57 results about "Tissue protection" patented technology

The invention relates to the technical field of data processing, and discloses a self-adaptive anti-shake control method and system for a mechanical arm of a neurosurgical robot. The method comprises the steps that tissue contact force, intracranial pressure variation and vascular pulsation frequency are collected, jitter feature vectors are obtained through fusion of a neurosurgery special extended Kalman filtering algorithm, compensation strategy parameters are generated through a neurosurgery scene self-adaptive prediction model, a tissue protective super-distortion sliding mode controller outputs a control signal, and the tissue protective super-distortion sliding mode controller is used for controlling the tissue protective super-distortion sliding mode controller. And the intracranial constraint flexible execution mechanism is driven to realize self-adaptive anti-shake control. According to the method, by constructing the extended Kalman filtering algorithm special for neurosurgery based on multi-modal sensor fusion and the LSTM prediction model, and combining with the tissue protective super-distortion sliding mode controller, the jitter suppression precision and the adaptive adjustment capability of the neurosurgical robot in a complex intracranial environment are remarkably improved.

This invention relates to the field of medical device technology, specifically to a tissue protection shielding device for laparoscopic surgery. The device includes a shielding assembly and a pull cord. The shielding assembly comprises several shielding plates; each shielding plate has a perforation, and an elastic element connects adjacent shielding plates. The elastic element provides elastic force to allow the shielding assembly to roll into a cylindrical shape when no external force is applied, at which point the shielding assembly is in its initial state. The pull cord has a limiting element. When the shielding assembly is in its initial state, pulling the pull cord reduces the length of the cord that is threaded through the shielding assembly, causing adjacent shielding plates to rotate relative to each other. This allows the shielding assembly to bend in the opposite direction into an arc shape, and the elastic element is compressed by the corresponding two shielding plates, resulting in a protruding structure protruding from the inner surface of the shielding assembly. This tissue protection shielding device for laparoscopic surgery can improve the protection of the liver, preventing injury or cuts to the liver.

The present application relates to the field of data processing technology, and discloses a method and system for adaptive anti-shake control of a neurosurgery robot arm. The method comprises: collecting tissue contact force, intracranial pressure change, and vascular pulsation frequency, fusing the jitter feature vector through a neurosurgery-specific extended Kalman filter algorithm, generating compensation strategy parameters through a neurosurgery scene adaptive prediction model, and outputting a control signal from a tissue-protective super-twisted sliding mode controller to drive an intracranial constraint flexible actuator to achieve adaptive anti-shake control. The present application significantly improves the jitter suppression accuracy and adaptive adjustment capability of the neurosurgery robot in a complex intracranial environment by constructing a neurosurgery-specific extended Kalman filter algorithm and an LSTM prediction model based on multimodal sensor fusion, combined with a tissue-protective super-twisted sliding mode controller.

Systems and methods for preventing the seeding of cancerous cells during morcellation of a tissue specimen inside a patient's body and removal of the tissue specimen from inside the patient through a minimally-invasive body opening to outside the patient are provided. One system includes a cut-resistant tissue guard removably insertable into a containment bag. The tissue specimen is isolated and contained within the containment bag and the guard is configured to protect the containment bag and surrounding tissue from incidental contact with sharp instrumentation used during morcellation and extraction of the tissue specimen. The guard is adjustable for easy insertion and removal and configured to securely anchor to the body opening. Protection-focused and containment-based systems for tissue removal are provided that enable minimally invasive procedures to be performed safely and efficiently.

The invention discloses a probiotic which is derived from human milk and has the effects of resisting oxidation, resisting inflammation, protecting tissues and protecting intestinal barriers and application of the probiotic. Lactobacillus paracasei DPUMW-M14-9 is preserved in the general microbiological center of the China Committee for Culture Collection of Microorganisms, and the preservation number is CCTCC M 20252990. The strain has the characteristics of acid resistance, bile resistance, strong oxidation resistance, high surface hydrophobicity, self-aggregation capability and the like. The lactobacillus paracasei DPUMW-M14-9 can effectively adhere to epithelial cells, promote cell proliferation and regulate and control the process of a cell cycle. The bacterial strain can be used for inhibiting proinflammatory cytokines (TNF-alpha, IL-6 and IL-1beta) induced by lipopolysaccharide (LPS) and repairing tight junction proteins (ZO-1, Occludin and Claudin-1) at the same time, so that the integrity of epithelial cells is enhanced.

