53results about How to "Convenient research" patented technology

The utility model relates to the technical field of rice breeding, in particular to a germination accelerating and seedling raising device for rice breeding, which comprises a mounting frame, a placing frame, a sliding block, a mounting frame, a seedling raising frame, a connecting plate, a buckling groove, a movable plate and a buckling column, multiple sets of placing frames are sequentially installed in the installation frame from top to bottom, sliding blocks slidably connected with the installation frame are installed at the rear ends of the two sides of the placing frames, and multiple sets of seedling raising frames used for placing rice seedlings are arranged in the placing frames in a buckled mode; according to the seedling raising device, the placement frame can easily slide in the mounting frame through the design of the sliding blocks, meanwhile, the pulling plates, the buckling columns and other assemblies are arranged, a user can conveniently and rapidly fold or disassemble the seedling raising frames, and the seedling raising device is convenient to use and high in practicability. Through the design of the buckling grooves, multiple groups of seedling raising frames can be conveniently connected together or detached for checking, and the growth condition of each group of rice seedlings can be conveniently managed and observed.

This invention discloses a modeling method for an engine thermal management system, comprising the following steps: determining the composition of the engine thermal management system; determining the connection sequence of each component of the engine thermal management system; selecting appropriate libraries and components in the software; selecting and setting the engine model; selecting and setting the thermostat model; selecting and setting the water pump model; selecting and setting the expansion tank model; selecting the HEAT plugin icon; selecting and setting the radiator model; selecting and setting the electronically controlled silicone oil clutch fan model; setting vehicle and environmental parameters; and setting the effect of different vehicle speeds on the radiator's heat dissipation performance. This invention simultaneously uses models from both the cooling system library and the HEAT library to model the components in the engine thermal management system. Compared with modeling using only the cooling system library, this allows for more complex control strategies and higher accuracy, laying the foundation for further research on engine thermal management systems.

The application relates to the technical field of metal matrix composite structure preparation, in particular to a SiC fiber reinforced metal matrix composite joint sample and a preparation method and application thereof. The structural design of the joint sample comprises an inclined plane joint and a conical surface joint, and the preparation method comprises the following steps: the SiC fiber reinforced metal matrix composite precursor wire and an alloy rod with an inclined plane or a conical surface structure at one end are jointly loaded into a hollow cylindrical alloy sheath, then hot isostatic pressing is adopted, and mechanical processing is carried out, so that the SiC fiber reinforced metal matrix composite joint sample with a specific structural form is obtained. Different forms of metal matrix composite and alloy connection are provided by designing different joint structures. The whole forming of the alloy and the composite material is realized through hot isostatic pressing, the obtained joint can be processed to prepare a tensile sample, the tensile test is carried out, and the research on the mechanical properties and failure behavior of the joint is realized.

This invention belongs to the field of biomedical technology, specifically disclosing the use of FOXO1 in the prevention and treatment of calcific aortic valve disease. It mainly involves the application of FOXO1 or its expression-promoting agents in the prevention and treatment of calcific aortic valve disease, and the application of FOXO1 in the preparation of animal models of calcific aortic valve disease. This invention increases or maintains FOXO1 expression to maintain the binding of FOXO1 to Runx2, and further maintains the normal valvular mechanism levels, thereby preventing and alleviating the occurrence of calcific aortic valve disease. Simultaneously, this invention also provides a new animal model for the study of calcific aortic valve disease, facilitating subsequent research on this condition.

The application relates to the technical field of screw pile composite foundation testing, in particular to a screw pile body strain gauge installation auxiliary device and a method, the auxiliary device comprises a sleeve and an installation rod capable of being inserted into the sleeve, one end of the sleeve is provided with a sealing head, the sealing head is rotationally connected with the sleeve so that the sealing head can be opened or closed, and the strain gauge is arranged on the installation rod, so that the strain gauge can be conveniently installed into the screw pile, and the screw pile can be conveniently and deeply researched.

