599 results about "Benzofuran" patented technology

Pharmaceutically active benzofuran compositions for the treatment of mental disorders or for mental enhancement, including for entactogenic therapy. The present invention also includes benzofuran compounds, compositions, and methods for generally modulating central nervous system activity and treating central nervous system disorders.

The invention belongs to the technical field of OLEDs, and provides a polycyclic compound containing triphenyl silicon and a polyalkyl substituent group and an organic electroluminescent device containing the polycyclic compound. The structural general formula of the polycyclic compound is as shown in formula I in the specification. Benzofuran with higher electronegativity is introduced to a ring structure composed of nitrogen atoms and boron atoms, triphenyl silicon is introduced to the para-position of boron, and the synergistic effect of benzofuran and triphenyl silicon can significantly enhance the multiple resonance of a light-emitting core and reduce vibration relaxation. Due to simultaneous use of the benzofuran and the triphenyl silicon, the problems of vibration relaxation increase, spectrum widening and the like caused by introduction of the polyalkyl substituent are remarkably improved, the luminous efficiency of the material is remarkably improved, and the color purity is improved, so that the requirement of BT.2020 wide color gamut display standard on a luminescent spectrum is met. I

The invention relates to compounds that are useful for the prevention or treatment of TRPM3 mediated disorders, more in particular disorders including pain, inflammatory pain or inflammatory hypersensitivity, and epilepsy. The invention also relates to a method for the prevention or treatment of said TRPM3 mediated disorders.

The invention provides a benzofuranone compound as well as a pharmaceutical composition and application thereof, and relates to the technical field of medicines. The benzofuranone compound is a compound as shown in a formula I, a stereoisomer thereof, a tautomer thereof, a crystalline hydrate thereof, a solvate thereof, a prodrug thereof or a pharmaceutically acceptable salt thereof. The benzofuranone compound and the pharmaceutical composition and the pharmaceutical preparation prepared from the benzofuranone compound can prevent or treat organ injury diseases, and have good treatment effects in kidney injury, liver injury, lung injury, brain injury and heart injury.

The invention discloses an organic compound containing phenanthrene benzofuran, and an organic electroluminescent device, a display device and a lighting device comprising the same. The structural general formula of the organic compound is as shown in formula I; wherein L1 and L2 each independently represent any one of a single bond and an arylene group with a carbon atom number of C6-C12; ar1 represents a substituted or unsubstituted aryl group having a carbon atom number of C6-C60; ar2 represents a group represented by formula II, and ring A represents phenanthryl. By introducing a phenanthrene benzofuran substituent substituted by a specific site into the structure, the molecular high-energy linear state energy level can be adjusted while the molecular polarity is adjusted, and the carrier injection and energy level difference are improved, so that the internal quantum efficiency of the material is improved. And the phenanthrene benzofuran substituent at the specific site and anthryl present a rigid structure, which is beneficial for ordered arrangement of molecules according to a certain orientation, so that the light extraction efficiency is improved, and the device performance can be significantly improved. I; iI

The invention discloses an organic compound, a composition, an electronic device and a display panel. The organic compound has a structure as shown in formula (1): (1); the organic compound provided by the invention is an arylamine compound taking dibenzofuran or dibenzothiophene substituted by a heterocyclic group containing a nitrogen atom, an oxygen atom or a sulfur atom as a core structure, and can have a relatively high refractive index; when the organic compound provided by the invention is used in a covering layer of an electronic device, the refractive index of the covering layer can be effectively improved, so that the luminous efficiency of the electronic device is improved, and the electronic device with excellent performance can be realized.

