38 results about "Aminoquinoline" patented technology

This invention relates to a method for preparing and applying an acidic medium-based iron ion recognition indicator. The indicator contains an aminoquinoline structure and a sulfosalicylic acid structure. It exhibits excellent dual colorimetric and fluorescence responses to ferric ions. When the sample contains Fe... 3+ At that time, Fe 3+ It can undergo complexation reactions with the -NH-CO-, -OH, and quinoline-N groups in the indicator, changing the solution from colorless to brown. This allows for qualitative analysis of iron ions by naked-eye observation. Simultaneously, the fluorescence weakens, and the fluorescence intensity is similar to that of Fe. 3+ The content exhibits a good linear relationship, reaching the nanomolar level, enabling quantitative detection of iron ions and Fe. 3+ It has extremely excellent selectivity, and can identify and detect iron ions not only in normal environments, but also accurately identify iron ions under extreme conditions of strong acidity. It is stable, can be used in acidic media, and has strong anti-interference ability.

The invention relates to a quinoline hydrazone compound containing a hydrazone structure as well as a preparation method and application of the quinoline hydrazone compound, and relates to the technical field of chemical engineering and pesticides. According to the invention, 5-aminoquinoline is used as a raw material to synthesize a series of quinoline hydrazone compounds containing a hydrazone structure; the prepared compound can effectively prevent and treat plant fungal diseases including cucumber gray mold, potato late blight, sclerotinia rot of colza, tomato gray mold, wheat scab, rice blast, kiwi fruit phomopsis and rice sheath blight disease.

To provide a rubber composition for sidewall that has superior ozone resistance and maintains high levels of elongation at break (EB) and tensile strength (TB) after aging, even in the absence of the antioxidant 6PPD.SOLUTION: A rubber composition comprising a rubber component and an aminoquinoline-based antioxidant represented by the following general formula (1). [In formula (1), A is a single bond or a double bond; R11 and R12 are each independently hydrogen, a C1-C12 alkyl group, a C3-C6 cycloalkyl group, or a phenyl group; R13 to R19 are each independently hydrogen or a C1-C12 alkyl group].SELECTED DRAWING: None

Disclosed is a catalyst composition containing a phosphine-imino-quinoline ligand and a transition metal complex having a phosphine-imino-quinoline ligand. These catalyst compositions are useful in ethylene oligomerization processes to produce 1-hexene and 1-octene.

The invention belongs to the technical field of health, clinical and medical related detection, and relates to a liquid chromatography-mass spectrometry detection kit and a detection method for serum seleno-amino acid labeled on the basis of a mass spectrometry probe. The detection kit comprises a mass spectrum probe solution, a protein precipitant solution and a buffering agent solution, the mass spectrum probe is 6-aminoquinolyl-N-hydroxysuccinimido carbamic acid ester, and the mass spectrum probe is 2-aminoquinolyl-N- The buffer solution contains a seleno-amino acid isotope internal standard. According to the kit, a mass spectrum probe is used for labeling, a serum sample is subjected to protein precipitation and then mixed with the mass spectrum probe at room temperature, and simultaneous high-flux accurate quantification of multiple seleno-amino acids can be directly achieved through liquid chromatography-tandem mass spectrometry in a conventional reversed-phase chromatography mode. The 6-aminoquinolyl-N-hydroxysuccinimido carbamate mass spectrum probe adopted in the kit disclosed by the invention has the advantages of high reaction activity, convenience in operation, high sensitivity and the like.

The present invention discloses a zinc ion fluorescent probe based on 8-aminoquinoline, its preparation method and application. The zinc ion fluorescent probe based on 8-aminoquinoline has the following structural formula. The present invention uses 8-aminoquinoline as a matrix, introduces an acetylamino group at position 2 and reacts with salicylaldehyde at position 8 to design and synthesize a highly selective zinc ion fluorescent probe. 2+ The fluorescent probe APYQ is not interfered by other metal ions, and its synthesis steps are simple and the purification process is easy. The fluorescent probe of the present invention has excellent detection limit (1.87nM) and response time (5s). These two indicators are better than other Zn 2+ The fluorescent probe of the present invention can be used to detect Zn with naked eyes in ethanol / HEPES buffer solution and on test paper. 2+ , can also be used to detect Zn in Hela cells 2+ Fluorescence imaging has good application prospects.