The application relates to a fluorinated two-dimensional inorganic nanofiller reinforced PEO-based solid-state polymer electrolyte and a preparation method and application thereof, and comprises the following steps: S1, obtaining fluorinated two-dimensional inorganic nanofillers by treating two-dimensional inorganic materials with a mixed gas of fluorine and nitrogen; S2, dissolving polyethylene oxide and a lithium salt in a polar solvent, then adding the fluorinated two-dimensional inorganic nanofillers obtained in the step S1, mixing, and obtaining a uniform mixed polymer solution; and S3, pouring the mixed polymer solution obtained in the step S2 on a polytetrafluoroethylene mold, vacuum drying, and obtaining the PEO-based solid-state polymer electrolyte. Compared with the prior art, the preparation process is simple and easy to operate, the ionic conductivity of the polymer electrolyte based on the fluorinated two-dimensional inorganic nanofillers can be improved, the electrochemical stability window can be widened, and the interface stability between the electrolyte and a lithium metal electrode can be improved.

The invention discloses an eurytopic chlamydomonas reinhardtii expression vector based on a PSAD promoter and a 3 * Flag tag as well as a construction method and application of the eurytopic chlamydomonas reinhardtii expression vector. The nucleotide sequence of the eurytopic chlamydomonas reinhardtii expression vector is shown as SEQ ID No.1; the vector comprises a PSAD promoter, a target gene insertion site EcoR V, a 3 * Flag tag at the 3'terminal, an rbcS2 terminator, a TUB2 promoter, a hygromycin B screening gene and an rbcS2 terminator. The construction method comprises the following steps: constructing a skeleton of a pHyg-PSAD-3Flag vector; constructing a sequence fragment fused with a 3 * Flag tag; and connecting the sequence fragment fused with the 3 * Flag tag with a plasmid skeleton fragment through T4 DNA (deoxyribonucleic acid) enzyme so as to construct the pHyg-PSAD-3Flag vector. According to the invention, the expression plasmid of the chlamydomonas pHyg-PSAD-3Flag can be used for efficiently screening algae strains capable of stably expressing target protein.

The application provides a laser multi-material mixed melting device and a melting method, and relates to the technical field of additive manufacturing. A first feeder is used for taking different materials and mixing them respectively, and a translation assembly is used for moving the first feeder to different positions of a second feeder, so that the first feeder can feed different materials into different mixers in the second feeder; the second feeder discharges the mixed different powders to a forming platform, and a leveling assembly levels the powder layer to make the upper surface of the powder layer flat; a laser assembly melts and forms the powder layer; after a layer of the powder layer is processed and formed, a lifting assembly lowers the height of the layer of the powder layer, and the above forming step is repeated until the product is completed. The laser multi-material mixed melting device can lay different powders with different components at different positions on the forming platform and perform laser forming, and the material components are various, which brings convenience for multi-material printing and material high-throughput preparation and research.

This invention belongs to the field of fuel cell catalysis, specifically relating to a preparation method and application of a platinum-based alloy-rare earth oxide La2O3 hybrid interface catalyst. The specific preparation method includes the following steps: (1) preparing a carbon support material via oxidative polymerization and high-temperature pyrolysis; (2) loading a metal component onto the carbon support material via co-precipitation-impregnation; (3) subjecting the metal-loaded support to high-temperature heat treatment under a reducing atmosphere to finally obtain the catalyst. The preparation process of this invention is safe, simple, and low-cost. By reducing the platinum loading, the problem of high raw material costs is further solved. The half-wave potential of this invention reaches 0.876V, and the mass activity reaches 1.48 A·mg. ‑1 Pt @0.9V, which is 12.3 times the mass activity of commercial 40% Pt / C catalysts, indicating that it has superior oxygen reduction catalytic activity; in addition, after 60,000 cycles of cyclic voltammetry testing, its half-wave potential only decreased by 13 mV, indicating that the present invention has excellent long-term cycling stability.