The invention discloses a novel PARP / CK2 double-target kinase inhibitor small molecule as well as a pharmaceutical composition and application thereof, the small molecule takes benzofuran pyrimidone as a parent drug effect ring and a benzene ring as a connector in drug design, and is coupled with a 1-amino-2-methylisothiourea group, so that the novel PARP / CK2 double-target kinase inhibitor is obtained. The compound has good inhibitory activity on exogenous PARP enzyme, exogenous CK2 alpha enzyme and proliferation activity of various cancer cells, and can be used for preparing antitumor drugs. # imgabs0 #

The invention discloses a high-color-purity near ultraviolet heat exciton compound with circular polarization property and application thereof in preparation of a circular polarization organic electroluminescent device, and belongs to the technical field of organic photoelectric materials. The electroluminescent material disclosed by the invention is a high-color-purity near ultraviolet heat exciton compound with circular polarization property, and two pairs of near ultraviolet enantiomers are successfully designed and synthesized by combining a chiral group binaphthol, a weak donor dibenzothiophene, dibenzofuran and an acceptor cyanophenyl; the compounds show obvious circular polarization luminescence property and high fluorescence quantum yield. The electroluminescent devices prepared based on the enantiomers all show near ultraviolet emission, CIE coordinates are respectively (0.168, 0.040) and (0.166, 0.040), and the external quantum efficiencies are respectively 4.3% and 3.4%. According to the near ultraviolet heat exciton material, a new visual angle is provided for developing the near ultraviolet heat exciton material with circular polarization luminescence and high color purity at the same time, and 3D and wide color gamut display can be directly achieved in the future.

The invention relates to application of a benzofuran terphenyl compound in medicines, belongs to the field of medicinal chemistry, and particularly relates to a terphenyl compound which comprises a stereoisomer, a geometric isomer, a tautomer, nitrogen oxide, hydrate, solvate, metabolite and ester of the terphenyl compound. The pharmaceutically acceptable salt or the prodrug thereof and the pharmaceutical composition containing the compound are used as medicines, especially used for treating and / or preventing related diseases caused by HIF.

The invention belongs to the technical field of medicinal chemistry, and discloses a preparation method and application of a benzofuran [2, 3-b] pyridine derivative of a targeted nuclear receptor co-activator 4 (NCOA4). The derivative has a structural general formula as shown in the following formula (I), wherein R1, R2 and R3 substituent groups can be combined at will. The compounds are combined with NCOA4 to interfere the cell iron autophagy process and effectively inhibit the ferroptosis of various cells induced by RSL3 or Erastin. Particularly, the binding affinity of the compound 4k and NCOA4 is optimal (Kd is equal to 0.78 mu M), and the compound 4k has remarkable ferroptosis inhibition activity and can be used for research and development of medicines for ferroptosis-related diseases. # imgabs0 #

The invention discloses a novel benzofuran component in eupatorium chinense and application of the benzofuran component in anti-inflammatory activity. The obtained compound is separated from an eupatorium chinense extract. The eupatorium chinense root extract is separated by using an extraction method, macroporous adsorption resin impurity removal, Sephadex LH-20 gel column chromatography, high performance liquid chromatography and other methods. According to the present invention, all the separated compounds and the analogues thereof have good inhibition activity on target cyclooxygenase-2 of inflammation-related diseases, and have good inhibition activity on COX-2 enzyme, and the molecular docking experiment results show that the compounds and the target proteins have good binding energy. Therefore, the compound can be used for preparing drugs for treating inflammatory related diseases, or anti-inflammatory and analgesic drugs, or tumor drugs by inhibiting COX-2 enzyme, such as drugs for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, Alzheimer's disease and the like, and related natural lead compounds are provided.

The invention provides an organic metal compound and an organic light-emitting device comprising the same, and belongs to the field of organic photoelectric materials, the organic metal compound has a structure shown in a general formula I. The organic metal compound has a structure shown in a general formula I by changing the combination of substituent groups on 2-(dibenzo [b, d] furan-4-yl) pyridine, and the organic light-emitting device with the organic metal compound can be obtained by synthesizing 2-(dibenzo [b, d] furan-4-yl) pyridine. The organic metal compound is generated by adding-CN,-F, branched alkyl, substituted or non-substituted aryl and substituted or non-substituted naphthenic base, intermolecular spatial configuration is improved, the organic metal compound has good space twisting capability, carrier migration is avoided, and after the organic metal compound serves as a specific doping material of a luminescent layer and is applied to an organic electroluminescent device, the organic electroluminescent device has high luminous efficiency. The driving voltage of the device is reduced, so that carrier migration is avoided, the driving voltage is obviously reduced, the luminous efficiency is obviously improved, and the service life is obviously prolonged.

