728 results about "Benzofuran" patented technology

Pharmaceutically active benzofuran compositions for the treatment of mental disorders or for mental enhancement, including for entactogenic therapy. The present invention also includes benzofuran compounds, compositions, and methods for generally modulating central nervous system activity and treating central nervous system disorders.

The invention belongs to the technical field of OLEDs, and provides a polycyclic compound containing triphenyl silicon and a polyalkyl substituent group and an organic electroluminescent device containing the polycyclic compound. The structural general formula of the polycyclic compound is as shown in formula I in the specification. Benzofuran with higher electronegativity is introduced to a ring structure composed of nitrogen atoms and boron atoms, triphenyl silicon is introduced to the para-position of boron, and the synergistic effect of benzofuran and triphenyl silicon can significantly enhance the multiple resonance of a light-emitting core and reduce vibration relaxation. Due to simultaneous use of the benzofuran and the triphenyl silicon, the problems of vibration relaxation increase, spectrum widening and the like caused by introduction of the polyalkyl substituent are remarkably improved, the luminous efficiency of the material is remarkably improved, and the color purity is improved, so that the requirement of BT.2020 wide color gamut display standard on a luminescent spectrum is met. I

The invention relates to compounds that are useful for the prevention or treatment of TRPM3 mediated disorders, more in particular disorders including pain, inflammatory pain or inflammatory hypersensitivity, and epilepsy. The invention also relates to a method for the prevention or treatment of said TRPM3 mediated disorders.

The invention provides a benzofuranone compound as well as a pharmaceutical composition and application thereof, and relates to the technical field of medicines. The benzofuranone compound is a compound as shown in a formula I, a stereoisomer thereof, a tautomer thereof, a crystalline hydrate thereof, a solvate thereof, a prodrug thereof or a pharmaceutically acceptable salt thereof. The benzofuranone compound and the pharmaceutical composition and the pharmaceutical preparation prepared from the benzofuranone compound can prevent or treat organ injury diseases, and have good treatment effects in kidney injury, liver injury, lung injury, brain injury and heart injury.

The invention discloses an organic compound containing phenanthrene benzofuran, and an organic electroluminescent device, a display device and a lighting device comprising the same. The structural general formula of the organic compound is as shown in formula I; wherein L1 and L2 each independently represent any one of a single bond and an arylene group with a carbon atom number of C6-C12; ar1 represents a substituted or unsubstituted aryl group having a carbon atom number of C6-C60; ar2 represents a group represented by formula II, and ring A represents phenanthryl. By introducing a phenanthrene benzofuran substituent substituted by a specific site into the structure, the molecular high-energy linear state energy level can be adjusted while the molecular polarity is adjusted, and the carrier injection and energy level difference are improved, so that the internal quantum efficiency of the material is improved. And the phenanthrene benzofuran substituent at the specific site and anthryl present a rigid structure, which is beneficial for ordered arrangement of molecules according to a certain orientation, so that the light extraction efficiency is improved, and the device performance can be significantly improved. I; iI

The invention discloses an organic compound, a composition, an electronic device and a display panel. The organic compound has a structure as shown in formula (1): (1); the organic compound provided by the invention is an arylamine compound taking dibenzofuran or dibenzothiophene substituted by a heterocyclic group containing a nitrogen atom, an oxygen atom or a sulfur atom as a core structure, and can have a relatively high refractive index; when the organic compound provided by the invention is used in a covering layer of an electronic device, the refractive index of the covering layer can be effectively improved, so that the luminous efficiency of the electronic device is improved, and the electronic device with excellent performance can be realized.