The invention relates to the technical field of medical instruments, and particularly discloses an ultrasonic ablation system. In order to solve the problems that in the ultrasonic ablation process, the temperature of cooling liquid in a balloon cannot be stably controlled, attachment is affected by pressure fluctuation, and the balloon cannot actively adapt to different blood vessel sizes, the ultrasonic ablation catheter comprises an ultrasonic catheter body, an ultrasonic transducer, a fluid circulation device and a main machine, and the ultrasonic catheter body comprises an inner tube, a multi-cavity tube, the balloon communicated with the end of the multi-cavity tube and a needle seat; the ultrasonic transducer is arranged in the balloon, the fluid circulation device is communicated with the needle seat, the host is electrically connected with the fluid circulation device and the ultrasonic transducer, in the process that the ultrasonic transducer emits energy to ablate target nerves, the host controls the fluid circulation device to operate, and cooling liquid continuously flows into the balloon through the liquid inlet; meanwhile, the liquid is continuously discharged from the balloon through the liquid outlet. Accurate temperature control and effective tissue protection are achieved, and guarantee is provided for long-time, safe and effective ablation operation.

Systems and methods for preventing the seeding of cancerous cells during morcellation of a tissue specimen inside a patient's body and removal of the tissue specimen from inside the patient through a minimally-invasive body opening to outside the patient are provided. One system includes a cut-resistant tissue guard removably insertable into a containment bag. The tissue specimen is isolated and contained within the containment bag and the guard is configured to protect the containment bag and surrounding tissue from incidental contact with sharp instrumentation used during morcellation and extraction of the tissue specimen. The guard is adjustable for easy insertion and removal and configured to securely anchor to the body opening. Protection-focused and containment-based systems for tissue removal are provided that enable minimally invasive procedures to be performed safely and efficiently.

The invention discloses a path establishing and distraction device suitable for neurosurgery endoscopic surgery and an operation method.The path establishing and distraction device is provided with an annular base, an annular gear coaxial with the base is arranged at one end of the base, and the annular gear can rotate on the base around a common shaft; side gears are rotatably and uniformly arranged on the outer side surface of the base, the side gears are meshed with the annular gear, fins corresponding to the side gears are arranged on the inner side surface of the base, and the side gears are fixedly connected with the lower ends of the fins through center shafts; each fin is provided with a convex outer side face and a concave inner side face, the lower end of each outer side face is attached to the inner side face of the base, and the fins are arranged in a stacked mode. Methods of using the distraction device suitable for neurosurgical endoscopic surgery path establishment are also disclosed. The path establishing and distraction device has the complete process function of establishing, distraction, stabilizing and removing, the operation efficiency and the tissue protection effect are improved, and the path establishing and distraction device has good clinical practical value and popularization prospects.

This invention discloses a method for improving the quality stability of frozen oysters and a frozen oyster meat product, relating to the field of aquatic product processing technology. The method for improving the quality stability of frozen oysters provided by this invention employs ultrasonic treatment combined with citric acid solution soaking. It utilizes the cavitation effect, microjets, and mechanical vibration generated when ultrasound propagates in a liquid medium to effectively disrupt the mass transfer resistance on the surface of oyster tissue, significantly promoting the penetration and uniform distribution of citric acid within the muscle tissue. This solves the problems of low penetration efficiency of active ingredients and insufficient internal tissue protection in traditional citric acid soaking treatments, achieving effective inhibition of lipid and protein oxidation. This invention features a simple process, high safety, requires no complex equipment, and is suitable for large-scale application in the aquatic product processing industry.