The invention relates to the technical field of organic synthesis, in particular to 1-chloro-8-fluorine-7-isopropyl benzofuro [2, 3-c] pyridine as well as a synthesis method and an application of the 1-chloro-8-fluorine-7-isopropyl benzofuro [2, 3-c] pyridine. According to the invention, 1-chloro-8-fluoro-7-isopropyl benzofuro [2, 3-c] pyridine and nanogold are cooperated to cover the surface of a glassy carbon electrode (GCE), and a novel electrochemical modified electrode AuNPs / 1 / GCE is developed. The modified glassy carbon electrode shows good selectivity, high stability and sensitivity and wide detection range on the detection of the antibiotic furacilin.

The application discloses a kind of flame-retardant expandable polystyrene and its preparation method.It includes the following raw materials: styrene, nucleating agent, desalted water, organic compound containing peroxide functional group, inorganic salt, bromine flame retardant, dispersant, solvent.The product powder and bulk material prepared by the application are less, and the prepared polystyrene board has excellent mechanical properties.After one week or even one month, no collapse, deformation and other phenomena occur, the combustion performance completely reaches B level, and has efficient flame-retardant fireproof performance.Meanwhile, the product obtained by the application has high bromine content, good thermal stability, low bleeding, no toxicity, little influence on material mechanical properties, and no toxic gas such as polybrominated dibenzo-p-dioxin and polybrominated dibenzofuran is produced during thermal cracking or combustion, which completely meets the requirements of European dioxin regulations and does not harm the environment.

The invention relates to a novel compound as well as a preparation method and application thereof, in particular to (Z / E)-1-(2, 2-dimethyl-2, 3-dihydrobenzofuran-5-yl)-3-aryl-2-(1H-pyrazol-1-yl)-2-propylene-1-ketone as well as a preparation method and application thereof in preparation of an anti-tumor drug, and discloses a preparation method of (Z / E)-1-(2, 2-dimethyl-2, 3-dihydrobenzofuran-5-yl)-3-aryl-2-(1H-pyrazol-1-yl)-2-propylene-1-ketone. The structural formula of the compound 1-(2, 2-dimethyl-2, 3-dihydrobenzofuran-5-yl)-3-aryl-2-(1H-pyrazol-1-yl)-2-propylene-1-ketone is as shown in a formula I or a formula II: # imgabs 0 #, and the structural formula of the compound 1-(2, 2-dimethyl-2, 3-dihydrobenzofuran-5-yl)-3-aryl-2-(1H-pyrazol-1-yl)-2-propylene-1-ketone is as shown in a formula II. Wherein R1 is selected from a methoxy group, an ethyoxyl group or a propoxy group; r1 is selected from methyl, methoxy, ethyoxyl, nitro, iodine, bromine, chlorine, fluorine, 2, 4-difluoro, 2, 4-dichloro, 2, 3, 4-trichloro, 2, 4-dimethoxy and 2, 3, 4-trimethoxy, and R2 is selected from methyl, methoxy, ethyoxyl, nitro, iodine, bromine, chlorine, fluorine, 2, 4-difluoro, 2, 4-dichloro, 2, 3, 4-trichloro, 2, 4-dimethoxy and 2, 3, 4-trimethoxy.