The invention relates to a novel compound and a preparation method thereof, in particular to a polysubstituted indeno [1, 2-c] aminoquinoline derivative as well as a synthesis method and application thereof. The invention relates to a novel polysubstituted indeno [1, 2-c] aminoquinoline derivative which is prepared by taking substituted isatin, substituted phenylacetic acid and various amine compounds as raw materials through four-step conventional chemical reaction and simple post-treatment operation. Research finds that the novel polysubstituted indeno [1, 2-c] aminoquinoline derivative has good anti-tumor activity and can be applied to research and development of anti-tumor drugs. The synthesis method of the polysubstituted indeno [1, 2-c] aminoquinoline derivative has the advantages of cheap and easily available raw materials, simple and safe treatment operation after reaction and the like, and the developed brand new indeno [1, 2-c] aminoquinoline derivative is expected to be developed into an important lead compound of antitumor drugs.

The present invention relates to compounds that have activity as cluster of differentiation 38 (CD38) inhibitors, compositions of such compounds, and methods using such compounds for preventing or treating diseases and disorders such as, for example, diseases and disorders of metabolism.

The present disclosure provides a compound represented by formula (I): wherein R1a, R1b, R2a, R2b, R2c, R3a, R3b, R3c, R3d, R3e, R3f, and R3g are as defined in the specification, or a salt, solvate, or stereoisomer thereof. The present disclosure also provides compositions, vulcanized elastomer articles, lubricant compositions, combustible fuel compositions, and fuel additive compositions comprising the compounds disclosed herein. The present disclosure also provides methods for making the compositions and vulcanized elastomeric articles described herein. The present disclosure also provides a method for retreading a tire using the composition described herein. The present disclosure also provides kits comprising the compositions described herein. (I)

The invention relates to the technical field of anticorrosive coatings, in particular to a weather-resistant anticorrosive coating for protecting a metal tank body and a preparation method of the weather-resistant anticorrosive coating. Comprising 100 parts of quick-hardening sulphoaluminate cement, 40-55 parts of slaked lime, 50-65 parts of fly ash, 60-80 parts of quartz powder, 10-20 parts of reinforced fibers, 5-10 parts of an air entraining agent, 10-20 parts of a foam stabilizer, 60-80 parts of waterborne epoxy resin, 3-5 parts of a polycarboxylic acid high-performance water reducing agent, 4-8 parts of calcium formate, 65-85 parts of water, 15-25 parts of a quinoline-containing POSS derivative, 1-2 parts of a curing agent and 0.5-1 part of a silane coupling agent. The quinoline-containing POSS derivative is prepared from octacarboxyl POSS and 3, 4-diaminoquinoline through a reaction of octacarboxyl POSS and 3, 4-diaminoquinoline. According to the preparation method, octacarboxyl POSS and 3, 4-diaminoquinoline are subjected to acylation reaction for the first time to prepare the quinoline-containing POSS derivative with a cage-shaped POSS inner core and quinolyl rigid outer arm structure, the quinoline-containing POSS derivative is used as an anti-corrosion synergist to be applied to a coating, and the weather resistance and corrosion resistance of the coating are improved through triple mechanisms of physical barrier, chemical passivation and microbial inhibition.

The invention relates to a near-infrared ratiometric fluorescent probe for mercury ions of targeted mitochondria as well as preparation and application of the near-infrared ratiometric fluorescent probe. According to the preparation method of the fluorescent probe, (E)-4-(2-(7-(diethylamino)-2-oxo-2H-chromene-3-yl) vinyl)-1-(4-((diphenylselenophosphoryl) oxy) benzyl) is obtained by taking (E)-7-diethylamino-3-(4-quinolyl) vinyl coumarin, diphenylselenophosphoryl and p-hydroxybenzyl as fluorophore, recognition group and connecting arm respectively, and (E)-4-(2-(7-(diethylamino)-2-oxo-2H-chromene-3-yl) vinyl)-1-(4-((diphenylselenophosphoryl) oxy) benzyl) quinoline-1-bromide, namely a compound 1; according to the application of the fluorescent probe, mercury ions are detected by utilizing the change of the fluorescence intensity ratio F721nm / F578nm at two different emission wavelengths, and the fluorescent probe is used for targeted imaging of mercury ions and mitochondria in living cells. The fluorescent probe is simple to prepare, and has the advantages of good selectivity, high sensitivity, high response speed and the like in a coexistence system of mercury ions and other metal ions.

