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62 results about "Neurogenic inflammation" patented technology

Neurogenic inflammation is inflammation arising from the local release by afferent neurons of inflammatory mediators such as Substance P, Calcitonin Gene-Related Peptide (CGRP), neurokinin A (NKA), and endothelin-3 (ET-3). TRPA1 channels stimulated by lipopolysaccharide (LPS) may also cause acute neurogenic inflammation. Once released, these neuropeptides induce the release of histamine from adjacent mast cells. In turn, histamine evokes the release of substance P and calcitonin gene-related peptide; thus, a bidirectional link between histamine and neuropeptides in neurogenic inflammation is established.

Preparation method and application of marine fungi aspergillus terreus butyrolactone compound butyrolactone-I

The invention relates to a preparation method and application of a marine fungi aspergillus terreus butyrolactone compound butyrolactone-I. The invention discloses application of the marine fungi aspergillus terreus butyrolactone compound butyrolactone-I as shown in a formula (I) to preparation of medicaments for resisting to peripheral and neurogenic inflammation and resisting to neurodegenerative diseases. The formula is shown in the description. The invention finds that besides a DPPH free radical, butyrolactone-I can also well remove an ABTS free radical and an OH free radical; the marinefungi aspergillus terreus butyrolactone compound butyrolactone-I has better oxidation resistance and inflammation resistance and has better neuroprotection activity; therefore, the marine fungi aspergillus terreus butyrolactone compound butyrolactone-I has a wide application prospect in the aspect of preparing the medicaments for resisting to peripheral and neurogenic inflammation and resisting toneurodegenerative diseases. Meanwhile, by the preparation method of the butyrolactone-I, which is provided by the invention, the butyrolactone-I can be successfully prepared; the method is simple andeasy to realize large-scale production; culture conditions can also be optimized by addition of an inducer, so that yield of the butyrolactone-I is greatly improved.
Owner:SHENZHEN INST OF GUANGDONG OCEAN UNIV +1

Preparations containing an extract of eperua falcata and/or constituents of the latter

A cosmetic, pharmaceutical or dermatological preparation containing extract of the plant Eperua falcata, active principles of the plant Eperua falcata, astilbin or engeletin. The preparation is useful to inhibit release of pro-imflammatory mediators and neuropeptides, including CGRP and SP, for skin and hair treatment, including, sensitive skin, acne, scalp itch and neurogenous inflammation.
Owner:COGNIS FRANCE SA

Penta-or tetrapeptide binding to somatostatin receptors and the use of the same

The subject matter of the present invention is a cyclic or linear tetra- or pentapeptide binding to somatostatin receptors. The compounds of the invention are characterised in that they contain the radical of an amino carboxylic acid bearing a five-membered ring in the peptide backbone which may optionally contain O, S, Se, N, or P. These compounds are easy to prepare and display increased stability against peptidases. The compounds of the present invention induce apoptosis of tumour cells and the use of said compounds for cancer therapy is described. In particular, the compounds are characterised in that they are active even against tumour cells displaying resistance against other somatostatin derivatives such as octreotide. In addition, the use of the compounds of the invention for tumour diagnosis by means of positron-emission tomography is described, as well as their use as agents against neurogenic inflammation.
Owner:NOVASPIN BIOTECH

Beta3 adrenergic agonists

The present invention relates to a beta3 adrenergic receptor agonist of formula (I) or a pharmaceutical salt thereof, which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type II diabetes and / or obesity. The compound can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compound can be used to reduced neurogenic inflammation or as an antidepressant agent. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for decreasing gut motility are also disclosed.
Owner:ELANCO US INC

Pharmaceutical composition for curing rheumatoid arthritis

The invention relates to a pharmaceutical composition for curing rheumatoid arthritis, belonging to traditional Chinese medicines. The pharmaceutical composition comprises the following active materials in percentage by weight: 14-30 beta-eucalyptol, 12-30 inocosterone, 30-50 phellodendron total alkaloid and 30-50 coix seed alcohol extract, is used for curing symptoms, such as the damp invasion of lower energizer, foot and knee inflammation, muscle and joint pain, and the like and has the actions of clearing heat and promoting diuresis.
Owner:JILIN ZIXIN PHARMA

Composition for treating ischemic diseases or neurogenic inflammatory disorders, containing secretome of neural progenitor cells as active ingredient

The present invention provides a composition for treating ischemic diseases or neurogenic inflammatory disorders, containing a secretome of neural progenitor cells (NPCs) as an active ingredient. Thesecretome of NPCs, of the present invention, reduces an ischemic injury site and enables neurological functions to recover by means of roles such as anti-inflammation, neovascularization regeneration,and activation and proliferation of inherent stem cells, thereby being usable as a therapeutic agent for ischemic diseases and degenerative nervous system disorders such as nerve damage diseases caused by inflammation. Particularly, the secretome of NPCs, of the present invention, has an excellent behavior improvement effect when administered multiple times.
Owner:S-BIOMEDICS CO LTD

Medicament for the Treatment of Pain and Inflammation

InactiveUS20110274743A1Least riskConvenient and safe and effectiveOrganic active ingredientsBiocidePeripheral neuropathic painVitamin
The use of vitamin D3 for the manufacture of a medicament for the transdermal treatment of neurogenic inflammation and neuropathic pain (including peripheral neuropathic pain); also a method for the relief of neurogenic inflammation and neuropathic pain using this medicament.
Owner:ANZAMED INT +1

Application of glycyrrhizic acid to prepare drugs for promoting medullary sheath regeneration to restrain neurogenic inflammation

The invention discloses an application of glycyrrhizic acid to prepare drugs for promoting medullary sheath regeneration to restrain neurogenic inflammation. Experiment proves that the glycyrrhizic acid can effectively relieve inflammatory reactions and restrain demyelinating lesion, and can relieve development of diseases courses of acute and chronic experimental autoimmuneencephalomyelitis. Theglycyrrhizic acid can promote medullary sheath regeneration in a cuprizone-induced cuprizone demyelination model, an in vitro mechanism study finds that the glycyrrhizic acid can directly regulate a GSK-3 beta signal channel to induce the polarization of oligodendroglia precursor cells, so that the mature polarization of the oligodendroglia cells can be notably promoted, and the synthesis of medullary sheath protein is stimulated. A mechanism for promoting medullary sheath regeneration by the lycyrrhizic acid proves that a new basis is provided for treating demyelinating diseases and multiplesclerosis, and clinical-usable new medicines are provided for central nervous system demyelinating diseases and the like.
Owner:SHAANXI NORMAL UNIV
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