The present invention relates to an organic light-emitting device employing, as a host of a light emission layer, an anthracene derivative compound having a characteristic structure by introduction of a benzofuran structure into the anthracene backbone, and as a dopant of the light emission layer, a polycyclic compound having a characteristic structure. The organic light-emitting device according to the present invention is an organic light-emitting device with significantly improved external quantum efficiency and can be advantageously utilized not only for lighting devices but also for various display devices, such as flat, flexible, and wearable displays.

The invention relates to the technical field of organic electroluminescent devices, in particular to an organic metal iridium complex, a preparation method of the organic metal iridium complex, a luminescent material and an organic electroluminescent device. The organic metal iridium complex is selected from a compound shown in the following structural formula: # imgabs0 #, wherein R1 to R14 are respectively and independently selected from any one of hydrogen, deuterium, tritium, halogen, cyano, trimethyl silicon, trimethyl germanium, substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C6-C20 aryl and substituted or unsubstituted 4-membered to 8-membered heterocyclic radical; the number of R10 on a benzene ring of dibenzofuran in the formula 1 is 1 or 2; s1 is selected from substituted or unsubstituted dibenzofuran, and S1 is fused with any position on a benzene ring of adjacent dibenzofuran. The organic metal iridium complex is low in synthesis cost, simple in synthesis process and difficult to purify, and an organic electroluminescent device formed by the organic metal iridium complex is high in luminous efficiency, long in service life and low in driving voltage.

Provided are a compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same and a use thereof, where the compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.

The invention discloses a preparation method of a six-membered azaspiro dihydrobenzofuran compound. According to the method, a C2-alkyne benzofuran derivative is taken as a raw material, metal palladium is taken as a catalyst, and a corresponding product is generated through reaction in an organic solvent at the temperature of 40-120 DEG C under the combined action of a ligand and acetic anhydride. Under the action of palladium, a ligand, a solvent and acetic anhydride, alkyne triple bonds and indole double bonds are subjected to triple addition and bicyclic addition, and rapid construction of a six-membered azaspiro structure dihydrobenzofuran product is achieved. The reaction conditions are mild, the operation is simple and convenient, and the method has the advantages of easily available reaction raw materials, wide substrate applicability, excellent yield and enantioselectivity, easily separated target products and the like.

The utility model relates to the technical field of reaction kettles, in particular to a reaction kettle for benzofuranone hydrogenation reaction, which comprises a kettle body and a hopper mounted at the top of the kettle body and communicated with an inner cavity of the kettle body, a scraper rotatably scrapes the inner wall of the reaction kettle, reaction solution residues are reduced, normal reaction can be ensured, and air discharged through an exhaust hole can be recycled. A fan is arranged to supply air to a plurality of stirring paddles on one hand and supply air to a spray head mounted at a feeding opening of a hopper on the other hand, so that air in the reaction kettle is prevented from escaping from the hopper, and the accuracy of detecting the condition of discharged air is improved; meanwhile, the materials are accelerated to enter the reaction kettle from the hopper, so that the solid raw materials are prevented from remaining at the material inlet of the hopper, the accurate and reliable formula proportion of each substance participating in the reaction is ensured, the gas generated by the reaction is prevented from being gathered and remaining in the reaction kettle, and the accuracy of the detection result of the gas discharged by the gas outlet pipe is further improved.

A method for preparing compound 1 and compound 2 having a structure as shown below, the method includes the following steps:1) subjecting 2,3-dihydrobenzofuran-7-amine as a raw material to a selective-dibromination with a brominating reagent to obtain 4,6-dibromo-2,3-dihydrobenzofuran-7-amine;2) subjecting 4,6-dibromo-2,3-dihydrobenzofuran-7-amine obtained in the step 1) to Sandmeyer reaction for chlorination to obtain 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran;3-1) selectively debrominating from 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran obtained in the step 2) using a strong base, and then adding a formylation reagent to obtain compound 1;3-2) selectively debrominating from 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran obtained in the step 2) using a strong base, and then reacting with 4-cyclopropyl benzaldehyde to obtain compound 2.

