, as well as long half-life 8-aminoquinolines, such as tafenoquine.

The application discloses application of a sulfonamide compound, a mycobacterium tuberculosis inhibitor, a pharmaceutical composition and application thereof, and belongs to the technical field of biological medicines. The application proposes application of the sulfonamide compound in preparation of a preparation for inhibiting diseases caused by mycobacterium tuberculosis and / or non-mycobacterium tuberculosis infection, wherein the sulfonamide compound comprises 2-amino-N-quinolin-8-yl-benzenesulfonamide. It is found that the sulfonamide compound can inhibit mycobacterium tuberculosis and / or non-mycobacterium tuberculosis, so that the sulfonamide compound can be used as a new type of antibacterial agent or medicine for developing mycobacterium tuberculosis and abscesses.

The invention provides a preparation method of a 5-difluoroalkyl-8-aminoquinoline amide compound as shown in a formula (I), transition metal palladium (Pd) is used as a catalyst and is matched with an additive triethoxysilane, efficient difluoroalkyl at C5 site of an 8-aminoquinoline amide substrate is realized for the first time, and the synthesis method is mild in reaction condition, excellent in yield and suitable for industrial production. The defects of the existing method can be overcome, and a new way can be provided for construction of fluorine-containing drug molecules.

The present disclosure provides compounds represented by Formula (I): or salts, solvates, or stereoisomers thereof, wherein R1a, R1b, R2a, R2b, R2c, R3a, R3b, R3c, R3d, R3e, R3f, and R3g are as defined in the specification. The present disclosure also provides compositions, vulcanized elastomeric articles, lubricant compositions, combustible fuel compositions, and fuel additive compositions comprising a compound disclosed herein. The present disclosure also provides processes for preparing the compositions and vulcanized elastomeric articles described herein. The present disclosure also provides a process for retreading tires using a composition described herein. The present disclosure also provides kits comprising a composition described herein.

The application provides a method for preparing 6-((((9H-fluoren-yl)methoxy)carbonyl)amino)quinoline-4-carboxylic acid and belongs to the technical field of drug synthesis. The method uses 2-hydroxyquinoline-4-carboxylic acid as a raw material to prepare 6-((((9H-fluoren-yl)methoxy)carbonyl)amino)quinoline-4-carboxylic acid. The method has the advantages of easy-to-obtain raw material, simple steps and low cost, is suitable for industrial production, and has a wide application prospect.

The invention discloses a corrosion inhibition bactericide for inhibiting subscale corrosion of a subsea pipeline and a preparation method of the corrosion inhibition bactericide. The method comprises the following steps: uniformly mixing and stirring aminopyridine and aminoquinoline, slowly dropwise adding a hydroxide aqueous solution, cooling to below 30 DEG C after dropwise adding, slowly dropwise adding carbon disulfide with the temperature not exceeding 40 DEG C in the whole dropwise adding process, reacting for 8-12 hours at 20-40 DEG C after dropwise adding, and blowing nitrogen for 30 minutes to obtain an intermediate A, adding distilled water and a complex platinum catalyst, carrying out reflux reaction for 2-4 hours at the temperature of 100-110 DEG C, adding glutaraldehyde and isothiazolinone, carrying out reflux reaction for 2-4 hours, cooling to 60 DEG C or below, adding a sulfur-containing compound and low-molecular alcohol, and stirring and dissolving to obtain the sulfur-containing compound. The invention aims at corrosion and bacteria under the scale of the offshore oilfield subsea pipeline, has the advantages of small dosage, good permeability, high corrosion inhibition rate and high sterilization rate, and is suitable for relieving the corrosion under the scale of the subsea pipeline and killing the bacteria under the scale.