3results about How to "Improve glucose tolerance" patented technology

The invention relates to the technical field of microorganisms, in particular to application of Zymomonas mobilis ZM4 to improvement of diabetes mellitus, which comprises the following steps: performing liquid culture, centrifugation and resuspension on the Zymomonas mobilis ZM4 with the preservation number of ATCC31821 to obtain a bacterial suspension, and then using the bacterial suspension to improve the diabetes mellitus, wherein the Zymomonas mobilis ZM4 in the bacterial suspension still has activity after being centrifuged and resuspended; the bacterial suspension does not contain a fermentation product of the Zymomonas mobilis ZM4. According to the application of the Zymomonas mobilis ZM4 in improvement of diabetes mellitus, the probiotic characteristics of the Zymomonas mobilis ZM4 are utilized to improve the types and abundance of intestinal flora, so that the blood sugar of a mouse with type II diabetes mellitus is reduced, the oral glucose tolerance of the mouse is improved, the contents of glycosylated hemoglobin, blood insulin and GLP-1 are adjusted, and the diabetes mellitus is improved. The level of inflammatory factors related to diabetes mellitus is reduced, and damaged islet cells can be improved and recovered to a certain extent.

The application discloses a polysaccharide with lipid-lowering and weight-reducing effects, and a preparation method and application thereof. The polysaccharide is obtained by extracting a crude extract from plant raw materials and performing multi-stage separation and purification, and has a single component with lipid-lowering and weight-reducing effects. The polysaccharide can reduce or control weight gain, reduce fat content or lipid load, improve or restore liver morphology, inhibit or reduce liver weight gain, inhibit or reverse liver steatosis, improve sugar and lipid metabolism, improve intestinal flora structure and the like.

The application belongs to the technical field of biological medicine, and particularly relates to Lactobacillus murinus MF26 and application thereof in prevention and treatment of heart failure. The preservation number of the Lactobacillus murinus MF26 is CCTCC NO: M 20251548, and the preservation organization is China Center for Type Culture Collection (CCTCC). The Lactobacillus murinus MF26 can significantly improve left ventricular diastolic dysfunction of HFpEF mice, reduce myocardial fibrosis, relieve high blood pressure, significantly improve intestinal barrier permeability, reduce the inflammation level of the organism, and significantly increase the GLP-1 level in serum, thereby effectively improving the fasting blood glucose level and glucose tolerance of the HFpEF mice. Therefore, the Lactobacillus murinus MF26 can be used for preparing a drug or a functional food for preventing, relieving or / and treating the heart failure with preserved ejection fraction.