The present application provides a kind of hydrophilic cerium oxide nanoparticles and its dispersion liquid.Hydrophilic cerium oxide nanoparticles include cerium oxide nanoparticles core and the hydrophilic polymer compound coated on its surface, and cerium element in cerium oxide nanoparticles exists in two valence states of Ce 3+ And Ce 4+ . The hydrophilic polymer compound is coated on the surface of cerium oxide nanoparticles, which can improve its dispersibility and stability in aqueous system.The present application also provides a preparation method of hydrophilic cerium oxide nanoparticles, which can be carried out in aqueous system under normal temperature and pressure, and has mild process and simple operation.The obtained hydrophilic cerium oxide nanoparticles have good free radical scavenging capacity, dispersion stability and oxidative stress regulation activity, can form stable dispersion liquid in water system, and show good antioxidant and tissue protection effect in cell and animal oxidative stress model.The present application also provides the application of hydrophilic cerium oxide nanoparticles or its dispersion liquid in antioxidant, oxidative stress regulation and related preparations.

The invention belongs to the technical field of medical instruments, and relates to an auxiliary surgical instrument for arthroscopic treatment of carpal tunnel syndrome, which comprises a cannula, a tail cap connected with the cannula and a slotting structure arranged on the back of the middle section of the cannula. The cannula is used for forming a continuous tissue isolation channel in the carpal canal, the tail cap is used for achieving stable connection of the arthroscope and the cannula and keeping the axis consistent, and the open groove corresponds to the area where the transverse ligament of the carpal canal is located after the instrument is positioned and is used for forming a controlled local operation window. Through cooperation of the cannula, the tail cap and the open groove in spatial position and function, the arthroscope view, the tissue protection area and the surgical operation window form a stable whole, and on the premise that the cannula continuously isolates and protects tissue in the carpal canal, visual and directional release of the transverse ligament is achieved. The arthroscope device is simple in structure, controllable in operation, beneficial for improving operation safety and stability and suitable for arthroscope treatment of the carpal tunnel syndrome.

The application discloses a medicine composition for promoting wound healing and a preparation method and application thereof. The medicine composition comprises the following components in parts by weight: 1-10 parts of hemoglobin molecules, 1-5 parts of lipoic acid, 0.1-1 part of acetylcysteine, and 40-80 parts of a solvent; the hemoglobin molecules comprise at least one cysteine part and at least one histidine part, wherein the cysteine part comprises an acetyl group or an ethyl maleoyl group, and the histidine part comprises a benzimidazole derivative group. The application applies lipoic acid and acetylcysteine to the external medicine composition of the hemoglobin molecules modified by acetyl groups or ethyl maleoyl groups in combination, effectively relieves the irritant reaction caused by the hemoglobin modification to the skin through the synergistic antioxidant and tissue protection effects, and thus improves the safety and applicability of the medicine composition in skin wound treatment, and the medicine composition is suitable for treating multiple types of wounds such as external injuries, burns, postoperative wounds and ulcer wounds.

New compositions and methods are described herein operable for delivery of therapeutic agents while mitigating damage to healthy tissues. In one aspect, a conjugate comprises a linker joining a pharmaceutical component and a targeting ligand, wherein the linker is at least one of radiolabile, photolabile, thermolabile, chemically labile, magnetically labile, or acoustolabile for release of the targeting ligand and / or the pharmaceutical component from the conjugate.

The invention discloses a herpes zoster treatment laser device with a function of protecting tissues outside a target area, and belongs to the technical field of herpes zoster laser treatment equipment.The herpes zoster treatment laser device comprises a fixed base, a lifting assembly, a laser treatment device and an area limiting assembly, and the area limiting assembly is arranged on the lifting assembly; the device is used for constraining a laser beam of the laser treatment device in a herpes zoster area. According to the invention, the laser beam of the laser therapeutic apparatus is restrained in the herpes zoster region through the region limiting assembly, so that the laser energy of the laser therapeutic apparatus is accurately focused on the diseased region of the herpes zoster in the treatment process, thereby avoiding the situation that the laser irradiation range is too large or deviates from the core region of a focus, and improving the treatment efficiency. Therefore, the action effect of laser on herpes viruses and damaged tissues is improved, innocent tiredness of part of normal tissues is avoided, and the rehabilitation process of a patient is guaranteed.

