144 results about "Chronic urticaria" patented technology

The invention concerns bifunctional fusion molecules for the treatment of IgE-mediated allergic conditions and FcepsiRI-mediated autoimmune conditions. The invention provides a new therapeutic approach for the treatment of both acute and late-phase allergic responses due to ingestion, inhalation, cutaneous and parenteral exposure to allergens, responses including asthma, allergic rhinitis, atopic dermatitis, severe food allergies, chronic urticaria and angioedema, as well as anaphylactic reactions due to exposures such as bee stings or penicillin allergy. In addition, the invention provides for a novel, safer and more efficacious form of allergy vaccination.

The invention concerns bifunctional fusion molecules for the treatment of IgE-mediated allergic conditions and FcεRI-mediated autoimmune conditions. The invention provides a new therapeutic approach for the treatment of both acute and late-phase allergic responses due to ingestion, inhalation, cutaneous and parenteral exposure to allergens, responses including asthma, allergic rhinitis, atopic dermatitis, severe food allergies, chronic urticaria and angioedema, as well as anaphylactic reactions due to exposures such as bee stings or penicillin allergy. In addition, the invention provides for a novel, safer and more efficacious form of allergy vaccination.

Orally administered sodium cromoglycate has been found to be effective in the treatment of allergic conditions such as asthma, general food allergies, ulcerative colitis, atopic eczema, chronic urticaria and irritable bowel syndrome if it is presented such that the sodium cromoglycate becomes bioavailable within 10 minutes of exposure to intestinal fluid. The sodium cromoglycate may be presented as enteric-coated tablets or individually enteric-coated pellets or microgranules packaged with disintegrant in a ratio of at least 1.2:1 disintegrant:sodium cromoglycate (w:w). Optionally, the patients are first selected to have a total serum IgE level of at least 150 iu / ml.

The invention relates to a Chinese traditional medicine preparation and the preparation method, in particular to a Chinese traditional medicine preparation which has evident effect on treating skin diseases such as acute and chronic urticaria, acute eczema of wind-heat type or wind-heat-dampness type and the preparation method. The preparation is prepared by the raw materials with the proportion by weight, that is, the proportion of Lighiyellow Sophora Root, Japanese Atractylodes Rhizome, Radix Saposhnikoviae, Fineleaf Schizonepeta Herb, Puncturevine Caltrop Fruit, Sandalwood, Common Cnidium Fruit, Siberian Cocklebur Fruit, Scolopendra, Natural Indigo, Dandelion, Viola chinensis, Baical Skullcap Root, phellodendron, Golden Thread, Periostracum Cicadae, Radix Rehmanniae, Tree Peony Bark, Chinese Tamarisk Twing, Gromwell Root and Chinese wolfberry Root-bark equals to 125-225:50-150:25-125:125-225:50-150:75-175:50-150:25-125:25-125:25-125:100-200:75-175:25-125:25-125:25-125:50-150:50-150:50-150:50-150:50-150:75-175. The invention is a pure Chinese traditional medicine preparation and is characterized by accurate efficacy, good effect, no side effects like the Western medicine antihistamine, and good stability; besides, with 86.22 per cent total effective rate in treatment reaches, rich medicine sources and low cost, the invention has great development and application values.

The invention provides an artemisia pollen allergen vaccine, and a preparation method and application thereof. The artemisia pollen allergen vaccine comprises an artemisia sieversiana pollen allergen, an artemisia annua pollen allergen and an artemisia argyi pollen allergen. Compared with a single artemisia pollen allergen vaccine, the combined vaccine has the advantages that the effectiveness of treatment is improved while the safety can be ensured; and the artemisia pollen allergen vaccine can be used for treating allergic dermatitis, chronic urticaria, allergic rhinitis and allergic asthma which are caused by allergy to multiple artemisia pollens.

The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.

