Pore network model (PNM)-based bionic bone scaffold designing method

A pore network model and bionic bone technology, which is applied in computing, 3D modeling, bone implants, etc., can solve problems such as difficulty in ensuring structural functionality, poor control of porosity and connectivity, and large differences

Inactive Publication Date: 2011-06-08
上海蓝衍生物科技有限公司
View PDF3 Cites 53 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the reconstruction process, the microscopic pore structure of the existing bone scaffold is very different from the natural real bone. In terms of the microscopic tissue structure, t...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pore network model (PNM)-based bionic bone scaffold designing method
  • Pore network model (PNM)-based bionic bone scaffold designing method
  • Pore network model (PNM)-based bionic bone scaffold designing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0074] A preferred embodiment of the present invention, detailed description is as follows in conjunction with accompanying drawing: See figure 1 , the bionic bone scaffold construction method based on the pore network model, the operation steps are as follows:

[0075] 1. Process the Micro-CT data into a binary image by using the threshold method, and further process and reconstruct the cancellous bone model, and obtain the porosity, penetration rate and pore diameter distribution through measurement;

[0076]Micro-CT scanning was performed on natural bone to obtain tomographic images of microscopic three-dimensional porous structure information and three-dimensional spatial position density information of natural bone. The tomographic images obtained by the above-mentioned Micro-CT scans were binarized using the threshold method to obtain images with only two gray levels (see figure 2 ); in the gray-scale image above, select the image area of ​​cancellous bone and set the ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a pore network model (PNM)-based bionic bone scaffold constructing method. The method comprises the following steps of: acquiring a cross section image of microscopic three-dimensional micropore structural information and three-dimensional space position density information of a human bone by a micro computed tomography (Micro-CT) technology; performing threshold value processing to acquire binarized image data; extracting a spongy bone part, and measuring by using Mimics software to acquire porosity, penetration rate, aperture and the like; programming PNM bone scaffold parameters according to a PNM principle by using the acquired bone overall dimension data and internal size data; acquiring a generating program of the bone scaffold by using a programming tool C++ and OPENGRIP language programming; generating a three-dimensional model of the PNM bionic bone scaffold by using a Unigraphics (UG) secondary development platform; and finally leading the PNM bionic bone scaffold into the Mimics software to verify the parameters, such as the aperture, the penetration rate and the like of the PNM bionic bone scaffold. The bone scaffold well imitates a natural bone, and has high performance similar to that of the natural bone; and a good porous structure and the high penetration rate are favorable for differentiation and flowing of bone derived cells.

Description

technical field [0001] The invention relates to a design method of an artificial bone support for orthopedic surgical repair, in particular to a method for constructing a bionic bone support based on a pore network model (PNM). Background technique [0002] For a long time, the treatment of bone defects has been a major problem for human beings. With the rapid development of medical technology, especially orthopedic technology, the rapid improvement of health care and rehabilitation consumption levels, and the acceleration of modern life rhythms, the number of accidental bone trauma cases such as car accidents, coupled with the aging population, these Factors have directly led to people's increasingly urgent requirements for the repair and replacement of bone defects. In orthopedic surgery, the large defect of the long bone backbone of the limb has always been a difficult problem for orthopedic surgeons. It has been clinically proven that bone grafting is the best way to r...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61F2/28G06T17/00G06F17/50
Inventor 胡庆夕郭俊姚远
Owner 上海蓝衍生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap