Nanometer hydroxyapatite/natural polymer composite, preparation method and application thereof

A nano-hydroxyapatite and natural polymer technology, applied in the field of preparation of nano-hydroxyapatite, can solve the problems of high inorganic mineral content, unsatisfactory bone tissue engineering scaffold materials, etc., and achieve low cost and simple operation process Viable, Inexpensive Effects
CN101693774AInactive Publication Date: 2010-04-14JINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JINAN UNIVERSITY
Publication Date
2010-04-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to tissue engineering materials and particularly discloses a nanometer hydroxyapatite / natural polymer composite, a preparation method and an application thereof. The preparation method includes the steps of putting the natural polymer composite into the mixed solution of alcohol, water and urea and adding monosodium phosphate solution and calcium chloride solution to conduct sealing reaction and obtain the composite, wherein the volume ratio of the alcohol and the water in the mixed solution is 2-6:1, the concentration of urea in the mixed solution is 1-3g / 100ml. The method is quick and effective, the conditions of the reaction system are mild, the reaction method and the reaction system are easy to operate and control, the cost is low and investment of high energy source is saved. The composite obtained by the method has a thicker mineralization layer and therefore higher tensile and compressive strength and also can be applied to the field of the tissue engineering materials requiring high mechanical strength, for example the manufacture of bone tissue engineering materials.
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Description

technical field

[0001] The invention relates to the preparation of nano-hydroxyapatite, in particular to a nano-hydroxyapatite / natural polymer composite material and its preparation method and application. Background technique

[0002] Natural bone tissue is a biocomposite of nano-hydroxyapatite (HAP) and natural polymers, so the composite material of nano-hydroxyapatite has always been a research hotspot, but the exudation of nanoparticles may cause damage to the body. Therefore, biomineralization may be an effective method to improve the biocompatibility of materials while maintaining the mechanical properties of matrix materials. Biomineralization is based on the principle of bionics, using biological macromolecules as templates, and controlling the growth of inorganic crystals through self-assembly or self-organization to replicate the nanocomposite and gradient structures of natural bone tissue.

[0003] Natural polymer materials such as chitin, chitosan and its deriva...

Claims

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