The invention relates to the field of the formula of medicaments, in particular to decoction for treating chronic urticaria. The decoction is technically characterized by being prepared from the following raw materials in percentage by weight: 4 to 6 percent of cicada shell, 10 to 13 percent of stiff silkworm, 8 to 11 percent of rehmannia root, 7 to 11 percent of tuber fleeceflower root, 8 to 10 percent of Chinese angelica, 6 to 8 percent of Siberian cocklour fruit, 4 to 7 percent of densefruit pittany root-bark, 4 to 7 percent of belvedere fruit, 8 to 11 percent of fineleaf schizonepeta herb, 7 to 10 percent of divaricate saposhnikovia root, 6 to 9 percent of red paeony root and 3 to 5 percent of mint. A preparation method comprises the following steps of: soaking the raw materials in water, decocting and deslagging to obtain filtrate. The decoction has the advantages of low cost, high curative effect of treating the chronic urticaria, and small toxic and side effects.

The invention relates to a hydrogel preparation for improving the permeation of an active component glycyrrhetinic acid and / or its salt through a barrier via skins, its preparation method, and its application in the dermatology. The glycyrrhetinic acid hydrogel preparation comprises 0.01-10wt% of the active component glycyrrhetinic acid and / or its salt, 0.01-10wt% of a gel matrix, 0.01-10wt% of a humectant, 0.01-5wt% of an antiseptic, 0.01-5wt% of a pH adjustment agent, and the balance water. The glycyrrhetinic acid hydrogel preparation has the advantages of simple preparation method, good storage stability, substantial improvement of the penetration amount through the skins, no irritation or anaphylaxis, good absorbency, and good safety, and can be used for preparing medicinal preparations for treating dermatoses comprising chronic urticaria, eczema, contact dermatitis and the like through skin administration.

The invention relates to the field of a traditional Chinese medicine, and discloses a traditional Chinese medicine for treating chronic urticaria. The traditional Chinese medicine for treating the chronic urticaria is prepared from astragalus mongholicus, white atractylodes rhizome, radices sileris, schizonepeta, angelica sinensis, radix rehmanniae, root bark of the peony tree, periostracum cicada, bombyx batryticatus, zaocys dhumnade, oriental wormwood, liquorice, kuh-seng, cortex dictamni, and common threewingnut root (full root with bark). The traditional Chinese medicine for treating the chronic urticaria is good in a curative effect, short in treatment course, and high in recovery rate; and the recovery rate is 91.3%.

The present invention relates to novel bisaminoquinoline compounds, pharmaceutical compositions comprising these novel compounds and methods for inhibiting autophagy in biological systems. Methods of treating cancer in patients in need using compounds and / or compositions according to the present invention alone or in combination with at least one additional anticancer agent represent additional aspects of the invention. Methods of treating disease states and / or conditions in which inhibition of autophagy plays a favorable treatment role including rheumatoid arthritis, malaria, antiphospholipid antibody syndrome, lupus, chronic urticaria and Sjogren's disease, with compounds according to the present invention represent additional aspects of the invention.

The strong antipruritic pill for treating obstinate pruritus is prepared with black-tail snake, scorpion, centipede, cocklebur fruit, cnidium fruit and other over twenty kinds of Chinese medicinal materials, and through sorting, washing, stoving, decocting, crushing, making pill, sterilizing and other steps. The present invention has the functions of dispelling wind evil, eliminating itching, cooling blood, eliminating toxic matter, activating blood circulation, dredging meridian and nourishing skin. It is used to treat obstinate pruritus and various dermatosis, including chronic urticaria, chronic eczema, neurodermatitis, tinea, etc.

Disclosed is a medicinal broth for treating chronic urticaria and its preparing process, wherein the medicament is prepared from the following raw materials (by weight portion): tuber of multiflower knotweed, white atractylodes rhizome each 15-18g, baikal skullcap root, flavescent sophora root, broom cypress fruit, Chinese angelica root, cortex dictamni radicis, radix salvia miltiorrhiza each 12-15g, radix paeoniae rubrathe, ledebouriella root, cicada shell, black-tail snake 9-12g, Ligusticum wallichii, buthus martensi karsch, and licorice root each 5-7g.