The invention discloses a novel PARP / CK2 double-target kinase inhibitor small molecule as well as a pharmaceutical composition and application thereof, the small molecule takes benzofuran pyrimidone as a parent drug effect ring and a benzene ring as a connector in drug design, and is coupled with a 1-amino-2-methylisothiourea group, so that the novel PARP / CK2 double-target kinase inhibitor is obtained. The compound has good inhibitory activity on exogenous PARP enzyme, exogenous CK2 alpha enzyme and proliferation activity of various cancer cells, and can be used for preparing antitumor drugs. # imgabs0 #

The invention belongs to the field of organic electroluminescence, and discloses an organic electroluminescence material as well as a preparation method and application thereof. The structure of the organic electroluminescent material is as shown in a chemical formula I: # imgabs0 #. According to the organic electroluminescent material compound provided by the invention, an aryl-substituted dibenzofuran group and a triarylamine group are bridged through a naphthylene group to form a mother nucleus main body, the rigid dibenzofuran structure can effectively enhance the structural stability, and the existence of the triarylamine group can improve the hole transport efficiency of the material; furthermore, the naphthylene group is bridged between the two main body structures, so that a more efficient conjugated system can be formed, the electron mobility of the whole material is improved, and the device has high luminous efficiency and long service life, and can maintain lower driving voltage at the same time.

The invention discloses a high-color-purity near ultraviolet heat exciton compound with circular polarization property and application thereof in preparation of a circular polarization organic electroluminescent device, and belongs to the technical field of organic photoelectric materials. The electroluminescent material disclosed by the invention is a high-color-purity near ultraviolet heat exciton compound with circular polarization property, and two pairs of near ultraviolet enantiomers are successfully designed and synthesized by combining a chiral group binaphthol, a weak donor dibenzothiophene, dibenzofuran and an acceptor cyanophenyl; the compounds show obvious circular polarization luminescence property and high fluorescence quantum yield. The electroluminescent devices prepared based on the enantiomers all show near ultraviolet emission, CIE coordinates are respectively (0.168, 0.040) and (0.166, 0.040), and the external quantum efficiencies are respectively 4.3% and 3.4%. According to the near ultraviolet heat exciton material, a new visual angle is provided for developing the near ultraviolet heat exciton material with circular polarization luminescence and high color purity at the same time, and 3D and wide color gamut display can be directly achieved in the future.

The invention relates to application of a benzofuran terphenyl compound in medicines, belongs to the field of medicinal chemistry, and particularly relates to a terphenyl compound which comprises a stereoisomer, a geometric isomer, a tautomer, nitrogen oxide, hydrate, solvate, metabolite and ester of the terphenyl compound. The pharmaceutically acceptable salt or the prodrug thereof and the pharmaceutical composition containing the compound are used as medicines, especially used for treating and / or preventing related diseases caused by HIF.

The invention belongs to the technical field of medicinal chemistry, and discloses a preparation method and application of a benzofuran [2, 3-b] pyridine derivative of a targeted nuclear receptor co-activator 4 (NCOA4). The derivative has a structural general formula as shown in the following formula (I), wherein R1, R2 and R3 substituent groups can be combined at will. The compounds are combined with NCOA4 to interfere the cell iron autophagy process and effectively inhibit the ferroptosis of various cells induced by RSL3 or Erastin. Particularly, the binding affinity of the compound 4k and NCOA4 is optimal (Kd is equal to 0.78 mu M), and the compound 4k has remarkable ferroptosis inhibition activity and can be used for research and development of medicines for ferroptosis-related diseases. # imgabs0 #

The invention discloses a novel benzofuran component in eupatorium chinense and application of the benzofuran component in anti-inflammatory activity. The obtained compound is separated from an eupatorium chinense extract. The eupatorium chinense root extract is separated by using an extraction method, macroporous adsorption resin impurity removal, Sephadex LH-20 gel column chromatography, high performance liquid chromatography and other methods. According to the present invention, all the separated compounds and the analogues thereof have good inhibition activity on target cyclooxygenase-2 of inflammation-related diseases, and have good inhibition activity on COX-2 enzyme, and the molecular docking experiment results show that the compounds and the target proteins have good binding energy. Therefore, the compound can be used for preparing drugs for treating inflammatory related diseases, or anti-inflammatory and analgesic drugs, or tumor drugs by inhibiting COX-2 enzyme, such as drugs for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, Alzheimer's disease and the like, and related natural lead compounds are provided.