The application discloses a kind of urban high-density road network mixed traffic flow cell transmission simulation prediction methods, comprising: with urban high-density road network area as modeling object, with road boundary end as traffic flow input position and output position, the road section between input position and output position includes urban expressway basic road section, access ramp and interchange, and urban non-expressway basic road section and intersection, the road section between input position and output position is divided into cell, and mixed mixed traffic flow cell transmission model is established to the cell, and the state of urban road network is simulated and predicted.The application comprehensively considers the traffic flow of urban expressway and urban non-expressway, effectively connects the cell of urban expressway with the cell of urban non-expressway, and designs and improves the cell division and modeling method of interweaving area and intersection, which is beneficial to the comprehensive study of traffic flow change in urban road network area and the traffic flow state simulation prediction for traffic flow control.

The invention discloses a seismic data closure error correction method and device, equipment and a storage medium, and belongs to the technical field of seismic exploration. According to the method, the correlation coefficient between the first seismic sub-data and the second seismic sub-data is firstly determined, and the correlation coefficient can indicate the correlation degree between the seismic data of the two work areas, so that the splicing line position determined according to the correlation coefficient can indicate the optimal splicing position of the seismic data of the two work areas. And then based on the position of the splicing line, the first seismic data of the correction work area are sequentially subjected to spatial whole-channel closure error correction and sample-by-sample dynamic closure error correction, the spatial whole-channel closure error correction refers to closure error correction from a seismic channel level, and the sample-by-sample dynamic closure error correction refers to closure error correction from a sampling point level, so that the spatial whole-channel closure error correction and the sample-by-sample dynamic closure error correction are realized. Through the two kinds of correction processing, the closing error between the seismic data of the two work areas can be reduced to the maximum extent, and the accuracy of closing error correction is improved.

This invention discloses a method for preparing an ultrathin ordered macrocyclic molecular membrane. The method involves synthesizing macrocyclic molecules with high polymerization activity and amphiphilic guest molecules. The inclusion complexes formed by the macrocyclic molecules and guest molecules are orderedly assembled using Langmuir-Blodgett (LB) technology. Photopolymerization is then employed to achieve ordered cross-linking of the macrocyclic molecules, resulting in an ultrathin ordered macrocyclic molecular membrane. The macrocyclic molecular membrane prepared by this invention is monomolecular in thickness and possesses good mechanical strength. With the assisted orientation of the amphiphilic guest molecules, the macrocyclic molecules achieve ordered assembly at the water-air interface. The membrane preparation process proposed in this invention is simple, cost-effective, versatile, and easily scalable, making it significant for the field of high-performance separation membranes.

The invention discloses a double-shaft friction and wear testing machine with an unbalance loading torque loading function, and relates to the technical field of friction and wear testing, in particular to the double-shaft friction and wear testing machine with the unbalance loading torque loading function. The unbalance loading torque loading mechanism provided by the invention can meet the test requirements of friction and wear under actual loading in some special scenes. The device can meet the test of relative rolling friction wear under a common uniform loading condition, and can also apply a non-uniform load to a friction pair with two cylinders rolling relatively under the condition that the test bed is not disassembled, assembled and replaced, so as to realize the friction wear test of vertical non-uniform loading.

The utility model relates to the technical field of physical experiment teaching aids, in particular to a simple harmonic motion experiment instrument, which comprises a base, a liquid spraying device, a support arranged on the base and a paper feeding device arranged on the base, the support comprises a cross rod, a first vertical rod and a second vertical rod, the first vertical rod and the second vertical rod are arranged on two opposite sides of the cross rod, and the cross rod is provided with a cycloid and connected with a pendulum ball. A gap exists between the lowest point of the swing ball in the natural state and the base, a spring is fixed to the first vertical rod and is horizontally placed in the natural state, one end of the spring is detachably connected with the swing ball, the liquid spraying device comprises a spraying pipe, and the liquid outlet end of the spraying pipe is fixedly connected with the swing ball; a spring oscillator experiment and a simple pendulum experiment are integrated on one device, so that students can conveniently compare two simple harmonic motion phenomena on the same platform, the essence and generality of the simple harmonic motion can be deeply understood, and the teaching effect is optimized. Meanwhile, through the detachable connection design, quick switching between a spring oscillator experiment and a simple pendulum experiment is facilitated, and different experiment requirements are met.

