433 results about "Disease course" patented technology

The present application discloses methods for treating an IL-6-mediated disorder such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), systemic JIA (sJIA), polyarticular course JIA (pcJIA), systemic sclerosis, or giant cell arteritis (GCA), with subcutaneously administered antibody that binds interleukin-6 receptor (anti-IL-6R antibody). In particular, it relates to identification of a fixed dose of anti-IL-6R antibody, e.g. tocilizumab, which is safe and effective for subcutaneous administration in patients with IL-6-mediated disorders. In addition, formulations and devices useful for subcutaneous administration of an anti-IL-6R antibody are disclosed.

Aging, injury and / or other pathologies of joints, especially weight bearing joints, contribute to changes in natural biomechanics. Deviations from optimal biomechanics lead to acceleration of the natural history of joint pathology and ultimately osteoarthritis. A Magnetic Vector Control System made up of an assembly of magnetic field sources can be disposed at or near a joint typically on or in adjacent bones of the joint, on one side of a first mechanical axis that creates a torque or moment about a second different axis of the joint, that intersects the first mechanical axis, to decrease the joint reactive force at the joint surface or equivalently substantially shift the first mechanical axis to a new or preferred position.

The invention discloses a medicinal composition for treating gynecological inflammation, and belongs to the field of Chinese medicament. The medicinal composition consists of collagen and / or Chinese medicaments for releasing toxin and sterilizing such as collagen and lizardtail, glabrous greenbrier rhizome, Vietnamese sophora root and the like which are prepared into a plurality of dosage forms bycombining the prior art, and is mainly used for treating vaginitis, pelvic inflammation, urethritis and cervicitis diseases. The technical scheme overcomes the defects that the prior externally-applied preparations such as lotion, gel, suppository, ointment and the like have extremely slow response, longer disease course, repeated outbreak and the like, and creatively combines and applies the collagen and the Chinese medicament, can accelerate the healing of ulcer and erosion faces caused by the inflammation, and can greatly shorten the required time for tissue repair.

An embodiment of the invention provides a processing method and system of electronic medical records, belongs to the technical field of electronic medical records, and solves the problem that doctorsneed to consume a large amount of time to check the medical records in the prior art. The method includes: determining the medical record type and the sub-theme content block corresponding to each electronic medical record text in appointed electronic medical record text according to preset medical record types, a sub-theme classification model and the appointed electronic medical record text; extracting rule templates, medical record types and sub-theme content blocks according to terminological dictionaries and a parser to obtain the structured information corresponding to each electronic medical record text; acquiring the disease course abstract corresponding to each electronic medical record text according to the abstract generating rules corresponding the medical record types and thestructured information corresponding to each electronic medical record text; acquiring the disease course abstract sequence corresponding to the appointed electronic medical record text according to the time sequence and the disease course abstract corresponding to each electronic medical record text. The method is suitable for processing the electronic medical records.

The invention provides a turbidimetric rapid detection kit for myocardial infarction nano-immunoenhancement. The turbidimetric rapid detection kit comprises a reaction-detection integrated device, and a detection kit arranged in the reaction device, wherein a reagent R1, a reagent R2 and a calibrator are contained in the detection kit; simultaneously, quantitative detection for five important myocardial infarction-related biomarkers in one sample can be realized, and the five important biomarkers include content of troponin-I, content of D-dimer, content of myoglobin, content of hypersensitive C-reactive protein (hs-CRP) and content of heart-type fatty acid binding protein (FABP); and the turbidimetric rapid detection kit has an important clinical significance in the aspects of early diagnosis and disease course monitoring for myocardial infarction, treatment monitoring for medicines, and the like. The turbidimetric rapid detection kit provided by the invention realizes the integration of the reagents and the reaction device, and is simple, rapid and accurate to operate, high in sensitivity, strong in specificity, and low in detection cost; and the turbidimetric rapid detection kit is a detection / reagent measurement integrated kit suitable for outpatient and emergency treatment / clinical detection, and wide in instrument application range.

The invention discloses a dengue virus IgG / IgM antibody detection test strip, kit and preparation method thereof, and relates to the technical field of dengue virus detection. The dengue virus IgG / IgMantibody detection test strip of the invention comprises a sample pad, an immune combination pad, a nitrocellulose membrane and absorbent paper, wherein the sample pad is sequentially stuck to the bottom of polyvinyl chloride; the immune combination pad is coated with dengue virus recombinant antigen marked by colloidal gold and chicken IgY polyclonal antibody; the nitrocellulose membrane is coated with dengue virus anti-human IgM antibody, a detection line of IgG antibody and a quality control line of anti-chicken IgY polyclonal antibody. The test strip can detect whether dengue virus IgG / IgM antibody exists in a sample to be detected through a method for detecting a marker. The test strip and the detection card comprising the test strip can be used as supplement for antigen detection onthe early acute infection of the dengue virus, covering the middle and later stages of the disease course and reducing the risk of missed detection.

