2- normal-butyl-5-substituted amino benzofuran and preparation method thereof

A technology represented by tert-butoxycarbonyl, applied in the field of key intermediates of dronedarone and its preparation

Active Publication Date: 2010-09-22
AVENTIS PHARMA HAINAN
View PDF6 Cites 36 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Formula Ⅰ

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • 2- normal-butyl-5-substituted amino benzofuran and preparation method thereof
  • 2- normal-butyl-5-substituted amino benzofuran and preparation method thereof
  • 2- normal-butyl-5-substituted amino benzofuran and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

Embodiment 2

Embodiment 3

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
melting pointaaaaaaaaaa
Login to view more

Abstract

The invention discloses an important intermediate of dronedarone, which relates to a dronedarone intermediate shown by a formula I, wherein R is phenylmethoxycarbonyl, or tert-butoxycarbonyl or 9-fluorenylmethoxycarbonyl.

Description

technical field The present invention relates to a key intermediate of dronedarone represented by formula I and a preparation method thereof. Background technique Dronedarone (dronedarone), the chemical name is N-[2-n-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuryl] Methylsulfonamide, developed by Sanofi-Aventis of France, can be used to treat atrial fibrillation / flutter. In July 2009, it was approved for marketing by the US Food and Drug Administration (FDA). dronedarone Atrial fibrillation is a complex disease that can increase the risk of stroke by 5 times, worsen the prognosis and triple the mortality rate of patients with cardiovascular risk factors. Atrial flutter is another type of atrial arrhythmia that occurs less frequently but may develop into atrial fibrillation. In the United States, atrial fibrillation is the leading cause of hospitalizations for arrhythmias, and the number of hospitalizations due to atrial fibrillation in the United States ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/79
Inventor 陈安平刘迎春张志强
Owner AVENTIS PHARMA HAINAN
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap