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A technique for extracting and succulent, which is applied to the s. sylvatica extract and its application field, and achieves the effects of easy operation, simple technological process and mild thrombolytic activity
Active Publication Date: 2019-02-15
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology
However, there are few drugs on the market that have both thrombolytic and anticoagulant effects. Therefore, it is imperative to find a thrombolytic and anticoagulant drug that has less side effects and avoids reocclusion and reinfarction.
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Embodiment 1
[0019] Example 1 The preparation and activity comparison of the wet superfine pulverization and water decoction crude extract.
[0020] 1. Preparation of the crude extract from the ultrafine pulverization method of wet method
[0021] Weigh 200.0 g of dried muffins, add 8 times the mass of muffins in distilled water at 25°C, soak for 1 h, add it into an ultrafine pulverizer, and use wet ultrafine pulverization at 25°C for 10 min. Centrifuge the pulverized slurry at 10,000 r / min for 10 min at 4°C, take the supernatant, and freeze-dry it to obtain the crude extract of wet-process ultrafine pulverization.
[0022] 2. Preparation of the decoction crude extract
[0023] Weigh 200g of dried turmeric, add distilled water 8 times the mass of molasses, soak for 1 hour and then decoct for 3 hours. Take the decoction, centrifuge at 10,000 r / min for 10 min at 4°C to get the supernatant, concentrate under reduced pressure at 60°C, and freeze-dry to obtain the crude extract of the decocti...
Embodiment 2
[0037] Embodiment 2: the preparation of the extract of succulents with thrombolytic activity
[0038] 1. Preparation of Muscarina Extract
[0039] Weigh 200.0 g of dried muffins, add 8 times the mass of muffins in distilled water at 25°C, soak for 1 h, add it into an ultrafine pulverizer, and use wet ultrafine pulverization at 25°C for 10 min. The pulverized slurry was centrifuged at 10,000 r / min for 10 min at 4 °C, and the supernatant was collected. Add saturated ammonium sulfate solution to the supernatant until the saturation of ammonium sulfate in the system is 60%, stir slowly for 1 hour, let stand at 4°C for 2 hours, centrifuge at 10,000 r / min for 10 minutes, and discard the impurity protein precipitate , take the supernatant and continue to add saturated ammonium sulfate solution until the saturation of ammonium sulfate in the system is 80%, stir slowly for 1 h, let stand at 4°C for 2 h, centrifuge at 10,000 r / min for 10 min, and collect the precipitate. The precipita...
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Abstract
The invention provides a pillbug extract and an application thereof, relating to the field of pharmaceuticals. The pillbug extract has thrombolytic and anti-coagulant activities, and is prepared by adopting a method including the following steps: performing wet-process superfine grinding on pillbug, centrifuging, and collecting supernatant liquid to obtain the pillbug extract. The pillbug extract has thrombolytic and anti-coagulant activities, and is relatively mild in thrombolytic activity. According to the pillbug extract provided by the invention, a mode that fibrin is directly dissolved is not adopted, but a mode that plasminogen is activated to ensure that plasminogen is transformed into plasmin and thus fibrin is dissolved is adopted, so that the pillbug extract has relatively mild thrombolytic effects, the tendency of massive bleeding cannot be caused, and the risk of massive hemorrhage of tissues can be reduced. In addition, the pillbug extract provided by the invention is feasible and effective in preparation method, simple and convenient in technological process and easy to operate, and is suitable for industrial production. The pillbug extract provided by the invention can also be applied to the preparation of medicines for treating thrombotic diseases.
Description
technical field [0001] The invention relates to the field of pharmacy, in particular to an extract of sativa and its application. Background technique [0002] Thrombosis is the root cause of three deadly cardiovascular diseases (heart attack, stroke, and venous thromboembolism) with high incidence and increasing worldwide. According to the data provided by the International Thrombosis and Hemostasis Society, in the United States, 100,000-300,000 people die of venous thrombosis every year; in Europe, 500,000 people die of venous thrombosis every year, exceeding AIDS, breast cancer , forward prostate cancer and highway traffic accident deaths; in China, the number of deaths due to thrombotic diseases and their complications is also large. At present, although antithrombotic drugs in clinical use can greatly reduce the mortality and disability rates, these thrombolytic drugs still have disadvantages, such as large bleeding side effects, difficult to control the dose, and ...
Claims
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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/64A61P7/02
Inventor 吴勉华李博郭立玮田周
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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