The present invention addresses the problem of providing a rubber composition with which it is possible to suppress the occurrence of cracks while also improving fuel efficiency. As a means for solving said problem, this rubber composition is characterized by including: a diene rubber (A); a heterocyclic compound (B) having at least one heterocycle selected from the group consisting of a pyrimidine ring, a pyridazine ring, a pyrazine ring, a triazine ring, and a tetrazine ring; and an anti-aging agent (C). The rubber composition is also characterized in that the anti-aging agent (C) includes at least one selected from the group consisting of phenylenediamine-based anti-aging agents (C1-1) represented by a specific structural formula and aminoquinoline-based anti-aging agents (C1-2) represented by a specific structural formula.

The present invention addresses the problem of providing a rubber composition having excellent wear resistance, mechanical strength before and after thermal degradation, and ozone resistance. As a means for solving said problem, this rubber composition is characterized by including a rubber component (A), syndiotactic 1,2-polybutadiene (B), an anti-aging agent (C), and an organic peroxide (D), wherein the anti-aging agent (C) includes at least one selected from the group consisting of phenylenediamine-based anti-aging agents (C1-I) represented by general formula (1-I) and aminoquinoline-based anti-aging agents (C1-II) represented by general formula (1-II).

This invention relates to the field of pharmaceutical biotechnology, providing the application of aminoquinoline compounds (such as hydroxychloroquine and chloroquine) in the preparation of drugs for treating hyperparathyroidism. These compounds restore the expression of calcium-sensitive receptors (CaSRs) on the cell membrane surface by inhibiting the lysosomal degradation pathway of CaSRs in parathyroid cells. Experiments have confirmed that 4-aminoquinoline compounds, used alone or in combination with calcimimetics (such as cinacalcet), significantly reduce serum PTH and calcium levels in a model of refractory secondary hyperparathyroidism (SHPT) and inhibit glandular hyperplasia. In particular, the combination therapy regimen exhibits a significant synergistic effect, effectively reversing calcimimetics resistance. This invention is the first to discover a novel use for the antimalarial / antirheumatic drug hydroxychloroquine in the treatment of hyperparathyroidism, realizing a new use for an existing drug; and providing a safe and effective new drug treatment strategy for clinically refractory SHPT.

Disclosed are methods and compositions for treating or preventing non-viral tick-borne diseases and symptoms thereof by administering a long half-life 8-aminoquinoline such as tafenoquine. The present invention discloses a kit, including a device for detecting non-viral tick-borne diseases and / or symptoms thereof, as well as long half-life 8-aminoquinolines, such as tafenoquine.

The application discloses application of a sulfonamide compound, a mycobacterium tuberculosis inhibitor, a pharmaceutical composition and application thereof, and belongs to the technical field of biological medicines. The application proposes application of the sulfonamide compound in preparation of a preparation for inhibiting diseases caused by mycobacterium tuberculosis and / or non-mycobacterium tuberculosis infection, wherein the sulfonamide compound comprises 2-amino-N-quinolin-8-yl-benzenesulfonamide. It is found that the sulfonamide compound can inhibit mycobacterium tuberculosis and / or non-mycobacterium tuberculosis, so that the sulfonamide compound can be used as a new type of antibacterial agent or medicine for developing mycobacterium tuberculosis and abscesses.

The invention provides a preparation method of a 5-difluoroalkyl-8-aminoquinoline amide compound as shown in a formula (I), transition metal palladium (Pd) is used as a catalyst and is matched with an additive triethoxysilane, efficient difluoroalkyl at C5 site of an 8-aminoquinoline amide substrate is realized for the first time, and the synthesis method is mild in reaction condition, excellent in yield and suitable for industrial production. The defects of the existing method can be overcome, and a new way can be provided for construction of fluorine-containing drug molecules.

The application provides a method for preparing 6-((((9H-fluoren-yl)methoxy)carbonyl)amino)quinoline-4-carboxylic acid and belongs to the technical field of drug synthesis. The method uses 2-hydroxyquinoline-4-carboxylic acid as a raw material to prepare 6-((((9H-fluoren-yl)methoxy)carbonyl)amino)quinoline-4-carboxylic acid. The method has the advantages of easy-to-obtain raw material, simple steps and low cost, is suitable for industrial production, and has a wide application prospect.

