Pore network model (PNM)-based bionic bone scaffold designing method

Abstract

The invention relates to a pore network model (PNM)-based bionic bone scaffold constructing method. The method comprises the following steps of: acquiring a cross section image of microscopic three-dimensional micropore structural information and three-dimensional space position density information of a human bone by a micro computed tomography (Micro-CT) technology; performing threshold value processing to acquire binarized image data; extracting a spongy bone part, and measuring by using Mimics software to acquire porosity, penetration rate, aperture and the like; programming PNM bone scaffold parameters according to a PNM principle by using the acquired bone overall dimension data and internal size data; acquiring a generating program of the bone scaffold by using a programming tool C++ and OPENGRIP language programming; generating a three-dimensional model of the PNM bionic bone scaffold by using a Unigraphics (UG) secondary development platform; and finally leading the PNM bionic bone scaffold into the Mimics software to verify the parameters, such as the aperture, the penetration rate and the like of the PNM bionic bone scaffold. The bone scaffold well imitates a natural bone, and has high performance similar to that of the natural bone; and a good porous structure and the high penetration rate are favorable for differentiation and flowing of bone derived cells.

Description

technical field [0001] The invention relates to a design method of an artificial bone support for orthopedic surgical repair, in particular to a method for constructing a bionic bone support based on a pore network model (PNM). Background technique [0002] For a long time, the treatment of bone defects has been a major problem for human beings. With the rapid development of medical technology, especially orthopedic technology, the rapid improvement of health care and rehabilitation consumption levels, and the acceleration of modern life rhythms, the number of accidental bone trauma cases such as car accidents, coupled with the aging population, these Factors have directly led to people's increasingly urgent requirements for the repair and replacement of bone defects. In orthopedic surgery, the large defect of the long bone backbone of the limb has always been a difficult problem for orthopedic surgeons. It has been clinically proven that bone grafting is the best way to r...

AI Technical Summary

Problems solved by technology

However, during the reconstruction process, the microscopic pore structure of the existing bone scaffold is very different from the natural real bone. In terms of the microscopic tissue structure, the porosity and connectivity cannot be effectively controlled, or because the pore channel structure is too regular, it is difficult to ensure its Structural functionality and difficult parameter control

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