The invention relates to a Chinese medicinal composition for treatment of chronic urticaria. The Chinese medicinal composition is made of the following Chinese medicinal materials by weight: 5-25 parts of Puerarin, 5-20 parts of papaya, 10-30 parts of bighead atractylodes rhizome, 5-20 parts of periostracum cicada, 5-20 parts of lumbricus, 5-20 parts of Mangnolia officinalis, 5-20 parts of Schizonepeta, 5-20 parts of cortex moutan, 5-20 parts of red peony roots, 5-20 parts of Great Burdock Achene, 5-25 parts of Salvia miltiorrhiza, 5-15 parts of cassia twigs, 5-25 parts of Fructus Kochiae, 10-30 parts of astragalus, 5-20 parts of Poria cocos, 10-30 parts of Phaseolus Calcaratus, 5-15 parts of Adenophora stricta, 5-20 parts of radix lithospermi, 5-25 parts of Chinese angelica, and 5-15 parts of safflower. With the efficacy of dispelling wind and relieving exterior syndromes, clearing away heat and purging pathogenic fire, strengthening spleen and harmonizing stomach, eliminating dampness and relieving itching, the Chinese medicinal composition has obvious chronic urticaria treatment effects and reliable functions. The Chinese medicinal composition disclosed in the invention has the characteristics of wide ingredient medicine sources, simple preparation, mild medicine properties, and no toxic or side effect.

The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.

Disclosed is a rapid, non-invasive and highly specific and sensitive diagnostic assay for the identification of individuals with autoimmune chronic urticaria, which makes use of CD203c, and in some embodiments, additional proteins, as a marker for the disease. Test kits for diagnosis of an individual suspected of having autoimmune chronic urticaria are also disclosed. Also disclosed are a method of identifying compounds useful for treating autoimmune chronic urticaria and a method of treating autoimmune chronic urticaria.

The present invention relates to novel bisaminoquinoline compounds, pharmaceutical compositions comprising these novel compounds and methods for inhibiting autophagy in biological systems. Methods of treating cancer in patients in need using compounds and / or compositions according to the present invention alone or in combination with at least one additional anticancer agent represent additional aspects of the invention. Methods of treating disease states and / or conditions in which inhibition of autophagy plays a favorable treatment role including rheumatoid arthritis, malaria, antiphospholipid antibody syndrome, lupus, chronic urticaria and Sjogren's disease, with compounds according to the present invention represent additional aspects of the invention.

Disclosed is a medicinal broth for treating chronic urticaria and its preparing process, wherein the medicament is prepared from the following raw materials (by weight portion): astragalus root, tuber of multiflower knotweed, white atractylodes rhizome each 15-18g, Chinese angelica root, cortex dictamni radicis, radix salvia miltiorrhiza each 12-15g, pilose asiabell root, root of herbaceous peony, prepared rhizome of rehmannia, radix paeoniae rubrathe, ledebouriella root, cicada shell, black-tail snake each 9-12g, Chinese dates, Ligusticum wallichii, and licorice root each 5-7g.

An oral disintegrating tablet of loratadine for treating allergic rhinitis, urticaria and other allergic skin diseases is prepared from loratadine and medicinal auxiliary.

The invention provides a pharmaceutical composition for treating allergic diseases, which comprises a dust mite allergen, a dust mite allergen and a pharmaceutically acceptable carrier. The invention also relates to a preparation method of the pharmaceutical composition. The composition of the invention can be used for the treatment of allergic asthma, allergic rhinitis, allergic dermatitis, chronic urticaria and the like.