The invention discloses a corrosion inhibition bactericide for inhibiting subscale corrosion of a subsea pipeline and a preparation method of the corrosion inhibition bactericide. The method comprises the following steps: uniformly mixing and stirring aminopyridine and aminoquinoline, slowly dropwise adding a hydroxide aqueous solution, cooling to below 30 DEG C after dropwise adding, slowly dropwise adding carbon disulfide with the temperature not exceeding 40 DEG C in the whole dropwise adding process, reacting for 8-12 hours at 20-40 DEG C after dropwise adding, and blowing nitrogen for 30 minutes to obtain an intermediate A, adding distilled water and a complex platinum catalyst, carrying out reflux reaction for 2-4 hours at the temperature of 100-110 DEG C, adding glutaraldehyde and isothiazolinone, carrying out reflux reaction for 2-4 hours, cooling to 60 DEG C or below, adding a sulfur-containing compound and low-molecular alcohol, and stirring and dissolving to obtain the sulfur-containing compound. The invention aims at corrosion and bacteria under the scale of the offshore oilfield subsea pipeline, has the advantages of small dosage, good permeability, high corrosion inhibition rate and high sterilization rate, and is suitable for relieving the corrosion under the scale of the subsea pipeline and killing the bacteria under the scale.

The invention discloses a preparation method of 2-methyl-4-aminoquinoline, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: by taking 2-methylquinoline as a raw material, carrying out nitrogen oxidation reaction under the action of 3-chloroperoxybenzoic acid (mCPBA) without purification; then carrying out nitration reaction in iron nitrate nonahydrate and isopropanol; then, under the tetrahydroxy diboron / alkaline condition, 2-methyl-4-aminoquinoline is generated through reduction. Easily available 2-methylquinoline is adopted as a raw material, nitrogen oxidation is performed, a ferric nitrate nitration system is adopted, and finally amino is introduced through reduction, so that harsh conditions in a traditional method are avoided, the route is simple and efficient, product separation and purification are simple, and the method is suitable for being carried out under industrial amplification conditions.

The invention discloses a lysosome targeted copper ion fluorescent probe with an AIE (aggregation-induced emission) effect, which is obtained by taking 7-(diphenylamino)-2-oxo-2H-benzopyran-3-carboxylic acid (I) and 8-aminoquinoline (II) as raw materials and reacting and synthesizing under the action of 2-(7-azabenzotriazole)-N, N, N ', N'-tetramethylurea hexafluorophosphate and triethylamine. The chemical structural formula of the fluorescent probe is shown as a formula (III), and the fluorescent probe has an AIE effect, has the advantages of high selectivity and high sensitivity on Cu < 2 + > recognition and the like, and can be used for effectively detecting Cu < 2 + > in an environmental water sample; besides, the probe has good biocompatibility, can be positioned in a lysosome, and is applied to real-time fluorescence imaging monitoring of Cu < 2 + > concentration change in an autophagy process caused by starvation or a chemical inducer in living cells and zebra fish bodies; the invention provides a copper ion detection tool with excellent performance, which has huge potential in the fields of environmental monitoring and life science research.

The invention relates to a magnetic bistable complex as well as a preparation method and application thereof. The molecular formula of the complex is [Fe (C16H10N2OCl) 2] 4 (W10O32). 4CH3CN; the preparation method comprises the following steps: dissolving 8-aminoquinoline and salicylaldehyde in methanol, heating and refluxing for 3 hours, adding triethylamine and ferric trichloride, and collecting precipitate to obtain [Fe (C16H10N2OCl) 2] Cl; dissolving the obtained product in dichloromethane, and placing at the bottom of a test tube as a lower layer; adding a mixed solution of dichloromethane and acetonitrile as a transition layer, wherein the upper layer is an acetonitrile solution dissolved with [(n-C4H9) 4N] 4 [W10O32]; slowly diffusing to obtain a black strip-shaped crystal finished product; the limitation of traditional heat balance regulation and control is broken through, and support is provided for practical application of magnetic materials.

The application provides a method for constructing a constipation model. The method is as follows: C57BL / 6J mice are selected as experimental animals for pre-feeding, then 2-aminoquinoline is used for intragastrical administration, the intragastrical administration is performed once a day, and the intragastrical administration is performed for a total of 2 weeks, so that an animal constipation model is obtained. The animal constipation model has the substantial advantages of simple operation, low cost, high success rate, strong repeatability and unity with clinical constipation.

Disclosed in the present invention are a galactose-masked aminoquinoline compound and the use thereof. The compound has a structural formula of, wherein R is acetyl, propionyl, or butyryl. After deacetylation, depropionylation, or debutyrylation by means of esterase hydrolysis in cells, the compound of the present invention can be activated by senescence-associated β-galactosidase in the lysosomes of senescent cells to release aminoquinoline (NCQ), thereby inhibiting the survival of senescent cells in vivo or in vitro.

