249 results about "Benzofuran" patented technology

The invention provides a benzofuranone compound as well as a pharmaceutical composition and application thereof, and relates to the technical field of medicines. The benzofuranone compound is a compound as shown in a formula I, a stereoisomer thereof, a tautomer thereof, a crystalline hydrate thereof, a solvate thereof, a prodrug thereof or a pharmaceutically acceptable salt thereof. The benzofuranone compound and the pharmaceutical composition and the pharmaceutical preparation prepared from the benzofuranone compound can prevent or treat organ injury diseases, and have good treatment effects in kidney injury, liver injury, lung injury, brain injury and heart injury.

The invention discloses a novel benzofuran component in eupatorium chinense and application of the benzofuran component in anti-inflammatory activity. The obtained compound is separated from an eupatorium chinense extract. The eupatorium chinense root extract is separated by using an extraction method, macroporous adsorption resin impurity removal, Sephadex LH-20 gel column chromatography, high performance liquid chromatography and other methods. According to the present invention, all the separated compounds and the analogues thereof have good inhibition activity on target cyclooxygenase-2 of inflammation-related diseases, and have good inhibition activity on COX-2 enzyme, and the molecular docking experiment results show that the compounds and the target proteins have good binding energy. Therefore, the compound can be used for preparing drugs for treating inflammatory related diseases, or anti-inflammatory and analgesic drugs, or tumor drugs by inhibiting COX-2 enzyme, such as drugs for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, Alzheimer's disease and the like, and related natural lead compounds are provided.

The application discloses a kind of flame-retardant expandable polystyrene and its preparation method.It includes the following raw materials: styrene, nucleating agent, desalted water, organic compound containing peroxide functional group, inorganic salt, bromine flame retardant, dispersant, solvent.The product powder and bulk material prepared by the application are less, and the prepared polystyrene board has excellent mechanical properties.After one week or even one month, no collapse, deformation and other phenomena occur, the combustion performance completely reaches B level, and has efficient flame-retardant fireproof performance.Meanwhile, the product obtained by the application has high bromine content, good thermal stability, low bleeding, no toxicity, little influence on material mechanical properties, and no toxic gas such as polybrominated dibenzo-p-dioxin and polybrominated dibenzofuran is produced during thermal cracking or combustion, which completely meets the requirements of European dioxin regulations and does not harm the environment.

The present invention relates to an organic light-emitting device employing, as a host of a light emission layer, an anthracene derivative compound having a characteristic structure by introduction of a benzofuran structure into the anthracene backbone, and as a dopant of the light emission layer, a polycyclic compound having a characteristic structure. The organic light-emitting device according to the present invention is an organic light-emitting device with significantly improved external quantum efficiency and can be advantageously utilized not only for lighting devices but also for various display devices, such as flat, flexible, and wearable displays.

Provided are a compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same and a use thereof, where the compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.

The invention provides a sodium ion specific fluorescence labeled transparent soil sample as well as a preparation method and application thereof, and belongs to the technical field of rock soil and geological engineering. The method comprises the following steps: firstly, sequentially carrying out hydrophilization treatment, solvent evaporation and dissolution on a sodion combined benzofuran isophthalate probe to obtain a probe mother solution; mixing the probe mother solution, a buffer solution, an inorganic sodium salt solution and a solvent to prepare a fluorescence labeling pore solution; and finally, mixing the sodium polyacrylate particles and the fluorescence labeled pore liquid, and performing vacuum saturation treatment to obtain the transparent soil sample. The transparent soil sample provided by the invention still keeps excellent optical transparency while having sodium ion specific response capability, so that a stable and reliable experimental medium is provided for in-situ, real-time and full-field observation of sodium ion migration.

The invention relates to the technical field of organic light-emitting display, in particular to an asymmetric substituted dibenzofuran compound and application thereof. The asymmetric substituted dibenzofuran compound has a structure as shown in formula (I), and can be used as a hole transport material. The compound has an asymmetric dibenzofuran bis-substituted arylamine parent structure, is high in bond energy between atoms, has good thermal stability, is beneficial to solid-state accumulation between molecules, is high in hole transition capability, and can effectively reduce the voltage of a device and prolong the service life of the material when being used as a hole transport material. The invention also provides an organic electroluminescent device and a display device containing the compound shown in the formula (I).