Provided herein is a flexible sheet-like tissue protective material comprising: a porous body that can be swollen due to water absorption; and a support that contains a biocompatible polymer. Consequently, a useful tissue protective material and the like are provided.

The invention discloses a medicine composition for promoting wound healing as well as a preparation method and application thereof. The pharmaceutical composition comprises the following components in parts by weight: 1-10 parts of hemoglobin molecules, 1-5 parts of lipoic acid, 0.1-1 part of acetylcysteine and 40-80 parts of a solvent, the hemoglobin molecule comprises at least one cysteine moiety and at least one histidine moiety, where the cysteine moiety comprises an acetyl or ethylmaleoyl group and the histidine moiety comprises a benzimidazole derivative group. According to the invention, lipoic acid and acetylcysteine are jointly applied to the external pharmaceutical composition of hemoglobin molecules modified by acetyl or ethylmaleoyl and the like, and irritant reaction on skin after hemoglobin modification is effectively relieved through synergistic antioxidation and tissue protection effects; therefore, the safety and applicability of the pharmaceutical composition in skin wound treatment are improved, and the pharmaceutical composition is suitable for treatment of multiple types of wounds such as trauma, burn, postoperative wounds, ulcer wounds and the like.

A multi-layer balloon membrane material (1) is described, which combines one or several layers of elastically deformable material (2) with one or several layers of plastically deformable, inelastic material (3), wherein the inelastic layers counteract the straightening properties of the elastic layers in the case of planar folding or bending of the balloon membrane material. In particular, the cross-sectional area of the eye- or channel-like structures (6) for guiding secretions or liquids, which are typically produced in the region of the plicated invagination of the balloon membrane with dimensional redundancy in organ cavities or body cavities, can be reduced, and in particular stabilized in the case of a periodic change in the balloon filling pressure, whereby an optimal sealing closure or packing result is achieved over as large a range of filling pressure amplitudes as possible.

This invention discloses a hair cell protectant based on a ferritin nanoplatform and its application in treating hearing loss, belonging to the field of biomedicine. The ferritin nanoparticles of this invention, loaded with cimicifugin, include ferritin (Fn) as a carrier and cimicifugin (Ci@Fn) loaded within the ferritin. By loading cimicifugin (Ci), an extract of cimicifugin, into ferritin, it is endowed with additional anti-inflammatory and tissue-protective functions, thereby achieving a more precise and effective therapeutic effect. After injection through the round window membrane (RWM) behind the ear, Ci@Fn is transported to the basement membrane along with the flow of perilymph and endolymph, ultimately targeting the inner ear hair cells (HCs). After entering the hair cells, Ci@Fn is taken up and degraded by lysosomes, releasing cimicifugin (Ci), thereby exerting a protective effect on the hair cells.

The utility model discloses a tunnel puncture outfit and a medical instrument used for subcutaneous puncture, the tunnel puncture outfit is the medical instrument suitable for subcutaneous puncture, the tunnel puncture outfit comprises a handle used for being held by hand; the puncture head is used for penetrating into the subcutaneous part and penetrating out of the subcutaneous part; one end of the tunnel rod is connected with the handle, the other end of the tunnel rod is connected with the puncture head, the tunnel rod comprises a plurality of sections of connecting rods, and the wall thickness of at least one section of connecting rod is different from that of other connecting rods, so that the rigidity of the tunnel rod is different in the length direction. According to the tunnel puncture outfit and the medical instrument for subcutaneous puncture, gradient distribution of rigidity of the tunnel puncture outfit can be achieved, puncture strength and tissue protection are both considered, and the problem that a traditional single rigid rod is too rigid or too soft is solved.

The system provides a method for surgically removing tissue through small incision sites and / or body openings. [Solution] The tissue containment and containment system includes a primary chamber, and a secondary channel extending from this primary chamber is interconnected with the primary chamber. A tissue specimen is placed into the primary chamber through a first opening 12 while floating in a body cavity. The first opening is drawn in through a first incision or body opening, and a narrower secondary channel is positioned at a second incision or body opening. A second opening 14 provided at the end of the secondary channel allows observation of the tissue specimen in the primary chamber, which is being cut through the first opening, by a scope inserted through the secondary opening. Other systems and methods are provided for sealing the second opening to create a closed system that enables deployment, containment, volume reduction, and safe retrieval of the tissue specimen.

