2-n-butyl-5-substituted aminobenzofuran and its preparation method

A technology of benzyloxycarbonyl and compound, applied in the key intermediate of dronedarone and its preparation field
CN101838252BActive Publication Date: 2016-05-04AVENTIS PHARMA HAINAN
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
AVENTIS PHARMA HAINAN
Publication Date
2016-05-04

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Abstract

The invention discloses an important intermediate of dronedarone, which relates to a dronedarone intermediate shown by a formula I, wherein R is phenylmethoxycarbonyl, or tert-butoxycarbonyl or 9-fluorenylmethoxycarbonyl.
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Description

technical field

[0001] The present invention relates to a key intermediate of dronedarone represented by formula I and a preparation method thereof.

[0002] Background technique

[0003] Dronedarone (dronedarone), the chemical name is N-[2-n-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuryl] Methylsulfonamide, developed by Sanofi-Aventis of France, can be used to treat atrial fibrillation / flutter. In July 2009, it was approved for marketing by the US Food and Drug Administration (FDA).

[0004]

[0005] dronedarone

[0006] Atrial fibrillation is a complex disease that can increase the risk of stroke by 5 times, worsen the prognosis and triple the mortality rate of patients with cardiovascular risk factors. Atrial flutter is another type of atrial arrhythmia that occurs less frequently but may develop into atrial fibrillation. In the United States, atrial fibrillation is the leading cause of hospitalizations for arrhythmias, and the number of hospitalizati...

Claims

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