22 results about "Aminoquinoline" patented technology

The present invention relates to compounds that have activity as cluster of differentiation 38 (CD38) inhibitors, compositions of such compounds, and methods using such compounds for preventing or treating diseases and disorders such as, for example, diseases and disorders of metabolism.

The present invention addresses the problem of providing a rubber composition with which it is possible to suppress the occurrence of cracks while also improving fuel efficiency. As a means for solving said problem, this rubber composition is characterized by including: a diene rubber (A); a heterocyclic compound (B) having at least one heterocycle selected from the group consisting of a pyrimidine ring, a pyridazine ring, a pyrazine ring, a triazine ring, and a tetrazine ring; and an anti-aging agent (C). The rubber composition is also characterized in that the anti-aging agent (C) includes at least one selected from the group consisting of phenylenediamine-based anti-aging agents (C1-1) represented by a specific structural formula and aminoquinoline-based anti-aging agents (C1-2) represented by a specific structural formula.

The present invention addresses the problem of providing a rubber composition having excellent wear resistance, mechanical strength before and after thermal degradation, and ozone resistance. As a means for solving said problem, this rubber composition is characterized by including a rubber component (A), syndiotactic 1,2-polybutadiene (B), an anti-aging agent (C), and an organic peroxide (D), wherein the anti-aging agent (C) includes at least one selected from the group consisting of phenylenediamine-based anti-aging agents (C1-I) represented by general formula (1-I) and aminoquinoline-based anti-aging agents (C1-II) represented by general formula (1-II).

This invention relates to the field of pharmaceutical biotechnology, providing the application of aminoquinoline compounds (such as hydroxychloroquine and chloroquine) in the preparation of drugs for treating hyperparathyroidism. These compounds restore the expression of calcium-sensitive receptors (CaSRs) on the cell membrane surface by inhibiting the lysosomal degradation pathway of CaSRs in parathyroid cells. Experiments have confirmed that 4-aminoquinoline compounds, used alone or in combination with calcimimetics (such as cinacalcet), significantly reduce serum PTH and calcium levels in a model of refractory secondary hyperparathyroidism (SHPT) and inhibit glandular hyperplasia. In particular, the combination therapy regimen exhibits a significant synergistic effect, effectively reversing calcimimetics resistance. This invention is the first to discover a novel use for the antimalarial / antirheumatic drug hydroxychloroquine in the treatment of hyperparathyroidism, realizing a new use for an existing drug; and providing a safe and effective new drug treatment strategy for clinically refractory SHPT.

Disclosed are methods and compositions for treating or preventing non-viral tick-borne diseases and symptoms thereof by administering a long half-life 8-aminoquinoline such as tafenoquine. The present invention discloses a kit, including a device for detecting non-viral tick-borne diseases and / or symptoms thereof, as well as long half-life 8-aminoquinolines, such as tafenoquine.

The invention provides a preparation method of a 5-difluoroalkyl-8-aminoquinoline amide compound as shown in a formula (I), transition metal palladium (Pd) is used as a catalyst and is matched with an additive triethoxysilane, efficient difluoroalkyl at C5 site of an 8-aminoquinoline amide substrate is realized for the first time, and the synthesis method is mild in reaction condition, excellent in yield and suitable for industrial production. The defects of the existing method can be overcome, and a new way can be provided for construction of fluorine-containing drug molecules.

The application provides a method for preparing 6-((((9H-fluoren-yl)methoxy)carbonyl)amino)quinoline-4-carboxylic acid and belongs to the technical field of drug synthesis. The method uses 2-hydroxyquinoline-4-carboxylic acid as a raw material to prepare 6-((((9H-fluoren-yl)methoxy)carbonyl)amino)quinoline-4-carboxylic acid. The method has the advantages of easy-to-obtain raw material, simple steps and low cost, is suitable for industrial production, and has a wide application prospect.

The invention discloses a preparation method of 2-methyl-4-aminoquinoline, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: by taking 2-methylquinoline as a raw material, carrying out nitrogen oxidation reaction under the action of 3-chloroperoxybenzoic acid (mCPBA) without purification; then carrying out nitration reaction in iron nitrate nonahydrate and isopropanol; then, under the tetrahydroxy diboron / alkaline condition, 2-methyl-4-aminoquinoline is generated through reduction. Easily available 2-methylquinoline is adopted as a raw material, nitrogen oxidation is performed, a ferric nitrate nitration system is adopted, and finally amino is introduced through reduction, so that harsh conditions in a traditional method are avoided, the route is simple and efficient, product separation and purification are simple, and the method is suitable for being carried out under industrial amplification conditions.