The invention discloses a mesenchymal stem cell injection and a preparation method of the mesenchymal stem cell injection and an application in preparation of a medicine for treating ulcerative colitis, wherein the mesenchymal stem cell injection consists of the following components: 2*105-1*107 pieces / ml of mesenchymal stem cells, 5-10% of dimethyl sulfoxide (DMSO) by volume, 1-6% of human albumin by mass-to-volume ratio, and 1% of low molecular dextran and compound electrolyte solution. According to the mesenchymal stem cell injection, the preparation method and the application of the mesenchymal stem cell injection in preparation of the medicine for treating ulcerative colitis, the mesenchymal stem cell injection is used for correcting immune dysfunction of a patient of ulcerative colitis, and preventing the autoimmune dysfunction from continuously damaging the intestinal tract; meanwhile, many cell growth factors and repair factors are secreted, to promote pathologically changed intestinal ulcer to heal, therefore, the purpose of foundational treating the ulcerative colitis is achieved. The disease course of the ulcerative colitis can be reversed, the patient can be helped in escaping out of influence of stomachache and diarrhea on the life as well as toxic and side effects of the medicine, so as to treat the ulcerative colitis thoroughly.

A traditional Chinese medicine composition for treating hyperthyroidism and a preparation method and a use method thereof resolve the problem that the existing traditional Chinese medicine for treating hyperthyroidism does not have common adaptability and is not favorable for industrial production. The composition comprises the following raw materials as effective components: 15-60 parts of astragalus mongholicus, 15-50 parts of radix scrophulariae, 15-60 parts of oyster, 15-50 parts of thunberg fritillary bulb and 10-60 parts of selfheal. The composition changes composition ratio of the raw material medicine according to difference of clinical symptoms of hyperthyroidism, thereby being suitable for the front stage, the middle stage and the later stage of the hyperthyroidism. The composition adopts the start point design- response surface method to optimize process parameter extracted from the effective components of the raw material medicine. The traditional Chinese medicine composition is based on heteropathy in the whole generation and development processes of the disease and has the advantages of being quick, good and high in treatment effect, small in side effect, convenient to take and the like. The disease is not apt to reappear by means of the composition.

The invention provides nine micro RNA (Ribonucleic Acid) (miRNA) molecular markers for diagnosing rheumatoid arthritis and an application thereof to a detection kit. The miRNA molecular markers have abnormal expression in blood of patients with the rheumatoid arthritis to diagnose the rheumatoid arthritis; the miRNA molecular marker has high combination sensitivity and specificity; materials are convenient to fetch; the miRNA molecular marker is safe and noninvasive and provides important evidences to early diagnosis of diseases and disease course monitoring. The invention further provides a kit for diagnosing the rheumatoid arthritis and the application of the miRNA molecular marker to the diagnosing kit. The kit is characterized by comprising the combination of the nine miRNA molecular markers for detecting blood plasma and a reagent for detecting the nine miRNA molecular markers.

The invention provides a heart failure detection method based on an electrocardio-interval sequence normalized histogram and a device thereof. The detection method comprises the following steps: (1) electrocardiosignals of a testee are collected; (2) the analog-digital conversion is carried out on the electrocardiosignals, and electrocardio-waveform data are stored; (3) R wave peak value points of the electrocardiosignals are extracted to construct an electrocardio-interval sequence RR; (4) the effectiveness of the RR sequence is tested; (5) the RR electrocardio-interval sequence normalized histogram is constructed; (6) two specific indexes of center-edge rate (CER) and cumulative energy (CE) of the normalized histogram are calculated; (7) the heart failure course of the testee is evaluated according to the indexes of CER and CE. The detection device comprises an electrocardiosignal detection module, an analog-digital conversion device and a computer. Based on the two specific indexes of CER and CE of the electrocardio-interval sequence normalized histogram, the heart failure course of the testee is evaluated, the heart failure course of the testee can be detected noninvasively, conveniently and quantitatively, and the discrimination index is high.

