Injectable cartilage tissue protection and repair material containing xanthan gum

Abstract

The invention discloses an injectable cartilage tissue protection and repair material containing xanthan gum. The material comprises 1-10 parts of the xanthan gum, 0.5-10 parts of sodium hydrogen phosphate, 0.5-10 parts of monosodium phosphate and 250-500 parts of water for injection, wherein the average relative molecular weight of the xanthan gum is 2.10-9.90 million. The molecular weight section of the xanthan gum is lower, so that the xanthan gum can have better physical filling and lubrication functions on damaged joints; the injectable cartilage tissue protection and repair material containing the xanthan gum has good viscoelasticity, safety and stability as well as better filling and lubrication functions, can form a lubrication pad layer on the surface of articular cartilage, isolate damage of stimuli to the articular cartilage, promote repair of articular cartilage tissue, be remained for a long time on the surface layer of the articular cartilage, protect the articular cartilage, stabilize chondrocyte phenotypes, reduce damage to the articular cartilage, promote repair of the articular cartilage and slow a process of degenerative changes of the cartilage.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an injectable cartilage tissue protection and repair material containing xanthan gum. Background technique [0002] Cartilage tissue has poor self-repair and regeneration capabilities due to its anatomical structure without nerves and blood vessels. Cartilage damage is a common disease. Trauma, inflammation, tumor, degeneration and other reasons can cause cartilage damage, causing intractable Pain and joint movement disorders seriously affect normal production and life, so the prevention and treatment of cartilage damage has become an urgent problem to be solved. [0003] Traditional bone repair materials need to be prefabricated in vitro and implanted in the body after surgical incision. The patient needs to bear a large trauma and cannot completely fill the bone defect. Viscoelastic materials can effectively solve this problem, such as hyaluronic acid for injection And medica...

AI Technical Summary

Problems solved by technology

[0003] Traditional bone repair materials need to be prefabricated in vitro and implanted in the body after surgical incision. The patient needs to bear a large trauma and cannot completely fill the bone defect. Viscoelastic materials can effectively solve this problem, such as hyaluronic acid for injection And medical chitosan, hyaluronic acid is called sodium hyaluronate, although hyaluronic acid for injection can protect and repair damaged cartilage, but its action time is short, the repair speed is slow, multiple injections are required and the curative effect is long; medical chitin Although sugar has viscoelasticity and slow absorption, due to the poor thermal stability of medical chitosan, injections are not resistant to high temperatures, injections cannot be sterilized at high temperatures, and can only be sterilized by filtration. The risk of product contamination is high

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