The invention discloses an animal collagen oral soluble membrane and a preparation method thereof, and relates to the technical field of traditional Chinese medicines and medicinal and edible preparations. The animal collagen oral soluble membrane comprises animal collagen, a filling agent, an
adhesive, a
penetration enhancer, a plasticizing forming agent and a
seasoning component, and the animal collagen is prepared by the following steps: stirring a solution containing
pepsin and diluted
hydrochloric acid and the animal collagen in deionized water, then adjusting the pH value to 8-9 by using a
sodium dihydrogen
phosphate buffer solution, centrifuging, filtering, and
drying to obtain the animal collagen oral soluble membrane. The small-molecule animal collagen is obtained and placed on the tongue, the small-molecule animal collagen can be rapidly dissolved and release
medicine in
saliva without drinking water, the compliance of a user can be greatly improved, the preparation process has low requirements on preparation instruments and low cost, large-scale industrial production is facilitated, no or little three wastes are generated, and the requirement for
sustainable development is met. Good application prospects are realized.