The invention relates to an injectable artemisia pollen allergen vaccine and a preparation method thereof. The injectable artemisia pollen allergen vaccine contains artemisia pollen allergens and an aluminum adjuvant, wherein the artemisia pollen allergens comprise artemisia sieversiana pollen allergens, sweet wormwood pollen allergens and argy wormwood pollen allergens. The injectable artemisia pollen allergen vaccine has obvious effects of treating hypersensitivity diseases such as allergic dermatitis, chronic urticaria, allergic rhinitis and allergic asthma.

Disclosed is a medicinal broth for treating chronic urticaria and its preparing process, wherein the medicament is prepared from the following raw materials (by weight portion): astragalus root, tuber of multiflower knotweed, white atractylodes rhizome each 15-18g, cortex dictamni radicis, root of red rooted saliva, sweet wormwood, arctium fruit, peppermint each 12-15g, radix paeoniae rubrathe, ledebouriella root, cicada shell, black-tail snake 9-12g, Ligusticum wallichii, buthus martensi karsch, and licorice root each 5-7g.

The invention relates to a traditional Chinese medicine composition for treating chronic urticaria. The traditional Chinese medicine composition comprises the following traditional Chinese medicine ingredients in part by weight: 10-40 parts of dried rehmannia root, 10-40 parts of nacre mother of pearl, 10-40 parts of dens draconis, 10-30 parts of root of common peony, 10-30 parts of radix paeoniae alba, 5-20 parts of peach kernel, 10-30 parts of coxtex moutan, 10-40 parts of poria cocos, 5-20 parts of chrysanthemum, 10-30 parts of cortex albiziae, 5-20 parts of smoked plum, 10-40 parts of tribulus terrestris, and 10-40 parts of the root of red-rooted salvia. The traditional Chinese medicine composition has the efficacies of clearing heat, soothing the nerves, promoting blood circulation to remove meridian obstruction, nourishing blood, soothing the liver, nourishing yin, promoting the secretion of saliva or body fluid, and strengthening the spleen and stomach, has an obvious curative effect on treating chronic urticaria, has reliable effects, and has the advantages of wide ingredient medicinal herbs resources, simplicity and convenience in preparation, mild drug properties and no toxic and side effects.

The invention discloses a traditional Chinese medicine composition for treating chronic urticaria. The traditional Chinese medicine composition is prepared from kudzu root, cassia twig, figwort, radix angelicae pubescentis, semen plantaginis, notopterygium root, almond, mint, skunk bugbane, Chinese violet, bamboo shavings, semen pharbitidis, toosendan fruit, common cnidium fruit, atractylodes rhizome, bupleurum, gentian, forsythia, giant knotweed, angelica, dangshen, prepared monkshood, rhizoma alismatis, grifola, Chinese yam and bighead atractylodes rhizome. The traditional Chinese medicine composition can be clinically used for treating chronic urticaria.

The invention discloses a traditional Chinese medicine for treating chronic urticaria and application thereof. The traditional Chinese medicine is prepared from the following raw materials by weight: 30g of fernlike asparagus root, 30g of slenderscape amitostigma herb, 15g of toddalia, 15g of herba schizonepetae, 15g of radix sileris, 30g of radix rehmanniae, 15g of angelica, 15g of white peony root, 15g of chuanxiong rhizome, 18g of kuh-seng, 6g of cassia twig and 6g of licorice. The traditional Chinese medicine is unique in compatibility of medicines, exact in curative effect on chronic urticaria, free of toxic or side effect, capable of quickly curing urticaria, stable in curative effect and low in price; autologous lung channel Chize blood is taken and respectively injected into corresponding acupuncture points, can treat both symptoms and root causes, can be used for treating chronic urticaria independently and can be combined with the traditional Chinese medicine to play a synergetic effect; and the traditional Chinese medicine has double effects of expelling evil and strengthening the body resistance, thereby avoiding the defect that the chronic urticaria is easy to recur when being treated by conventional medicines.

