4 results about "Propargyl ether" patented technology

The invention discloses a method for preparing indene by copper-catalyzed propargyl ether rearrangement reaction, which is characterized by comprising the following step: in the presence of a copper catalyst, a ligand and di-tert-butyl peroxide, in an organic solvent, heating a compound in a formula (1) and a compound in a formula (2) to react to generate an indene compound in a formula (3) or a formula (4). The invention discloses a method for preparing benzofuran by copper-catalyzed propargyl ether rearrangement reaction, which is characterized by comprising the following steps: in the presence of a copper catalyst and alkali, in an organic solvent, heating a compound in a formula (5) to react to generate a benzofuran compound in a formula (6). The preparation method provided by the invention has the advantages of cheap and easily available reaction raw materials, simple reaction operation, wide application range of reaction substrates, easy amplification of reaction, mild reaction conditions and the like, and can realize industrial production and application.

The application discloses a preparation method of a benzopyran derivative containing hexafluoroisopropyl ester, which comprises the following steps: reacting propargyl ether compound, hexafluoroisopropanol and N-iodosuccinimide at room temperature for 15 min, then adding palladium acetate, tris(2-furyl)phosphine, formic acid, acetic anhydride and potassium phosphate to react at 60 DEG C for 24 hours, and after the reaction is completed, post-treatment is carried out to obtain the benzopyran derivative containing hexafluoroisopropyl ester. The preparation method uses hexafluoroisopropanol as a reactant and a promoter, uses formic acid as a carbonyl source, has mild reaction conditions, simple operation, a wide functional group tolerance range of a substrate and high reaction efficiency. According to actual needs, a plurality of benzopyran derivatives containing hexafluoroisopropyl ester can be synthesized, and the method is convenient to operate and wide in practicability.

The application discloses a preparation method of a benzopyran derivative containing a thioester structure, and comprises the following steps: adding a propargyl ether compound, hexafluoroisopropanol and N-iodosuccinimide into a solvent to react at 50-70 DEG C for 0.5-5 h, then adding a sulfonyl chloride compound, a palladium catalyst, a ligand, a carbonyl molybdenum and a base to react at 80-100 DEG C for 20-28 hours, and after the reaction is completed, post-treatment is carried out to obtain the benzopyran derivative containing the thioester structure; the preparation method uses the sulfonyl chloride compound as a reactant and a sulfur source, uses the carbonyl molybdenum as a carbonyl source, has mild reaction conditions, simple operation, a wide functional group tolerance range of a substrate and high reaction efficiency. According to actual needs, various benzopyran derivatives containing the thioester structure can be synthesized, and the method is convenient to operate and wide in practicability.

The application discloses a preparation method of a benzopyran derivative containing an amide structure, which comprises the following steps: reacting propargyl ether compound, hexafluoroisopropanol and N-iodosuccinimide at 60 DEG C for 1 h, then adding a nitro compound, palladium acetate, 2-diphenylphosphine-biphenyl, carbonyl molybdenum, potassium carbonate and water to react at 100 DEG C for 24 h, and after the reaction is completed, post-treatment is carried out to obtain the benzopyran derivative containing the amide structure. The preparation method uses the nitro compound as a reactant and a nitrogen source, and uses the carbonyl molybdenum as a carbonyl source, has mild reaction conditions, simple operation, a wide functional group tolerance range of a substrate and high reaction efficiency. According to actual needs, various benzopyran derivatives containing the amide structure can be synthesized, and the method is convenient to operate and wide in practicability.