This invention discloses a method for predicting the outcome of
in vitro fertilization-
embryo transfer (IVF-ET) based on static
embryo images, used to distinguish between biochemical
pregnancy and
clinical pregnancy. It belongs to the field of medical
artificial intelligence and
assisted reproductive technology and is applicable to single
embryo transfer (SET) and dual
embryo transfer (DET) scenarios. The method includes: acquiring a
static image of at least one embryo to be transferred; preprocessing and standardizing the embryo image, and then inputting it into a
feature extraction model based on a
convolutional neural network. The model uses DenseNet-169 as the
backbone network and combines it with a Feature
Pyramid Network (FPN) for multi-scale
feature fusion. When the input is a dual embryo image, a Trophectoderm–Inner
Cell Attention (TEIC-Attn) attention module is introduced to adaptively weight and fuse the features of the two embryos to characterize the contribution of different embryos to the final transfer outcome. When the input is a single embryo image, the prediction is completed based on the corresponding embryo features. The model ultimately outputs a probability prediction result of whether the IVF
treatment outcome is a biochemical
pregnancy or a
clinical pregnancy. Furthermore, this invention combines a gradient-based
class activation mapping method to generate interpretable visual heatmaps, highlighting key morphological regions closely related to
embryo transfer outcomes, such as the
inner cell mass and trophectoderm, thereby providing clinicians and patients with intuitive and reliable decision-making support. This invention enables unified prediction and interpretation of single and double
embryo transfer outcomes without relying on time-
series data, improving the accuracy and
interpretability of in-vitro fertilization treatment decisions and demonstrating promising clinical application prospects.