The invention provides an organic metal compound and an organic light-emitting device comprising the same, and belongs to the field of organic photoelectric materials, the organic metal compound has a structure shown in a general formula I. The organic metal compound has a structure shown in a general formula I by changing the combination of substituent groups on 2-(dibenzo [b, d] furan-4-yl) pyridine, and the organic light-emitting device with the organic metal compound can be obtained by synthesizing 2-(dibenzo [b, d] furan-4-yl) pyridine. The organic metal compound is generated by adding-CN,-F, branched alkyl, substituted or non-substituted aryl and substituted or non-substituted naphthenic base, intermolecular spatial configuration is improved, the organic metal compound has good space twisting capability, carrier migration is avoided, and after the organic metal compound serves as a specific doping material of a luminescent layer and is applied to an organic electroluminescent device, the organic electroluminescent device has high luminous efficiency. The driving voltage of the device is reduced, so that carrier migration is avoided, the driving voltage is obviously reduced, the luminous efficiency is obviously improved, and the service life is obviously prolonged.

The invention relates to the technical field of organic synthesis, in particular to 1-chloro-8-fluorine-7-isopropyl benzofuro [2, 3-c] pyridine as well as a synthesis method and an application of the 1-chloro-8-fluorine-7-isopropyl benzofuro [2, 3-c] pyridine. According to the invention, 1-chloro-8-fluoro-7-isopropyl benzofuro [2, 3-c] pyridine and nanogold are cooperated to cover the surface of a glassy carbon electrode (GCE), and a novel electrochemical modified electrode AuNPs / 1 / GCE is developed. The modified glassy carbon electrode shows good selectivity, high stability and sensitivity and wide detection range on the detection of the antibiotic furacilin.

The application discloses a kind of flame-retardant expandable polystyrene and its preparation method.It includes the following raw materials: styrene, nucleating agent, desalted water, organic compound containing peroxide functional group, inorganic salt, bromine flame retardant, dispersant, solvent.The product powder and bulk material prepared by the application are less, and the prepared polystyrene board has excellent mechanical properties.After one week or even one month, no collapse, deformation and other phenomena occur, the combustion performance completely reaches B level, and has efficient flame-retardant fireproof performance.Meanwhile, the product obtained by the application has high bromine content, good thermal stability, low bleeding, no toxicity, little influence on material mechanical properties, and no toxic gas such as polybrominated dibenzo-p-dioxin and polybrominated dibenzofuran is produced during thermal cracking or combustion, which completely meets the requirements of European dioxin regulations and does not harm the environment.

Described herein are crystalline forms of (3, 5-dibromo-4-hydroxyphenyl) (2-(1-hydroxyethyl) benzofuran-3-yl-4, 5, 6, 7-d4) methanone, and solvates thereof.

The invention relates to a novel compound as well as a preparation method and application thereof, in particular to (Z / E)-1-(2, 2-dimethyl-2, 3-dihydrobenzofuran-5-yl)-3-aryl-2-(1H-pyrazol-1-yl)-2-propylene-1-ketone as well as a preparation method and application thereof in preparation of an anti-tumor drug, and discloses a preparation method of (Z / E)-1-(2, 2-dimethyl-2, 3-dihydrobenzofuran-5-yl)-3-aryl-2-(1H-pyrazol-1-yl)-2-propylene-1-ketone. The structural formula of the compound 1-(2, 2-dimethyl-2, 3-dihydrobenzofuran-5-yl)-3-aryl-2-(1H-pyrazol-1-yl)-2-propylene-1-ketone is as shown in a formula I or a formula II: # imgabs 0 #, and the structural formula of the compound 1-(2, 2-dimethyl-2, 3-dihydrobenzofuran-5-yl)-3-aryl-2-(1H-pyrazol-1-yl)-2-propylene-1-ketone is as shown in a formula II. Wherein R1 is selected from a methoxy group, an ethyoxyl group or a propoxy group; r1 is selected from methyl, methoxy, ethyoxyl, nitro, iodine, bromine, chlorine, fluorine, 2, 4-difluoro, 2, 4-dichloro, 2, 3, 4-trichloro, 2, 4-dimethoxy and 2, 3, 4-trimethoxy, and R2 is selected from methyl, methoxy, ethyoxyl, nitro, iodine, bromine, chlorine, fluorine, 2, 4-difluoro, 2, 4-dichloro, 2, 3, 4-trichloro, 2, 4-dimethoxy and 2, 3, 4-trimethoxy.