The invention belongs to the technical field of nano-antibacterial materials, and provides a micromolecule coated nano-zinc oxide monodisperse antibacterial colloid, the colloid comprises nano-zinc oxide powder, a dispersant and water, the total mass ratio of the nano-zinc oxide powder to the dispersant is (1: 1)-(10: 1), the mass ratio of the nano-zinc oxide powder to the water is (1: 100)-(1: 10000), the total mass ratio of the nano-zinc oxide powder to the dispersant is (1: 1)-(1: 10000), and the mass ratio of the nano-zinc oxide powder to the water is (1: 100)-(1: 10000). The diameter of the nano zinc oxide particles in the colloid is 60 nm to 100 nm. According to the invention, the micro-molecular dispersant is introduced to modify the nano-zinc oxide, and the total mass ratio of the nano-zinc oxide powder to the dispersant and the mass ratio of the nano-zinc oxide powder to water are optimized, so that the nano-zinc oxide can be completely coated with the nano-zinc oxide powder by micro-molecules, and the surface energy of the nano-zinc oxide and Van der Waals force and electrostatic attraction among particles are reduced; and the dispersion performance of the nano-zinc oxide in water can be improved.

The invention discloses a preparation method and application of an electrochemical biosensor based on a self-protection palindromic DNA (deoxyribonucleic acid) nanosphere. The electrochemical biosensor comprises an HP-trigger, a target miRNA (micro ribonucleic acid) and a self-protection DNA palindromic nanosphere core structure. The DNA nanosphere is of a three-dimensional spherical structure formed by four single-stranded DNAs through complementary base pairing, the three single strands of SEP-Sa, SEP-Sb and SEP-Sc contain 12 nt palindromic cohesive ends and 15 nt single-stranded arms, the single strand of HP-Sc contains 35 nt prolonged hairpin structures, the structural stability is enhanced through a self-protection mechanism of a palindromic sequence, and structural dissociation triggered by target miRNA is achieved. The target miRNA is combined with an HP-Sc hairpin structure to trigger conformational change, release complementary chains and dissociate palindromic nanospheres, and exposed DNA sites are combined with MB to generate electrochemical signals, so that a novel tool is provided for early diagnosis of tumors.

The utility model discloses a device for testing the compressive pull-out strength of a bolt of a fiber cement board. The device is characterized by comprising a testing device main body, a first connector, a second connector and a third connector, an opening hole for mounting the second connector is formed in the testing device main body; a main body screw hole is formed in the bottom of the testing device main body; a third bolt is formed at the top of the third connector and can be in threaded connection and fixation with the main body screw hole; a side opening groove is formed in one end of the side face of the testing device body, the side opening groove is used for limited directional sliding insertion or push-out of the fiber cement board provided with the testing bolt, and a limiting groove face used for limiting the fiber cement board is arranged in the side opening groove. A second screw hole is formed in the bottom of the second connector; according to the utility model, the compressive strength and the pull-out strength of the test bolt on the fiber cement board can be accurately tested, an accurate stress-strain curve is obtained, and the research of technicians is more convenient.

The invention discloses a low-temperature phase change material temperature field visualization test platform based on a schlieren method. The platform comprises a schlieren optical imaging system, a low-temperature Dewar and an image acquisition and processing system. In the schlieren optical imaging system, light emitted by a light source forms parallel test light beams through a beam expanding collimator, and the parallel test light beams penetrate through a low-temperature phase change material area in a sample cavity in a low-temperature Dewar system, then enter a convergent lens and form focusing light spots on a focal plane of the convergent lens; the blade is arranged at the focal plane and is used for partially cutting off a focusing light spot, so that light deflection caused by the refractive index gradient in the phase change material is converted into gray scale contrast change, and a schlieren image is recorded by the high-speed camera; and the image acquisition and processing system performs background correction, deflection angle calculation, refractive index gradient inversion, temperature gradient reconstruction and temperature field reconstruction on the schlieren image, and performs dynamic visual display. The invention provides a non-contact full-field visualization test means for researching low-temperature PCM phase change temperature field distribution and phase interface evolution.

The application discloses a CALPHAD-based cross-system knowledge transfer alloy design method, which comprises the following steps: performing CALPHAD balance calculation on a source aluminum alloy and a target Al-Mg-Zn alloy to construct an initial feature set; deriving mean value and variance of phase fraction weighting and multi-step heat treatment addition / difference features; locking an optimal feature subset through three-step feature selection assisted by source data set; training 300 base models through bagging, integrating mean value and standard deviation to obtain a high-stability predictor; and coupling NSGA-II and high-throughput CALPHAD to search for a Pareto frontier with double targets of strength and elongation and determine a composition-process scheme; and the application significantly improves the model interpretability and generalization performance by constructing a CALPHAD descriptor with physical interpretability as a model feature, thereby improving the alloy design efficiency and reducing the experimental workload.

The application relates to a real-time solution method for spacecraft orbit pursuit-evasion game, and relates to the field of real-time solution of spacecraft orbit pursuit-evasion game. The existing spacecraft pursuit-evasion game based on the maximum principle needs to solve the boundary value problem of the saddle point solution, and the method based on the heuristic method or the nonlinear programming method cannot meet the demand of on-orbit application in terms of calculation time and convergence guarantee, which becomes the biggest obstacle for the on-orbit application of the game theory. The method comprises the following steps: solving equivalent one-sided minimum time optimal control equations by using the separation property of the Hamilton function and the linear co-state equation; adopting the least square method to fit a transformation matrix based on the one-sided minimum time optimal control equation, determining an analytical boundary by using a dynamic ellipsoid, and taking the terminal time as the boundary of the set; based on the terminal geometric condition, solving the zero point of f(t f ) to obtain the optimal game time and the optimal game strategy, and realizing the online solution of the spacecraft pursuit-evasion game.

The utility model relates to the field of die cutting machining, and discloses a double-layer independent feeding device which is characterized in that stable supports are fixedly connected to the two sides of the bottom of a working table body, a working table plate is fixedly connected to the top of the working table body, and a fixing frame is fixedly connected to one side of the top of the working table plate; a rectangular plate is fixedly connected to one side of the surface of the workbench plate and close to the fixing frame, and a first discharging shaft is fixedly connected to one side of the surface of the rectangular plate and close to the top. By arranging the first discharging shaft, the second discharging shaft, the upper-layer feeding rubber roller, the lower-layer feeding rubber roller, the material pressing passing roller, the material avoiding passing roller, the lower-layer material pulling rubber roller, the upper-layer material pulling rubber roller, the upper-layer winding shaft and the lower-layer winding shaft, independent assembly feeding of main materials through the double-layer independent feeding mechanism is facilitated; and it is guaranteed that defective joints of materials independently sense feeding jump cutting, unnecessary secondary manual selection of defective products and time waste are reduced, and the efficiency is greatly improved by developing a double-layer independent feeding device.

