36 results about "Tissue protection" patented technology

This invention relates to the field of medical device technology, specifically to a tissue protection shielding device for laparoscopic surgery. The device includes a shielding assembly and a pull cord. The shielding assembly comprises several shielding plates; each shielding plate has a perforation, and an elastic element connects adjacent shielding plates. The elastic element provides elastic force to allow the shielding assembly to roll into a cylindrical shape when no external force is applied, at which point the shielding assembly is in its initial state. The pull cord has a limiting element. When the shielding assembly is in its initial state, pulling the pull cord reduces the length of the cord that is threaded through the shielding assembly, causing adjacent shielding plates to rotate relative to each other. This allows the shielding assembly to bend in the opposite direction into an arc shape, and the elastic element is compressed by the corresponding two shielding plates, resulting in a protruding structure protruding from the inner surface of the shielding assembly. This tissue protection shielding device for laparoscopic surgery can improve the protection of the liver, preventing injury or cuts to the liver.

The invention discloses a probiotic which is derived from human milk and has the effects of resisting oxidation, resisting inflammation, protecting tissues and protecting intestinal barriers and application of the probiotic. Lactobacillus paracasei DPUMW-M14-9 is preserved in the general microbiological center of the China Committee for Culture Collection of Microorganisms, and the preservation number is CCTCC M 20252990. The strain has the characteristics of acid resistance, bile resistance, strong oxidation resistance, high surface hydrophobicity, self-aggregation capability and the like. The lactobacillus paracasei DPUMW-M14-9 can effectively adhere to epithelial cells, promote cell proliferation and regulate and control the process of a cell cycle. The bacterial strain can be used for inhibiting proinflammatory cytokines (TNF-alpha, IL-6 and IL-1beta) induced by lipopolysaccharide (LPS) and repairing tight junction proteins (ZO-1, Occludin and Claudin-1) at the same time, so that the integrity of epithelial cells is enhanced.

The invention relates to the technical field of medical instruments, and particularly discloses an ultrasonic ablation system. In order to solve the problems that in the ultrasonic ablation process, the temperature of cooling liquid in a balloon cannot be stably controlled, attachment is affected by pressure fluctuation, and the balloon cannot actively adapt to different blood vessel sizes, the ultrasonic ablation catheter comprises an ultrasonic catheter body, an ultrasonic transducer, a fluid circulation device and a main machine, and the ultrasonic catheter body comprises an inner tube, a multi-cavity tube, the balloon communicated with the end of the multi-cavity tube and a needle seat; the ultrasonic transducer is arranged in the balloon, the fluid circulation device is communicated with the needle seat, the host is electrically connected with the fluid circulation device and the ultrasonic transducer, in the process that the ultrasonic transducer emits energy to ablate target nerves, the host controls the fluid circulation device to operate, and cooling liquid continuously flows into the balloon through the liquid inlet; meanwhile, the liquid is continuously discharged from the balloon through the liquid outlet. Accurate temperature control and effective tissue protection are achieved, and guarantee is provided for long-time, safe and effective ablation operation.

Systems and methods for preventing the seeding of cancerous cells during morcellation of a tissue specimen inside a patient's body and removal of the tissue specimen from inside the patient through a minimally-invasive body opening to outside the patient are provided. One system includes a cut-resistant tissue guard removably insertable into a containment bag. The tissue specimen is isolated and contained within the containment bag and the guard is configured to protect the containment bag and surrounding tissue from incidental contact with sharp instrumentation used during morcellation and extraction of the tissue specimen. The guard is adjustable for easy insertion and removal and configured to securely anchor to the body opening. Protection-focused and containment-based systems for tissue removal are provided that enable minimally invasive procedures to be performed safely and efficiently.