The invention relates to the field of medicines, and particularly provides 2-benzylbenzofuran and diaryl acetone compounds which are separated from a traditional Chinese medicine argillaceae and have a novel structure or pharmaceutically acceptable salts thereof, and application of the 2-benzylbenzofuran and diaryl acetone compounds or pharmaceutically acceptable salts thereof in myocardial protection. And a good myocardial protection effect is achieved.

Salt morphic forms, morphic salt mixtures, and specified salt mixtures of pharmaceutically active benzofuran compositions are provided for the treatment of mental disorders or for mental enhancement, including for entactogenic therapy. The present invention also includes salt morphic forms, morphic salt mixtures, and specified salt mixtures of benzofuran compounds, compositions thereof, and methods for generally modulating central nervous system activity and treating central nervous system disorders.

The present invention relates to an organic light-emitting device employing, as a host of a light emission layer, an anthracene derivative compound having a characteristic structure by introduction of a benzofuran structure into the anthracene backbone, and as a dopant of the light emission layer, a polycyclic compound having a characteristic structure. The organic light-emitting device according to the present invention is an organic light-emitting device with significantly improved external quantum efficiency and can be advantageously utilized not only for lighting devices but also for various display devices, such as flat, flexible, and wearable displays.

The invention relates to the technical field of organic electroluminescent devices, in particular to an organic metal iridium complex, a preparation method of the organic metal iridium complex, a luminescent material and an organic electroluminescent device. The organic metal iridium complex is selected from a compound shown in the following structural formula: # imgabs0 #, wherein R1 to R14 are respectively and independently selected from any one of hydrogen, deuterium, tritium, halogen, cyano, trimethyl silicon, trimethyl germanium, substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C6-C20 aryl and substituted or unsubstituted 4-membered to 8-membered heterocyclic radical; the number of R10 on a benzene ring of dibenzofuran in the formula 1 is 1 or 2; s1 is selected from substituted or unsubstituted dibenzofuran, and S1 is fused with any position on a benzene ring of adjacent dibenzofuran. The organic metal iridium complex is low in synthesis cost, simple in synthesis process and difficult to purify, and an organic electroluminescent device formed by the organic metal iridium complex is high in luminous efficiency, long in service life and low in driving voltage.

Provided are a compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same and a use thereof, where the compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.

The invention relates to the technical field of organic electroluminescent materials, and provides a compound, an organic electroluminescent device containing the same and an electronic device. The structure of the compound comprises a mother nucleus structure of phenanthro [2, 1-b] benzofuran, and the mother nucleus is connected with substituted triazinyl through a specific position to serve as an electron transport type main body material. When the compound is used as an electron transport type material in a mixed type main body material, the carrier balance in a light-emitting layer can be improved, the carrier recombination area can be widened, the exciton generation and utilization efficiency can be improved, the light-emitting efficiency of a device can be improved, and the service life of the device can be prolonged.

The invention discloses a preparation method of a six-membered azaspiro dihydrobenzofuran compound. According to the method, a C2-alkyne benzofuran derivative is taken as a raw material, metal palladium is taken as a catalyst, and a corresponding product is generated through reaction in an organic solvent at the temperature of 40-120 DEG C under the combined action of a ligand and acetic anhydride. Under the action of palladium, a ligand, a solvent and acetic anhydride, alkyne triple bonds and indole double bonds are subjected to triple addition and bicyclic addition, and rapid construction of a six-membered azaspiro structure dihydrobenzofuran product is achieved. The reaction conditions are mild, the operation is simple and convenient, and the method has the advantages of easily available reaction raw materials, wide substrate applicability, excellent yield and enantioselectivity, easily separated target products and the like.

The invention belongs to the technical field of lithium ion batteries, and particularly relates to a lithium ion battery high-voltage electrolyte and a lithium ion battery. The high-voltage electrolyte comprises a lithium salt, a first additive, a second additive, an auxiliary additive and an organic solvent, the first additive is a sulfur-containing siloxy boric acid ester derivative, and the second additive is a benzofuran boric acid ester derivative. Borate groups and benzofuran groups in the first additive and the second additive can promote generation of CEI and SEI protective films on the surfaces of a positive electrode and a negative electrode, the stability of the material is enhanced, electrolyte decomposition is inhibited, and the high-voltage performance of the lithium battery is improved; the trimethylsiloxy group can remove HF in the system, can reduce the corrosion to the positive and negative electrode interface of the battery, and improves the cycle performance of the battery; boron and sulfur atoms in the additive can significantly reduce the internal resistance of the battery and improve the performance of the high-voltage battery at low temperature.