This invention provides a method and system for predicting the risk of aortic remodeling after aortic dissection, comprising the following steps: receiving CTA images of the patient's chest and abdomen at multiple time points, such as preoperative and short or mid-operative postoperatively, and obtaining aortic segmentation results based on the CTA images; obtaining the displacement field of each voxel point between the two time points based on the aortic segmentation results, and obtaining vascular deformation mapping results based on the displacement field; extracting multi-dimensional features from the three-dimensional aortic segmentation model and the vascular deformation mapping results respectively; and predicting the risk of adverse aortic remodeling after surgery based on the multi-dimensional features. The beneficial effects of this invention are: by comprehensively utilizing multi-dimensional, dynamic, and static features, the prediction model constructed by this invention theoretically has higher discrimination and calibration than existing single-index models. Therefore, this invention can detect early, local abnormal deformations that cannot be detected by traditional diameter measurement, significantly advancing the risk identification time point.

This invention provides a polymer electrolyte, its preparation method, and its application. The raw materials of the polymer electrolyte, by mass, include the following components: 8-12 parts of an olefin polymer, 4-8 parts of a sodium salt, 0.4-1.2 parts of hydrophobic fumed silica (SiO2), 7-30 parts of a fluorinated small-molecule plasticizer, and 35-85 parts of a solvent. The polymer electrolyte of this invention uses a fluorinated small-molecule plasticizer with weak solvation ability as the plasticizer in the electrolyte, which improves the mechanical properties of the electrolyte membrane. Simultaneously, it forms a competitive coordination effect with the residual solvent with strong solvation ability, which is beneficial for inhibiting the corrosion effect of sodium salt on the current collector. The hydrophobic fumed silica filler reduces the crystallinity of the polymer matrix and enhances the mobility of the polymer matrix segments, thereby improving the ionic conductivity.

The invention discloses a preparation method and application of an oxide glass electrode of a lithium ion capacitor, and belongs to the technical field of oxide glass electrodes, and the preparation method of the oxide glass mainly comprises the following steps: weighing glass raw materials according to glass composition, uniformly mixing, heating, melting, cooling and annealing, grinding the annealed glass into glass powder, and preparing for preparing an electrode plate; the preparation method comprises the following steps: weighing an active substance, a conductive agent and a binder in proportion, mixing in a ball milling tank, and dropwise adding a proper amount of dispersant for ball milling; blade-coating the slurry on a metal aluminum foil current collector for drying; and cutting the dried pole piece into electrode slices by using a slicing machine to prepare for assembling the lithium ion capacitor. According to the preparation method and application of the oxide glass electrode of the lithium ion capacitor, the obtained oxide glass electrode shows excellent electrochemical performance, meanwhile, the production process is simple, no pollution is caused to the environment, good application prospects are achieved, and more choices are provided for electrode materials of the lithium ion capacitor.

The application discloses an iron-based cathode material for wastewater treatment and a preparation method and application thereof. The application proposes a strategy of cation layer regulating a cathode surface / peroxysulfate in view of the problem that the peroxysulfate is inhibited in cathode activation due to electrostatic repulsion between the cathode surface and the peroxysulfate in a cathode-activated peroxysulfate reaction system. A metal cation layer is deposited on the cathode surface, an interface with a positive Zeta potential appears, the electrostatic repulsion of the interface is effectively weakened, the interface aggregation effect of the peroxysulfate on the cathode is significantly strengthened, and the activation of the peroxysulfate is improved. The iron-based cathode material can be used for electrochemical activation of the peroxysulfate to degrade organic matters in water, and has a wide application prospect.

This invention discloses a method, apparatus, device, and medium for determining the efficiency of a fuel cell system. The method includes: calculating hydrogen consumption based on the hydrogen injection valve duty cycle and hydrogen pressure; and calculating the efficiency of the fuel cell system based on the hydrogen consumption. The hydrogen consumption includes instantaneous hydrogen consumption and / or average hydrogen consumption over a set time period. Correspondingly, the efficiency includes instantaneous efficiency and / or average efficiency. This technical solution first calculates instantaneous hydrogen consumption and / or average hydrogen consumption over a set time period using the hydrogen injection valve duty cycle and hydrogen pressure, and then calculates the instantaneous efficiency and / or average efficiency of the fuel cell system based on the hydrogen consumption. This achieves real-time and accurate determination of the fuel cell system efficiency, facilitating research by developers and efficient use by users, thereby promoting the continuous development of fuel cell technology.