The invention discloses a preparation method and application of a benzofuran component in eupatorium chinense. The benzofuran component is separated from an eupatorium chinense extract. The eupatorium chinense root extract is separated by using an extraction method, macroporous adsorption resin impurity removal, HW-40F gel column chromatography, high performance liquid chromatography and other methods to obtain the benzofuran compound. According to the present invention, the inhibition activity of the separated compound on the diabetes-related target alpha-glucosidase is tested, the experimental result shows that the compound has good inhibition activity on the alpha-glucosidase, and the molecular docking experiment shows that the compound has good binding energy with the target protein alpha-glucosidase. Therefore, the compound can be used for preparing drugs for preventing, delaying or treating alpha-glucosidase diseases, especially type II diabetes and obesity, or can be used as a lead compound of the drugs.

The invention relates to an intermediate of a chemical synthetic drug and a preparation method of the intermediate, in particular to an intermediate compound for preparing dronedarone and a preparation method of the intermediate compound. The intermediate is a new compound 2-n-valeryl-5-methanesulfonamide benzofuranone, and the compound can be applied to synthesis of a dronedarone drug through butt joint with 1-phenoxy-3-di-n-butylamine propane. The new intermediate is used for synthesizing dronedarone, raw materials and auxiliary materials are rich in source, low in price and easy to obtain, the process steps are short, the cost is low, the reaction conditions are mild and environmentally friendly, the target product preparation efficiency is high, no reaction device with special requirements exists, and the industrial production requirement can be met.

The invention provides benzofuran compounds derived from marine fungi and application of the benzofuran compounds in preparation of drugs for resisting pathogenic fungi of crops, and relates to the field of marine natural products. The invention discloses three novel benzofuran compounds, i.e., stribenfuran R, stribenfuran T and stribenfuran U. The structural formula of the benzofuran compounds is as shown in formula (I), in the formula (I), the compounds of the stribenfuran R are as follows: R1 = CH3, R2 = CH2OH; or a compound stribenfuran T: R1 is H, and R2 is COCH3; or a compound stribenfuran U: R1 is equal to CH3, and R2 is equal to CHO. According to the present invention, the compounds of the stribenfuran R, the stribenfuran T and the stribenfuran U have good inhibition activity on twelve types of crop pathogenic fungi, such that the alternative compounds are provided for the development of the new anti-crop pathogenic fungi. # imgabs0 #

The invention provides a sodium ion specific fluorescence labeled transparent soil sample as well as a preparation method and application thereof, and belongs to the technical field of rock soil and geological engineering. The method comprises the following steps: firstly, sequentially carrying out hydrophilization treatment, solvent evaporation and dissolution on a sodion combined benzofuran isophthalate probe to obtain a probe mother solution; mixing the probe mother solution, a buffer solution, an inorganic sodium salt solution and a solvent to prepare a fluorescence labeling pore solution; and finally, mixing the sodium polyacrylate particles and the fluorescence labeled pore liquid, and performing vacuum saturation treatment to obtain the transparent soil sample. The transparent soil sample provided by the invention still keeps excellent optical transparency while having sodium ion specific response capability, so that a stable and reliable experimental medium is provided for in-situ, real-time and full-field observation of sodium ion migration.

The invention belongs to the technical field of natural pharmaceutical chemistry, and discloses a benzofuran compound in dalbergia odorifera and a preparation method and application thereof.The benzofuran compound is separated from dalbergia odorifera of a leguminous dalbergia plant, the heartwood of the dalbergia odorifera is extracted and concentrated to obtain extract, and the extract is filtered to obtain the benzofuran compound. The extract is taken and sequentially subjected to silica gel column chromatography, medium-pressure ODS column chromatography and gel column chromatography separation for multiple times, then semi-preparative high performance liquid chromatography is used for purification, and the benzofuran compounds can be obtained. According to the present invention, lipopolysaccharide (LPS) is adopted to induce RAW 264.7 cells to establish an inflammation model, such that the compound has good anti-inflammatory activity, IC50 is 14.33 [mu] M, and expression of inflammatory factor interleukin-6 (IL-6) and interleukin-1 [beta] (IL-1 [beta]) can be inhibited;