The subject of the invention is N-substituted derivatives of l-(l-phenyl-3-aryl)-lH-pyrazol-4-yl)methanamine with the general formula 1, where ¥ represents CH or N, R1 represents hydrogen, R2 represents no substituent, R3 represents hydrogen, while R4 represents N-propylbenzamide, benzo[b]furan, dihydrobenzo [b] furan, methylenedioxybenzene, ethyl benzoate, or propyl benzoate, substituted accordingly, their method of production and application, and the method of obtaining and application of N-substituted derivatives of l-(l-phenyl-3-aryl)-IH-pyrazol-4-yl)methanamine with the general formula 1, where Y represents C, CH, or N, R1 represents hydrogen or a methyl group, R2 represents a methyl group or no substituent, R3 represents hydrogen or a methyl group, while R4 represents dimethylpyrazole, methylpyrazole, dimethylimidazo[l,2-a]pyrimidine, or isopropoxybenzene, substituted accordingly. The compounds that are the subject of the invention are obtained through reductive amination using borohydride derivatives as the reducing agent, advantageously sodium triacetoxyborohydride, in the amount of 1.4-2.0 eq, amine in the amount of 1.0-1.1 eq, advantageously in slight excess, base, advantageously triethylamine in the amount of 1.0-1.1 eq (in the case of using amine in the form of hydrochloride), and the starting aldehyde. The reaction is conducted in a nonpolar solvent environment, advantageously dichloroethane at a concentration of about 0.1 M. The crude product is purified by column chromatography on silica gel using a methanol in dichloromethane mixture as the eluent, in concentration ranges from 2% to 5%. In order to obtain a solid form and improve the physicochemical parameters, the free bases are converted into hydrochloride form, and then crystallized from a polar solvent, advantageously ethanol or propanol.

This invention discloses a benzofuran compound and its application in lowering uric acid activity. Compounds 1-3 were isolated from the fermentation products of the endophytic fungus *Septoriella phragmitis*, with compound 1 being a novel compound. The fermentation products were purified using mixed solvent extraction, normal silica gel column chromatography, and high-performance liquid chromatography to obtain compounds 1-3. The inhibitory activity of compounds 1-3 on xanthine oxidase, a target related to gout symptoms, was tested. Experimental results showed that the novel compound 1 exhibited good inhibitory activity against xanthine oxidase. Molecular docking experiments also demonstrated that compound 1 had a good binding energy to the target protein. Therefore, compound 1 can be used to prepare a natural lead compound for delaying or treating diseases caused by xanthine oxidase, providing a potential therapeutic agent for hyperuricemia and gout.

A benzofuran-based N-acylhydrazone derivative according to the present invention has an excellent anticancer effect while having low toxicity and excellent solubility, and thus a pharmaceutical composition comprising the derivative can be usefully used to prevent or treat a cell proliferative disorder including various cancers.

The application discloses a host material, an organic electroluminescent material containing double hosts and application thereof, and relates to the field of organic electroluminescent materials. The structure of the host material is shown in general formula 1: the first host material with a triazine skeleton is connected with two benzene mother nuclei at different positions of a naphthalene ring, and the rigid planar structure brings high glass transition temperature and thermal decomposition temperature. One benzene is fixed at an ortho position of the triazine ring, and a dibenzofuran is used as a main host group at another position of the triazine ring, which can efficiently transport electrons, balance electrons and holes, realize a wider exciton recombination region and higher exciton utilization, and effectively reduce the driving voltage and efficiency roll-off. Meanwhile, the second host with a triarylamine structure is matched, which can simultaneously enhance the hole transport and electron transport capacity, so that when the holes are injected into the p-type host and the electrons are injected into the n-type host, the driving voltage is reduced, and the luminous efficiency and the service life are also significantly enhanced.

This application relates to a method for preparing melitracen hydrochloride intermediates, belonging to the field of chemical preparation. The preparation method includes the following steps: dissolving 3,3-dimethyl-2-benzofuran-1(3H)-one in an organic solvent, adding a catalyst and heating the reaction, followed by purification after the reaction to obtain 10,10-dimethylanthrone. The catalyst includes at least one selected from ferric chloride, ferrous chloride, zinc chloride, and anhydrous aluminum trichloride; the organic solvent includes benzene. This preparation method has not been reported in the literature, significantly shortens the process flow for synthesizing melitracen intermediates, avoids the use of concentrated sulfuric acid, reduces waste, and saves costs.

