75 results about "Degenerative change" patented technology

The invention which relates to the medicinal field discloses an application of butylphthalide and derivatives thereof in the preparation of medicines for preventing and treating ALS (amyotrophic lateral sclerosis). Butylphthalide and the derivatives, which can delay the disease time of an SOD1-G93A transgenic mouse, prolong the lifetime of the mouse, reduce the degenerative change of spinal motorneurons, obviously increase the survival number of spinal anterior horn motor neurons of the mouse, reduce the electrophysiological abnormality of the transgenic mouse, obviously improve the action potential amplitude and the motion unit number of compound muscles, substantially inhibit the activation of astrocytes and microglial cells in the spinal cord of the mouse, and obviously reduce the expression level of iNOS and NF-kappaBp65, have good application prospects in the prevention and the treatment of the ALS.

The invention relates to an exosome derived from human pluripotent stem cells, a preparation based on the exosome and use of the exosome and preparation, and belongs to the technical fields of cell biology, molecular biology and drug research and development. The human pluripotent stem cell exosome or the preparation based on the human pluripotent stem cell exosome has the uses of A, being an additive cultured in vitro for maintaining the stemness of adult stem cells and inhibiting the senility of the adult stem cells; B, being an additive cultured in vitro for maintaining the proliferative activity of various tissue primary culture cells; C, being applied in preparing medicine for treating bone and cartilage degenerative changes; D, being applied in preparing medicine for preventing the bone and cartilage degenerative changes; E, being applied in preparing medicine for treating orthopedic diseases such as osteonecrosis, bone nonunion, fractures, cartilage injuries, tendon injuries, frozen shoulders or tendon adhesion. Compared with the prior art, the exosome secreted by the pluripotent stem cells has powerful functions of promoting tissue cell regeneration, preventing senility andtreating bone diseases.

A system and method are provided for making an access channel through a vertebral body to access a site of neural compression, decompressing it, and repairing the channel to restore vertebral integrity. System elements include an implantable vertebral plate, a guidance device for orienting bone cutting tools and controlling the path of a cutting tool, a bone cutting tool to make a channel in the vertebral body, a tool for opening or partially-resecting the posterior longitudinal ligament of the spine, a tool for retrieving a herniated disc, an implantable device with osteogenic material to fill the access channel, and a retention device that lockably-engages the bone plate to retain it in position after insertion. System elements may be included in a surgery to decompress an individual nerve root, the spinal cord, or the cauda equina when compressed, for example, by any of a herniated disc, an osteophyte, a thickened ligament arising from degenerative changes within the spine, a hematoma, or a tumor.

The present invention provides a composition for regenerating cartilage or treating a cartilage disease containing a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for regenerating cartilage that improves cartilage regenerative action and ease of application to a cartilage injury lesion, and a composition for treating a cartilage disease, which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing a cartilage injury lesion, and inhibiting inflammation and pain of joint tissue.

An LED planar transparent soft-base conformal phototherapy body is provided. The soft-base conformal phototherapy body capable of bending with changes of human body shape is used for human skin-contacting irradiation therapies in medical treatment, and is composed of high-power LED chips, flexible circuit boards, flexible silica gel plates, and high-transparency polyester films. The high-power LED chips having wavelength of 510-910nm and irradiating power density of 1-150 mW/cm2 are adopted as irradiation sources , and light output power density may be changed by adjusting current magnitude. The LED planar transparent soft-base conformal phototherapy body is suitable for large spot irradiation therapies of tissue damages and inflammations, bone joint degenerative changes and aches, and body surface photodynamic therapy.

The invention relates to an application of ligustilide in preparing a composition for preventing and treating senile dementia, which comprises ligustilide as an effective component and other components acceptable pharmaceutically and/or acceptable in food or auxiliary components. As required, the effective components can comprise at least one of acetylcholinesterase inhibitor, excitatory amino acid and peptide transmitter components, Abeta fibration and sedimentation disturbance components, antioxidant, microcirculation improving components and calcium antagonist accounting for 10%-40% of the total weight. Shown by experimental results, through the protective actions of the ligustilide on damage caused by oxidation, apoptosis and inflammatory reaction induced by the Abeta amyloid peptide fragment and aging neuron degenerative change, the composition can obviously improve the descending of learning and memory caused by the Abeta amyloid peptide fragment and the aging neuron degenerative change, and can be used as a medicine and/or a health food composition.

The invention discloses an arthralgia relief composition, an arthralgia relief health-care product, and application of the arthralgia relief composition. The arthralgia relief composition comprises D-glucosamine sulfate potassium chloride, calcium carbonate, chondroitin sulfate, type II collagen, non-denatured type II collagen, turmeric extract, vitamin K2 powder, and vitamin D3 powder. Human feeding trials prove that the components are synergistic, allowing arthralgia to be relieved shortly, promoting joint activity improvement, and preventing further degenerative changes in articular cartilages; the arthralgia relief composition has good safety and effect, and a quick, effective scheme is provided for relief of osteoarthritis or rheumatoid arthritis pains.