The invention discloses a path establishing and distraction device suitable for neurosurgery endoscopic surgery and an operation method.The path establishing and distraction device is provided with an annular base, an annular gear coaxial with the base is arranged at one end of the base, and the annular gear can rotate on the base around a common shaft; side gears are rotatably and uniformly arranged on the outer side surface of the base, the side gears are meshed with the annular gear, fins corresponding to the side gears are arranged on the inner side surface of the base, and the side gears are fixedly connected with the lower ends of the fins through center shafts; each fin is provided with a convex outer side face and a concave inner side face, the lower end of each outer side face is attached to the inner side face of the base, and the fins are arranged in a stacked mode. Methods of using the distraction device suitable for neurosurgical endoscopic surgery path establishment are also disclosed. The path establishing and distraction device has the complete process function of establishing, distraction, stabilizing and removing, the operation efficiency and the tissue protection effect are improved, and the path establishing and distraction device has good clinical practical value and popularization prospects.

This invention discloses a method for improving the quality stability of frozen oysters and a frozen oyster meat product, relating to the field of aquatic product processing technology. The method for improving the quality stability of frozen oysters provided by this invention employs ultrasonic treatment combined with citric acid solution soaking. It utilizes the cavitation effect, microjets, and mechanical vibration generated when ultrasound propagates in a liquid medium to effectively disrupt the mass transfer resistance on the surface of oyster tissue, significantly promoting the penetration and uniform distribution of citric acid within the muscle tissue. This solves the problems of low penetration efficiency of active ingredients and insufficient internal tissue protection in traditional citric acid soaking treatments, achieving effective inhibition of lipid and protein oxidation. This invention features a simple process, high safety, requires no complex equipment, and is suitable for large-scale application in the aquatic product processing industry.

The present application provides a kind of hydrophilic cerium oxide nanoparticles and its dispersion liquid.Hydrophilic cerium oxide nanoparticles include cerium oxide nanoparticles core and the hydrophilic polymer compound coated on its surface, and cerium element in cerium oxide nanoparticles exists in two valence states of Ce 3+ And Ce 4+ . The hydrophilic polymer compound is coated on the surface of cerium oxide nanoparticles, which can improve its dispersibility and stability in aqueous system.The present application also provides a preparation method of hydrophilic cerium oxide nanoparticles, which can be carried out in aqueous system under normal temperature and pressure, and has mild process and simple operation.The obtained hydrophilic cerium oxide nanoparticles have good free radical scavenging capacity, dispersion stability and oxidative stress regulation activity, can form stable dispersion liquid in water system, and show good antioxidant and tissue protection effect in cell and animal oxidative stress model.The present application also provides the application of hydrophilic cerium oxide nanoparticles or its dispersion liquid in antioxidant, oxidative stress regulation and related preparations.

The invention belongs to the technical field of medical instruments, and relates to an auxiliary surgical instrument for arthroscopic treatment of carpal tunnel syndrome, which comprises a cannula, a tail cap connected with the cannula and a slotting structure arranged on the back of the middle section of the cannula. The cannula is used for forming a continuous tissue isolation channel in the carpal canal, the tail cap is used for achieving stable connection of the arthroscope and the cannula and keeping the axis consistent, and the open groove corresponds to the area where the transverse ligament of the carpal canal is located after the instrument is positioned and is used for forming a controlled local operation window. Through cooperation of the cannula, the tail cap and the open groove in spatial position and function, the arthroscope view, the tissue protection area and the surgical operation window form a stable whole, and on the premise that the cannula continuously isolates and protects tissue in the carpal canal, visual and directional release of the transverse ligament is achieved. The arthroscope device is simple in structure, controllable in operation, beneficial for improving operation safety and stability and suitable for arthroscope treatment of the carpal tunnel syndrome.

The application discloses a medicine composition for promoting wound healing and a preparation method and application thereof. The medicine composition comprises the following components in parts by weight: 1-10 parts of hemoglobin molecules, 1-5 parts of lipoic acid, 0.1-1 part of acetylcysteine, and 40-80 parts of a solvent; the hemoglobin molecules comprise at least one cysteine part and at least one histidine part, wherein the cysteine part comprises an acetyl group or an ethyl maleoyl group, and the histidine part comprises a benzimidazole derivative group. The application applies lipoic acid and acetylcysteine to the external medicine composition of the hemoglobin molecules modified by acetyl groups or ethyl maleoyl groups in combination, effectively relieves the irritant reaction caused by the hemoglobin modification to the skin through the synergistic antioxidant and tissue protection effects, and thus improves the safety and applicability of the medicine composition in skin wound treatment, and the medicine composition is suitable for treating multiple types of wounds such as external injuries, burns, postoperative wounds and ulcer wounds.