The application belongs to the technical field of OLED, and specifically comprises an organic compound for a double light-emitting layer blue light device and application thereof.The structural general formula of the organic compound is shown in the following.The application can fully exert the double light-emitting layer mechanism by directly connecting a benzofuranphenanthrol group at the 7th position of a benzanthracene nucleus, improve the device efficiency, and further, when the benzanthracene nucleus directly connected position is a phenanthrene group fragment on the benzofuranphenanthrol group, the electron mobility can be further enhanced, so that the prepared device obtains lower voltage and higher efficiency.In summary, the application improves the voltage and efficiency of the double light-emitting layer device through special design of the substituent and substitution site on the benzanthracene nucleus.I

The present invention relates to materials for organic electroluminescent devices. In particular, the present invention relates to amines having dibenzofuran, dibenzothiophene and fluorene groups for use as triplet matrix materials, in particular in organic electroluminescent devices. The invention also relates to a method for producing the compounds according to the invention and to electronic devices comprising said compounds.

The invention discloses a benzofuran glycoside compound as well as a separation and extraction method, a pharmaceutical composition and application thereof. The compound 1 is separated from an eupatorium chinense extract. And separating and purifying chemical components of the n-butyl alcohol part of the eupatorium chinense root to obtain the benzofuran compound. The inhibition activity of target cyclooxygenase-2 of inflammatory related diseases of all the separated compounds 1 is tested, and the compounds 1 have good inhibition activity on COX-2 enzyme and have good binding energy with target protein. In addition, the compound also has a good NLRP3-related inhibition effect, can be independently used or combined with other medicines to regulate NLRP3-related proteins, and is used for treating NLRP3-related mediated diseases and / or diseases and preparing medicines for preventing or treating the diseases or diseases. The compound 1 also has a good inhibition effect on acetylcholin esterase, and can be used for treating Alzheimer's disease, myasthenia gravis, Parkinson's disease and other diseases.

The invention relates to the technical field of organic electroluminescent materials, and provides an organic compound, an organic electroluminescent device containing the same and an electronic device. The arylamine compound comprises a dibenzofuran carbazole mother nucleus structure, and when the compound is used as a hole-type main body material in a mixed main body material, the carrier balance in a light-emitting layer can be improved, the carrier recombination area can be widened, the exciton generation and utilization efficiency can be improved, the light-emitting efficiency of a device can be improved, and the service life of the device can be prolonged.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of a 3-phenoxy substituted benzofuran compound. In an inert gas environment, a 2-fluorobenzyl phenyl ether compound as shown in a formula 1 and a methyl benzoate compound as shown in a formula 2 are mixed with an organic solvent tetrahydrofuran to react in the presence of bis (trimethylsilyl) caesium amino, and the 3-phenoxy substituted benzofuran compound as shown in a formula 3 is synthesized under a heating condition. According to the method, the raw materials which are easy to obtain are used, benzofuran is synthesized through a transition-metal-free method, and the method has potential application value in synthesis of active pharmaceutical ingredients.

Provided are L-arginine salts of 4-chloro-5-[4-(2, 6-dichlorophenyl) sulfonylpiperazin-1-yl]-1-benzofuran-2-carboxylic acid, and forms thereof, as well as methods for preparing the same. Also provided are pharmaceutical or veterinary compositions comprising the L-arginine salts and their use for the treatment of a number of diseases.

Compounds of Formula (I) are provided, as well as compositions and methods of use thereof, wherein values of variables R1, R2, R5, X, X1 and X2 are provided herein. The compounds inhibit salt-inducible kinase activity and are useful in the treatment of various inflammatory diseases.

The application discloses a synthesis method of aromatic aldehyde, comprising the following steps: under inert atmosphere, a compound shown in formula I and a compound shown in formula II are reacted in an organic solvent containing a photocatalyst, a nickel catalyst, a ligand, a base and water under blue light irradiation to obtain aromatic aldehyde shown in formula III; formula I, formula II and formula III are structures as follows, ring A is selected from benzene, pyridine, thiophene, furan, pyridazine, indazole, indole, isoquinoline, quinoline, naphthalene, benzothiophene, dibenzofuran or dibenzothiophene; the application generates formyl radicals under the nickel synergistic photo-oxidation and reduction catalytic condition, and the formylation of bromobenzene and its derivatives is realized in a simple and efficient one-pot way, aromatic aldehyde is constructed, and the reaction has the characteristics of cheap and easily available raw materials, mild reaction conditions, controllable synthesis process, high separation yield / yield, green environmental protection, wide substrate applicability and the like.

[Problem] To provide a substance having an activity of antagonizing the binding of histamine to histamine-H3 receptor, or having an activity of inhibiting the homeostatic activity of histamine-H3 receptor. [Means for Solution] A compound of the following formula (I) is provided: [wherein X, Y, Z and W each independently represent a methine group optionally having 1 or 2 substituents, or a nitrogen atom (provided that a case where all of X, Y, Z and W are an optionallysubstituted methine group); A, B and D represent C(0)-, etc.; Q represents a methine group or a nitrogen atom; R represents an optionallysubstituted group of the following formula (II-1): (wherein R7 and R8 each independently represent a lower alkyl group, etc.)].