The invention discloses a doping material for an organic electroluminescent layer, a preparation method and an organic electroluminescent device, a compound in the doping material adopts a specific structure, phenyl dibenzofuran groups at specific positions are introduced on dibenzofuran, and some groups are added, so that the doping material is prepared. According to the present invention, the doping material compound changes the molecular space structure, the electrochemical characteristics of the compound are adjusted, the dipole moment of the intermolecular structure is improved, the prepared compound is used as the light emitting layer doping material in the organic electroluminescent device, the driving voltage is significantly reduced, and the light emitting efficiency and the service life are significantly improved.

The utility model relates to the technical field of reaction kettles, in particular to a reaction kettle for benzofuranone hydrogenation reaction, which comprises a kettle body and a hopper mounted at the top of the kettle body and communicated with an inner cavity of the kettle body, a scraper rotatably scrapes the inner wall of the reaction kettle, reaction solution residues are reduced, normal reaction can be ensured, and air discharged through an exhaust hole can be recycled. A fan is arranged to supply air to a plurality of stirring paddles on one hand and supply air to a spray head mounted at a feeding opening of a hopper on the other hand, so that air in the reaction kettle is prevented from escaping from the hopper, and the accuracy of detecting the condition of discharged air is improved; meanwhile, the materials are accelerated to enter the reaction kettle from the hopper, so that the solid raw materials are prevented from remaining at the material inlet of the hopper, the accurate and reliable formula proportion of each substance participating in the reaction is ensured, the gas generated by the reaction is prevented from being gathered and remaining in the reaction kettle, and the accuracy of the detection result of the gas discharged by the gas outlet pipe is further improved.

A method for preparing compound 1 and compound 2 having a structure as shown below, the method includes the following steps:1) subjecting 2,3-dihydrobenzofuran-7-amine as a raw material to a selective-dibromination with a brominating reagent to obtain 4,6-dibromo-2,3-dihydrobenzofuran-7-amine;2) subjecting 4,6-dibromo-2,3-dihydrobenzofuran-7-amine obtained in the step 1) to Sandmeyer reaction for chlorination to obtain 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran;3-1) selectively debrominating from 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran obtained in the step 2) using a strong base, and then adding a formylation reagent to obtain compound 1;3-2) selectively debrominating from 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran obtained in the step 2) using a strong base, and then reacting with 4-cyclopropyl benzaldehyde to obtain compound 2.

The invention discloses a preparation method and application of a benzofuran component in eupatorium chinense. The benzofuran component is separated from an eupatorium chinense extract. The eupatorium chinense root extract is separated by using an extraction method, macroporous adsorption resin impurity removal, HW-40F gel column chromatography, high performance liquid chromatography and other methods to obtain the benzofuran compound. According to the present invention, the inhibition activity of the separated compound on the diabetes-related target alpha-glucosidase is tested, the experimental result shows that the compound has good inhibition activity on the alpha-glucosidase, and the molecular docking experiment shows that the compound has good binding energy with the target protein alpha-glucosidase. Therefore, the compound can be used for preparing drugs for preventing, delaying or treating alpha-glucosidase diseases, especially type II diabetes and obesity, or can be used as a lead compound of the drugs.

The invention relates to an intermediate of a chemical synthetic drug and a preparation method of the intermediate, in particular to an intermediate compound for preparing dronedarone and a preparation method of the intermediate compound. The intermediate is a new compound 2-n-valeryl-5-methanesulfonamide benzofuranone, and the compound can be applied to synthesis of a dronedarone drug through butt joint with 1-phenoxy-3-di-n-butylamine propane. The new intermediate is used for synthesizing dronedarone, raw materials and auxiliary materials are rich in source, low in price and easy to obtain, the process steps are short, the cost is low, the reaction conditions are mild and environmentally friendly, the target product preparation efficiency is high, no reaction device with special requirements exists, and the industrial production requirement can be met.