New compositions and methods are described herein operable for delivery of therapeutic agents while mitigating damage to healthy tissues. In one aspect, a conjugate comprises a linker joining a pharmaceutical component and a targeting ligand, wherein the linker is at least one of radiolabile, photolabile, thermolabile, chemically labile, magnetically labile, or acoustolabile for release of the targeting ligand and / or the pharmaceutical component from the conjugate.

A multi-layer balloon membrane material (1) is described, which combines one or several layers of elastically deformable material (2) with one or several layers of plastically deformable, inelastic material (3), wherein the inelastic layers counteract the straightening properties of the elastic layers in the case of planar folding or bending of the balloon membrane material. In particular, the cross-sectional area of the eye- or channel-like structures (6) for guiding secretions or liquids, which are typically produced in the region of the plicated invagination of the balloon membrane with dimensional redundancy in organ cavities or body cavities, can be reduced, and in particular stabilized in the case of a periodic change in the balloon filling pressure, whereby an optimal sealing closure or packing result is achieved over as large a range of filling pressure amplitudes as possible.

The utility model discloses a tunnel puncture outfit and a medical instrument used for subcutaneous puncture, the tunnel puncture outfit is the medical instrument suitable for subcutaneous puncture, the tunnel puncture outfit comprises a handle used for being held by hand; the puncture head is used for penetrating into the subcutaneous part and penetrating out of the subcutaneous part; one end of the tunnel rod is connected with the handle, the other end of the tunnel rod is connected with the puncture head, the tunnel rod comprises a plurality of sections of connecting rods, and the wall thickness of at least one section of connecting rod is different from that of other connecting rods, so that the rigidity of the tunnel rod is different in the length direction. According to the tunnel puncture outfit and the medical instrument for subcutaneous puncture, gradient distribution of rigidity of the tunnel puncture outfit can be achieved, puncture strength and tissue protection are both considered, and the problem that a traditional single rigid rod is too rigid or too soft is solved.

The system provides a method for surgically removing tissue through small incision sites and / or body openings. [Solution] The tissue containment and containment system includes a primary chamber, and a secondary channel extending from this primary chamber is interconnected with the primary chamber. A tissue specimen is placed into the primary chamber through a first opening 12 while floating in a body cavity. The first opening is drawn in through a first incision or body opening, and a narrower secondary channel is positioned at a second incision or body opening. A second opening 14 provided at the end of the secondary channel allows observation of the tissue specimen in the primary chamber, which is being cut through the first opening, by a scope inserted through the secondary opening. Other systems and methods are provided for sealing the second opening to create a closed system that enables deployment, containment, volume reduction, and safe retrieval of the tissue specimen.

This invention relates to the field of biodetection technology, specifically disclosing a multiplex fluorescent staining kit for tissue samples. The kit includes an antibody dissociation buffer, a signal amplification deposition solution, a fluorescent labeling reagent, a tissue-protective imaging medium, and an autofluorescence background inhibitor. This invention utilizes a non-destructive elution technique achieved through the synergistic effect of a low-pH buffer and a directional electric field. It leverages the positively charged nature of antibodies under acidic conditions to drive them away from the tissue and towards the negative electrode, achieving gentle and efficient antibody removal. Simultaneously, it employs a two-step cascade amplification strategy of small molecule deposition and copper-free click chemical labeling, balancing deep penetration with ultra-high sensitivity. This invention can stably support 6-12 cycles of staining, exhibits high elution efficiency, preserves tissue morphology, and can detect low-abundance targets. It is suitable for spatial analysis of the tumor microenvironment, monitoring of transplant immune rejection, and pathological evaluation of neurodegenerative diseases, demonstrating promising clinical application prospects.