The application belongs to the technical field of natural medicinal chemistry, and discloses a benzofuran compound in Jinyunming and a preparation method and application thereof. The benzofuran compound is separated from Jinyunming of the plant Dalbergia hupeana Tutch in the family of Leguminosae. The heartwood of Jinyunming is extracted and concentrated to obtain extract, the extract is sequentially separated by multiple silica gel column chromatography, medium-pressure ODS column chromatography and gel column chromatography, and then purified by semi-preparative high-performance liquid chromatography, so that the benzofuran compound can be obtained. The application establishes an inflammation model by inducing RAW 264.7 cells with lipopolysaccharide (LPS), and shows that the compound has good anti-inflammatory activity, the IC50 is 14.33 μM, and the expression of inflammatory factors interleukin-6 (IL-6) and interleukin-1β (IL-1β) can be inhibited.

The invention discloses a lipid droplet specific fluorescent probe as well as a preparation method and application thereof, and relates to the technical field of biological medicines. The invention provides a structural formula of the lipid droplet specific fluorescent probe, and during preparation, 2-formaldehyde-6-(diethylamino) benzo [B] furan and a malononitrile derivative are used for preparing a fluorescent probe with an extended pi conjugated system under the action of an alkali environment; the fluorescent probe has the characteristic of intramolecular charge transfer (TICT), fluorescence in an aqueous solution is extremely weak, fluorescence in sunflower seed oil is remarkably enhanced, and the fluorescent probe has remarkable Stokes shift, excellent biocompatibility, excellent light stability and high signal-to-noise ratio. Meanwhile, the fluorescent probe shows extremely high sensitivity and signal-to-noise ratio in the aspect of cell lipid droplet imaging, and dynamic and accurate targeted imaging of lipid droplets can be easily realized. Therefore, the fluorescent probe disclosed by the invention is expected to become an alternative scheme for accurate detection of atherosclerosis.

The invention discloses an organic electroluminescent compound and an organic electroluminescent device comprising the same. The organic electroluminescent compound is selected from a general formula structure as shown in a formula I in the specification. In the invention, by introducing a special molecular structure formed by aryl substituent groups on two specific sites, namely Ar2 and Ar3 positions, the following effects are generated: firstly, a carbon-hydrogen bond of a fused aryl fragment on relatively weak fused aryl benzofuran is substituted by aryl and then becomes a more stable carbon-carbon bond; secondly, a special spatial three-dimensional structure can improve the transmission of carriers, reduce the retention of polaron in the device on a single molecule, and reduce the probability of interaction of polaron, exciton, carriers and the like, thereby reducing the quenching and degradation of a main body material in the operation process of the device, prolonging the service life of the device, and improving the efficiency of the device; and thirdly, the recombination energy of current carriers is obviously reduced, so that the current carriers are transmitted more quickly, and the voltage of the device is reduced. # imgabs0 # I

The invention discloses application of benzofuran components in eupatorium chinense to reduction of uric acid, compounds 1-3 are obtained by being separated from an eupatorium chinense extract, and the compound 1 is a new compound. The eupatorium chinense root extract is separated by using an extraction method, macroporous adsorption resin impurity removal, HW-40F gel column chromatography, high performance liquid chromatography and other methods to obtain the benzofuran compound. According to the present invention, the inhibition activity of the gout disease related target xanthine oxidase of the separated compound 1-3 is tested, the experimental result shows that the compound 1-3 has good inhibition activity on the xanthine oxidase, and the molecular docking experiment shows that the compound 1-3 has good binding energy with the target protein. Therefore, the compounds 1-3 can be used for preparing a natural lead compound for delaying or treating diseases caused by xanthine oxidase and providing a natural lead compound in the field of treatment of hyperuricemia and gout.