The invention discloses a lysosome targeted copper ion fluorescent probe with an AIE (aggregation-induced emission) effect, which is obtained by taking 7-(diphenylamino)-2-oxo-2H-benzopyran-3-carboxylic acid (I) and 8-aminoquinoline (II) as raw materials and reacting and synthesizing under the action of 2-(7-azabenzotriazole)-N, N, N ', N'-tetramethylurea hexafluorophosphate and triethylamine. The chemical structural formula of the fluorescent probe is shown as a formula (III), and the fluorescent probe has an AIE effect, has the advantages of high selectivity and high sensitivity on Cu < 2 + > recognition and the like, and can be used for effectively detecting Cu < 2 + > in an environmental water sample; besides, the probe has good biocompatibility, can be positioned in a lysosome, and is applied to real-time fluorescence imaging monitoring of Cu < 2 + > concentration change in an autophagy process caused by starvation or a chemical inducer in living cells and zebra fish bodies; the invention provides a copper ion detection tool with excellent performance, which has huge potential in the fields of environmental monitoring and life science research.

Disclosed in the present invention are a galactose-masked aminoquinoline compound and the use thereof. The compound has a structural formula of, wherein R is acetyl, propionyl, or butyryl. After deacetylation, depropionylation, or debutyrylation by means of esterase hydrolysis in cells, the compound of the present invention can be activated by senescence-associated β-galactosidase in the lysosomes of senescent cells to release aminoquinoline (NCQ), thereby inhibiting the survival of senescent cells in vivo or in vitro.

The application discloses a galactose-masked aminoquinoline compound and application thereof, and a structural formula of the compound is shown in the following formula: wherein R is acetyl, propionyl or butyryl. After being hydrolyzed by an esterase to remove acetylation, propionylation or butyrylation in cells, the application can be activated by a senescence-associated beta-galactosidase in a lysosome of a senescent cell, so that an aminoquinoline (NCQ) is released to inhibit survival of a senescent cell in vivo or in vitro.

This invention discloses methods and compositions for treating or preventing nonviral tick-borne diseases and their symptoms by administering long-half-life 8-aminoquinolines such as tafenoxane. This invention also discloses a kit comprising a device for detecting nonviral tick-borne diseases and / or their symptoms, and a long-half-life 8-aminoquinoline, such as tafenoxane.

The present invention addresses the problem of providing a vulcanized rubber for tires which has excellent grip performance on ice and has improved durability and ozone resistance. The problem is solved by a vulcanized rubber for tires that is characterized by having a plurality of voids and comprising a rubber component (A), a filler (B), and an anti-aging agent (C), wherein the content of the filler (B) is at least 65 parts by mass with respect to 100 parts by mass of the rubber component (A), the proportion of carbon black is at least 70 mass% and the proportion of silica is 0-20 mass% with respect to 100 mass% of the filler (B), and the anti-aging agent (C) contains at least one agent selected from the group consisting of phenylenediamine-based anti-aging agents (C1-I) represented by general formula (1-I) and aminoquinoline-based anti-aging agents (C1-II) represented by general formula (1-II).

This invention relates to the field of anti-corrosion coating technology, and more particularly to a weather-resistant anti-corrosion coating for metal tank protection and its preparation method. By weight, it comprises: 100 parts rapid-hardening sulfoaluminate cement, 40-55 parts quicklime, 50-65 parts fly ash, 60-80 parts quartz powder, 10-20 parts reinforcing fiber, 5-10 parts air-entraining agent, 10-20 parts foam stabilizer, 60-80 parts waterborne epoxy resin, 3-5 parts polycarboxylate high-performance water-reducing agent, 4-8 parts calcium formate, 65-85 parts water, 15-25 parts quinoline-containing POSS derivative, 1-2 parts curing agent, and 0.5-1 parts silane coupling agent; wherein the quinoline-containing POSS derivative is prepared by reacting octacarboxylated POSS with 3,4-diaminoquinoline. This invention is the first to utilize the acylation reaction between octacarboxylated POSS and 3,4-diaminoquinoline to prepare a quinoline-containing POSS derivative with a structure of "cage-like POSS core and quinoline-based rigid outer arm". This derivative is then used as an anti-corrosion synergist in coatings, improving the weather resistance and anti-corrosion performance of the coating through a triple mechanism of physical barrier, chemical passivation and microbial inhibition.

The purpose of the present invention is to provide a rubber composition with which it is possible to achieve high-level wet grip performance, fuel efficiency performance, and wear resistance performance, as well as excellent resistance to discoloration and improved ozone resistance.　The present invention is a rubber composition including a rubber component, a filler, and an anti-aging agent, said rubber composition characterized in that the rubber component contains at least two types of styrene-butadiene rubber, and the anti-aging agent contains an aminoquinoline-based anti-aging agent represented by general formula (1) or a phenylenediamine-based anti-aging agent represented by general formula (2).