The present invention provides compositions and methods for alleviation or reduction of the symptoms and signs associated with damaged neuronal tissues whether resulting from tissue trauma, or from chronic or acute degenerative changes. In particular, some embodiments of the present invention provide one or more pharmaceutical compositions comprising as an active ingredient a BMP2A inhibitor further comprising a pharmaceutically acceptable diluent or carrier. An additional embodiment provides a method for reducing damage to the central nervous system in a patient who has suffered an injury to the central nervous system, comprising administering to the patient a pharmaceutical composition in a dosage sufficient to reduce the damage. Yet another embodiment provides of the use of a BMP2A inhibitor for the preparation of a medicament for promoting or enhancing recovery in a patient who has suffered an injury to the central nervous system. Preferable inhibitors according to some embodiments of the invention are siRNA molecules and neutralizing antibodies. An additional embodiment provides a method for identifying a chemical compound that modulates apoptosis. Further, a process for diagnosing a neurodegenerative disease or an ischemic event in a subject is provided. The preferred methods, materials, and examples that will now be described are illustrative only and are not intended to be limiting; materials and methods similar or equivalent to those described herein can be used in practice or testing of the invention. Other features and advantages of the invention will be apparent from the following detailed description, and from the claims.

The invention provides cartilage preserving fluid and a utilization method thereof. The cartilage preserving fluid is prepared from monopotassium phosphate, histidine or histidine salt, lactobionic acid, saccharose, allopurinol, low-molecular dextran-40, NaCl, KCl, magnesium sulfate, penicillin, reduced glutathione, adenosine, trehalose, catechin, vitamin E and chondroitin sulfate, deionized waterserves as a solvent, a pH value is 7.35-7.52, and the cartilage preserving fluid is used for cartilage preservation at a temperature of 0-4 DEG C. The cartilage preserving fluid and the utilization method thereof have advantages that bioactivity of articular cartilage cells can be kept, degenerative changes of articular cartilages can be delayed, and assistances are provided for clinical treatment of large-area articular cartilage defects and cartilage tissue transplantation.

The invention belongs to the field of food, and discloses a composition for preventing or treating joint diseases. The composition is mainly prepared from the following raw materials: zaocys dhumnade,eucommia flower, pawpaw, coix lacryma-jobi, pseudo-ginseng, beautiful millettia root, ginseng, cartilage, sugar and peptide. The prepared composition taking zaocys dhumnade, eucommia flower, coix lacryma-jobi, pawpaw, pseudo-ginseng, beautiful millettia root and ginseng as raw materials integrally has the effects of strengthening tendons and activating collaterals, expelling wind-damp and relieving arthralgia, tonifying liver and kidney and strengthening tendons and bones; shark cartilage powder, chitosan oligosaccharide and bovine bone collagen peptide are adopted for matching to lubricate joints. The composition has a good prevention or treatment effect on joint diseases, especially joint diseases caused by knee joint degenerative changes, can effectively improve symptoms such as ankylosis and aching pain, and has no side effect after long-term administration.

The invention relates to a rotary cervical curvature tractor. A supporting point is arranged at the rear part of the cervical vertebra of a human body and the traction is carried out along the curvature arc direction of the cervical vertebra of the human body. By the technical scheme, an active mechanical acting force is utilized to carry out curvature traction on the cervical vertebra, so that not only is the safety of the cervical vertebra ensured and new damage to the cervical vertebra cannot be caused, but also the cervical vertebra of a patient suffering from the cervical vertebra disease can be recovered to the normal and original physiological curvature; due to the adoption of the curvature traction, the intervertebral space can be widened and the stability and the normal physiological functions of the cervical vertebra can be recovered; the muscle spasm is relieved, adhered tissues are stripped and loosened and the inflammation is eliminated; and the blood supply is improved and the rotary cervical curvature tractor is beneficial for recovering the nervous tissue function and has a certain relieving and recovering effects on the degenerative change of the vertebral column of the human body, the neck pain and the cervical spondylotic radiculopathy which are caused by the case that the patient bends over a table to work, study and drive for a long time.

The invention provides a pharmaceutical composition for degenerative changes of bone and bone joints. The pharmaceutical composition is prepared from D-glucosamine sulfate, red deer bone powder, medicinal cyathula root, rhizoma drynariae, salvia miltiorrhiza, wolfberry fruit, Chinese yam, radix puerariae, hawthorn and mint. According to the pathogenesis characteristics of diseases, the pharmaceutical composition has excellent treatment effects on both degenerative osteoarthropathy and osteoporosis according to the basic rule of treatment of treating both cause and symptoms and combining tonifying and dredging; and the pharmaceutical composition conforms to the clinical practice of general coexistence of the two diseases in middle-aged and elder patients and overcomes the defect of single efficacy of the existing products.