The invention discloses an application of TRAF7 in screening of anti-lung injury drugs. In an LPS-induced A549 cell acute lung injury model, TRAF7 gene knock-down significantly aggravates cell apoptosis and inflammatory response, which shows that inflammatory factor release is increased, and cell injury is aggravated; and TRAF7 overexpression can obviously inhibit the pathological change. The result shows that the TRAF7 has a protection effect on alveolar epithelial cells, the expression level of the TRAF7 is in negative correlation with the in-vitro lung injury degree, and it is proved that the TRAF7 has a negative regulation effect in acute lung injury. In a mouse ALI model, TRAF7 overexpression can significantly reduce the total number of cells, the total protein content and the wet / dry weight ratio of lung tissue in bronchoalveolar lavage fluid (BALF), relieve the pathological injury score of the lung and inhibit LY6Gneutrophil and CD68 macrophage infiltration. The TRAF7 can effectively relieve LPS-induced pulmonary edema, vascular permeability increase and tissue inflammation, and the anti-inflammatory and tissue protection functions of the TRAF7 in an in-vivo model are verified.

A tool combines both stabilization and shielding components for protecting a patient's sensitive tissues, such as a spinal cord, during robotic spinal and other procedures. The combination stabilization-shielding tool is mounted on a first surgical robot arm and an operative surgical tool is mounted on a second surgical robot arm. The first surgical robot arm is positioned both to engage the stabilizing element against a stabilizing location on the patient's bony anatomy and to locate the shielding element between a target location and the sensitive tissue. The second surgical robot arm is positioned to place the operative surgical tool at the target location, and the robotic surgical procedure is performed while the stabilizing element remains engaged with the stabilizing location on the patient's bony anatomy and the shielding element remains positioned between the target anatomy and the sensitive tissue.

Hyaluronic acid-based polymers which can crosslink within joint tissue either by photo-crosslinking or chemical crosslinking to provide a hydrogel within the joint tissue to aid with joint tissue protection, regeneration, and repair.

The invention relates to the technical field of medical instruments, in particular to a tissue protection shielding device for endoscopic surgery, which comprises a shielding assembly and a pull rope, and the shielding assembly comprises a plurality of shielding pieces; through holes are formed in the shielding pieces, an elastic piece is connected between every two adjacent shielding pieces, the elastic pieces are used for providing elastic force so that the shielding assembly can be rolled into a barrel shape when no external force exists, and at the moment, the shielding assembly is in an initial state; when the shielding assembly is in the initial state, the length, used for penetrating through the shielding assembly, of the pull rope is reduced by pulling the pull rope, the two adjacent shielding pieces rotate relatively, the shielding assembly can be bent to be in an arc shape in the reverse direction, the elastic pieces are squeezed by the two corresponding shielding pieces, and therefore the shielding assembly can be bent to be in an arc shape. The extruded elastic piece is of a protruding structure protruding out of the inner side face of the shielding assembly. According to the tissue protection shielding device for the endoscopic surgery, the liver protection effect can be improved, and the liver is prevented from being tied or cut.

The invention relates to the technical field of medical instruments, and provides a microwave ablation needle positioning and fixing device applied under CT (Computed Tomography) guidance in order to solve the problems of puncture path control, device stability and fixation and normal tissue protection in an ablation operation, the microwave ablation needle positioning and fixing device comprises a support frame, and two sides of the support frame are connected with fixing bands; the fixing mechanism is arranged at the bottom of the supporting frame and used for achieving stable connection between the device and the body surface of the patient; the positioning mechanism is arranged in the supporting frame in a penetrating mode and used for adjusting and locking the puncture position of the microwave ablation needle and meanwhile providing protection for normal tissue. The device can realize multi-degree-of-freedom angle adjustment, stable fixation, intraoperative tissue protection and waste liquid synchronous treatment, and is simple and convenient to operate and high in universality.

The application provides a polypeptide type PROTAC molecule targeting degradation of a STING protein and application thereof in treatment of dry eye, and belongs to the technical field of biotechnology.The polypeptide type PROTAC molecule provided by the application comprises a STING targeting unit capable of specific binding with the STING protein, a connecting arm and an E3 ubiquitin ligase ligand, and can specifically degrade the STING protein.The application further provides application of the polypeptide type PROTAC molecule in preparation of a medicine for treating and / or preventing dry eye and a medicine for preventing and / or treating dry eye, has significant anti-inflammatory and tissue protection effects, can improve corneal epithelial damage, inflammatory reaction and goblet cell loss, and has excellent biocompatibility and safety, and is suitable for long-term or repeated administration on an ocular surface.