The invention discloses an antibacterial easy-to-demould composite material for a food mould, relates to the technical field of polymer composite materials, and aims to improve the easy-to-demould performance and antibacterial performance of a food mould material and improve the raw materials of the food mould. Firstly, terephthalic acid, a modified antibacterial monomer and ethylene glycol are used as raw materials and are subjected to esterification polycondensation, so that a modified antibacterial monomer structure is introduced into a PET chain segment, and fluorine in trifluoromethyl introduced by 4-trifluoromethyl-2-aminoquinoline effectively reduces the surface energy of the material, so that the antibacterial property of the material is improved, and the antibacterial property of the material is improved. The hydrophobic and oleophobic performance of the material surface is improved, adsorption of food to a mold is reduced, the demolding performance of the mold is improved, and food residues on the material surface are reduced, so that the growth environment of pathogenic bacteria is further reduced, and the safety of the food mold is effectively improved.

This invention discloses a self-adhesive coating for amorphous silicon steel sheets and its preparation method, belonging to the field of coating preparation technology. First, an epoxy resin is generated by polymerizing epichlorohydrin with 4-aminoquinoline, improving thermal stability and effectively reducing mechanical losses after coating. Then, it is reacted with phloroglucinol to obtain a modified epoxy resin, which exhibits tight inward molecular aggregation, increasing crosslinking density. Next, the ring-opening reaction of ethylene glycol diglycidyl ether with 3,5-dichloroaniline enhances crosslinking properties, followed by a reaction with lacquer resin to improve coating stability. The resulting self-adhesive coating can bond tightly to the iron core, reducing NVH levels, decreasing eddy current losses and iron losses, improving the energy conversion efficiency of the motor, and enhancing hydrophobicity.

The present invention addresses the problem of providing a tire rubber composition with which it is possible to suppress the occurrence of cracks while also achieving better tire fuel efficiency and wear resistance. As a means for solving said problem, this tire rubber composition is characterized by including a rubber component (A) and an anti-aging agent (B), wherein the rubber component (A) includes a copolymer (A1) of cyclopentene and a norbornene-based compound, which has a specific structure, and a modified polymer (A2), and the anti-aging agent (B) includes at least one selected from the group consisting of phenylenediamine-based anti-aging agents (B1-1) represented by a specific structural formula and aminoquinoline-based anti-aging agents (B1-2) represented by a specific structural formula.

Disclosed are methods and compositions for treating or preventing non-viral tick-borne diseases and symptoms thereof by administering a long half-life 8-aminoquinoline such as tafenoquine. The present invention discloses a kit, including a device for detecting non-viral tick-borne diseases and / or symptoms thereof, as well as long half-life 8-aminoquinolines, such as tafenoquine.

The invention relates to a combination of substituted 2,4 diamino-quinoline compounds and MEK inhibitors, pharmaceutical compositions containing it and its use as a medicament. The invention further relates to a combination of substituted 2,4 diamino-quinoline compounds and MEK inhibitors, for use in the prevention and / or decreasing and / or treatment of liver cancers. The substituted 2,4 diamino-quinoline compounds and MEK inhibitors constituting said combination can be used simultaneously, separately or sequentially.

This invention discloses a method for Ag + This paper discusses quinoline fluorescent probes for detection, their preparation methods, and applications. It aims to address existing methods for detecting Ag. + The existing fluorescent probes suffer from technical problems such as low sensitivity, long response time, short fluorescence wavelength, small Stokes shift, and poor biocompatibility. This invention addresses these issues with the detection of Ag. + The structure of the quinoline-based fluorescent probe for detection is as follows: it is obtained by reacting 6-(dimethylamino)quinoline-2-carboxaldehyde with aminothiourea to obtain a Schiff base intermediate, followed by a cyclization addition reaction with bromoacetophenone. This intermediate is then used as a fluorescent probe for Ag... + Qualitative and quantitative detection. Unaffected by coexisting ions in the environment and unaffected by acidic or alkaline conditions. Can be used for Ag... + Testing field.

The invention relates to the technical field of chemical synthesis, in particular to a synthesis method and application of asymmetric 1, 10-phenanthroline. The synthesis method of the asymmetric 1, 10-phenanthroline, provided by the invention, comprises the following steps: reacting 8-aminoquinoline and crotonaldehyde under the acidic condition and the catalytic action of NaI to obtain an intermediate 1; carrying out oxidation reaction on the intermediate 1 under an acidic condition to obtain an intermediate 2; and reacting the intermediate 2 with phosphorus oxyhalide to obtain the asymmetric 1, 10-phenanthroline. According to the synthesis method of the asymmetric 1, 10-phenanthroline, through three-step efficient reaction, the synthesis period is short, the production efficiency is high, the used raw materials are easy to obtain and low in cost, a convenient and efficient synthesis means is provided for researchers, and the asymmetric 1, 10-phenanthroline modification method and substrate range are widened; meanwhile, the method is suitable for large-scale industrial production and meets the large demand of the market on the phenanthroline derivative.