The invention provides a method for detecting fMRI brain network dynamic covariations. The method comprises the following steps of: obtaining a sample; Firstly, constructing a brain functional networkby utilizing functional magnetic resonance data; according to a certain basis (factors such as age, disease course length, education degree and the like), different network matrixes are arranged in sequence;obtaining a cross-tested network matrix sequence; then, a sliding window method is used for researching a covariant relationship between ROI brain regions which cross a tested object; and obtaining a series of covariant matrixes, and depicting the difference of the brain interval collaborative activity modes under the trans-tested scale is by calculating mathematical indexes for describing covariant relationship variability or through statistical inspection, so that the interactive relationship between brain regions in the network can be better understood.

The invention belongs to the field of prognosis estimation and canceration risk prediction on clinic of molecular biology, and particularly relates to application of a molecule of a detection ANO1 protein in the preparation of a kit or a detection agent for the prognosis estimation and precancerous disease progression risk prediction of esophageal squamous carcinoma. The molecule expressed by the detection ANO1 protein can be a nucleic acid, a protein or a compound, thus showing that the ANO1 protein can be used as a molecular marker for the prognosis estimation and precancerous disease progression risk prediction of the esophageal squamous carcinoma.

The invention discloses an electronic medical record information correction method and system. The method comprises the steps of establishing a medical knowledge graph; receiving first disease courserecord information input based on the admission record, the latest examination result and doctor's advice information of a patient; receiving first ward round disease course record information input based on the first disease course record, the latest examination result and the doctor's advice information; receiving subsequent disease course record information input based on the previous two disease course records, the latest examination result and the doctor's advice information of the patient; receiving and displaying discharge record information input based on the admission record, all disease course records, the latest examination result and doctor's advice of the patient. In the process, the admission record information, the first disease course record information, the first ward round disease course record information, the subsequent disease course record information and the discharge record information of the secondary patient are subjected to information correction by using themedical knowledge graph, and the correction result is displayed, so that the efficiency of writing medical records by doctors is effectively improved.

The invention relates to the use of gene expression profiles, obtained in vitro from a patient sample, for the generation of criteria for the prediction of an individual course of disease in sepsis. The invention is further of use for determining the probability of survival in sepsis, the assessment of the course of disease in sepsis during treatment and for the classification of sepsis patients.

Methods of identifying Crohn's disease patients who may require early surgery and / or who are susceptible to developing complications during the course of disease. Anti-laminarin (anti-L) and anti-chitin (anti-C) antibodies, both independently and combined, can serve as diagnostic and prognostic indices for Crohn's disease.

The invention relates to application of GMFB (glia maturation factor beta) as a biomarker for early diagnosis of diabetic retinopathy and for diabetes progression, application of GMFB as a therapeutic target of diabetic retinopathy, a GMFB disrupter and application of the GMFB disrupter. Compared with the prior art, the invention proves that the GMFB content in vitreous body is significantly improved in early period of diabetes in rats of STZ-induced I type diabetes (TIDM). The invention is the first to prove that GMFB content gradually drops with the development of DR (diabetic retinopathy), therefore the GMFB is applicable to dynamic detection of DR progress; the invention is the first to prove that by interfering GMFB expression in rats of DR, visual function can be protected; and the invention is the first to prove that GMFB mediates retinopathy mechanism, including causing decrease of glutamine synthetase of Muller cell, death of ganglion cells and inducing autophagy of photoreceptor cells.

The invention belongs to the technical field of make-ups, and particularly relates to an acne removing preparation. The acne removing preparation is prepared from the following components in parts byweight: 1-3 parts of plant oil control factor, 0.5-2 parts of carboxymethyl yeast beta-glucan, 3-10 parts of acne bane, 0.2-1 part of asiaticoside, 0.05-0.2 part of dipotassium glycyrrhizinate and 1-6parts of folium / caulis myrothamni flabellifoliae extract. The preparation has a fast significant acne removing effect, a scar removing effect, an effect of significantly removing active oxygen in neutrophil, a bacteriostasis effect, effects of enhancing cell activity and promoting TIMP-1 factor secretion, and more uncommonly, a very good effect of repairing scars left in a disease course within one year.

The invention relates to a medical information processing system and a medical information processing method. The method comprises the following steps of: scanning medical record books by adoption of a scanner or an intelligent portable terminal; converting scanned medical record book picture information into document data by a computer connected with the scanner or the intelligent portable terminal, and transmitting the document data into a server; numbering the document data by the server, and storing the numbered document data into a memory in the server so as to store the medical record data of the patient for a long time; setting a plurality of classified storage units in the memory and carrying out classified storage on the document data by the plurality of classified storage units according to the numbers; and inputting the numbers of the document data to a mobile terminal, and calling the document data with corresponding numbers to be checked by the doctors, so that the medical workers can conveniently carry out long-term tracking and diagnosis on the disease courses of the patients, the time is saved and statistical biases are not easy to occur.

