The invention discloses a method for predicting an
RNA (Ribonucleic Acid)
methylation site, which is based on a multi-
modal feature fusion and
semantic vector embedding technology and is used for remarkably improving the recognition precision of an m7G modification site. The method comprises the following steps: firstly, constructing an
RNA sequence
data set containing positive and negative samples, and dividing the
RNA sequence
data set into a
training set and an independent
test set according to a predetermined proportion; then, multi-
modal features are extracted through One-hot coding (One-hot),
nucleotide chemical property coding (NCP),
electron-
ion interaction potential coding (EIIP) and local
nucleotide composition coding (ENAC), and context
semantic information of a
nucleotide sequence is obtained in combination with
a DNA2Vec model; according to the model, a multi-
modal feature fusion path (MRF) and
a DNA2Vec embedding path are adopted, after
feature dimension compression is carried out through a full connection layer, a Transform
encoder is used for capturing a long-range dependency relationship, and a
prediction probability is calculated through a
Sigmoid activation function. In the optimization process, batch normalization, Dropout and Adam optimizers are adopted, and the binary
cross entropy loss function is minimized. Finally, the performance of the model is evaluated through five-fold
cross validation, and the generalization ability of the model is verified on an independent
test set. According to the method, through multi-source
feature fusion and
hierarchical modeling, the analysis capability of sequence information is remarkably improved, and an accurate calculation tool is provided for RNA modification prediction.