This invention relates to the field of biodetection technology, specifically disclosing a multiplex fluorescent staining kit for tissue samples. The kit includes an antibody dissociation buffer, a signal amplification deposition solution, a fluorescent labeling reagent, a tissue-protective imaging medium, and an autofluorescence background inhibitor. This invention utilizes a non-destructive elution technique achieved through the synergistic effect of a low-pH buffer and a directional electric field. It leverages the positively charged nature of antibodies under acidic conditions to drive them away from the tissue and towards the negative electrode, achieving gentle and efficient antibody removal. Simultaneously, it employs a two-step cascade amplification strategy of small molecule deposition and copper-free click chemical labeling, balancing deep penetration with ultra-high sensitivity. This invention can stably support 6-12 cycles of staining, exhibits high elution efficiency, preserves tissue morphology, and can detect low-abundance targets. It is suitable for spatial analysis of the tumor microenvironment, monitoring of transplant immune rejection, and pathological evaluation of neurodegenerative diseases, demonstrating promising clinical application prospects.

The invention discloses an application of TRAF7 in screening of anti-lung injury drugs. In an LPS-induced A549 cell acute lung injury model, TRAF7 gene knock-down significantly aggravates cell apoptosis and inflammatory response, which shows that inflammatory factor release is increased, and cell injury is aggravated; and TRAF7 overexpression can obviously inhibit the pathological change. The result shows that the TRAF7 has a protection effect on alveolar epithelial cells, the expression level of the TRAF7 is in negative correlation with the in-vitro lung injury degree, and it is proved that the TRAF7 has a negative regulation effect in acute lung injury. In a mouse ALI model, TRAF7 overexpression can significantly reduce the total number of cells, the total protein content and the wet / dry weight ratio of lung tissue in bronchoalveolar lavage fluid (BALF), relieve the pathological injury score of the lung and inhibit LY6Gneutrophil and CD68 macrophage infiltration. The TRAF7 can effectively relieve LPS-induced pulmonary edema, vascular permeability increase and tissue inflammation, and the anti-inflammatory and tissue protection functions of the TRAF7 in an in-vivo model are verified.

A tool combines both stabilization and shielding components for protecting a patient's sensitive tissues, such as a spinal cord, during robotic spinal and other procedures. The combination stabilization-shielding tool is mounted on a first surgical robot arm and an operative surgical tool is mounted on a second surgical robot arm. The first surgical robot arm is positioned both to engage the stabilizing element against a stabilizing location on the patient's bony anatomy and to locate the shielding element between a target location and the sensitive tissue. The second surgical robot arm is positioned to place the operative surgical tool at the target location, and the robotic surgical procedure is performed while the stabilizing element remains engaged with the stabilizing location on the patient's bony anatomy and the shielding element remains positioned between the target anatomy and the sensitive tissue.

Hyaluronic acid-based polymers which can crosslink within joint tissue either by photo-crosslinking or chemical crosslinking to provide a hydrogel within the joint tissue to aid with joint tissue protection, regeneration, and repair.

The invention discloses a ternary co-modified engineered cornu cervi pantotrichum MSCs exosome and a preparation method and application thereof, and belongs to the technical field of biological medicine, the ternary co-modified engineered cornu cervi pantotrichum MSCs exosome comprises a cornu cervi pantotrichum MSCs exosome, a poly-arginine polypeptide-deoxyribonuclease I compound located on the surface of the cornu cervi pantotrichum MSCs exosome, and an RGD polypeptide modified on the surface of the cornu cervi pantotrichum MSCs exosome and containing an Arg-Gly-Asp sequence. In order to solve the problem that an integrated treatment mode of multiple pathological links cannot be realized during existing RA treatment, three active components, namely poly-arginine polypeptide (P-Arg), deoxyribonuclease I (Dnase I) and RGD polypeptide, are cooperatively modified on the surface of an exosome of pilose antler MSCs for the first time to form a surface engineering modified exosome complex; multiple functions of immunoregulation, cfDNA removal, targeted delivery and tissue protection can be realized in RA focuses, and a brand-new and systematic treatment means is provided for rheumatoid arthritis.