Disclosed is a medicinal broth for treating chronic urticaria and its preparing process, wherein the medicament is prepared from the following raw materials (by weight portion): astragalus root, tuber of multiflower knotweed, white atractylodes rhizome each 15-18g, Chinese angelica root, Chinese dittany bark each 12-15g, ledebouriella root, cicada shell, Chinese ephedra, cassia twig, speranskia herb, black-tail snake 9-12g, Ligusticum wallichii, buthus martensi karsch, and licorice root each 5-7g.

A traditional Chinese medicine prescription for treating urticaria is prepared by, by weight, 20g of radix astragali, 15g of rhizoma atractylodis macrocephalae, 15g of radix paeoniae alba, 15g of saposhnikovia divaricata, 15g of bupleurum falcatum, 15g of fructus mume, 15g of fructus schizandrae, 10g of herba schizonepetae and 10g of radix glycyrrhizae. A preparation method of the traditional Chinese medicine prescription includes: placing the cleaned traditional Chinese medicine materials into a marmite, adding 1000-1500ml of clear water, soaking for 20 minutes, boiling with big fire, decocting with slow fire for about 20 minutes, and filtering residues to obtain first liquid medicine; adding 1000-1500ml of water into the marmite, soaking for 20 minutes, boiling with big fire, decocting with slow fire for about 20 minutes, filtering residues to obtain second liquid medicine, mixing the first liquid medicine and the second liquid medicine, decocting for 10 minutes, and equally dividing into two parts. A patient takes one part of the obtained decoction in the morning while the decoction is warm and takes the other part of the obtained decoction in the evening while the decoction is warm. The traditional Chinese medicine prescription has the advantages that the traditional Chinese medicine prescription is made of the traditional Chinese medicine materials, the effects of the traditional Chinese medicine materials are utilized, the traditional Chinese medicine materials are reasonable combined to effectively reduce the toxicological effect of the medicine, the defects that western medicine cannot effectively control relapse and has toxic and side effects when being taken for a long time are overcome, and an effective treatment method is provided for the clinical treatment of the urticaria.

Disclosed is a medicinal broth for treating chronic urticaria and its preparing process, wherein the medicament is prepared from the following raw materials (by weight portion): astragalus root, tuber of multiflower knotweed, white atractylodes rhizome each 15-18g, Chinese angelica root, cortex dictamni radicis, root of red rooted saliva, puncturevine, ducksmeat, Schizonepeta tenuifolia, cocklebur fruit each 12-15g, radix paeoniae rubrathe, ledebouriella root, cicada shell, black-tail snake each 9-12g, Ligusticum wallichii, buthus martensi karsch, and licorice root each 5-7g.

The invention relates to the use of fresh rehmannia root extract in preparing pharmaceutical composition for the treatment and / or prevention of type I allergic reaction related diseases including allergic asthma, anaphylactic rhinitis, allergic ophthalmocace, allergic skin diseases, anaphylactic dermitis, acute and chronic urticaria.

The invention discloses an application of cannabidiol CBD and nanometer milk thereof to preparations for urticaria or / and rhinitis. The cannabidiol CBD nanometer milk preparation is prepared from the following raw materials in mass ratio of 5-20% of cannabidiol CBD, 1-10% of fatty alcohol polyoxyethylene ether, 1-5% of PEG-400, 1-5% of sorbitol, 1-10% of sweet orange oil, 0.02-0.1% of potassium sorbate and the balance water, wherein the sum of the components is 100%. The cannabidiol CBD nanometer milk preparation can rapidly restrain symptoms of acute and chronic urticaria, acute and chronic rhinitis and nasosinusitis, cannot cause skin sensibility, is free from toxic and side effects, and is obvious in treatment effects. The effective component namely the cannabidiol CBD and the nanometer milk thereof, is an effective preparation being free from side effects and low in recurrence rate, through combination of the preparation of the nanometer milk, the drug effect is further reinforced, and the problems that when a conventional drug is used for treating the urticaria and the rhinitis, repeated attack is easy to cause, and skin sensibility is easy to cause, and the conventional drug is short in quality guarantee period and instable in drug effects, can be solved.