The embodiment of the invention provides a case processing method and device, and belongs to the technical field of computers. By receiving medical order execution information used for representing execution conditions of a patient on the basis of medical order information and fed back by a first user terminal, complication occurrence conditions appearing after the patient leaves a hospital can be monitored at any time, the situation that tracking, nursing and treatment seed guidance are conducted in the whole disease course of tumor chemotherapy patients due to lack of special case managers is effectively avoided, and the overall case management effect is further enhanced. Besides, according to symptom information or examination reports sent by the patient, the case managers can effectively guide diseases in a targeted mode, guidance information is sent to the first user terminal, accordingly the patient can be nursed or seek treatment according to the guidance information. The patient can make an appointment and register by inquiring the community hospital nearest to the position where the patient is currently located, and the overall case management effect is further enhanced.

The invention relates to identify prostate cancer. The invention provides a method for predicting the recurrence or aggressiveness of prostate cancer, comprising a) determining the Gleason score of a prostate sample, and b) determining the methylation status of a Marker in a biological sample for those patients having a Gleason score of 7 or greater; wherein methylation that exceeds a pre-determined value is indicative of an aggressive or recurrent cancer and methylation that does not exceed such pre-determined value is indicative of indolent cancer. The invention also provides a kit used for predicting the course or aggressiveness of the prostate cancer, which comprising nucleic acid amplification test reagent and a synopsis which instructs the patients having the Gleason score of 7 or greater in the use of the reagent.

The invention provides a safety management system for venous thromboembolism of an inpatient and application of the system. The system comprises a server, a nursing control module and a doctor controlmodule, wherein the nursing control module and the doctor control module are connected with the server through communication equipment separately; the server comprises a risk assessment module, an intervention measure module, a calculation module, a judgment module, a management module, a disease course recording module and a storage module. Grading management is carried out according to different grading values, and excessive treatment of the inpatient is avoided. According to the system, the high-risk inpatient can be subjected to mandatory VTE assessment, and VTE risk assessment can be completely implemented. Unified grading standards and informatization management processes are suitable for all clinical departments, the comprehensive strength for VTE prevention and treatment of a hospital is further improved, and the system has extremely high clinical application value.

The invention provides a predictive image generation method and a predictive image generation device. The method includes: acquiring characteristic information of a patient; determining the disease course stage corresponding to a lesion image of the patient according to the characteristic information of the patient; inputting the lesion image and the disease course stage into a pre-established image prediction model to generate a predictive lesion image of the patient, wherein the predictive lesion image is the lesion image corresponding to the evolutionary stage of the disease course stage. After the disease course stage corresponding to the lesion image of the patient is determined, the lesion image, namely the disease course stage is inputted into the pre-established image prediction model to generate the predictive lesion image of the patient, and therefore, the patient can visually observe future evolution of lesions according to the generated predictive lesion image.

The invention discloses a health-care medicine composition. The composition is prepared from, by mass, 60-600 parts of glutathione, 50-300 parts of silymarin, 1-100 parts of auricled hedyotis herb extracts, 1-100 parts of potentilla disclor bunge extracts, 1-100 parts of cordyceps cicadae extracts and auxiliary materials. The composition comprises, by mass, one or more of 50-200 parts of vitamin C, 50-200 parts of vitamin E, 100-300 parts of astaxanthin, 100-300 parts of lycopene, 100-300 parts of xanthophylls, 100-300 parts of beta-carotene, 100-300 parts of grape seed extracts, 100-300 parts of anthocyanin, 100-300 parts of ganoderma spore powder, 200-1000 of coenzyme Q10 and 200-1500 parts of garlic essence oil. The composition has the functions of clearing away toxin, treating radiation diseases, carrying out radiation protection, protecting the liver, enhancing immunity, improving the disease course and symptoms of some diseases, resisting allergy, beautifying faces, nourishing skin, improving eyesight, treating eye diseases, resisting aging and the like.

