7 results about "Propargyl ether" patented technology

The application discloses a method for preparing alpha, beta-unsaturated aldehyde based on nickel and visible light synergistic catalysis propargyl ether rearrangement reaction, which comprises the following steps: in the presence of a nickel catalyst, a ligand, a photocatalyst and a base and under the condition of blue light irradiation, propargyl ether of formula (1) is reacted with bromide of formula (2) in an organic solvent to generate alpha, beta-unsaturated aldehyde compound of formula (3). The preparation method has the advantages of cheap and easily available reaction raw materials, simple reaction operation, wide application range of reaction substrates, easy reaction amplification, mild reaction conditions and the like, and can realize industrial production and application.

The invention discloses a preparation method of an indene derivative containing hexafluoroisopropyl ester, which comprises the following steps: reacting a propargyl ether compound, hexafluoroisopropanol and N-iodosuccinimide at room temperature for 0.5 hour, then adding palladium acetate, bis (2-diphenylphosphinophenyl) ether, formic acid, acetic anhydride, sodium carbonate and dimethyl sulfoxide, reacting at 120 DEG C for 24 hours, filtering, washing and drying to obtain the hexafluoroisopropyl ester-containing indene derivative. And after the reaction is completed, carrying out post-treatment to obtain the indene derivative containing hexafluoroisopropyl ester. According to the preparation method, hexafluoroisopropanol is taken as a reactant, formic acid is taken as a carbonyl source, the reaction condition is mild, the operation is simple, the tolerance range of substrate functional groups is wide, and the reaction efficiency is high. Various indene derivatives containing hexafluoroisopropyl ester can be synthesized according to actual needs, so that the method is convenient to operate, and the practicability of the method is widened.

The invention discloses a method for preparing indene by copper-catalyzed propargyl ether rearrangement reaction, which is characterized by comprising the following step: in the presence of a copper catalyst, a ligand and di-tert-butyl peroxide, in an organic solvent, heating a compound in a formula (1) and a compound in a formula (2) to react to generate an indene compound in a formula (3) or a formula (4). The invention discloses a method for preparing benzofuran by copper-catalyzed propargyl ether rearrangement reaction, which is characterized by comprising the following steps: in the presence of a copper catalyst and alkali, in an organic solvent, heating a compound in a formula (5) to react to generate a benzofuran compound in a formula (6). The preparation method provided by the invention has the advantages of cheap and easily available reaction raw materials, simple reaction operation, wide application range of reaction substrates, easy amplification of reaction, mild reaction conditions and the like, and can realize industrial production and application.

The present invention discloses a method for synthesizing (5S,6R)-5,6-epoxy-2-heptadecyn-1-ol. The synthesis method is as follows: After reacting (Z)-1-bromotetradecene with a substituted phenyl propargyl ether, an epoxidation reaction occurs under the action of an epoxidation catalyst, and then the substituted phenyl group is removed under the action of an oxidizing agent to obtain (5S,6R)-5,6-epoxy-2-heptadecyn-1-ol. The synthesis conditions of the present invention are mild, the operation is simple, the yield is high, the preparation cost is low, and it has good economic benefits.

The application discloses a preparation method of a benzopyran derivative containing hexafluoroisopropyl ester, which comprises the following steps: reacting propargyl ether compound, hexafluoroisopropanol and N-iodosuccinimide at room temperature for 15 min, then adding palladium acetate, tris(2-furyl)phosphine, formic acid, acetic anhydride and potassium phosphate to react at 60 DEG C for 24 hours, and after the reaction is completed, post-treatment is carried out to obtain the benzopyran derivative containing hexafluoroisopropyl ester. The preparation method uses hexafluoroisopropanol as a reactant and a promoter, uses formic acid as a carbonyl source, has mild reaction conditions, simple operation, a wide functional group tolerance range of a substrate and high reaction efficiency. According to actual needs, a plurality of benzopyran derivatives containing hexafluoroisopropyl ester can be synthesized, and the method is convenient to operate and wide in practicability.

The application discloses a preparation method of a benzopyran derivative containing a thioester structure, and comprises the following steps: adding a propargyl ether compound, hexafluoroisopropanol and N-iodosuccinimide into a solvent to react at 50-70 DEG C for 0.5-5 h, then adding a sulfonyl chloride compound, a palladium catalyst, a ligand, a carbonyl molybdenum and a base to react at 80-100 DEG C for 20-28 hours, and after the reaction is completed, post-treatment is carried out to obtain the benzopyran derivative containing the thioester structure; the preparation method uses the sulfonyl chloride compound as a reactant and a sulfur source, uses the carbonyl molybdenum as a carbonyl source, has mild reaction conditions, simple operation, a wide functional group tolerance range of a substrate and high reaction efficiency. According to actual needs, various benzopyran derivatives containing the thioester structure can be synthesized, and the method is convenient to operate and wide in practicability.

The application discloses a preparation method of a benzopyran derivative containing an amide structure, which comprises the following steps: reacting propargyl ether compound, hexafluoroisopropanol and N-iodosuccinimide at 60 DEG C for 1 h, then adding a nitro compound, palladium acetate, 2-diphenylphosphine-biphenyl, carbonyl molybdenum, potassium carbonate and water to react at 100 DEG C for 24 h, and after the reaction is completed, post-treatment is carried out to obtain the benzopyran derivative containing the amide structure. The preparation method uses the nitro compound as a reactant and a nitrogen source, and uses the carbonyl molybdenum as a carbonyl source, has mild reaction conditions, simple operation, a wide functional group tolerance range of a substrate and high reaction efficiency. According to actual needs, various benzopyran derivatives containing the amide structure can be synthesized, and the method is convenient to operate and wide in practicability.