The application discloses an experimental device and experimental method for simulating aircraft wake cloud generation and evolution, and relates to the field of experimental devices for simulating aircraft wake cloud generation and evolution. The experimental device for simulating aircraft wake cloud generation and evolution comprises a gas supply system, an altitude simulation system, a wake cloud generation and evolution system and a gas extraction system. The altitude simulation system comprises a test cabin provided with an aero-engine. The first gas supply system delivers low-temperature gas towards the aero-engine. The wake cloud generation and evolution system comprises an environment cabin, a nozzle and a dilution assembly. The dilution assembly receives and dilutes exhaust gas of the aero-engine and delivers the diluted exhaust gas to the nozzle. The nozzle sprays the exhaust gas into the environment cabin. The second gas supply system delivers low-temperature and high-humidity gas towards the environment cabin. The gas extraction system extracts gas in the test cabin, the aero-engine and the environment cabin. The experimental device for simulating aircraft wake cloud generation and evolution can realize the generation and evolution of simulated wake clouds, thereby facilitating the subsequent research on the influence of aviation emissions on global climate.

The application belongs to the technical field of animal experiment models, and discloses a method for constructing a mouse model of autism spectrum disorder and application. Pregnant mice are orally exposed to different doses of 1-NP every day during the whole gestation period, the pregnant mice naturally give birth, and the offspring mice are evaluated for autism-like behaviors at PND28 after birth by using a three-chamber social experiment. The offspring mice are evaluated for autism-like behaviors at PND70 after birth by using a three-chamber social experiment. Maternal 1-NP exposure during pregnancy delays the migration of intermediate neurons in the forebrain of fetal mice, and the autism-like behaviors. 1-NP exposure during pregnancy down-regulates the expression of intermediate neuron migration-related genes by reducing DNA hydroxymethylation of the intermediate neuron migration-related genes. 1-NP exposure during pregnancy damages the synthesis of mitochondrial tricarboxylic acid cycle alpha-ketoglutarate (alpha-KG). Maternal alpha-KG supplementation during pregnancy improves the migration of intermediate neurons in 1-NP exposed fetal mice and the autism-like behaviors of offspring mice.

A data-driven model-based method for predicting and classifying particle flow inside a rotary drum is presented. This method combines particle flow data generated by a discrete element method (DEM) model of the rotary drum to extract features related to particle motion behavior. A data-driven model is constructed using a Long Short-Term Memory (LSTM) method to predict the temporal characteristics of the flow data of mixed particles inside the rotary drum, and further classifies the rotary drum under various operating conditions. This method, combined with the DEM model, provides visualization of the trajectory of each particle and collects macroscopic and microscopic data representing the characteristics of particle flow inside the drum. Based on the data-driven model, this method extracts feature representations related to particle motion behavior from historical data of the DEM simulation and establishes a mapping relationship related to the motion state by mining the entire process data of mixed particle motion. Therefore, the prediction and classification method for mixed particle flow inside a rotary drum can be implemented at low cost, higher efficiency, and faster.

The present application provides a complex model combining a humanized in situ liver cancer nude mouse and a KRAS G12D nude plasmid transgene, which can quickly reach 100% tumorigenesis in 7 weeks from modeling, and presents histological features similar to human clinical hepatocellular carcinoma, is suitable for a complex model for new drug research and development in the fields of precise treatment of liver cancer, PROTAC targeted protein degradation agents, small molecule drugs, small nucleic acid drugs and gene therapy, and can achieve efficient and economical modeling of human hepatocarcinogenic gene-induced liver cancer humanized mice.