This invention provides an organic electroluminescent device. The organic electroluminescent device comprises a first compound having the structure shown in Formula I and a second compound having the structure shown in Formula II, wherein the first compound is a polysubstituted benzodiazole structure, and the second compound is an amine compound having a benzofuran group, a benzothiophene group, a carbazole group, or a fluorene group. This invention provides that the first and second compounds have better structural matching, better hole injection capability, and excellent charge generation capability. Combining the first and second compounds to prepare the organic electroluminescent device can reduce the device voltage, improve device efficiency, and extend device lifespan.

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method and application of a benzofuranone compound. The benzofuranone compound is prepared through a combined technical scheme of alpha-bromoketone / ethyl acetate + t-BuOH / NaOAc + efficient short-time mild cyclization, and the method is high in reaction efficiency, good in selectivity and mild in condition, conforms to green chemistry and has a good application prospect.

Provided is a method for producing an olaparib precursor, said method comprising the step of performing the following steps (a) to (c) continuously without isolating a reaction intermediate. (a) Reacting dimethyl(3-oxo-1,3-dihydro-2-benzofuran-1-yl)phosphonate and 2-fluoro-5-formylbenzoic acid in DMF, acetonitrile, or THF and in the presence of diazabicycloundecene. (b) Reacting the reaction mixture obtained in the reaction of (a) with hydrazine. (c) Adjusting the reaction liquid obtained in the reaction of (b) to a pH of not more than 4, to obtain 2-fluoro-5-(4-oxo-3,4-dihydro-phthalazine-1-ylmethyl)-benzoic acid, which is an olaparib precursor.

An organic compound that easily exhibits thermally activated delayed fluorescence (TADF) is provided. An organic compound represented by General Formula (G1) is provided. In General Formula (G1), R1 to R8 are each independently any one of hydrogen, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms, and a substituted or unsubstituted diarylamino group; at least one of R1 to R8 is a substituted or unsubstituted diarylamino group; α is a substituted or unsubstituted phenylene group; n is an integer of 0 to 4; and A represents a substituted or unsubstituted benzofuropyrimidine skeleton or benzothienopyrimidine skeleton.

This invention relates to the field of rose separation and purification technology, specifically a novel benzofuran compound from rose petals, its extraction method, and its application. The method involves extracting the total rose extract obtained by heating and reflux of dried rose petals, then extracting the petroleum ether fraction. After elution and separation, the third fraction is further eluted with silica gel, the second fraction is eluted again, and the third fraction is purified by elution. The novel benzofuran compound from rose petals is obtained at 21.0 minutes. This invention discloses for the first time the extraction and isolation of a benzofuran compound from rose petals, and its antibacterial pharmacodynamic effects were tested. The experiments clearly showed that the compound has a strong inhibitory effect on Staphylococcus aureus and Escherichia coli, thus enabling its application in the preparation of antibacterial drugs and antibacterial health products.

The present application relates to a kind of big condensed ring organic compound, belong to organic light-emitting material technical field, simultaneously relate to the application of this kind of compound and the organic electroluminescent device comprising it.The organic compound of the present application has the structure shown as formula (1).The compound of the present application takes indolobenzofuran or indolobenzothiophene as parent nucleus and contains arylamine structure, such compound has good transport performance and stability, when being applied to organic electroluminescent device, it is suitable to be used as light-emitting host material, can effectively improve the service life of device.

This invention provides a method for preparing high-purity olaparib, belonging to the field of pharmaceutical synthesis technology. The method uses dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphate as the starting material, reacting it with compound 2 via a Wittig reaction to generate compound 3. Compound 3 reacts with hydrazine hydrate to generate compound 4. Compound 4 is hydrolyzed and acidified to give compound 5. Compound 5 reacts with thionyl chloride to give compound 6. Compound 6 is then condensed with compounds 7 and 9 to obtain olaparib. This invention uses readily available raw materials, is simple to operate and process, has mild reaction conditions, achieves a total yield of up to 90%, a purity >99%, is environmentally friendly, and is suitable for industrial production.

A polycyclic aromatic compound according to the present invention has a structure composed of one or two or more structural units represented by formula (1). In the polycyclic aromatic compound of the present invention, a carbazole ring and a benzofuran ring or benzothiophene ring represented by formula (b) and the like are fused on a central parent skeleton containing Y1 (for example, B) and nitrogen (N) in formula (1), and at least one of RNY1 to RNY3 has a group represented by formula (a).