The invention relates to the technical field of medical instruments, in particular to a tissue protection shielding device for endoscopic surgery, which comprises a shielding assembly and a pull rope, and the shielding assembly comprises a plurality of shielding pieces; through holes are formed in the shielding pieces, an elastic piece is connected between every two adjacent shielding pieces, the elastic pieces are used for providing elastic force so that the shielding assembly can be rolled into a barrel shape when no external force exists, and at the moment, the shielding assembly is in an initial state; when the shielding assembly is in the initial state, the length, used for penetrating through the shielding assembly, of the pull rope is reduced by pulling the pull rope, the two adjacent shielding pieces rotate relatively, the shielding assembly can be bent to be in an arc shape in the reverse direction, the elastic pieces are squeezed by the two corresponding shielding pieces, and therefore the shielding assembly can be bent to be in an arc shape. The extruded elastic piece is of a protruding structure protruding out of the inner side face of the shielding assembly. According to the tissue protection shielding device for the endoscopic surgery, the liver protection effect can be improved, and the liver is prevented from being tied or cut.

The invention relates to a personalized customized soft tissue protection device for a lumbar surgery under a microscope. The personalized customized soft tissue protection device comprises a passage main body, a tightening closing piece and a distraction fixing piece, the passage body comprises a sleeve, an opening extending in the axial direction of the sleeve is formed in the side wall of the sleeve, and sliding rails are symmetrically arranged outside the two side wall faces of the opening. The tightening closing piece comprises a top cover and a tightening part connected to the lower portion of the top cover, and two sliding grooves I matched with the sliding rails are symmetrically formed in the inner side of the tightening part; the opening fixing piece comprises an outer side arc-shaped piece, an inner side arc-shaped piece and an opening portion connected between the outer side arc-shaped piece and the inner side arc-shaped piece, sliding grooves II are formed in the two sides of the opening fixing piece in the circumferential direction, and the sliding grooves II can be arranged on the two side wall faces of the opening of the sleeve in a sleeving mode and slide in the axial direction of the opening of the sleeve. The distraction device is simple in structure and convenient to operate, distraction fixing pieces of different specifications can be selected according to the needed view field range so that the sleeve can be distraction to the ideal size, personalized customization can be achieved, the distraction device is highly matched with the physical condition of a patient, the surgical operation efficiency can be improved, and complications and uncomfortable conditions can be reduced.

The invention relates to the technical field of medical instruments, and provides a microwave ablation needle positioning and fixing device applied under CT (Computed Tomography) guidance in order to solve the problems of puncture path control, device stability and fixation and normal tissue protection in an ablation operation, the microwave ablation needle positioning and fixing device comprises a support frame, and two sides of the support frame are connected with fixing bands; the fixing mechanism is arranged at the bottom of the supporting frame and used for achieving stable connection between the device and the body surface of the patient; the positioning mechanism is arranged in the supporting frame in a penetrating mode and used for adjusting and locking the puncture position of the microwave ablation needle and meanwhile providing protection for normal tissue. The device can realize multi-degree-of-freedom angle adjustment, stable fixation, intraoperative tissue protection and waste liquid synchronous treatment, and is simple and convenient to operate and high in universality.

The application provides a polypeptide type PROTAC molecule targeting degradation of a STING protein and application thereof in treatment of dry eye, and belongs to the technical field of biotechnology.The polypeptide type PROTAC molecule provided by the application comprises a STING targeting unit capable of specific binding with the STING protein, a connecting arm and an E3 ubiquitin ligase ligand, and can specifically degrade the STING protein.The application further provides application of the polypeptide type PROTAC molecule in preparation of a medicine for treating and / or preventing dry eye and a medicine for preventing and / or treating dry eye, has significant anti-inflammatory and tissue protection effects, can improve corneal epithelial damage, inflammatory reaction and goblet cell loss, and has excellent biocompatibility and safety, and is suitable for long-term or repeated administration on an ocular surface.