The invention relates to the technical field of animal stem cells, in particular to a tissue protection solution, a separation and purification method of canine and cat testis albuginea-derived mesenchymal stem cells and application of the canine and cat testis albuginea-derived mesenchymal stem cells. According to the special tissue protection liquid and the special mesenchymal stem cell culture medium for the dog and cat testis albuginea-derived mesenchymal stem cells, the cell activity in the tissue transportation process and the cell proliferation efficiency and stability of in-vitro culture can be remarkably improved, and a key support is provided for separation and purification of the dog and cat testis albuginea-derived mesenchymal stem cells.

The application discloses an interlamina stabilizing mechanism with a tissue protection function and a use method thereof, which comprises a stabilizing support arranged between two laminae and a binding assembly for fixing the two laminae, the stabilizing support comprises a front end part and a rear end part, the front end part and the rear end part are connected through a middle connecting body, the front end part is provided with a coating or a sticking piece, the rear end part is provided with an auxiliary clamping mechanism, the middle part of the middle connecting body is provided with an auxiliary compression hole, an auxiliary supporting block is integrally formed above the middle connecting body, the rear convex part of the auxiliary supporting block can prevent the middle connecting body from moving forward, the binding assembly comprises auxiliary binding plates arranged on the laminae, the two auxiliary binding plates are connected through binding flat wires, and the shape of the auxiliary binding plate is an anatomical shape and is consistent with the shape of the lamina. The application can elastically bear a load between the laminae, takes into account the axial movement of a spinal segment, is convenient to implant, has small tissue damage, is reliable in fixation, improves the convenience of surgical treatment, and has low surgical risk.

The utility model provides a laparoscopic free viscera retractor, which belongs to the field of medical instruments, and comprises a forceps head end, a forceps handle and an inflatable abdominal wall fixing device, the bottom of the forceps head end is rotatably connected with the surface of a connecting shaft, the surface of the forceps handle is provided with a forceps cavity, one end of the connecting shaft is provided with a limit block, and the other end of the connecting shaft is provided with an inflatable abdominal wall fixing device. An adjusting knob is arranged at the other end of the connecting shaft, the middle of the bottom of the connecting shaft is connected with the top of a tissue protection clamping piece through a connecting piece, a thin line is arranged in the tissue protection clamping piece, and a long needle is arranged at the bottom of the thin line. According to the forceps, visceral organs can be gently grabbed conveniently in the operation process through the forceps openings at the forceps head ends and the auxiliary teeth on the inner walls of the forceps heads, the forceps openings are allowed to rotate within the range of 360 degrees through the axial point design at the position of the connecting shaft, and the fine line is used for fixing the position of a traction device in the operation; and two through holes in the surface of the tissue protection clamping piece are matched, so that the traction direction of the visceral organs can be further adjusted.

The invention describes a multilayer balloon membrane material (1) which combines one or several layers of elastically deformable material (2) with one or several layers of plastically deformable, inelastic material (3), wherein the inelastic layers counteract the straightening properties of the elastic layers in the case of planar folding or bending of the balloon membrane material. In particular, the cross-sectional area of the eye- or channel-like structures (6) for guiding secretions or liquids, which are typically produced in the region of the plicated invagination of the balloon membrane with dimensional redundancy in organ cavities or body cavities, can be reduced, and in particular stabilized in the case of a periodic change in the balloon filling pressure, whereby an optimal sealing closure or packing result is achieved over as large a range of filling pressure amplitudes as possible.

A probe configured to deliver energy to a first tissue is placed in the first tissue, and an imaging device is configured to image a second tissue with the probe placed in the first tissue. Image data from the second tissue is processed to evaluate the effect of the energy source on the second tissue. In some embodiments, the image data from the second tissue is used to adjust the energy to the first tissue, for example, by increasing or decreasing the energy to the second tissue. In some embodiments, image data from the first tissue or the second tissue or force sensor data from the probe is used to evaluate placement of the probe in the first tissue, and the placement of the probe in the first tissue is adjusted to reduce tissue changes in the second tissue associated with the probe placement in the first tissue.