The invention belongs to the technical field of traditional Chinese medicine, and particularly provides a medicine composition for treating central nervous system diseases. The medicine composition is prepared from the following bulk pharmaceutical chemicals in parts by weight: 10-30 parts of ferulic acid, 6-12 parts of baicalin and 3-5 parts of ligustilide. The invention also provides a preparation method and specific application of the medicine composition. Drug effect experiments prove that the medicine combination provided by the invention can effectively improve the cognitive function of dementia or cognitive disorder patients, improve behavioral abnormity, improve the life quality of patients, can effectively treat brain cell oxidation stress injury and microinflammation injury, and has good therapeutic effect on degenerative change of a central nervous system.

The invention belongs to the field of bedding articles and relates to a partitioned height adjusting apparatus for beds, and the apparatus helps to solve the problems that when a user lies on a conventional bed in a supine position or in a lateral position, joints, ligaments, muscles and tendons of all parts cannot keep a relax state. By employing the apparatus capable of adjusting the height of all parts of a user lying on a bed in a supine position or in a lateral position, strain or degenerative changes caused by pressure stress change of ligaments, muscles and tendons and long-term unbalance of joint positions of the user body are avoided, and the user feels extremely comfortable.

The invention provides a moving stabilization system for an elastic vertebral arch pedicle nail of the spinal column. The elastic vertebral arch pedicle nails are connected with each other by special bent wire cables, the wire cables are arranged in grooves on the tails of the vertebral arch pedicle nails fixed in the upper and lower vertebral bodies of the pathological vertebra gap and tightly locked by locking nuts so as to form the movable stabilizing device. When the vertebral column of a human body is bent towards the front, the back, the left side and the right side and slightly rotates, the wire cables can be moved in any direction. The moving artificial vertebral unit keeps the moving function of the intervertebral disk and the intervertebral joints, and facilitates the restoration and regeneration of the intervertebral disk and the prevention of accelerated degeneration of adjacent segments due to intervertebral fusion; moreover, the wire cables have the functions of reducing the load of the intervertebral disk and the intervertebral joints, retarding the degenerative change of the intervertebral disk and the intervertebral small joints, and imitating the moving unit of the human vertebral column to the maximum extent.

The present invention provides compositions and methods for treating a joint disease containing as an active ingredient thereof a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for treating a joint disease which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing cartilage injuries, suppressing inflammation and pain of joint tissue, inhibiting degeneration of synovial tissue, and inhibiting osteochondral destruction.

The invention belongs to the technical field of traditional Chinese medicines and in particular provides a medicine composition used for treating neurodegenerative disease. The medicine composition used for treating neurodegenerative disease is prepared from the following bulk pharmaceutical chemicals in parts by weight: 25-40 parts of scutellaria baicalensis, 18-30 parts by weight of ligusticum wallichii and 6-10 parts of Chinese angelica. The invention also provides a preparation method and a concrete purpose of the medicine composition. Pharmacodynamic experiment proves that the medicine composition has a better therapeutical effect on degenerative change of a central nervous system according to related objective indicators of a mouse dementia model, a vascular rat dementia model, a mouse pia mater microcirculation model and the like in an experimental group.

The invention discloses a gene TMED2 which can serve as a molecular marker for diagnosing the intervertebral disc degenerative change. Experiments prove that in comparison with a normal person, the expression quantity of the gene TMED2 in intervertebral disc degenerative change patients is large. The invention further discloses the gene TMED2 which can be used for preparing a drug for treating the intervertebral disc degenerative change. Apoptosis experiments prove that overexpression of the gene TMED2 can promote nucleus pulposus cell apoptosis. The research result provides a new intervertebral disc degenerative change clinic diagnosis method and provides a drug new target for treating the intervertebral disc degenerative change.

The invention provides a bicycle pedal and a manufacturing method thereof. The bicycle pedal comprises a pedal body and a rotating shaft. The pedal body is used for containing a foot of a rider and is used for limiting the foot from five directions including the front, the rear, two sides and the upper position. Force exerted on the front position, the rear position and the upper position of the foot by the rider is transferred to the rotating shaft through the pedal body. The rotating shaft is arranged on the pedal body, and a bicycle is driven to run by the fact that the rotating shaft operates along with the pedal body. Through the arrangement of the pedal body, the foot is limited from the five directions including the front, the rear, two sides and the upper position of the foot, a pedal bottom board is not arranged at the sole of the foot, namely the pedal is a bottomless shoe-shaped pedal, the rider can ride the bicycle to run through force from upward raising, forward pushing and backward pulling, the muscle such as quadriceps femoris is exercised, pressure friction of knee joints can be avoided or reduced, and the pedal is beneficial for delaying degenerative change of the knee joints and improving living quality of patient groups.