The invention relates to a Chinese medicinal composition preparation for treating a behcet syndrome, and a preparation method of the Chinese medicinal composition preparation. The Chinese medicinal composition comprises the following Chinese herbal medicines in part by weight: 18 to 22 parts of honeysuckle flower, 22 to 28 parts of eclipta alba, 18 to 22 parts of common selfheal fruit-spike, 28 to 32 parts of glabrous greenbrier rhizome, 8 to 12 parts of phellodendron, 18 to 22 parts of Chinese angelica, 18 to 22 parts of pariphyllin, 18 to 22 parts of hairyvein agrimonia herb and bud, 28 to 32 parts of towel gourd vegetable sponge, 22 to 28 parts of kadsura pepper stem, 28 to 32 parts of rehmannia root, 8 to 12 parts of liquoric root, 8 to 12 parts of raw coix seed, 12 to 18 parts of Sinkiang arnebia root and 12 to 18 parts of sappan wood, wherein the Chinese herbal medicines are processed to be qualified and are decocted in water, and decoction is mixed and concentrated to be the proper amount. The Sinkiang arnebia root, the honeysuckle flower, the kadsura pepper stem, the common selfheal fruit-spike, the Chinese angelica, the hairyvein agrimonia herb and bud and the eclipta alba are extracted by the reflux of ethanol, are mixed with the concentrated solution and are mixed with fine powder of the sappan wood, the phellodendron, the glabrous greenbrier rhizome and the borneol uniformly and sieved to obtain Chinese medicinal powder for treating behcet syndrome. The Chinese medicinal composition has quick response and a small side effect and can fulfill the aims of performing treatment between inside and outside and addressing both symptoms and root causes under the action of monarch medicines, minister medicines, adjuvant medicines and conductant medicines. Therefore the Chinese medicinal composition can relieve the clinical symptoms of behcet syndrome and shorten disease course obviously, and has an obvious treatment effect.

The present invention provides non-specific exciton gene VdNEP of Verticillium dahliae capable of causing disease resisting allergic reaction on cotton and other plant and its application. VdNEP protein can induce the expression of Arabidopsis thalianum disease course related gene. Low concentration VdNEP protein can induce suspended cotton cell to synthesize gossypol as phytoalexin, while high concentration VdNEP protein can induce the allergic death of suspended cotton cell. When it is injection to cotton cotyledon, the protein in low concentration may cause allergic necrosis spot and the protein in high concentration may cause cotyledon wilting. Treating mature cotton euphylla with the protein will cause the euphylla dewatering. Applying VdNEP provides new way of improving plant disease resistance and has wide application foreground.

A medicine for treating bed sore, nail-like deep-rooted boil, furuncle, sore, carbuncle, etc is prepared from 7 Chinese-medicinal materials including castor seed, camphor, myrrh, borneol, etc. Its preparing process is also disclosed.

The invention provides an establishment method of an animal model for acute Stanford A-type aortic dissection (AD) accompanied with MODS (multiple organ dysfunction syndrome), a use of emodin for preparing a medicine for treating acute Stanford A-type AD accompanied with MODS as well as a viscera protective agent for acute Stanford A-type AD accompanied with MODS. In the invention, an AD surgery method is improved and meanwhile manually controlled hypertension is formed by continuously pumping adrenaline into veins so as to promote expansion of the AD stripping range and accelerate disease progression, thus acute Stanford A-type AD accompanied with MODS can be rapidly formed so as to successfully make the model. The animal model for acute Stanford A-type AD accompanied with MODS creates conditions for further deep research in application foundation and intervention treatment.

A Chinese medicine for treating throat itching and dry cough pertains to a Chinese medicine for treating cough. The main recipe includes 6g cicada slough, 10g stiff silkworm, 10g ballonflower root, 10g schizonepeta tenuifolia, 10g dried citrus peel, 15g stemona root, 10g white swallowwort root, 10g aster root and 5g liquorice. The auxiliary recipe is: for people with chest tightness and nausea, adding20g snakegoured shell and 10g hovenia dulcis; for people with sticky sputum, adding 10g rhizoma anemarrhenae and 15g mulberry bark; for people with short course of disease, serious cough and throat engorgement, adding 20g cordate houttuynia and 3g nantural oindigo; for people with long course of disease and dry lip, adding 15g dwarf lilyturf tuber and 20g reed rhizome; for people with serious cough at night, adding 10g schisandra. Due to simple recipe, natural Chinese herbs in the recipe, convenient use, simple production method, good internal curative effect and low price, the Chinese medicine is particularly suitable for people who live far away from the urban area and in remote villages. For people who have throat itching and dry cough, the treatment cost is quite low, which solves the curative problem of low-income families, those living in poverty and places lack of medical conditions.