The utility model discloses a kind of negative pressure suction type puncture biopsy apparatus, it is related to medical instrument field.The biopsy apparatus includes needle tube, needle core and pressure device, pressure device is detachably connected with needle tube, is fixed by clamping limiting portion.It has beneficial effect including improving sample quality, convenient operation and improving diagnostic efficiency.Needle tube has scale outside, bottom and needle core cooperate closely.Handle has antiskid line, connecting port and pressure device connecting pipe are closely adhered through conical structure.Needle core surface is smooth, and needle tube is closely adhered.Pressure device can be balloon expansion pressure pump etc., clamping limiting portion improves the stability of connecting portion.Under image guidance, puncture is operated as needed, and sample is obtained by adjusting negative pressure.The biopsy apparatus overcomes the problem that existing puncture biopsy mode is difficult to balance sample efficiency and tissue protection, and the problem of inconvenient operation, can adapt to different texture tissue, improve sample quality and representativeness, reduce operation difficulty and risk.

The present invention relates to a method for manufacturing a spray-type hemostatic agent mixed with kaolin and cellulose, and a spray-type hemostatic agent manufactured thereby. The method comprises the steps of: adding hyaluronic acid to sterile distilled water; adding lecithin to the mixture; adding kaolin and cellulose to the mixture; cooling the mixture; injecting the mixture into a spray-type container; and filling the container with gas. Due to being mixed with hyaluronic acid and lecithin in addition to kaolin and cellulose, the present invention is excellent in terms of re-bleeding prevention rate, absorption rate, and applicability, has excellent tissue protection and infection prevention effects on a wound surface compared to conventional injection and gel types, and can prevent situations where patients are at risk due to excessive bleeding.

The invention relates to the technical field of agricultural disciplines, in particular to an identification method for improving the morbidity of southern rice black-streaked dwarf disease, which comprises the following steps: (1) cultivating sogatella furcifera with viruses; (2) performing minimal trauma pretreatment on leaf sheaths of the rice seedlings; (3) virus transmission of sogatella furcifera; (3) inoculating a rice material; (4) performing rice transplanting and incidence phenotype statistics; according to the technical scheme, from the aspect of the overall synergistic effect, screening of sogatella furcifera with viruses provides a basis for sufficient virus input, sheath minimally invasive pretreatment and composite modified microneedles guarantee efficient virus migration and tissue protection, the optimized virus transmission environment creates conditions for the stable virus transmission process, all the steps are matched with one another and progressive layer by layer, and the virus transmission efficiency is improved. Finally, the rice morbidity is stably improved; meanwhile, the identification period is shortened to be within 35 days, the problems that a traditional method is low in morbidity, long in period and poor in accuracy are effectively solved, and the requirement for rapid screening of disease-resistant rice varieties can be efficiently met.

The present application relates to the technical field of medical devices, in particular to a medical digestive tract tube anastomat, which comprises a handle main body, the front end of the handle main body is fixedly connected with a coaxially arranged nail cartridge pipe, the output end of the handle main body and the inner side of the nail cartridge pipe are throughly provided with a center rod, the front end of the nail cartridge pipe is fixedly connected with a minimally invasive adaptive head shell, the inner side of the head shell is installed with a flexible expansion mechanism for adapting to digestive tracts with different diameters, the outer side of the center rod is movably connected with a clamping shaft, the front end of the clamping shaft is installed with a tissue-protecting nail abutting seat mechanism, which cooperates with a first electric push rod to adapt to the tissue tolerance pressure and output the pushing force, so as to realize the flexible and uniform expansion of the inner wall of the digestive tract, and solve the problem of mucosal damage caused by excessive local stress during the expansion of the prior art; the cutting assembly adopts a passivation blade cooperating with a circumferential rotation cutting mode, which avoids the defect that the traditional linear cutting is easy to tear the tissue, and realizes the non-invasive resection of the redundant tissue.