The application discloses a galactose-masked aminoquinoline compound and application thereof, and a structural formula of the compound is shown in the following formula: wherein R is acetyl, propionyl or butyryl. After being hydrolyzed by an esterase to remove acetylation, propionylation or butyrylation in cells, the application can be activated by a senescence-associated beta-galactosidase in a lysosome of a senescent cell, so that an aminoquinoline (NCQ) is released to inhibit survival of a senescent cell in vivo or in vitro.

This invention discloses methods and compositions for treating or preventing nonviral tick-borne diseases and their symptoms by administering long-half-life 8-aminoquinolines such as tafenoxane. This invention also discloses a kit comprising a device for detecting nonviral tick-borne diseases and / or their symptoms, and a long-half-life 8-aminoquinoline, such as tafenoxane.

The present invention addresses the problem of providing a vulcanized rubber for tires which has excellent grip performance on ice and has improved durability and ozone resistance. The problem is solved by a vulcanized rubber for tires that is characterized by having a plurality of voids and comprising a rubber component (A), a filler (B), and an anti-aging agent (C), wherein the content of the filler (B) is at least 65 parts by mass with respect to 100 parts by mass of the rubber component (A), the proportion of carbon black is at least 70 mass% and the proportion of silica is 0-20 mass% with respect to 100 mass% of the filler (B), and the anti-aging agent (C) contains at least one agent selected from the group consisting of phenylenediamine-based anti-aging agents (C1-I) represented by general formula (1-I) and aminoquinoline-based anti-aging agents (C1-II) represented by general formula (1-II).

The invention belongs to the field of medicinal chemistry, and discloses 2-substituted-4-aminoquinoline derivatives as shown in formulas I and II. Wherein R is selected from-OMe and-OH; r1 is selected from the group consisting of thiophen-2-yl and p-meta-phenyl, and R2 is selected from the group consisting of thiophen-2-yl and p-meta-phenyl; r2 is selected from-CH3,-F,-H and-Ph. The raw materials of the 2-substituted-4-aminoquinoline derivative are easy to obtain, the synthesis method is simple, and the operation is simple and convenient. The 2-substituted-4-aminoquinoline derivative has good acetylcholinesterase inhibitory activity, the activity of an individual compound is higher than that of a clinical drug rivastigmine, and the 2-substituted-4-aminoquinoline derivative is expected to be developed into a novel cholinesterase inhibitor type anti-Alzheimer's disease drug.

This invention relates to the field of anti-corrosion coating technology, and more particularly to a weather-resistant anti-corrosion coating for metal tank protection and its preparation method. By weight, it comprises: 100 parts rapid-hardening sulfoaluminate cement, 40-55 parts quicklime, 50-65 parts fly ash, 60-80 parts quartz powder, 10-20 parts reinforcing fiber, 5-10 parts air-entraining agent, 10-20 parts foam stabilizer, 60-80 parts waterborne epoxy resin, 3-5 parts polycarboxylate high-performance water-reducing agent, 4-8 parts calcium formate, 65-85 parts water, 15-25 parts quinoline-containing POSS derivative, 1-2 parts curing agent, and 0.5-1 parts silane coupling agent; wherein the quinoline-containing POSS derivative is prepared by reacting octacarboxylated POSS with 3,4-diaminoquinoline. This invention is the first to utilize the acylation reaction between octacarboxylated POSS and 3,4-diaminoquinoline to prepare a quinoline-containing POSS derivative with a structure of "cage-like POSS core and quinoline-based rigid outer arm". This derivative is then used as an anti-corrosion synergist in coatings, improving the weather resistance and anti-corrosion performance of the coating through a triple mechanism of physical barrier, chemical passivation and microbial inhibition.

The purpose of the present invention is to provide a rubber composition with which it is possible to achieve high-level wet grip performance, fuel efficiency performance, and wear resistance performance, as well as excellent resistance to discoloration and improved ozone resistance.　The present invention is a rubber composition including a rubber component, a filler, and an anti-aging agent, said rubber composition characterized in that the rubber component contains at least two types of styrene-butadiene rubber, and the anti-aging agent contains an aminoquinoline-based anti-aging agent represented by general formula (1) or a phenylenediamine-based anti-aging agent represented by general formula (2).